Search Results - "Marche, Patrice"
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Human Endogenous Retroviruses in Neurological Diseases
Published in Trends in molecular medicine (01-04-2018)“…The causes of multiple sclerosis and amyotrophic lateral sclerosis have long remained elusive. A new category of pathogenic components, normally dormant within…”
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2
Spatial resolution in prism-based surface plasmon resonance microscopy
Published in Optics express (22-09-2014)“…Several optical surface sensing techniques, such as Surface Plasmon Resonance (SPR), work by imaging the base of a prism by one of its faces. However, such a…”
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3
Analysis of the toxicity of gold nano particles on the immune system: effect on dendritic cell functions
Published in Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology (01-01-2010)“…The effect of manufactured gold nanoparticles (NPs) on the immune system was analysed through their ability to perturb the functions of dendritic cells (DCs),…”
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4
Modulating the Crosstalk between the Tumor and Its Microenvironment Using RNA Interference: A Treatment Strategy for Hepatocellular Carcinoma
Published in International journal of molecular sciences (24-07-2020)“…Hepatocellular carcinoma (HCC) is the most common primary liver malignancy with one of the highest mortality rates among solid cancers. It develops almost…”
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5
Targeting Akt in Hepatocellular Carcinoma and Its Tumor Microenvironment
Published in International journal of molecular sciences (11-02-2021)“…Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related deaths worldwide, and its incidence is rising. HCC develops almost…”
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6
Human endogenous retrovirus protein activates innate immunity and promotes experimental allergic encephalomyelitis in mice
Published in PloS one (06-12-2013)“…Multiple sclerosis (MS) is a complex multifactorial disease of the central nervous system (CNS) for which animal models have mainly addressed downstream…”
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7
Inflammatory response of endothelial cells to a human endogenous retrovirus associated with multiple sclerosis is mediated by TLR4
Published in International immunology (01-11-2015)“…The MSRV (multiple sclerosis-associated retrovirus) belongs to the human endogenous retrovirus HERV-W family. The envelope protein originating from the MSRV…”
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Effect of Novel AKT Inhibitor Vevorisertib as Single Agent and in Combination with Sorafenib on Hepatocellular Carcinoma in a Cirrhotic Rat Model
Published in International journal of molecular sciences (19-12-2022)“…Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide. The AKT pathway is often activated in HCC cases, and a…”
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9
Tailoring nanostructured lipid carriers for the delivery of protein antigens: Physicochemical properties versus immunogenicity studies
Published in Biomaterials (01-08-2017)“…Abstract New vaccine formulations are still highly anticipated in the near-future to face incoming health challenges, such as emergence or reemergence of…”
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10
Immune checkpoints on T and NK cells in the context of HBV infection: Landscape, pathophysiology and therapeutic exploitation
Published in Frontiers in immunology (28-03-2023)“…In hepatitis B virus (HBV) infection, the interplay between the virus and the host immune system is crucial in determining the pathogenesis of the disease…”
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11
Enantioselective Approach for Expanding the Three‐Dimensional Space of Tetrahydroquinoline to Develop BET Bromodomain Inhibitors
Published in Chemistry : a European journal (16-11-2022)“…The pharmaceutical industry has a pervasive need for chiral specific molecules with optimal affinity for their biological targets. However, the mass production…”
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12
Induction of Proinflammatory Multiple Sclerosis-Associated Retrovirus Envelope Protein by Human Herpesvirus-6A and CD46 Receptor Engagement
Published in Frontiers in immunology (06-12-2018)“…The aberrant expression of human endogenous retrovirus (HERV) elements of the HERV-W family has been associated with different diseases, including multiple…”
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13
Intracellular accumulation and immunological response of NIR-II polymeric nanoparticles
Published in International journal of pharmaceutics (05-01-2023)“…[Display omitted] Polymeric nanoparticles (NPs) are extremely promising for theranostic applications. However, their interest depends largely on their…”
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14
Synthesis and use of an amphiphilic dendrimer for siRNA delivery into primary immune cells
Published in Nature protocols (01-01-2021)“…Using siRNAs to genetically manipulate immune cells is important to both basic immunological studies and therapeutic applications. However, siRNA delivery is…”
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15
Hepatitis C virus (HCV) evades NKG2D-dependent NK cell responses through NS5A-mediated imbalance of inflammatory cytokines
Published in PLoS pathogens (01-11-2010)“…Understanding how hepatitis C virus (HCV) induces and circumvents the host's natural killer (NK) cell-mediated immunity is of critical importance in efforts to…”
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16
Predictive toxicology of cobalt ferrite nanoparticles: comparative in-vitro study of different cellular models using methods of knowledge discovery from data
Published in Particle and fibre toxicology (29-07-2013)“…Cobalt-ferrite nanoparticles (Co-Fe NPs) are attractive for nanotechnology-based therapies. Thus, exploring their effect on viability of seven different cell…”
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DEN-Induced Rat Model Reproduces Key Features of Human Hepatocellular Carcinoma
Published in Cancers (04-10-2021)“…Hepatocellular carcinoma (HCC) is the most common type of liver cancer. The majority of HCC cases are associated with liver fibrosis or cirrhosis developing…”
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18
Modeling Diet-Induced NAFLD and NASH in Rats: A Comprehensive Review
Published in Biomedicines (02-04-2021)“…Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, characterized by hepatic steatosis without any alcohol abuse. As the…”
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The Envelope Protein of a Human Endogenous Retrovirus-W Family Activates Innate Immunity through CD14/TLR4 and Promotes Th1-Like Responses
Published in Journal of Immunology (15-06-2006)“…Multiple sclerosis-associated retroviral element (MSRV) is a retroviral element, the sequence of which served to define the W family of human endogenous…”
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20
A Top-Down Synthesis Route to Ultrasmall Multifunctional Gd-Based Silica Nanoparticles for Theranostic Applications
Published in Chemistry : a European journal (03-05-2013)“…New, ultrasmall nanoparticles with sizes below 5 nm have been obtained. These small rigid platforms (SRP) are composed of a polysiloxane matrix with DOTAGA…”
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