Search Results - "Marchalonis, John J."

Characterization of arrangement and expression of the T cell receptor γ locus in the sandbar shark by Chen, Hao, Kshirsagar, Sarika, Jensen, Ingvill, Lau, Kevin, Covarrubias, Roman, Schluter, Samuel F, Marchalonis, John J

“…Ig and T cell receptor (TCR) genes consist of separate genomic elements, which must undergo rearrangement and joining before a functional protein can be…”
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Cloning of a Functional Vitamin D Receptor from the Lamprey (Petromyzon marinus), an Ancient Vertebrate Lacking a Calcified Skeleton and Teeth by Whitfield, G. Kerr, Dang, Hope T. L, Schluter, Samuel F, Bernstein, Ralph M, Bunag, Tara, Manzon, Lori A, Hsieh, Grace, Encinas Dominguez, Carlos, Youson, John H, Haussler, Mark R, Marchalonis, John J

“…The nuclear vitamin D receptor (VDR) mediates the actions of its 1,25-dihydroxyvitamin D3 ligand to control gene expression in terrestrial vertebrates…”
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Evolution of the acute phase response: iron release by echinoderm ( Asterias forbesi) coelomocytes, and cloning of an echinoderm ferritin molecule by Beck, Gregory, Ellis, Thomas W., Habicht, Gail S., Schluter, Samuel F., Marchalonis, John J.

“…That the plasma concentration of certain divalent cations change during an inflammatory insult provides a major host defense response in vertebrate animals…”
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A role for T lymphocytes in mediating cardiac diastolic function by Yu, Qianli, Watson, Ronald R, Marchalonis, John J, Larson, Douglas F

“…The induction of T helper (TH) lymphocytes by distinct TH ligands results in a differentiation to TH1/TH2 subsets based on their unique pattern of cytokine…”
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Cloning of shark RAG2 and characterization of the RAG1/RAG2 gene locus by Schluter, Samuel F., Marchalonis, John J.

“…The recombination‐activating genes (RAG) encode a site‐specific recombinase that is centrally responsible for the rearrangement of genomic V(D)J exons…”
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Natural recognition repertoire and the evolutionary emergence of the combinatorial immune system by Marchalonis, John J., Kaveri, Srini, Lacroix‐Desmazes, Sébastien, Kazatchkine, Michel D.

“…ABSTRACT The primordial combinatorial immune recognition repertoire arose in the evolution of jawed vertebrates ~450 million years ago as a rapid genetic…”
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The antibody repertoire in evolution: Chance, selection, and continuity by Marchalonis, John J., Adelman, Miranda K., Schluter, Samuel F., Ramsland, Paul A.

“…All jawed vertebrates contain the genetic elements essential for the function of the adaptive/combinatorial immune response, have diverse sets of natural…”
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Endogenous Retroviruses in Systemic Lupus Erythematosus: Candidate Lupus Viruses by Adelman, Miranda K., Marchalonis, John J.

“…Although the etiology of systemic lupus erythematosus (SLE) remains unclear, there is substantial circumstantial evidence that the development of SLE is…”
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Primordial Emergence of the Recombination Activating Gene 1 (RAG1): Sequence of the Complete Shark Gene Indicates Homology to Microbial Integrases by Bernstein, Ralph M., Schluter, Samuel F., Bernstein, Harris, Marchalonis, John J.

“…The rearrangement of antibody and T-cell receptor gene segments is indispensable to the vertebrate immune response. All extant jawed vertebrates can rearrange…”
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Rapid clearance of bacteria and their toxins: development of therapeutic proteins by Kunkel, Meghan, Vuyisich, Momchilo, Gnanakaran, Gnana, Bruening, George E, Dandekar, Abhaya M, Civerolo, Edwin, Marchalonis, John J, Gupta, Goutam

“…The emergence of pathogens and toxins with resistance against conventional drugs, vaccines, and host defense peptides and proteins warrants novel…”
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The natural antibody repertoire of sharks and humans recognizes the potential universe of antigens by Adelman, Miranda K, Schluter, Samuel F, Marchalonis, John J

“…In ancestral sharks, a rapid emergence in the evolution of the immune system occurred, giving jawed-vertebrates the necessary components for the combinatorial…”
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IgT lives! A matter of semantics? by Marchalonis, John J, Cone, Robert E

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A New High Molecular Weight Immunoglobulin Class from the Carcharhine Shark: Implications for the Properties of the Primordial Immunoglobulin by Bernstein, Ralph M., Schluter, Samuel F., Shen, Shanxiang, Marchalonis, John J.

“…All immunoglobulins and T-cell receptors throughout phylogeny share regions of highly conserved amino acid sequence. To identify possible primitive…”
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Recombinant shark natural antibodies to thyroglobulin by Schluter, Samuel F., Jensen, Ingvill, Ramsland, Paul A., Marchalonis, John J.

“…As cartilaginous fish are the vertebrates most distal from man to produce antibodies, fundamental information regarding conservation and variation of the…”
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Specificity mapping of human anti‐T cell receptor monoclonal natural antibodies: defining the properties of epitope recognition promiscuity by Robey, Ian F., Edmundson, Allen B., Schluter, Samuel F., Yocum, David E., Marchalonis, John J.

“…The classical concept of antibody binding is defined as an exclusive and high‐affinity interaction with one epitope. The emerging reality about antibody…”
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Structural, antigenic and evolutionary analyses of immunoglobulins and T cell receptors by Marchalonis, John J., Jensen, Ingvill, Schluter, Samuel F.

“…We have had the pleasure of collaborating with Allen Edmundson for the past 15 years on the structure, binding properties and evolution of immunoglobulins and…”
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Human monoclonal natural autoantibodies against the T‐cell receptor inhibit interleukin‐2 production in murine T cells by Robey, Ian F., Schluter, Samuel F., Akporiaye, Emmanuel, Yocum, David E., Marchalonis, John J.

“…Summary Natural autoantibodies (NAAbs) specific for the T‐cell receptor (TCR) are present in all human sera, but individuals with rheumatoid arthritis (RA)…”
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Response to the Letter from Dr. van Oss by Adelman, Miranda K., Schluter, Samuel F., Marchalonis, John J.

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Heavy‐chain variable regions in carcharhine sharks: Development of a comprehensive model for the evolution of V H domains among the gnathanstomes by SHEN, SHAN XIANG, BERNSTEIN, RALPH M, SCHLUTER, SAMUEL F, MARCHALONIS, JOHN J

“…Summary We determined the sequence of 18 DNA clones encoding V H regions of sandbar shark and bull shark. All of these sequences exhibit key structural coding…”
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Rapid Evolutionary Emergence of the Combinatorial Recognition Repertoire by Marchalonis, John J., Whitfield, G. Kerr, Schluter, Samuel F.

“…Although the capacity of cells to respond to environmental challenges such as oxidative damage are ancient evolutionary developments that have been carried…”
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