Search Results - "Marchán, Vicente"

A Green Light-Triggerable RGD Peptide for Photocontrolled Targeted Drug Delivery: Synthesis and Photolysis Studies by Gandioso, Albert, Cano, Marc, Massaguer, Anna, Marchán, Vicente

“…We describe for the first time the synthesis and photochemical properties of a coumarin-caged cyclic RGD peptide and demonstrate that uncaging can be…”
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Photocontrolled DNA Binding of a Receptor-Targeted Organometallic Ruthenium(II) Complex by Barragán, Flavia, López-Senín, Paula, Salassa, Luca, Betanzos-Lara, Soledad, Habtemariam, Abraha, Moreno, Virtudes, Sadler, Peter J, Marchán, Vicente

“…A photoactivated ruthenium(II) arene complex has been conjugated to two receptor-binding peptides, a dicarba analogue of octreotide and the Arg-Gly-Asp (RGD)…”
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Exploring Structural-Photophysical Property Relationships in Mitochondria-Targeted Deep-Red/NIR-Emitting Coumarins by Izquierdo-García, Eduardo, Rovira, Anna, Forcadell, Joan, Bosch, Manel, Marchán, Vicente

“…Organic fluorophores operating in the optical window of biological tissues, namely in the deep-red and near-infrared (NIR) region of the electromagnetic…”
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Synthesis of Janus Compounds for the Recognition of G‑U Mismatched Nucleobase Pairs by Artigas, Gerard, Marchán, Vicente

“…The design and synthesis of two Janus-type heterocycles with the capacity to simultaneously recognize guanine and uracyl in G-U mismatched pairs through…”
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Synthesis and Tau RNA Binding Evaluation of Ametantrone-Containing Ligands by Artigas, Gerard, Marchán, Vicente

“…We describe the synthesis and characterization of ametantrone-containing RNA ligands based on the derivatization of this intercalator with two neamine moieties…”
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Exploring the HIV-1 Rev Recognition Element (RRE)–Rev Inhibitory Capacity and Antiretroviral Action of Benfluron Analogs by Chumillas, Sergi, Loharch, Saurabh, Beltrán, Manuela, Szewczyk, Mateusz P., Bernal, Silvia, Puertas, Maria C., Martinez-Picado, Javier, Alcamí, José, Bedoya, Luis M., Marchán, Vicente, Gallego, José

“…Human immunodeficiency virus-type 1 (HIV-1) remains one of the leading contributors to the global burden of disease, and novel antiretroviral agents with…”
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A simple method for the synthesis of N-difluoromethylated pyridines and 4-pyridones/quinolones by using BrCF2COOEt as the difluoromethylation reagent by Gandioso, Albert, Mohamed El Fakiri, Rovira, Anna, Marchán, Vicente

“…We describe a novel transition metal-free method for the synthesis of N-difluoromethylated pyridines and 4-pyridones/quinolones by using readily available…”
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SARS-CoV-2 Inhibitors Identified by Phenotypic Analysis of a Collection of Viral RNA-Binding Molecules by Simba-Lahuasi, Alvaro, Cantero-Camacho, Ángel, Rosales, Romel, McGovern, Briana Lynn, Rodríguez, M Luis, Marchán, Vicente, White, Kris M, García-Sastre, Adolfo, Gallego, José

“…Antiviral agents are needed for the treatment of SARS-CoV-2 infections and to control other coronavirus outbreaks that may occur in the future. Here we report…”
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Identification of Ligands for the Tau Exon 10 Splicing Regulatory Element RNA by Using Dynamic Combinatorial Chemistry by López-Senín, Paula, Gómez-Pinto, Irene, Grandas, Anna, Marchán, Vicente

“…We describe the use of dynamic combinatorial chemistry (DCC) to identify ligands for the stem‐loop structure located at the exon 10‐5′‐intron junction of Tau…”
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Novel Tumor-Targeted Self-Nanostructured and Compartmentalized Water-in-Oil-in-Water Polyurethane-Polyurea Nanocapsules for Cancer Theragnosis by Bonelli, Joaquín, Velasco-de Andrés, María, Isidro, Neus, Bayó, Cristina, Chumillas, Sergi, Carrillo-Serradell, Laura, Casadó-Llombart, Sergi, Mok, Cheryl, Benítez-Ribas, Daniel, Lozano, Francisco, Rocas, Josep, Marchán, Vicente

“…Encapsulation of water-soluble bioactive compounds for enabling specific accumulation in tumor locations, while avoiding premature clearance and/or degradation…”
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Solid-phase synthesis and DNA binding studies of dichloroplatinum(ii) conjugates of dicarba analogues of octreotide as new anticancer drugs by Barragán, Flavia, Moreno, Virtudes, Marchán, Vicente

“…The first dichloroplatinum(ii) conjugates of dicarba analogues of octreotide, which is expected to act as a 'tumour-targeting device', have been efficiently…”
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Exploring the effect of aminoglycoside guanidinylation on ligands for Tau exon 10 splicing regulatory element RNA by López-Senín, Paula, Artigas, Gerard, Marchán, Vicente

“…We describe the effect of guanidinylation of the aminoglycoside moiety on acridine-neamine-containing ligands for the stem-loop structure located at the exon…”
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Multivariate Curve Resolution Applied to the Analysis and Resolution of Two-Dimensional [1H,15N] NMR Reaction Spectra by Jaumot, Joaquim, Marchán, Vicente, Gargallo, Raimundo, Grandas, Anna, Tauler, Romà

“…Multivariate curve resolution is proposed for the study of complex chemical reactions monitored by two-dimensional (2D) NMR spectroscopy. In particular, in…”
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COUPY Coumarins as Novel Mitochondria-Targeted Photodynamic Therapy Anticancer Agents by Ortega-Forte, Enrique, Rovira, Anna, Gandioso, Albert, Bonelli, Joaquín, Bosch, Manel, Ruiz, José, Marchán, Vicente

“…Photodynamic therapy (PDT) for cancer treatment has drawn increased attention over the last decades. Herein, we introduce a novel family of…”
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Redesigning the Coumarin Scaffold into Small Bright Fluorophores with Far-Red to Near-Infrared Emission and Large Stokes Shifts Useful for Cell Imaging by Gandioso, Albert, Bresolí-Obach, Roger, Nin-Hill, Alba, Bosch, Manel, Palau, Marta, Galindo, Alex, Contreras, Sara, Rovira, Anna, Rovira, Carme, Nonell, Santi, Marchán, Vicente

“…Among the palette of previously described fluorescent organic molecules, coumarins are ideal candidates for developing cellular and molecular imaging tools due…”
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Development of Green/Red-Absorbing Chromophores Based on a Coumarin Scaffold That Are Useful as Caging Groups by Gandioso, Albert, Contreras, Sara, Melnyk, Ivanna, Oliva, Javier, Nonell, Santi, Velasco, Dolores, García-Amorós, Jaume, Marchán, Vicente

“…We report the design, synthesis, and spectroscopic characterization of a series of push–pull chromophores based on a novel coumarin scaffold in which the…”
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Towards Novel Photodynamic Anticancer Agents Generating Superoxide Anion Radicals: A Cyclometalated IrIII Complex Conjugated to a Far‐Red Emitting Coumarin by Novohradsky, Vojtech, Rovira, Anna, Hally, Cormac, Galindo, Alex, Vigueras, Gloria, Gandioso, Albert, Svitelova, Marie, Bresolí‐Obach, Roger, Kostrhunova, Hana, Markova, Lenka, Kasparkova, Jana, Nonell, Santi, Ruiz, José, Brabec, Viktor, Marchán, Vicente

“…Although cyclometalated IrIII complexes have emerged as promising photosensitizers for photodynamic therapy, some key drawbacks still hamper clinical…”
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Modulating Photostability and Mitochondria Selectivity in Far-Red/NIR Emitting Coumarin Fluorophores through Replacement of Pyridinium by Pyrimidinium by Rovira, Anna, Pujals, Miriam, Gandioso, Albert, López-Corrales, Marta, Bosch, Manel, Marchán, Vicente

“…Mitochondrial dysfunction has been associated with several human pathological conditions, including cancer, aging, and neurodegenerative diseases. Thus, the…”
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Mitochondria-Targeted COUPY Photocages: Synthesis and Visible-Light Photoactivation in Living Cells by López-Corrales, Marta, Rovira, Anna, Gandioso, Albert, Nonell, Santi, Bosch, Manel, Marchán, Vicente

“…Releasing bioactive molecules in specific subcellular locations from the corresponding caged precursors offers great potential in photopharmacology, especially…”
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High Photostability in Nonconventional Coumarins with Far-Red/NIR Emission through Azetidinyl Substitution by Gandioso, Albert, Palau, Marta, Bresolí-Obach, Roger, Galindo, Alex, Rovira, Anna, Bosch, Manel, Nonell, Santi, Marchán, Vicente

“…Replacement of electron-donating N,N-dialkyl groups with three- or four-membered cyclic amines (e.g., aziridine and azetidine, respectively) has been described…”
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