Search Results - "Marcelo, Kathrina L."

Regulation of Endothelial Cell Differentiation and Specification by Marcelo, Kathrina L, Goldie, Lauren C, Hirschi, Karen K

“…The circulatory system is the first organ system to develop in the vertebrate embryo and is critical throughout gestation for the delivery of oxygen and…”
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Hemogenic Endothelial Cell Specification Requires c-Kit, Notch Signaling, and p27-Mediated Cell-Cycle Control by Marcelo, Kathrina L., Sills, Tiffany M., Coskun, Suleyman, Vasavada, Hema, Sanglikar, Supriya, Goldie, Lauren C., Hirschi, Karen K.

“…Delineating the mechanism or mechanisms that regulate the specification of hemogenic endothelial cells from primordial endothelium is critical for optimizing…”
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The camKK2/camKIV relay is an essential regulator of hepatic cancer by Lin, Fumin, Marcelo, Kathrina L., Rajapakshe, Kimal, Coarfa, Cristian, Dean, Adam, Wilganowski, Nathaniel, Robinson, Holly, Sevick, Eva, Bissig, Karl‐Dimiter, Goldie, Lauren C., Means, Anthony R., York, Brian

“…Hepatic cancer is one of the most lethal cancers worldwide. Here, we report that the expression of Ca2+/calmodulin‐dependent protein kinase kinase 2 (CaMKK2)…”
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The Ca2+ /Calmodulin/CaMKK2 Axis: Nature's Metabolic CaMshaft by Marcelo, Kathrina L, Means, Anthony R, York, Brian

“…Calcium (Ca2+ ) is an essential ligand that binds its primary intracellular receptor calmodulin (CaM) to trigger a variety of downstream processes and…”
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The Ca(2+)/Calmodulin/CaMKK2 Axis: Nature's Metabolic CaMshaft by Marcelo, Kathrina L, Means, Anthony R, York, Brian

“…Calcium (Ca(2+)) is an essential ligand that binds its primary intracellular receptor calmodulin (CaM) to trigger a variety of downstream processes and…”
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Tumor Genotype Is Shaping Immunophenotype and Responses to Immune Checkpoint Inhibitors in Solid Tumors by Marcelo-Lewis, Kathrina L, Moorthy, Shhyam, Ileana-Dumbrava, Ecaterina

“…A major breakthrough in cancer treatment was ushered in by the development of immune checkpoint blockade therapy such as anti-CTLA4 antibody and anti-PD-1 and…”
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Pharmacological inhibition of CaMKK2 with the selective antagonist STO-609 regresses NAFLD by York, Brian, Li, Feng, Lin, Fumin, Marcelo, Kathrina L., Mao, Jianqiang, Dean, Adam, Gonzales, Naomi, Gooden, David, Maity, Suman, Coarfa, Cristian, Putluri, Nagireddy, Means, Anthony R.

“…Binding of calcium to its intracellular receptor calmodulin (CaM) activates a family of Ca 2+ /CaM-dependent protein kinases. CaMKK2 (Ca 2+ /CaM-dependent…”
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The Ca 2+ /Calmodulin/CaMKK2 Axis: Nature's Metabolic CaMshaft by Marcelo, Kathrina L., Means, Anthony R., York, Brian

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Research Resource: Roles for Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) in Systems Metabolism by Marcelo, Kathrina L, Ribar, Thomas, Means, Christopher R, Tsimelzon, Anna, Stevens, Robert D, Ilkayeva, Olga, Bain, James R, Hilsenbeck, Susan G, Newgard, Christopher B, Means, Anthony R, York, Brian

“…A number of epidemiological studies have implicated calcium (Ca2+) signaling as a major factor in obesity that contributes to aberrant systems metabolism…”
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Genetic and Environmental Models of Circadian Disruption Link SRC-2 Function to Hepatic Pathology by Fleet, Tiffany, Stashi, Erin, Zhu, Bokai, Rajapakshe, Kimal, Marcelo, Kathrina L., Kettner, Nicole M., Gorman, Blythe K., Coarfa, Cristian, Fu, Loning, O’Malley, Bert W., York, Brian

“…Circadian rhythmicity is a fundamental process that synchronizes behavioral cues with metabolic homeostasis. Disruption of daily cycles due to jet lag or shift…”
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HRAS Mutations Define a Distinct Subgroup in Head and Neck Squamous Cell Carcinoma by Coleman, Niamh, Marcelo, Kathrina L, Hopkins, Julia F, Khan, Nusrat Israr, Du, Robyn, Hong, Lingzhi, Park, Edward, Balsara, Binaifer, Leoni, Mollie, Pickering, Curtis, Myers, Jeffrey, Heymach, John, Albacker, Lee A, Hong, David, Gillison, Maura, Le, Xiuning

“…In head and neck squamous cell carcinoma (HNSCC), mutation is a new actionable oncogene driver. We aimed to evaluate mutational variants, comutation profile,…”
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Pre-clinical animal models are poor predictors of human toxicities in phase 1 oncology clinical trials by Atkins, Johnique T., George, Goldy C., Hess, Kenneth, Marcelo-Lewis, Kathrina L., Yuan, Ying, Borthakur, Gautam, Khozin, Sean, LoRusso, Patricia, Hong, David S.

“…Background Our objective was to determine the correlation between preclinical toxicity found in animal models (mouse, rat, dog and monkey) and clinical…”
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Isolation of Murine Embryonic Hemogenic Endothelial Cells by Fang, Jennifer S, Gritz, Emily C, Marcelo, Kathrina L, Hirschi, Karen K

“…The specification of hemogenic endothelial cells from embryonic vascular endothelium occurs during brief developmental periods within distinct tissues, and is…”
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Isolation of Murine Embryonic Hemogenic Endothelial Cells by Fang, Jennifer S., Gritz, Emily C., Marcelo, Kathrina L., Hirschi, Karen K.

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Retinoic Acid Regulation of Hemogenic Endothelial Cell Specification Requires c-Kit, Notch Signaling and p27-mediated Cell Cycle Control by Marcelo, Kathrina L., Sills, Tiffany M., Coskun, Suleyman, Vasavada, Hema, Sanglikar, Supriya, Goldie, Lauren C., Hirschi, Karen K.

“…Delineating the mechanism(s) that regulate the specification of hemogenic endothelial cells from primordial endothelium is critical for optimizing their…”
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