Search Results - "Marcellini, Valentina"

Synthesis and biological activity evaluation of 3-(hetero) arylideneindolin-2-ones as potential c-Src inhibitors by Princiotto, Salvatore, Musso, Loana, Manetti, Fabrizio, Marcellini, Valentina, Maga, Giovanni, Crespan, Emmanuele, Perini, Cecilia, Zaffaroni, Nadia, Beretta, Giovanni Luca, Dallavalle, Sabrina

“…Inhibition of c-Src is considered one of the most studied approaches to cancer treatment, with several heterocyclic compounds approved during the last 15 years…”
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Defective peripheral B cell selection in common variable immune deficiency patients with autoimmune manifestations by Friman, Vanda, Quinti, Isabella, Davydov, Alexey N., Shugay, Mikhail, Farroni, Chiara, Engström, Erik, Pour Akaber, Shirin, Barresi, Sabina, Mohamed, Ahmed, Pulvirenti, Federica, Milito, Cinzia, Granata, Guido, Giorda, Ezio, Ahlström, Sara, Karlsson, Johanna, Marasco, Emiliano, Marcellini, Valentina, Bocci, Chiara, Cascioli, Simona, Scarsella, Marco, Phad, Ganesh, Tilevik, Andreas, Tartaglia, Marco, Bemark, Mats, Chudakov, Dmitriy M., Carsetti, Rita, Grimsholm, Ola

“…Common variable immune deficiency (CVID) is a heterogeneous disorder characterized by recurrent infections, low levels of serum immunoglobulins, and impaired…”
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Dysregulated miR-155 and miR-125b Are Related to Impaired B-cell Responses in Down Syndrome by Farroni, Chiara, Marasco, Emiliano, Marcellini, Valentina, Giorda, Ezio, Valentini, Diletta, Petrini, Stefania, D'Oria, Valentina, Pezzullo, Marco, Cascioli, Simona, Scarsella, Marco, Ugazio, Alberto G, De Vincentiis, Giovanni C, Grimsholm, Ola, Carsetti, Rita

“…Children with Down Syndrome (DS) suffer from immune deficiency with a severe reduction in switched memory B cells (MBCs) and poor response to vaccination…”
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Functional CVIDs phenotype clusters identified by the integration of immune parameters after BNT162b2 boosters by Piano Mortari, Eva, Pulvirenti, Federica, Marcellini, Valentina, Terreri, Sara, Salinas, Ane Fernandez, Ferrari, Simona, Di Napoli, Giulia, Guadagnolo, Daniele, Sculco, Eleonora, Albano, Christian, Guercio, Marika, Di Cecca, Stefano, Milito, Cinzia, Garzi, Giulia, Pesce, Anna Maria, Bonanni, Livia, Sinibaldi, Matilde, Bordoni, Veronica, Di Cecilia, Serena, Accordini, Silvia, Castilletti, Concetta, Agrati, Chiara, Quintarelli, Concetta, Zaffina, Salvatore, Locatelli, Franco, Carsetti, Rita, Quinti, Isabella

“…Assessing the response to vaccinations is one of the diagnostic criteria for Common Variable Immune Deficiencies (CVIDs). Vaccination against SARS-CoV-2…”
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Effects of Pidotimod on recurrent respiratory infections in children with Down syndrome: a retrospective Italian study by Valentini, Diletta, Di Camillo, Chiara, Mirante, Nadia, Marcellini, Valentina, Carsetti, Rita, Villani, Alberto

“…Children with Down syndrome (DS) show a high susceptibility to recurrent infections (RI), caused by immune defects and abnormalities of the airways. Our goal…”
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Preserved antibody levels and loss of memory B cells against pneumococcus and tetanus after splenectomy: Tailoring better vaccination strategies by Rosado, M. Manuela, Gesualdo, Francesco, Marcellini, Valentina, Di Sabatino, Antonio, Corazza, Gino Roberto, Smacchia, Maria Paola, Nobili, Bruno, Baronci, Carlo, Russo, Lidia, Rossi, Francesca, Vito, Rita De, Nicolosi, Luciana, Inserra, Alessandro, Locatelli, Franco, Tozzi, Alberto E., Carsetti, Rita

“…Splenectomized patients are exposed to an increased risk of septicemia caused by encapsulated bacteria. Defense against infection is ensured by preformed serum…”
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Humoral and cellular immune response after mRNA SARS-CoV-2 vaccine in children on treatment for cancer: A pilot observational study by Mastronuzzi, Angela, Carsetti, Rita, De Ioris, Maria Antonietta, Agrati, Chiara, Del Baldo, Giada, Russo, Cristina, Cefalo, Maria Giuseppina, Merli, Pietro, Perno, Carlo Federico, dell'Anna, Vito Andrea, Serra, Annalisa, Bordoni, Veronica, Piano Mortari, Eva, Marcellini, Valentina, Albano, Christian, Linardos, Giulia, Costabile, Valentino, Sinibaldi, Matilde, Guercio, Marika, di Cecca, Stefano, Quintarelli, Concetta, Locatelli, Franco

“…Immunocompromised children are at risk of developing severe COVID-19 infection. We conducted a pilot prospective study to evaluate the impact of cancer…”
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Protection against Pertussis in Humans Correlates to Elevated Serum Antibodies and Memory B Cells by Marcellini, Valentina, Piano Mortari, Eva, Fedele, Giorgio, Gesualdo, Francesco, Pandolfi, Elisabetta, Midulla, Fabio, Leone, Pasqualina, Stefanelli, Paola, Tozzi, Alberto Eugenio, Carsetti, Rita

“…Pertussis is a respiratory infection caused by that may be particularly severe and even lethal in the first months of life when infants are still too young to…”
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B-cell hyperfunction in children with immune thrombocytopenic purpura persists after splenectomy by Giordano, Paola, Cascioli, Simona, Lassandro, Giuseppe, Marcellini, Valentina, Cardinale, Fabio, Valente, Federica, Locatelli, Franco, Carsetti, Rita

“…Background: Immune thrombocytopenic purpura (ITP) is characterized by reduced platelet count secondary to immune-mediated destruction, this results in an…”
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Reduced numbers of switched memory B cells with high terminal differentiation potential in Down syndrome by Carsetti, Rita, Valentini, Diletta, Marcellini, Valentina, Scarsella, Marco, Marasco, Emiliano, Giustini, Ferruccio, Bartuli, Andrea, Villani, Alberto, Ugazio, Alberto G.

“…Children with Down syndrome (DS) have increased susceptibility to infections and a high frequency of leukemia and autoimmune disorders, suggesting that…”
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Generation of switched memory B cells in response to vaccination in Down syndrome children and their siblings by Valentini, Diletta, Marcellini, Valentina, Bianchi, Simona, Villani, Alberto, Facchini, Marzia, Donatelli, Isabella, Castrucci, Maria Rita, Marasco, Emiliano, Farroni, Chiara, Carsetti, Rita

“…Highlights • Down syndrome is associated to a reduction of switched memory B cells. • Impaired production of specific switched memory B cells after primary…”
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The Interplay between CD27(dull) and CD27(brig)(ht) B Cells Ensures the Flexibility, Stability, and Resilience of Human B Cell Memory by Grimsholm, O., Mortari, E. P., Davydov, A. N., Shugay, M., Obraztsova, A. S., Bocci, C., Marasco, E., Marcellini, V., Aranburu, Alaitz, Farroni, C., Silvestris, D. A., Cristofoletti, C., Giorda, E., Scarsella, M., Cascioli, S., Barresi, S., Lougaris, V., Plebani, A., Cancrini, C., Finocchi, A., Moschese, V., Valentini, D., Vallone, C., Signore, F., de Vincentiis, G., Zaffina, S., Russo, G., Gallo, A., Locatelli, F., Tozzi, A. E., Tartaglia, M., Chudakov, D. M., Carsetti, R.

“…Memory B cells (MBCs) epitomize the adaptation of the immune system to the environment. We identify two MBC subsets in peripheral blood, CD27(dull) and…”
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Human B‐cell memory is shaped by age‐ and tissue‐specific T‐independent and GC‐dependent events by Aranburu, Alaitz, Piano Mortari, Eva, Baban, Anwar, Giorda, Ezio, Cascioli, Simona, Marcellini, Valentina, Scarsella, Marco, Ceccarelli, Sara, Corbelli, Sandro, Cantarutti, Nicoletta, Vito, Rita, Inserra, Alessandro, Nicolosi, Luciana, Lanfranchi, Arnalda, Porta, Fulvio, Cancrini, Caterina, Finocchi, Andrea, Carsetti, Rita

“…Switched and IgM memory B cells execute different and noninterchangeable functions. We studied memory B cells in children of different ages, in peripheral…”
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B‐cell activation with CD40L or CpG measures the function of B‐cell subsets and identifies specific defects in immunodeficient patients by Marasco, Emiliano, Farroni, Chiara, Cascioli, Simona, Marcellini, Valentina, Scarsella, Marco, Giorda, Ezio, Piano Mortari, Eva, Leonardi, Lucia, Scarselli, Alessia, Valentini, Diletta, Cancrini, Caterina, Duse, Marzia, Grimsholm, Ola, Carsetti, Rita

“…Around 65% of primary immunodeficiencies are antibody deficiencies. Functional tests are useful tools to study B‐cell functions in vitro. However, no accepted…”
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Parents as source of pertussis transmission in hospitalized young infants by Fedele, Giorgio, Carollo, Maria, Palazzo, Raffaella, Stefanelli, Paola, Pandolfi, Elisabetta, Gesualdo, Francesco, Tozzi, Alberto Eugenio, Carsetti, Rita, Villani, Alberto, Nicolai, Ambra, Midulla, Fabio, Ausiello, Clara Maria

“…Purpose This study was planned to collect evidences of familial pertussis transmission to infants younger than 6 months of age. Understanding the dynamics of…”
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Repeated vaccinations do not improve specific immune defenses against Hepatitis B in non-responder health care workers by Zaffina, Salvatore, Marcellini, Valentina, Santoro, Anna Paola, Scarsella, Marco, Camisa, Vincenzo, Vinci, Maria Rosaria, Musolino, Anna Maria, Nicolosi, Luciana, Rosado, M. Manuela, Carsetti, Rita

“…Abstract Hepatitis B is a major infectious occupational hazard for health care workers and can be prevented with a safe and effective vaccine. The serum titer…”
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Infants hospitalized for Bordetella pertussis infection commonly have respiratory viral coinfections by Frassanito, A, Nenna, R, Nicolai, A, Pierangeli, A, Tozzi, A E, Stefanelli, P, Carsetti, R, Concato, C, Schiavoni, I, Midulla, F

“…Whether viral coinfections cause more severe disease than Bordetella pertussis (B. pertussis) alone remains unclear. We compared clinical disease severity and…”
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The Interplay between CD27dull and CD27bright B Cells Ensures the Flexibility, Stability, and Resilience of Human B Cell Memory by Grimsholm, Ola, Piano Mortari, Eva, Davydov, Alexey N., Shugay, Mikhail, Obraztsova, Anna S., Bocci, Chiara, Marasco, Emiliano, Marcellini, Valentina, Aranburu, Alaitz, Farroni, Chiara, Silvestris, Domenico Alessandro, Cristofoletti, Cristina, Giorda, Ezio, Scarsella, Marco, Cascioli, Simona, Barresi, Sabina, Lougaris, Vassilios, Plebani, Alessandro, Cancrini, Caterina, Finocchi, Andrea, Moschese, Viviana, Valentini, Diletta, Vallone, Cristina, Signore, Fabrizio, de Vincentiis, Giovanni, Zaffina, Salvatore, Russo, Giandomenico, Gallo, Angela, Locatelli, Franco, Tozzi, Alberto E., Tartaglia, Marco, Chudakov, Dmitriy M., Carsetti, Rita

“…Memory B cells (MBCs) epitomize the adaptation of the immune system to the environment. We identify two MBC subsets in peripheral blood, CD27dull and…”
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Severe pertussis infection in infants less than 6 months of age: Clinical manifestations and molecular characterization by Stefanelli, Paola, Buttinelli, Gabriele, Vacca, Paola, Tozzi, Alberto E., Midulla, Fabio, Carsetti, Rita, Fedele, Giorgio, Villani, Alberto, Concato, Carlo

“…We conducted a study to determine the main traits of pertussis among unimmunized infants less than 6 months of age. From August 2012 to March 2015, 141…”
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The Interplay between CD27 dull and CD27 bright B Cells Ensures the Flexibility, Stability, and Resilience of Human B Cell Memory by Grimsholm, Ola, Piano Mortari, Eva, Davydov, Alexey N, Shugay, Mikhail, Obraztsova, Anna S, Bocci, Chiara, Marasco, Emiliano, Marcellini, Valentina, Aranburu, Alaitz, Farroni, Chiara, Silvestris, Domenico Alessandro, Cristofoletti, Cristina, Giorda, Ezio, Scarsella, Marco, Cascioli, Simona, Barresi, Sabina, Lougaris, Vassilios, Plebani, Alessandro, Cancrini, Caterina, Finocchi, Andrea, Moschese, Viviana, Valentini, Diletta, Vallone, Cristina, Signore, Fabrizio, de Vincentiis, Giovanni, Zaffina, Salvatore, Russo, Giandomenico, Gallo, Angela, Locatelli, Franco, Tozzi, Alberto E, Tartaglia, Marco, Chudakov, Dmitriy M, Carsetti, Rita

“…Memory B cells (MBCs) epitomize the adaptation of the immune system to the environment. We identify two MBC subsets in peripheral blood, CD27 and CD27 MBCs,…”
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