Search Results - "Marcel J.C. Bijvelds"

Activation of Intestinal Cl− Secretion by Lubiprostone Requires the Cystic Fibrosis Transmembrane Conductance Regulator by Bijvelds, Marcel J.C, Bot, Alice G.M, Escher, Johanna C, de Jonge, Hugo R

“…Background & Aims Lubiprostone alleviates constipation by stimulating intestinal fluid secretion, purportedly through activation of ClC-2–type Cl− channels…”
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Dynamics of Proliferative and Quiescent Stem Cells in Liver Homeostasis and Injury by Cao, Wanlu, Chen, Kan, Bolkestein, Michiel, Yin, Yuebang, Verstegen, Monique M.A., Bijvelds, Marcel J.C., Wang, Wenshi, Tuysuz, Nesrin, ten Berge, Derk, Sprengers, Dave, Metselaar, Herold J., van der Laan, Luc J.W., Kwekkeboom, Jaap, Smits, Ron, Peppelenbosch, Maikel P., Pan, Qiuwei

“…Adult liver stem cells are usually maintained in a quiescent/slow-cycling state. However, a proliferative population, marked by leucine-rich repeat-containing…”
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Impaired Intestinal Farnesoid X Receptor Signaling in Cystic Fibrosis Mice by Ikpa, Pauline T, Doktorova, Marcela, Meijsen, Kelly F, Nieuwenhuijze, Natascha D.A, Verkade, Henkjan J, Jonker, Johan W, de Jonge, Hugo R, Bijvelds, Marcel J.C

“…Background & AimsThe bile acid (BA)-activated farnesoid X receptor (FXR) controls hepatic BA synthesis and cell proliferation via the intestinal hormone…”
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Composition of mineralizing incisor enamel in cystic fibrosis transmembrane conductance regulator-deficient mice by Bronckers, Antonius L.J.J., Lyaruu, Don M., Guo, Jing, Bijvelds, Marcel J.C., Bervoets, Theodore J.M., Zandieh-Doulabi, Behrouz, Medina, Juan F., Li, Zhu, Zhang, Yan, DenBesten, Pamela K.

“…Formation of crystals in the enamel space releases protons that need to be buffered to sustain mineral accretion. We hypothesized that apical cystic fibrosis…”
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Bile Acid Handling in Cystic Fibrosis: Marked Phenotypic Differences Between Mouse Models by Bijvelds, Marcel J.C, de Jonge, Hugo R, Verkade, Henkjan J

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Reply to: Cystic fibrosis transmembrane conductance regulator (CFTR) variants and CFTR function in patients with pancreatitis by Melotti, Paola, Angyal, Dora, Bijvelds, Marcel J.C., Frulloni, Luca

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A functional CFTR assay using primary cystic fibrosis intestinal organoids by Dekkers, Johanna F, Wiegerinck, Caroline L, de Jonge, Hugo R, Bronsveld, Inez, Janssens, Hettie M, de Winter-de Groot, Karin M, Brandsma, Arianne M, de Jong, Nienke W M, Bijvelds, Marcel J C, Scholte, Bob J, Nieuwenhuis, Edward E S, van den Brink, Stieneke, Clevers, Hans, van der Ent, Cornelis K, Middendorp, Sabine, Beekman, Jeffrey M

“…Building on earlier work, Dekkers et al . describe the first application of their intestinal organoid culture technology to the study of human disease, in this…”
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Evidence for cross-species transmission of human coronavirus OC43 through bioinformatics and modeling infections in porcine intestinal organoids by Xu, Guige, Qiao, Zhiwen, Schraauwen, Rick, Avan, Amine, Peppelenbosch, Maikel P., Bijvelds, Marcel J.C., Jiang, Shijin, Li, Pengfei

“…Cross-species transmission of coronaviruses has been continuously posing a major challenge to public health. Pigs, as the major animal reservoirs for many…”
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Cystic fibrosis: Toward personalized therapies by Ikpa, Pauline T., Bijvelds, Marcel J.C., de Jonge, Hugo R.

“…Cystic fibrosis (CF), the most common, life-threatening monogenetic disease in Caucasians, is caused by mutations in the CFTR gene, encoding a cAMP- and…”
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Strategies for cystic fibrosis transmembrane conductance regulator inhibition: from molecular mechanisms to treatment for secretory diarrhoeas by Jonge, Hugo R., Ardelean, Maria C., Bijvelds, Marcel J. C., Vergani, Paola

“…Cystic fibrosis transmembrane conductance regulator (CFTR) is an unusual ABC transporter. It acts as an anion‐selective channel that drives osmotic fluid…”
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Differential thermostability and response to cystic fibrosis transmembrane conductance regulator potentiators of human and mouse F508del-CFTR by Bose, Samuel J, Bijvelds, Marcel J C, Wang, Yiting, Liu, Jia, Cai, Zhiwei, Bot, Alice G M, de Jonge, Hugo R, Sheppard, David N

“…Cross-species comparative studies have highlighted differences between human and mouse cystic fibrosis transmembrane conductance regulator (CFTR), the…”
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rAAV-CFTRDR Rescues the Cystic Fibrosis Phenotype in Human Intestinal Organoids and Cystic Fibrosis Mice by Vidovic, Dragana, Carlon, Marianne S, da Cunha, Mélanie F, Dekkers, Johanna F, Hollenhorst, Monika I, Bijvelds, Marcel J C, Ramalho, Anabela S, Van den Haute, Chris, Ferrante, Marc, Baekelandt, Veerle, Janssens, Hettie M, De Boeck, Kris, Sermet-Gaudelus, Isabelle, de Jonge, Hugo R, Gijsbers, Rik, Beekman, Jeffrey M, Edelman, Aleksander, Debyser, Zeger

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CFTR function is impaired in a subset of patients with pancreatitis carrying rare CFTR variants by Angyal, Dora, Kleinfelder, Karina, Ciciriello, Fabiana, Groeneweg, Tessa A., De Marchi, Giulia, de Pretis, Nicolò, Bernardoni, Laura, Rodella, Luca, Tomba, Francesco, De Angelis, Paola, Surace, Cecilia, Pintani, Emily, Alghisi, Federico, de Jonge, Hugo R., Melotti, Paola, Sorio, Claudio, Lucidi, Vincenzina, Bijvelds, Marcel J.C., Frulloni, Luca

“…Many affected by pancreatitis harbor rare variants of the cystic fibrosis (CF) gene, CFTR, which encodes an epithelial chloride/bicarbonate channel. We…”
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Transcriptome analysis of the distal small intestine of Cftr null mice by Ikpa, Pauline T., Meijsen, Kelly F., Nieuwenhuijze, Natascha D.A., Dulla, Kalyan, de Jonge, Hugo R., Bijvelds, Marcel J.C.

“…Cystic fibrosis (CF) is caused by mutations in the gene encoding the CFTR anion channel. Loss of CFTR function in pancreatic, biliary and intestinal epithelia,…”
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Assessing cell-specific effects of genetic variations using tRNA microarrays by Polte, Christine, Wedemeyer, Daniel, Oliver, Kathryn E, Wagner, Johannes, Bijvelds, Marcel J C, Mahoney, John, de Jonge, Hugo R, Sorscher, Eric J, Ignatova, Zoya

“…By definition, effect of synonymous single-nucleotide variants (SNVs) on protein folding and function are neutral, as they alter the codon and not the encoded…”
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Alterations of mucosa-attached microbiome and epithelial cell numbers in the cystic fibrosis small intestine with implications for intestinal disease by Kelly, Jennifer, Al-Rammahi, Miran, Daly, Kristian, Flanagan, Paul K., Urs, Arun, Cohen, Marta C., di Stefano, Gabriella, Bijvelds, Marcel J. C., Sheppard, David N., de Jonge, Hugo R., Seidler, Ursula E., Shirazi-Beechey, Soraya P.

“…Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator ( CFTR ) gene. Defective CFTR leads to accumulation of…”
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NHERF3 is necessary for Escherichia coli heat-stable enterotoxin-induced inhibition of NHE3: differences in signaling in mouse small intestine and Caco-2 cells by Chen, Tiane, Lin, Ruxian, Avula, Leela, Sarker, Rafiquel, Yang, Jianbo, Cha, Boyoung, Tse, Chung Ming, McNamara, George, Seidler, Ursula, Waldman, Scott, Snook, Adam, Bijvelds, Marcel J C, de Jonge, Hugo R, Li, Xuhang, Donowitz, Mark

“…Enterotoxigenic (ETEC) is a leading cause of childhood death from diarrhea and the leading cause of Traveler's diarrhea. heat-stable enterotoxin (ST) is a…”
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Pro-inflammatory cytokines stimulate CFTR-dependent anion secretion in pancreatic ductal epithelium by Angyal, Dora, Groeneweg, Tessa A, Leung, Anny, Desain, Max, Dulla, Kalyan, de Jonge, Hugo R, Bijvelds, Marcel J C

“…Loss of CFTR-dependent anion and fluid secretion in the ducts of the exocrine pancreas is thought to contribute to the development of pancreatitis, but little…”
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Rescue of chloride and bicarbonate transport by elexacaftor-ivacaftor-tezacaftor in organoid-derived CF intestinal and cholangiocyte monolayers by Bijvelds, Marcel J.C., Roos, Floris J.M., Meijsen, Kelly F., Roest, Henk P., Verstegen, Monique M.A., Janssens, Hettie M., van der Laan, Luc J.W., de Jonge, Hugo R.

“…•Intestinal and biliary epithelia were cultured from cystic fibrosis organoids.•Elexacaftor/ivacaftor/tezacaftor rescued chloride transport in both…”
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Guanylin and uroguanylin are produced by mouse intestinal epithelial cells of columnar and secretory lineage by Ikpa, Pauline T., Sleddens, Hein F. B. M., Steinbrecher, Kris A., Peppelenbosch, Maikel P., de Jonge, Hugo R., Smits, Ron, Bijvelds, Marcel J. C.

“…Guanylin (GN) and uroguanylin (UGN), through activation of guanylyl cyclase C (GCC), serve to control intestinal fluid homeostasis. Both peptides are produced…”
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