Search Results - "Marcel, Alfredo Meneses"

Antichagasic, Leishmanicidal, and Trichomonacidal Activity of 2‐Benzyl‐5‐nitroindazole‐Derived Amines by Fonseca‐Berzal, Cristina, Ibáñez‐Escribano, Alexandra, Vela, Nerea, Cumella, José, Nogal‐Ruiz, Juan José, Escario, José Antonio, da Silva, Patrícia Bernardino, Batista, Marcos Meuser, Soeiro, Maria de Nazaré C., Sifontes‐Rodríguez, Sergio, Meneses‐Marcel, Alfredo, Gómez‐Barrio, Alicia, Arán, Vicente J.

“…Three different series of new 5‐nitroindazole derivatives—1‐(ω‐aminoalkyl)‐2‐benzylindazolin‐3‐ones (series A; ten compounds),…”
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Validation of a modified fluorimetric assay for the screening of trichomonacidal drugs by Escribano, Alexandra Ibáñez, Marcel, Alfredo Meneses, Tugores, Yanetsy Machado, Ruiz, Juan José Nogal, Redó, Vicente J Arán, García-Trevijano, José Antonio Escario, Barrio, Alicia Gómez

“…A fluorimetric microassay that uses a redox dye to determine the viability of the flagellate Trichomonas vaginalis has been optimised to provide a more…”
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3-Alkoxy-1-Benzyl-5-Nitroindazole Derivatives Are Potent Antileishmanial Compounds by Mollineda-Diogo, Niurka, Sifontes-Rodríguez, Sergio, Aguirre-García, María Magdalena, Escalona-Montaño, Alma Reyna, Espinosa-Buitrago, Teresa, Mondragón-Flores, Ricardo, Mondragón-Castelán, Mónica Edith, Meneses-Marcel, Alfredo, Pérez-Olvera, Ofelia, Sánchez-Almaraz, Daniel Andrés, Perez-Castillo, Yunierkis, Arán-Redó, Vicente

“…Indazoles have previously been identified as molecules with antiprotozoal activity. In this study, we evaluate the in vitro activity of thirteen…”
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Antileishmanial activity of 5-nitroindazole derivatives by Mollineda-Diogo, Niurka, Chaviano-Montes de Oca, Claudia Sissely, Sifontes-Rodríguez, Sergio, Espinosa-Buitrago, Teresa, Monzote-Fidalgo, Lianet, Meneses-Marcel, Alfredo, Morales-Helguera, Aliuska, Perez-Castillo, Yunierkis, Arán-Redó, Vicente

“…Background: Currently, there is no safe and effective vaccine against leishmaniasis and existing therapies are inadequate due to high toxicity, cost and…”
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Evaluación de la toxicidad aguda del IHPLUS® sobre el biomodelo indicador de calidad del agua: Poecilia reticulata by Zoe Alicia Castañedo-Hernández, Alfredo Meneses-Marcel, Osmany Marrero-Chang, Keylin Sotolongo-González, Daniel Artiles-Martínez, Liliet González Sierra

“…La agricultura convencional depende de la aplicación de fertilizantes con el fin de lograr mayores rendimientos; sin embargo, es necesario encontrar un…”
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The efficacy of 2-nitrovinylfuran derivatives against Leishmania in vitro and in vivo by Sifontes-Rodríguez, Sergio, Monzote-Fidalgo, Lianet, Castañedo-Cancio, Nilo, Montalvo-Álvarez, Ana Margarita, López-Hernández, Yamilé, Diogo, Niurka Mollineda, Infante-Bourzac, Juan Francisco, Pérez-Martín, Oliver, Meneses-Marcel, Alfredo, García-Trevijano, José Antonio Escario, Cabrera-Pérez, Miguel Ángel

“…Despite recent advances in the treatment of some forms of leishmaniasis, the available drugs are still far from ideal due to inefficacy, parasite resistance,…”
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Efectos de Bacillus spp. en organismos no diana del ecosistema terrestre by Castañedo Hernández, Zoe Alicia, Meneses-Marcel, Alfredo, Marrero Chang, Osmany, Cruz-Martin, Mileidy

“…El aumento de la población mundial trae consigo la necesidad de incrementar la producción de alimentos y por ende la búsqueda de alternativas tecnológicas para…”
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A novel non-stochastic quadratic fingerprints-based approach for the ‘in silico’ discovery of new antitrypanosomal compounds by Montero-Torres, Alina, Vega, María Celeste, Marrero-Ponce, Yovani, Rolón, Miriam, Gómez-Barrio, Alicia, Escario, José Antonio, Arán, Vicente J., Martínez-Fernández, Antonio R., Meneses-Marcel, Alfredo

“…A non-stochastic quadratic fingerprints-based approach is introduced to classify and design, in a rational way, new antitrypanosomal compounds. A data set of…”
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Furvina (G-1). Efectividad in vitro sobre Microorganismos Aislados de Infecciones Dérmicas en Caninos by Díaz Díaz, Miriam, Meneses Marcel, Alfredo, Medina Marrero, Ricardo, Morales Helguera, Aliuska, García Bernal, Milagros, Sifontes Rodríguez, Sergio

“…Los objetivos del presente estudio consistieron en aislar microorganismos de la piel de caninos con piodermitis de la ciudad de Santa Clara, Cuba, y evaluar la…”
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A computer-based approach to the rational discovery of new trichomonacidal drugs by atom-type linear indices by Marrero-Ponce, Yovani, Machado-Tugores, Yanetsy, Pereira, David Montero, Escario, José Antonio, Barrio, Alicia Gómez, Nogal-Ruiz, Juan José, Ochoa, Carmen, Arán, Vicente J, Martínez-Fernández, Antonio R, Sánchez, Rory N García, Montero-Torres, Alina, Torrens, Francisco, Meneses-Marcel, Alfredo

“…Computational approaches are developed to design or rationally select, from structural databases, new lead trichomonacidal compounds. First, a data set of 111…”
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In Vitro and In Vivo Antileishmanial Activity of Thioridazine by Sifontes-Rodríguez, Sergio, Mollineda-Diogo, Niurka, Monzote-Fidalgo, Lianet, Escalona-Montaño, Alma Reyna, Escario García-Trevijano, José Antonio, Aguirre-García, María Magdalena, Meneses-Marcel, Alfredo

“…Introduction Leishmaniasis is a neglected disease with high prevalence and incidence in tropical and subtropical areas. Existing drugs are limited due to cost,…”
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HP-Lattice QSAR for dynein proteins: Experimental proteomics (2D-electrophoresis, mass spectrometry) and theoretic study of a Leishmania infantum sequence by Dea-Ayuela, María Auxiliadora, Pérez-Castillo, Yunierkis, Meneses-Marcel, Alfredo, Ubeira, Florencio M., Bolas-Fernández, Francisco, Chou, Kuo-Chen, González-Díaz, Humberto

“…The toxicity and inefficacy of actual organic drugs against Leishmaniosis justify research projects to find new molecular targets in Leishmania species…”
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Synthesis and in vitro and in vivo biological evaluation of substituted nitroquinoxalin-2-ones and 2,3-diones as novel trichomonacidal agents by Ibáñez-Escribano, Alexandra, Reviriego, Felipe, Nogal-Ruiz, Juan José, Meneses-Marcel, Alfredo, Gómez-Barrio, Alicia, Escario, José Antonio, Arán, Vicente J.

“…Two series of ten novel 7-nitroquinoxalin-2-ones and ten 6-nitroquinoxaline-2,3-diones with diverse substituents at positions 1 and 4 were synthesized and…”
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Drug repositioning for novel antitrichomonas from known antiprotozoan drugs using hierarchical screening by Meneses-Marcel, Alfredo, Marrero-Ponce, Yovani, Ibáñez-Escribano, Alexandra, Gómez-Barrio, Alicia, Escario, José A, Barigye, Stephen J, Terán, Enrique, García-Jacas, Cesar R, Machado-Tugores, Yanetsy, Nogal-Ruiz, Juan J, Arán-Redó, Vicente J

“…Metronidazole is the most widely used drug in trichomoniasis therapy. However, the emergence of metronidazole-resistant isolates calls for the search for new…”
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A sequential procedure for rapid and accurate identification of putative trichomonacidal agents by Ibáñez-Escribano, Alexandra, Meneses-Marcel, Alfredo, Marrero-Ponce, Yovani, Nogal-Ruiz, Juan José, Arán, Vicente J., Gómez-Barrio, Alicia, Escario, José Antonio

“…In the current report, a sequential step-wise methodology based on in silico, in vitro and in vivo experimental procedures for the prompt detection of…”
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Toxicity evaluation of Vitrofural® residues in agar on earthworms by Osmany Marrero Chang, Edisleidy Aguila Jiménez, Zoe Castañedo Hernández, Rosario Hernández Armengol, Alfredo Meneses-Marcel, Yuleiny Y Mederos Hurtado de Mendoza

“…Vitrofural® is an additive used for the chemical sterilization of plant culture media in the in vitro propagation of plants. At the end of its use, it becomes…”
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The efficacy of 2-nitrovinylfuran derivatives againstLeishmania in vitro and in vivo by Sifontes-Rodríguez, Sergio, Monzote-Fidalgo, Lianet, Castañedo-Cancio, Nilo, Montalvo-Álvarez, Ana Margarita, López-Hernández, Yamilé, Diogo, Niurka Mollineda, Infante-Bourzac, Juan Francisco, Pérez-Martín, Oliver, Meneses-Marcel, Alfredo, García-Trevijano, José Antonio Escario, Cabrera-Pérez, Miguel Ángel

“…Despite recent advances in the treatment of some forms of leishmaniasis, the available drugs are still far from ideal due to inefficacy, parasite resistance,…”
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Predicting antitrichomonal activity: A computational screening using atom-based bilinear indices and experimental proofs by Marrero-Ponce, Yovani, Meneses-Marcel, Alfredo, Castillo-Garit, Juan A., Machado-Tugores, Yanetsy, Escario, José Antonio, Barrio, Alicia Gómez, Pereira, David Montero, Nogal-Ruiz, Juan José, Arán, Vicente J., Martínez-Fernández, Antonio R., Torrens, Francisco, Rotondo, Richard, Ibarra-Velarde, Froylán, Alvarado, Ysaias J.

“…The two dimensions of TOMOCOMD-CARDD method: from dataset to QSAR models, and from QSAR models to biosilico drug discovery. Existing Trichomonas vaginalis…”
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Discovery of Novel Trichomonacidals Using LDA-Driven QSAR Models and Bond-Based Bilinear Indices as Molecular Descriptors by Rivera-Borroto, Oscar M., Marrero-Ponce, Yovani, Meneses-Marcel, Alfredo, Escario, José Antonio, Gómez Barrio, Alicia, Arán, Vicente J., Martins Alho, Miriam A., Montero Pereira, David, Nogal, Juan José, Torrens, Francisco, Ibarra-Velarde, Froylán, Montenegro, Yolanda Vera, Huesca-Guillén, Alma, Rivera, Norma, Vogel, Christian

“…Few years ago, the World Health Organization estimated the number of adults with trichomoniasis at 170 million worldwide, more than the combined numbers for…”
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A linear discrimination analysis based virtual screening of trichomonacidal lead-like compounds: Outcomes of in silico studies supported by experimental results by Meneses-Marcel, Alfredo, Marrero-Ponce, Yovani, Machado-Tugores, Yanetsy, Montero-Torres, Alina, Pereira, David Montero, Escario, José Antonio, Nogal-Ruiz, Juan José, Ochoa, Carmen, Arán, Vicente J., Martínez-Fernández, Antonio R., García Sánchez, Rory N.

“…A computational (virtual) screening test to identify potential trichomonacidals has been developed. Molecular structures of trichomonacidal and…”
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