Search Results - "Marc Mercken"

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics by Karran, Eric, Mercken, Marc, Strooper, Bart De

“…Key Points The amyloid cascade hypothesis posits that the deposition of the amyloid-β peptide in the brain parenchyma is a crucial step in Alzheimer's disease…”
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Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer’s disease by Janelidze, Shorena, Stomrud, Erik, Smith, Ruben, Palmqvist, Sebastian, Mattsson, Niklas, Airey, David C., Proctor, Nicholas K., Chai, Xiyun, Shcherbinin, Sergey, Sims, John R., Triana-Baltzer, Gallen, Theunis, Clara, Slemmon, Randy, Mercken, Marc, Kolb, Hartmuth, Dage, Jeffrey L., Hansson, Oskar

“…Cerebrospinal fluid (CSF) p-tau181 (tau phosphorylated at threonine 181) is an established biomarker of Alzheimer’s disease (AD), reflecting abnormal tau…”
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Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice by Peeraer, Eve, Bottelbergs, Astrid, Van Kolen, Kristof, Stancu, Ilie-Cosmin, Vasconcelos, Bruno, Mahieu, Michel, Duytschaever, Hilde, Ver Donck, Luc, Torremans, An, Sluydts, Ellen, Van Acker, Nathalie, Kemp, John A, Mercken, Marc, Brunden, Kurt R, Trojanowski, John Q, Dewachter, Ilse, Lee, Virginia M.Y, Moechars, Diederik

“…Abstract Neurofibrillary tangles composed of hyperphosphorylated fibrillized tau are found in numerous tauopathies including Alzheimer's disease. Increasing…”
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Epitope mapping and structural basis for the recognition of phosphorylated tau by the anti-tau antibody AT8 by Malia, Thomas J., Teplyakov, Alexey, Ernst, Robin, Wu, Sheng-Jiun, Lacy, Eilyn R., Liu, Xuesong, Vandermeeren, Marc, Mercken, Marc, Luo, Jinquan, Sweet, Raymond W., Gilliland, Gary L.

“…ABSTRACT Microtubule‐associated protein tau becomes abnormally phosphorylated in Alzheimer's disease and other tauopathies and forms aggregates of paired…”
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Passive immunotherapy with a novel antibody against 3pE-modified Aβ demonstrates potential for enhanced efficacy and favorable safety in combination with BACE inhibitor treatment in plaque-depositing mice by Janssens, Jonathan, Hermans, Bart, Vandermeeren, Marc, Barale-Thomas, Erio, Borgers, Marianne, Willems, Roland, Meulders, Greet, Wintmolders, Cindy, Van den Bulck, Dries, Bottelbergs, Astrid, Ver Donck, Luc, Larsen, Peter, Moechars, Dieder, Edwards, Wilson, Mercken, Marc, Van Broeck, Bianca

“…The imbalance between production and clearance of amyloid β (Aβ) peptides and their resulting accumulation in the brain is an early and crucial step in the…”
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Decreased Deposition of Beta-Amyloid 1-38 and Increased Deposition of Beta-Amyloid 1-42 in Brain Tissue of Presenilin-1 E280A Familial Alzheimer’s Disease Patients by Dinkel, Felix, Trujillo-Rodriguez, Diana, Villegas, Andres, Streffer, Johannes, Mercken, Marc, Lopera, Francisco, Glatzel, Markus, Sepulveda-Falla, Diego

“…Familial Alzheimer’s Disease (FAD) caused by Presenilin-1 (PS1) mutations is characterized by early onset, cognitive impairment and dementia. Impaired gamma…”
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Development and validation of a high‐sensitivity assay for measuring p217+tau in plasma by Triana‐Baltzer, Gallen, Moughadam, Setareh, Slemmon, Randy, Van Kolen, Kristof, Theunis, Clara, Mercken, Marc, Kolb, Hartmuth C.

“…Introduction Diagnosis of Alzheimer's disease (AD) based on amyloid beta (A), pathologic tau (T), and neurodegeneration (N) biomarkers in peripheral fluids…”
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BACE1 inhibition induces a specific cerebrospinal fluid β-amyloid pattern that identifies drug effects in the central nervous system by Mattsson, Niklas, Rajendran, Lawrence, Zetterberg, Henrik, Gustavsson, Mikael, Andreasson, Ulf, Olsson, Maria, Brinkmalm, Gunnar, Lundkvist, Johan, Jacobson, Laura H, Perrot, Ludovic, Neumann, Ulf, Borghys, Herman, Mercken, Marc, Dhuyvetter, Deborah, Jeppsson, Fredrik, Blennow, Kaj, Portelius, Erik

“…BACE1 is a key enzyme for amyloid-β (Aβ) production, and an attractive therapeutic target in Alzheimer's disease (AD). Here we report that BACE1 inhibitors…”
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Anti-tau intrabodies: From anti-tau immunoglobulins to the development of functional scFv intrabodies by Rodrigues Martins, Dina, Sha, Fern, Van der Elst, Wim, Shih, Pei-Yu, Devoght, Jens, Van Kolen, Kristof, Mercken, Marc, Van Broeck, Bianca, Declerck, Paul, Theunis, Clara

“…Over the last decade, there has been a growing interest in intrabodies and their therapeutic potential. Intrabodies are antibody fragments that are expressed…”
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2-Amino-3,4-dihydroquinazolines as Inhibitors of BACE-1 (β-Site APP Cleaving Enzyme):  Use of Structure Based Design to Convert a Micromolar Hit into a Nanomolar Lead by Baxter, Ellen W, Conway, Kelly A, Kennis, Ludo, Bischoff, François, Mercken, Marc H, De Winter, Hans L, Reynolds, Charles H, Tounge, Brett A, Luo, Chi, Scott, Malcolm K, Huang, Yifang, Braeken, Mirielle, Pieters, Serge M. A, Berthelot, Didier J. C, Masure, Stefan, Bruinzeel, Wouter D, Jordan, Alfonzo D, Parker, Michael H, Boyd, Robert E, Qu, Junya, Alexander, Richard S, Brenneman, Douglas E, Reitz, Allen B

“…A new aspartic protease inhibitory chemotype bearing a 2-amino-3,4-dihydroquinazoline ring was identified by high-throughput screening for the inhibition of…”
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Tear gasses CN, CR, and CS are potent activators of the human TRPA1 receptor by Brône, Bert, Peeters, Pieter J., Marrannes, Roger, Mercken, Marc, Nuydens, Ronny, Meert, Theo, Gijsen, Harrie J.M.

“…The TRPA1 channel is activated by a number of pungent chemicals, such as allylisothiocyanate, present in mustard oil and thiosulfinates present in garlic. Most…”
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γ-Secretase Modulators : Can We Combine Potency with Safety? by Gijsen, Harrie J. M., Mercken, Marc

“…γ-Secretase modulation has been proposed as a potential disease modifying anti-Alzheimer’s approach. γ-Secretase modulators (GSMs) cause a product shift from…”
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Comparison of size distribution and (Pro249-Ser258) epitope exposure in in vitro and in vivo derived Tau fibrils by Marreiro, André, Van Kolen, Kristof, Sousa, Cristiano, Temmerman, Liesbet, Vasconcelos, Bruno, Crespo-Rodriguez, Rosa, van Weering, Jan R. T, Van Dam, Debby, De Deyn, Peter P, Apetri, Adrian, Schoofs, Liliane, Mercken, Marc H

“…Abstract Background Although several studies demonstrate prion-like properties of Tau fibrils, the effect of size in the seeding capacity of these aggregates…”
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Presenilin 1 Associates with Glycogen Synthase Kinase-3β and Its Substrate Tau by Takashima, Akihiko, Murayama, Miyuki, Murayama, Ohoshi, Kohno, Toshiyuki, Honda, Toshiyuki, Yasutake, Kaori, Nihonmatsu, Naomi, Mercken, Marc, Yamaguchi, Haruyasu, Sugihara, Shiro, Wolozin, Benjamin

“…Families bearing mutations in the presenilin 1 (PS1) gene develop Alzheimer's disease. Previous studies have shown that the Alzheimer-associated mutations in…”
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Lack of neprilysin suffices to generate murine amyloid-like deposits in the brain and behavioral deficit in vivo by Madani, Rime, Poirier, Raphael, Wolfer, David P., Welzl, Hans, Groscurth, Peter, Lipp, Hans-Peter, Lu, Bao, Mouedden, Mohammed El, Mercken, Marc, Nitsch, Roger M., Mohajeri, M. Hasan

“…Accumulation of the β‐amyloid peptide (Aβ) in the brain is a major pathological hallmark of Alzheimer's disease (AD), leading to synaptic dysfunction, neuronal…”
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Prominent Axonopathy in the Brain and Spinal Cord of Transgenic Mice Overexpressing Four-Repeat Human tau Protein by Spittaels, Kurt, Van den Haute, Chris, Van Dorpe, Jo, Bruynseels, Koen, Vandezande, Kris, Laenen, Isabelle, Geerts, Hugo, Mercken, Marc, Sciot, Raf, Van Lommel, Alfons, Loos, Ruth, Van Leuven, Fred

“…Mutations in the human tau gene cause frontotemporal dementia and parkinsonism linked to chromosome 17. Some mutations, including mutations in intron 10,…”
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Prominent Cerebral Amyloid Angiopathy in Transgenic Mice Overexpressing the London Mutant of Human APP in Neurons by Van Dorpe, Jo, Smeijers, Liesbet, Dewachter, Ilse, Nuyens, Dieter, Spittaels, Kurt, Van den Haute, Chris, Mercken, Marc, Moechars, Dieder, Laenen, Isabelle, Kuiperi, Cuno, Bruynseels, Koen, Tesseur, Ina, Loos, Ruth, Vanderstichele, Hugo, Checler, Frédéric, Sciot, Raf, Van Leuven, Fred

“…Deposition of amyloid β-peptide (Aβ) in cerebral vessel walls (cerebral amyloid angiopathy, CAA) is very frequent in Alzheimer’s disease and occurs also as a…”
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Enhancement of therapeutic potential of a naturally occurring human antibody targeting a phosphorylated Ser422 containing epitope on pathological tau by van Ameijde, Jeroen, Crespo, Rosa, Janson, Roosmarijn, Juraszek, Jarek, Siregar, Berdien, Verveen, Hanneke, Sprengers, Imke, Nahar, Tariq, Hoozemans, Jeroen J, Steinbacher, Stefan, Willems, Roland, Delbroek, Lore, Borgers, Marianne, Dockx, Koen, Van Kolen, Kristof, Mercken, Marc, Pascual, Gabriel, Koudstaal, Wouter, Apetri, Adrian

“…Aggregation of tau protein and spreading of tau aggregates are pivotal pathological processes in a range of neurological disorders. Accumulating evidence…”
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Macrocyclic BACE inhibitors: Optimization of a micromolar hit to nanomolar leads by Huang, Yifang, Strobel, Eric D., Ho, Chih Y., Reynolds, Charles H., Conway, Kelly A., Piesvaux, Jennifer A., Brenneman, Douglas E., Yohrling, George J., Moore Arnold, H., Rosenthal, Daniel, Alexander, Richard S., Tounge, Brett A., Mercken, Marc, Vandermeeren, Marc, Parker, Michael H., Reitz, Allen B., Baxter, Ellen W.

“…Structural biology allowed the identification of 7 as a potent BACE inhibitor (IC 50 = 5 nM). We have identified macrocyclic inhibitors of the aspartic…”
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Secretase Modulators: Can We Combine Potency with Safety? by Gijsen, Harrie J. M., Mercken, Marc

“…Secretase modulation has been proposed as a potential disease modifying anti-Alzheimer’s approach. -Secretase modulators (GSMs) cause a product shift from the…”
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