Effects of a Phonologically Driven Treatment for Dyslexia on Lactate Levels Measured by Proton MR Spectroscopic Imaging

Effects of a Phonologically Driven Treatment for Dyslexia on Lactate Levels Measured by Proton MR Spectroscopic Imaging

Dyslexia is a language disorder in which reading ability is compromised because of poor phonologic skills. The purpose of this study was to measure the effect of a phonologically driven treatment for dyslexia on brain lactate response to language stimulation as measured by proton MR spectroscopic im...

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Bibliographic Details
Published in:American journal of neuroradiology : AJNR Vol. 21; no. 5; pp. 916 - 922
Main Authors: Richards, Todd L, Corina, David, Serafini, Sandra, Steury, Keith, Echelard, Denise R, Dager, Stephen R, Marro, Ken, Abbott, Robert D, Maravilla and, Kenneth R, Berninger, Virginia W
Format: Journal Article
Language:English
Published: Oak Brook, IL Am Soc Neuroradiology 01-05-2000
American Society of Neuroradiology
Subjects:
Biological and medical sciences
Brain
Brain - physiopathology
Child
Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes
Dyslexia - diagnosis
Dyslexia - physiopathology
Dyslexia - therapy
Follow-Up Studies
Humans
Lactic Acid - metabolism
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Male
Medical sciences
Nervous system (semeiology, syndromes)
Neurology
Phonetics
Remedial Teaching
Treatment Outcome
Human
Communication disorder
Lactates
Reading disorder
Central nervous system
Proton
Dyslexia
Exploration
NMR spectrometry
Child
Language disorder
Brain (vertebrata)
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Summary:Dyslexia is a language disorder in which reading ability is compromised because of poor phonologic skills. The purpose of this study was to measure the effect of a phonologically driven treatment for dyslexia on brain lactate response to language stimulation as measured by proton MR spectroscopic imaging. Brain lactate metabolism was measured at two different time points (1 year apart) during four different cognitive tasks (three language tasks and one nonlanguage task) in dyslexic participants (n = 8) and in control participants (n = 7) by using a fast MR spectroscopic imaging technique called proton echo-planar spectroscopic imaging (1 cm3 voxel resolution). The age range for both dyslexic and control participants was 10 to 13 years. Between the first and second imaging sessions, the dyslexic boys participated in an instructional intervention, which was a reading/science workshop. Before treatment, the dyslexic boys showed significantly greater lactate elevation compared with a control group in the left anterior quadrant (analysis of variance, P = .05) of the brain during a phonologic task. After treatment, however, brain lactate elevation was not significantly different from that of the control group in the left anterior quadrant during the same phonologic task. Behaviorally, the dyslexic participants improved in the phonologic aspects of reading. Instructional intervention that improved phonologic performance in dyslexic boys was associated with changes in brain lactate levels as measured by proton echo-planar spectroscopic imaging.
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SourceType-Scholarly Journals-1
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ISSN:0195-6108
1936-959X