Search Results - "Maraveyas, Anthony"

Cisplatin plus Gemcitabine versus Gemcitabine for Biliary Tract Cancer by Valle, Juan, Wasan, Harpreet, Palmer, Daniel H, Cunningham, David, Anthoney, Alan, Maraveyas, Anthony, Madhusudan, Srinivasan, Iveson, Tim, Hughes, Sharon, Pereira, Stephen P, Roughton, Michael, Bridgewater, John

“…In this randomized trial comparing cisplatin plus gemcitabine with gemcitabine alone for the treatment of biliary tract cancer, overall survival and…”
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Apixaban Suppresses the Release of TF-Positive Microvesicles and Restrains Cancer Cell Proliferation through Directly Inhibiting TF-fVIIa Activity by Featherby, Sophie, Madkhali, Yahya, Maraveyas, Anthony, Ettelaie, Camille

“…The activation of protease-activated receptor (PAR)-2 by factor Xa (fXa) promotes the release of tissue factor-positive microvesicles (TF MV), and contributes…”
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Oral anticoagulation is preferable to injected, but only if it is safe and effective: An interview study of patient and carer experience of oral and injected anticoagulant therapy for cancer-associated thrombosis in the select-d trial by Hutchinson, Ann, Rees, Sophie, Young, Annie, Maraveyas, Anthony, Date, Kathryn, Johnson, Miriam J

“…Background: Cancer patients have a four- to fivefold greater risk of thrombosis than the general population. Recommended treatment for cancer-associated…”
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Activation of PAR2 by tissue factor induces the release of the PTEN from MAGI proteins and regulates PTEN and Akt activities by Mohammad, Mohammad A., Greenman, John, Maraveyas, Anthony, Ettelaie, Camille

“…Tissue factor (TF) signalling has been associated with alterations in Akt activity influencing cellular survival and proliferation. TF is also shown to induce…”
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Cancer patients’ experiences of the diagnosis and treatment of incidental pulmonary embolism (a qualitative study) by Benelhaj, Naima E, Hutchinson, Ann, Maraveyas, Anthony, Johnson, Miriam J

“…Background The diagnosis of symptomatic cancer-associated thrombosis often causes distress and alarm for patients, especially for those unaware of the risk, or…”
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Deficient DNA mismatch repair and persistence of SARS-CoV-2 RNA shedding: a case report of hereditary nonpolyposis colorectal cancer with COVID-19 infection by Haque, Farzana, Lillie, Patrick, Haque, Farhana, Maraveyas, Anthony

“…Abstract Background Several independent risk factors have been reported to influence viral shedding following COVID-19 infection, but the influence of…”
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A Randomized, Double-Blind, Placebo-Controlled, Phase II Study Comparing the Tolerability and Efficacy of Ipilimumab Administered with or without Prophylactic Budesonide in Patients with Unresectable Stage III or IV Melanoma by WEBER, Jeffrey, THOMPSON, John A, SIEGEL, Jonathan, O'DAY, Steven J, HAMID, Omid, MINOR, David, AMIN, Asim, RON, Ilan, RIDOLFI, Ruggero, ASSI, Hazem, MARAVEYAS, Anthony, BERMAN, David

“…Purpose: Diarrhea (with or without colitis) is an immune-related adverse event (irAE) associated with ipilimumab. A randomized, double-blind,…”
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Assessing patients' anticoagulation preferences for the treatment of cancer-associated thrombosis using conjoint methodology by Noble, Simon, Matzdorff, Axel, Maraveyas, Anthony, Holm, Majbrit V, Pisa, Giovanni

“…Low molecular weight heparins have demonstrated superiority over coumarins in the extended treatment of cancer-associated thrombosis and are recommended as…”
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Cediranib or placebo in combination with cisplatin and gemcitabine chemotherapy for patients with advanced biliary tract cancer (ABC-03): a randomised phase 2 trial by Valle, Juan W, Prof, Wasan, Harpreet, MD, Lopes, Andre, MSc, Backen, Alison C, PhD, Palmer, Daniel H, Prof, Morris, Karen, PhD, Duggan, Marian, MSc, Cunningham, David, Prof, Anthoney, D Alan, MD, Corrie, Pippa, MD, Madhusudan, Srinivasan, MD, Maraveyas, Anthony, Prof, Ross, Paul J, MD, Waters, Justin S, PhD, Steward, Will P, Prof, Rees, Charlotte, MD, Beare, Sandy, PhD, Dive, Caroline, Prof, Bridgewater, John A, MD

“…Summary Background Cisplatin and gemcitabine is the standard first-line chemotherapy regimen for patients with advanced biliary tract cancer; expression of…”
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The risk of venous thromboembolism associated with peripherally inserted central catheters in ambulant cancer patients by Jones, Daniel, Wismayer, Kurt, Bozas, George, Palmer, June, Elliott, Mandi, Maraveyas, Anthony

“…Deep vein thrombosis (DVT) is a common complication of peripherally inserted central catheters (PICCs). PICCs are increasingly utilised in the management of…”
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Low molecular weight heparin and direct oral anticoagulants influence tumour formation, growth, invasion and vascularisation by separate mechanisms by Featherby, Sophie, Xiao, Yu Pei, Ettelaie, Camille, Nikitenko, Leonid L., Greenman, John, Maraveyas, Anthony

“…The bidirectional association between coagulation and cancer has been established. However, anticoagulant therapies have been reported to have beneficial…”
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Different strategies of sequential and combination chemotherapy for patients with poor prognosis advanced colorectal cancer (MRC FOCUS): a randomised controlled trial by Seymour, Matthew T, Prof, Maughan, Timothy S, Prof, Ledermann, Jonathan A, Prof, Topham, Clare, MD, James, Roger, Prof, Gwyther, Stephen J, MBBS, Smith, David B, MD, Shepherd, Stephen, MD, Maraveyas, Anthony, PhD, Ferry, David R, Prof, Meade, Angela M, PhD, Thompson, Lindsay, MSc, Griffiths, Gareth O, MSc, Parmar, Mahesh KB, Prof, Stephens, Richard J

“…Summary Background In the non-curative setting, the sequence in which anticancer agents are used, singly or in combination, may be important if patients are to…”
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Accumulation of tissue factor in endothelial cells promotes cellular apoptosis through over-activation of Src1 and involves β1-integrin signalling by Ethaeb, Ali M., Mohammad, Mohammad A., Madkhali, Yahya, Featherby, Sophie, Maraveyas, Anthony, Greenman, John, Ettelaie, Camille

“…Accumulation of tissue factor (TF) within cells leads to cellular apoptosis mediated through p38 and p53 pathways. In this study, the involvement of Src1 in…”
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Peptidyl-prolyl isomerase 1 (Pin1) preserves the phosphorylation state of tissue factor and prolongs its release within microvesicles by Ettelaie, Camille, Collier, Mary E.W., Featherby, Sophie, Greenman, John, Maraveyas, Anthony

“…The exposure and release of TF is regulated by post-translational modifications of its cytoplasmic domain. Here, the potential of Pin1 to interact with the…”
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Cancer patients’ experiences of living with venous thromboembolism: A systematic review and qualitative thematic synthesis by Benelhaj, Naima B, Hutchinson, Ann, Maraveyas, Anthony M, Seymour, Julie D, Ilyas, Muhammad Waqas, Johnson, Miriam J

“…Background: Cancer-associated thrombosis is common. Recommended treatment is daily injected low-molecular-weight heparin for 6 months. Most studies focus on…”
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Temporary treatment cessation compared with continuation of tyrosine kinase inhibitors for adults with renal cancer: the STAR non-inferiority RCT by Collinson, Fiona, Royle, Kara-Louise, Swain, Jayne, Ralph, Christy, Maraveyas, Anthony, Eisen, Tim, Nathan, Paul, Jones, Robert, Meads, David, Min Wah, Tze, Martin, Adam, Bestall, Janine, Kelly-Morland, Christian, Linsley, Christopher, Oughton, Jamie, Chan, Kevin, Theodoulou, Elisavet, Arias-Pinilla, Gustavo, Kwan, Amy, Daverede, Luis, Handforth, Catherine, Trainor, Sebastian, Salawu, Abdulazeez, McCabe, Christopher, Goh, Vicky, Buckley, David, Hewison, Jenny, Gregory, Walter, Selby, Peter, Brown, Julia, Brown, Janet

“…There is interest in using treatment breaks in oncology, to reduce toxicity without compromising efficacy. A Phase II/III multicentre, open-label,…”
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Chemoradiation in Pancreatic Adenocarcinoma: A Literature Review by Roy, Rajarshi, Maraveyas, Anthony

“…Adenocarcinoma of the exocrine pancreas has an annual incidence of 7,400 cases in the U.K. In comparison with other common cancers of solid organs, namely,…”
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Accumulation of tissue factor in endothelial cells induces cell apoptosis, mediated through p38 and p53 activation by ElKeeb, A M, Collier, M E W, Maraveyas, A, Ettelaie, C

“…We previously reported that high levels of tissue factor (TF) can induce cellular apoptosis in endothelial cells. In this study, TF-mediated mechanisms of…”
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De-Palmitoylation of Tissue Factor Regulates Its Activity, Phosphorylation and Cellular Functions by Ettelaie, Camille, Featherby, Sophie, Rondon, Araci M. R., Greenman, John, Versteeg, Henri H., Maraveyas, Anthony

“…In this study, the role of de-palmitoylation of tissue factor (TF) in the decryption of its activity was explored. TF-tGFP constructs were prepared by…”
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Microparticle-associated tissue factor is recycled by endothelial cells resulting in enhanced surface tissue factor activity by Collier, M E W, Mah, P-M, Xiao, Y, Maraveyas, A, Ettelaie, C

“…In this study the uptake of tissue factor (TF)-positive microparticles by endothelial cells and the recycling of the TF component were examined. Human dermal…”
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