Search Results - "Marasco, Canio J"

Novel Trypanocidal Analogs of 5′-(Methylthio)-Adenosine by SUFRIN, Janice R, SPIESS, Arthur J, MARASCO, Canio J, RATTENDI, Donna, BACCHI, Cyrus J

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Improved synthesis of beta-D-6-methylpurine riboside and antitumor effects of the beta-D- and alpha-D-anomers by Marasco, Jr, Canio J, Pera, Paula J, Spiess, Arthur J, Bernacki, Ralph, Sufrin, Janice R

“…6-Methylpurine-beta-D-riboside (beta-D-MPR) has been synthesized by coupling 6-methylpurine and 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribose using conditions that…”
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Synthesis and Evaluation of Analogues of 5‘-([(Z)-4-Amino-2-butenyl]methylamino)-5‘-deoxyadenosine as Inhibitors of Tumor Cell Growth, Trypanosomal Growth, and HIV-1 Infectivity by Marasco, Canio J, Kramer, Debora L, Miller, John, Porter, Carl W, Bacchi, Cyrus J, Rattendi, Donna, Kucera, Louis, Iyer, Nathan, Bernacki, Ralph, Pera, Paula, Sufrin, Janice R

“…A well-defined series of 5‘-([(Z)-4-amino-2-butenyl]methylamino)-5‘-deoxyadenosine analogues was designed and synthesized in order to further ascertain the…”
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5-Methyl-2'-Deoxycytidine in Single-Stranded DNA Can Act in Cis to Signal De novo DNA Methylation by Christman, Judith K., Sheikhnejad, Gholamreza, Marasco, Canio J., Sufrin, Janice R.

“…Methylation of cytosine residues in DNA plays an important role in regulating gene expression during vertebrate embryonic development. Conversely, disruption…”
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Abstract 5544: Attempts to synthesize 5,7-dihydroxy-3H-1,2-dithiolo[4,3-d]- pyrimidine, M-47, a potential new treatment for drug- resistant breast cancer by Marasco, Canio J., Dunn, Joseph A., Pera, Paula J., Macubbin, Alexander E.

“…M-47, 5,7-Dihydroxy-3H-1,2-dithiolo[4,3-d]pyrimidine, represents a novel class of antineoplastic agents both in structure and apparent mechanism of action. The…”
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Synthesis and evaluation of novel ether lipid nucleoside conjugates for anti-HIV-1 activity by Piantadosi, Claude, Marasco, Canio J, Morris-Natschke, Susan L, Meyer, Karen L, Gumus, Fatma, Surles, Jefferson R, Ishaq, Khalid S, Kucera, Louis S, Iyer, Nathan

“…Combinations of an amidoalkylphosphocholine, 8, and AZT have been found to cause an apparent synergistic action in suppressing infectious HIV-1 replication. In…”
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Synthesis of phosphocholine and quaternary amine ether lipids and evaluation of in vitro antineoplastic activity by Morris-Natschke, Susan L, Gumus, Fatma, Marasco, Canio J, Meyer, Karen L, Marx, Michael, Piantadosi, Claude, Layne, Matthew D, Modest, Edward J

“…The in vitro antineoplastic activity of many phosphorus-containing (e.g., phosphocholines) and non-phosphorus-containing (e.g., quaternary ammonium salts)…”
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Synthesis and biological activity of novel quaternary ammonium derivatives of alkylglycerols as potent inhibitors of protein kinase C by Marasco, Canio J, Piantadosi, Claude, Meyer, Karen L, Morris-Natschke, Susan, Ishaq, Khalid S, Small, George W, Daniel, Larry W

“…Alkylglycerols such as rac-1-O-octadecyl-2-O-methylglycerophosphochocholine (Et-18-OMe) have shown an inhibitory effect on the metastasis and growth of various…”
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Classroom attendance: Factors and perceptions of students and faculty in US schools of pharmacy by Persky, Adam M., Kirwin, Jennifer L., Marasco, Canio J., May, D. Byron, Skomo, Monica L., Kennedy, Kathleen B.

“…To determine which factors most influence pharmacy students’ decision to skip class from the perspective of students and faculty in schools of pharmacy in the…”
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Synthesis of quaternary amine ether lipids and evaluation of neoplastic cell growth inhibitory properties by Morris-Natschke, Susan L, Meyer, Karen L, Marasco, Canio J, Piantadosi, Claude, Rossi, Fiona, Godwin, Patrick L, Modest, Edward J

“…Novel quaternary amine ether lipids have been synthesized and tested for inhibition of neoplastic cell proliferation with the HL-60 promyelocytic leukemia cell…”
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Mechanism of inhibition of DNA (cytosine C5)-methyltransferases by oligodeoxyribonucleotides containing 5,6-dihydro-5-azacytosine by Sheikhnejad, G, Brank, A, Christman, J K, Goddard, A, Alvarez, E, Ford, Jr, H, Marquez, V E, Marasco, C J, Sufrin, J R, O'gara, M, Cheng, X

“…A key step in the predicted mechanism of enzymatic transfer of methyl groups from S-adenosyl-l-methionine (AdoMet) to cytosine residues in DNA is the transient…”
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Mechanism of inhibition of DNA (cytosine C5)-methyltransferases by oligodeoxyribonucleotides containing 5,6-dihydro-5-azacytosine 1 1Edited by R. Huber by Sheikhnejad, Gholamreza, Brank, Adam, Christman, Judith K., Goddard, Amanda, Alvarez, Estela, Ford, Harry, Marquez, Victor E., Marasco, Canio J., Sufrin, Janice R., O’Gara, Margaret, Cheng, Xiaodong

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Alkyl-linked diglycerides inhibit protein kinase C activation by diacylglycerols by Daniel, L W, Small, G W, Schmitt, J D, Marasco, C J, Ishaq, K, Piantadosi, C

“…Alkylacylglycerols are synthesized when choline-phospholipids are degraded by a phospholipase C. This class of compounds has been shown to have biological…”
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In vivo efficacies of 5'-methylthioadenosine analogs as trypanocides by BACCHI, C. J, SANABRIA, K, SPIESS, A. J, VARGAS, M, MARASCO, C. J, JIMENEZ, L. M, GOLDBERG, B, SUFRIN, J. R

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Antitrypanosomal activity of purine nucleosides can be enhanced by their conversion to O-acetylated derivatives by Sufrin, J R, Rattendi, D, Spiess, A J, Lane, S, Marasco, Jr, C J, Bacchi, C J

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Purine 2′, 3′-acyclonucleosides: Improved synthesis and antiparasitic actimity by Sufrin, Janice R., Spiess, Arthur J., Marasco, Canio J., Croft, Simon L., Snowdon, Diane, Yardley, Vanessa, Bacchi, Cyrus J

“…Synthesis of purine 2′,3′-acyclonucleosides has been improved by using methanol as solvent for sequential oxidation/reduction reactions on periodate- and…”
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A convenient method for the direct incorporation of 5-fluoro-2'-deoxycytidine into oligodeoxynucleotides by Marasco, Canio J., Sufrin, Janice R.

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In vitro evaluation of phosphocholine and quaternary ammonium containing lipids as novel anti-HIV agents by Meyer, Karen L, Marasco, Canino J, Morris-Natschke, Susan L, Ishaq, Khalid S, Piantadosi, Claude, Kucera, Louis S

“…A series of synthetic lipids containing a two- or three-carbon backbone substituted with a thio, oxy, or amidoalkyl functionality and either a phosphocholine…”
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The synthesis and biological activity of novel alkylglycerol derivatives as inhibitors of protein kinase C activity, neoplastic cell growth, and HIV-1 infectivity by Marasco, Canio J

“…The goal of this research was to develop more potent alkyl lipid inhibitors of protein kinase C (PKC), and thus, to potentially augment the antineoplastic and…”
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