Search Results - "Marappan, Sivapriya"

A highly selective KIT inhibitor MOD000001 suppresses IgE-mediated mast cell activation by Nakamura, Yuki, Urakami, Takeo, Ishimaru, Kayoko, Vuong Tran, Nguyen Quoc, Shimizu, Takafumi, Sinko, William, Takahashi, Taisuke, Marappan, Sivapriya, Narayanan, Kishore, Poddutoori, Ramulu, Terada, Yoh, Nakao, Atsuhito

“…The KIT receptor tyrosine kinase and its ligand, stem cell factor (SCF), control proliferation and survival of mast cells. Thus, targeting KIT signaling may…”
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Identification of MOD000001, A Novel Highly Selective and Orally Available KIT Inhibitor Designed for Treatment of Mast Cell-Associated Disorders by Urakami, Takeo, Takahashi, Taisuke, Shimizu, Takafumi, Sinko, William, Nakamura, Yuki, Ishimaru, Kayoko, Tran, Vuong, Poddutoori, Ramulu, Narayanan, Kishore, Marappan, Sivapriya, Nakao, Atsuhito, Terada, Yoh

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Isolation and purification of a novel antioxidant protein from the water extract of Sundakai ( Solanum torvum) seeds by Sivapriya, Marappan, Leela, Srinivas

“…Reactive oxygen species (ROS) at physiological concentrations may be required for normal cell function. Excessive production of ROS can be detrimental to…”
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Discovery of CA-4948, an Orally Bioavailable IRAK4 Inhibitor for Treatment of Hematologic Malignancies by Gummadi, Venkateshwar Rao, Boruah, Anima, Ainan, Bharathi Raja, Vare, Brahma Reddy, Manda, Srinivas, Gondle, Hari Prakash, Kumar, Shiva Nagendra, Mukherjee, Subhendu, Gore, Suraj T, Krishnamurthy, Narasimha Rao, Marappan, Sivapriya, Nayak, Shilpa S, Nellore, Kavitha, Balasubramanian, Wesley Roy, Bhumireddy, Archana, Giri, Sanjeev, Gopinath, Sreevalsam, Samiulla, Dodheri S, Daginakatte, Girish, Basavaraju, Aravind, Chelur, Shekar, Eswarappa, Rajesh, Belliappa, Charamanna, Subramanya, Hosahalli S, Booher, Robert N, Ramachandra, Murali, Samajdar, Susanta

“…Small molecule potent IRAK4 inhibitors from a novel bicyclic heterocycle class were designed and synthesized based on hits identified from Aurigene’s compound…”
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Abstract 1143: Evaluation of AU-18069, a novel small molecule CBP/p300 bromodomain inhibitor for the treatment of cancers by Abbineni, Chandrasekhar, Thiyagarajan, Saravanan, Senaiar, Ramesh S, Mukherjee, Subhendu, Jaleel, Mahaboobi, Marappan, Sivapriya, N R, Raghavendra, Renukappa, Girish Aggunda, B, Aravind A, R, Naveen Kumar, Reddy, Venkata Siva, Babu, Asha, Srinivas, Akhila, Yadlapalli, Prasad, Gore, Suraj T, Hemasankar, Pathange, Dey, Mamon, S, Samiulla D, Naik, Chandranath D, Antony, Thomas, Nellore, Kavitha, Chelur, Shekar, Daginakatte, Girish, Myllymäki, Mikko, Wohlfahrt, Gerd, Ramachandra, Murali, Samajdar, Susanta

“…Abstract Background: E1A binding protein (p300) and its paralog CREB binding protein (CBP or CREBBP) are ubiquitously expressed acetyl transferases (HAT) that…”
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Abstract 1753: Targeting cancer with selective cbp/p300 bromodomain inhibitors by Jaleel, Mahaboobi, Senaiar, Ramesh S., Abbineni, Chandrasekhar, Renukappa, Girish A., Mukherjee, Subhendu, Marappan, Sivapriya, Samiulla, DS, Aravind, AB, Kumar, Naveen R., Reddy, Venkata Siva N., Babu, Asha, Srinivas, Akhila P., Yadlapalli, Prasad, Tgore, Suraj, NR, Raghavendra, Naik, Chandranath D., Giri, Sanjeev, Antony, Thomas, Nellore, Kavitha, Chelur, Shekar, Daginakatte, Girish, Ravanti, laura, Myllymäki, Mikko, Wohlfahrt, Gerd, Mattila, Elina, Karlsson, Stefan, Björkman, Mari, Riikonen, Reetta, Ikonen, Tarja, Leimu, Laura, Mälmström, Chira, Korjamo, Timo, Moilanen, Anu, Ramachandra, Murali, Samajdar, Susanta

“…Abstract Background: The Bromodomain (BRD) and Extra-Terminal domain (BET) family of proteins are key regulators of epigenetic control. Although pan BET…”
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Abstract 1754: First in class orally bioavailable BETBRD degraders by Abbineni, Chandrasekhar, Jaleel, Mahaboobi, Mukherjee, Subhendu, Marappan, Sivapriya, Tiwari, Nirbhay Kumar, Samiulla, DS, Aravind, AB, Kumar, Naveen R, Bansal, Indu, Reddy, Raghurami B, Bandaru, NVM Rao, Srinivas, Akhila, Maben, Janith Mary, Tgore, Suraj, Kumar, Avainash, Nankar, Rakesh P., Naik, Chandranath D., Antony, Thomas, Nellore, Kavitha, Giri, Sanjeev, Daginakatte, Girish, Chelur, Shekar, Törmäkangas, Olli, Wohlfahrt, Gerd, Björkman, Mari, Mattila, Elina, Ravanti, Laura, Moilanen, Anu, Ramachandra, Murali, Samajdar, Susanta

“…Abstract Background: Inhibition of Bromodomain and extra-terminal (BET) family proteins by small molecules is actively being pursued as a therapeutic strategy…”
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Novel CDK12/13 Inhibitors AU-15506 and AU-16770 Are Potent Anti-Cancer Agents in EGFR Mutant Lung Adenocarcinoma with and without Osimertinib Resistance by Maity, Tapan K, Kim, Eun Young, Cultraro, Constance M, Venugopalan, Abhilash, Khare, Leena, Poddutoori, Ramulu, Marappan, Sivapriya, Syed, Samiulla D, Telford, William G, Samajdar, Susanta, Ramachandra, Murali, Guha, Udayan

“…Osimertinib is a third-generation epidermal growth factor receptor and tyrosine kinase inhibitor (EGFR-TKI) approved for the treatment of lung adenocarcinoma…”
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Abstract 4418: Pharmacological characterization of a preclinical candidate covalently inhibiting CDK12 by Poddutoori, Ramulu, Rajagopalan, Sujatha, Mukherjee, Subhendu, Marappan, Sivapriya, D. S., Samiulla, Sivakumar, Sasirekha, Nayak, Shilpa S, M V, Ravindra, TS, Devaraja, Kondela, Srinivas, Tgore, Suraj, Dhudashiya, Amit A, K. B, Charamanna, A B, Aravind, A, Amith, S, Pavithra, Pathange, Hema Sankar, Antony, Thomas, Jaleel, Mahaboobi, Giri, Sanjeev, Daginakatte, Girish, Nellore, Kavitha, Chelur, Shekar, Ramachandra, Murali, Samajdar, Susanta

“…Abstract Cyclin-dependent kinase 12 (CDK12) is a transcription-associated protein that plays a critical role in DNA damage response, splicing, pre-mRNA…”
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Abstract 4649: ODM-207, a novel BET-bromodomain inhibitor as a therapeutic approach for the treatment of prostate and breast cancer by Björkman, Mari, Mattila, Elina, Riikonen, Reetta, Sekhar, Chandra, Jaleel, Mahaboobi, Marappan, Sivapriya, Ikonen, Tarja, Nicorici, Daniel Nicorici, Rantala, Juha, Samajdar, Susanta, Ramachandra, Murali, Kallio, Pekka, Moilanen, Anu-Maarit

“…Abstract Introduction: BET (bromodomain and extraterminal) family proteins (BRD2, BRD3, BRD4, and BRDT) are epigenetic readers that bind to acetylated-lysine…”
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Abstract 118: Targeting cancer with a novel BET bromodomain inhibitor ODM-207 by Moilanen, Anu-Maarit, Björkman, Mari, Riikonen, Reetta, Abbineni, Chandrasekhar, Jaleel, Mahaboobi, Marappan, Sivapriya, Ikonen, Tarja, Daginakatte, Girish, A B, Aravind, Mattila, Elina, Rantala, Juha, Samajdar, Susanta, Ramachandra, Murali, Kallio, Pekka

“…Abstract Background: Bromodomain and extra-terminal (BET) family proteins are dual bromodomain-containing epigenetic readers that bind to acetylated-lysine…”
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Abstract 2384: Preclinical evaluation of PD and efficacy of novel potent selective and orally bioavailable CDK12 covalent inhibitors in TNBC model by Poddutoori, Ramulu, Rajagopalan, Sujatha, Mukherjee, Subhendu, Marappan, Sivapriya, S, Samiulla D, Sivakumar, Sasirekha, Nayak, Shilpa S., V, Ravindra M., Murtuza, Hadianawala, S, Devaraja T., Kondela, Srinivas, Tgore, Suraj, Dhudashiya, Amit A., B, Charamanna K., Antony, Thomas, Daginakatte, Girish, Giri, Sanjeev, Chelur, Shekar, Ramachandra, Murali, Pandit, Chetan, Samajdar, Susanta

“…Abstract Cyclin-dependent kinase 12 (CDK12) is a transcription-associated kinase that participates in various cellular processes such as DNA damage response,…”
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Abstract 3303: Paralogue selective p300 degraders induce synthetic lethality in pre-clinical models of CBP-deficient and p300-dependent malignancies by Thiyagarajan, Saravanan, Abbineni, Chandrasekhar, Chaitanya T, Krishna, Apte, Achala, Iqbal, Iram Khan, Kumar R, Naveen, A B, Aravind, Kumar, Avinash, Babu, Dabbeeru Madhu, Shwetha, Shwetha, Manna, Ankita, Mandal, Monalisha, Panigrahi, Rituparna, Marappan, Sivapriya, Gore, Suraj T, Fairus, Mohamad, Jin, Lim Yang, Mukherjee, Subhendu, Daginakatte, Girish, Chelur, Shekar, Nellore, Kavitha, Ramachandra, Murali, Samajdar, Susanta

“…Abstract EP300 (or p300) acts as histone acetyltransferase (HAT) and transcriptional adapter or co-activator regulating transcription via chromatin remodeling…”
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Abstract 6065: Identification and characterization of paralogue selective CBP degraders for potential use in cancer therapy by Thiyagarajan, Saravanan, Abbineni, Chandrasekhar, Chaitanya T, Krishna, Apte, Achala, Iqbal, Iram Khan, Kumar R, Naveen, A B, Aravind, Kumar, Avinash, A R, Girish, Kamath, Aishwarya B, Mane, Deepak Dattatray, Raj A, Gouri, Reghu, Reshma, Mohapatra, Subhasmita, Marappan, Sivapriya, Gore, Suraj T, Mukherjee, Subhendu, Daginakatte, Girish, Nellore, Kavitha, Chelur, Shekar, Ramachandra, Murali, Samajdar, Susanta

“…Abstract CBP and p300 are closely related epigenetic modulators that participate in chromatin remodeling and transcription and play an oncogenic role in a…”
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Abstract 3646: Novel IRAK-4 inhibitors exhibit highly potent anti-proliferative activity in DLBCL cell lines with activating MYD88 L265P mutation by Balasubramanian, Wesley Roy, Gummadi, Venkateshwar Rao, D, Ravi Krishna Babu, Marappan, Sivapriya, Choudhary, Bhavesh, Gopinath, Sreevalsam, Nellore, Kavitha, Chelur, Shekar, Daginakatte, Girish, Ramachandra, Murali

“…Abstract Interleukin-1 Receptor Associated Kinase-4 (IRAK-4) is a serine/threonine protein kinase belonging to tyrosine like kinase (TLK) family. IRAK-4 is one…”
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Debio 0617B Inhibits Growth of STAT3-Driven Solid Tumors through Combined Inhibition of JAK, SRC, and Class III/V Receptor Tyrosine Kinases by Murone, Maximilien, Vaslin Chessex, Anne, Attinger, Antoine, Ramachandra, Raghuveer, Shetty, Shankar J, Daginakatte, Girish, Sengupta, Saumitra, Marappan, Sivapriya, Dhodheri, Samiulla, Rigotti, Stefania, Bachhav, Yogeshwar, Brienza, Silvano, Traxler, Peter, Lang, Marc, Aguet, Michel, Zoete, Vincent, Michielin, Olivier, Nicholas, Courtney, Johnson, Faye M, Ramachandra, Murali, McAllister, Andres

“…Tumor survival, metastases, chemoresistance, and escape from immune responses have been associated with inappropriate activation of STAT3 and/or STAT5 in…”
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Abstract 4798: Efficacy and safety of highly selective novel IRAK4 inhibitors for treatment of ABC-DLBCL by Balasubramanian, Wesley Roy, Gummadi, Venkateshwar Rao, Nellore, Kavitha, Mukherjee, Subhendu, Marappan, Sivapriya, Basavaraju, Aravind, Ainan, Bharathi Raja, Daginakatte, Girish, Gopinath, Sreevalsam, Giri, Sanjeev, Antony, Thomas, Chelur, Shekar, Samajdar, Susanta, Pandit, Chetan, Ramachandra, Murali

“…Abstract Interleukin-1 receptor associated kinases (IRAKs) are serine/threonine protein kinases belonging to the tyrosine-like kinase (TLK) family. IRAKs…”
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Abstract B165: Potent selective and orally bioavailable inhibition of CDK12 by novel covalent inhibitors by Poddutoori, Ramulu, Rajagopalan, Sujatha, Mukherjee, Subhendu, Marappan, Sivapriya, D S, Samiulla, Kasturi, Venkateswarlu, Sivakumar, Sasirekha, Nayak, Shilpa, M V, Ravindra, Tgore, Suraj, Dhudashiya, Amit, K B, Charamanna, Antony, Thomas, M, Mahaboobi, Giri, Sanjeev, Daginakatte, Girish C., Chelur, Shekar, Ramachandra, Murali, Pandit, Chetan, Samajdar, Susanta

“…Abstract Background: Cyclin-dependent kinase 12 (CDK12) coordinately regulates the transcription, splicing, and alternative splicing of several large…”
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Abstract B164: Identification of a novel highly selective and orally bioavailable preclinical candidate for CDK7 covalent inhibition by Poddutoori, Ramulu, Khare Satyam, Leena, Mukherjee, Subhendu, Marappan, Sivapriya, Gopinath, Sreevalsam, KB, Charamanna, Kaza, Lakshmi Narayana, Pothuganti, Manoj Kumar, Rajagopalan, Sujatha, Sivakumar, Sasirekha, E N, Bharath, A B, Aravind, A, Amith, M V, Ravindra, Tgore, Suraj, Antony, Thomas, Pandit, Chetan, Chelur, Shekar, Daginakatte, Girish, Ramachandra, Murali, Samajdar, Susanta

“…Abstract Background: Cyclin-dependent kinase 7 (CDK7) is an important constituent of the cellular transcriptional machinery, where it phosphorylates the…”
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Abstract LB-317: Identification of a novel preclinical candidate for CDK7 inhibition by Satyam, Leena K., Poddutoori, Ramulu, Mukherjee, Subhendu, Marappan, Sivapriya, Gopinath, Sreevalsam, Basavaraju, Aravind, Kaza, Lakshmi Narayana, Pothuganti, Manoj Kumar, Nayak, Shilpa, C, Nandish, A, Amith, MV, Ravindra, Babu, Dabbeeru Madhu, A, Nagaraju, Tgore, Suraj, Antony, Thomas, Pandit, Chetan, Ramachandra, Murali, Chelur, Shekar, Daginakatte, Girish, Samajdar, Susanta

“…Abstract Cyclin-dependent kinase 7 (CDK7) is an important constituent of the cellular transcriptional machinery, where it phosphorylates the C-terminal domain…”
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