Search Results - "Maranville, Joseph C."

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases by Zheng, Jie, Haberland, Valeriia, Baird, Denis, Walker, Venexia, Haycock, Philip C., Hurle, Mark R., Gutteridge, Alex, Erola, Pau, Liu, Yi, Luo, Shan, Robinson, Jamie, Richardson, Tom G., Staley, James R., Elsworth, Benjamin, Burgess, Stephen, Sun, Benjamin B., Danesh, John, Runz, Heiko, Maranville, Joseph C., Martin, Hannah M., Yarmolinsky, James, Laurin, Charles, Holmes, Michael V., Liu, Jimmy Z., Estrada, Karol, Santos, Rita, McCarthy, Linda, Waterworth, Dawn, Nelson, Matthew R., Smith, George Davey, Butterworth, Adam S., Hemani, Gibran, Scott, Robert A., Gaunt, Tom R.

“…The human proteome is a major source of therapeutic targets. Recent genetic association analyses of the plasma proteome enable systematic evaluation of the…”
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Genome‐wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease by Yao, Chen, Chen, George, Song, Ci, Keefe, Joshua, Mendelson, Michael, Huan, Tianxiao, Sun, Benjamin B., Laser, Annika, Maranville, Joseph C., Wu, Hongsheng, Ho, Jennifer E., Courchesne, Paul, Lyass, Asya, Larson, Martin G., Gieger, Christian, Graumann, Johannes, Johnson, Andrew D., Danesh, John, Runz, Heiko, Hwang, Shih-Jen, Liu, Chunyu, Butterworth, Adam S., Suhre, Karsten, Levy, Daniel

“…Identifying genetic variants associated with circulating protein concentrations (protein quantitative trait loci; pQTLs) and integrating them with variants…”
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Elevated serum microRNA levels associate with absence of high-grade prostate cancer in a retrospective cohort by Mihelich, Brittany L, Maranville, Joseph C, Nolley, Rosalie, Peehl, Donna M, Nonn, Larisa

“…To reduce treatment of indolent prostate cancer (PCa), biomarkers are needed to improve identification of patients with a low-risk of having aggressive…”
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Interactions between glucocorticoid treatment and cis-regulatory polymorphisms contribute to cellular response phenotypes by Maranville, Joseph C, Luca, Francesca, Richards, Allison L, Wen, Xiaoquan, Witonsky, David B, Baxter, Shaneen, Stephens, Matthew, Di Rienzo, Anna

“…Glucocorticoids (GCs) mediate physiological responses to environmental stress and are commonly used as pharmaceuticals. GCs act primarily through the GC…”
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Combining genetic and nongenetic biomarkers to realize the promise of pharmacogenomics for inflammatory diseases by Maranville, Joseph C, Di Rienzo, Anna

“…Many drugs used to treat inflammatory diseases are ineffective in a substantial proportion of patients. Identifying patients that are likely to respond to…”
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Mapping Variation in Cellular and Transcriptional Response to 1,25-Dihydroxyvitamin D3 in Peripheral Blood Mononuclear Cells by Kariuki, Silvia N, Maranville, Joseph C, Baxter, Shaneen S, Jeong, Choongwon, Nakagome, Shigeki, Hrusch, Cara L, Witonsky, David B, Sperling, Anne I, Di Rienzo, Anna

“…The active hormonal form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) is an important modulator of the immune system, inhibiting cellular proliferation and…”
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Genetic Mapping with Multiple Levels of Phenotypic Information Reveals Determinants of Lymphocyte Glucocorticoid Sensitivity by Maranville, Joseph C., Baxter, Shaneen S., Witonsky, David B., Chase, Meredith A., Di Rienzo, Anna

“…Clinical response to glucocorticoids, steroid hormones widely used as pharmaceuticals, varies extensively in that many individuals (∼30%) show a weak response…”
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HDL-cholesterol levels and risk of age-related macular degeneration: a multiethnic genetic study using Mendelian randomization by Fan, Qiao, Maranville, Joseph C, Fritsche, Lars, Sim, Xueling, Cheung, Chui Ming Gemmy, Chen, Li Jia, Gorski, Mathias, Yamashiro, Kenji, Ahn, Jeeyun, Laude, Augustinus, Dorajoo, Rajkumar, Lim, Tock Han, Teo, Yik-Ying, Blaustein, Robert O, Yoshimura, Nagahisa, Park, Kyu-Hyung, Pang, Chi Pui, Tai, E Shyong, Khor, Chiea Chuen, Wong, Tien Yin, Runz, Heiko, Cheng, Ching-Yu

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Genetic, functional and molecular features of glucocorticoid receptor binding by Luca, Francesca, Maranville, Joseph C, Richards, Allison L, Witonsky, David B, Stephens, Matthew, Di Rienzo, Anna

“…Glucocorticoids (GCs) are key mediators of stress response and are widely used as pharmacological agents to treat immune diseases, such as asthma and…”
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Author Correction: Genome‐wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease by Yao, Chen, Chen, George, Song, Ci, Keefe, Joshua, Mendelson, Michael, Huan, Tianxiao, Sun, Benjamin B., Laser, Annika, Maranville, Joseph C., Wu, Hongsheng, Ho, Jennifer E., Courchesne, Paul, Lyass, Asya, Larson, Martin G., Gieger, Christian, Graumann, Johannes, Johnson, Andrew D., Danesh, John, Runz, Heiko, Hwang, Shih-Jen, Liu, Chunyu, Butterworth, Adam S., Suhre, Karsten, Levy, Daniel

“…In the originally published version of this Article, financial support was not fully acknowledged. The sentence “KS was supported by the ‘Biomedical Research…”
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A catalog of GWAS fine-mapping efforts in autoimmune disease by Caliskan, Minal, Brown, Christopher D., Maranville, Joseph C.

“…Genome-wide association studies (GWASs) have enabled unbiased identification of genetic loci contributing to common complex diseases. Because GWAS loci often…”
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Comparison of cellular and transcriptional responses to 1,25-dihydroxyvitamin d3 and glucocorticoids in peripheral blood mononuclear cells by Kupfer, Sonia S, Maranville, Joseph C, Baxter, Shaneen S, Huang, Yong, Di Rienzo, Anna

“…Glucocorticoids (GC) and 1,25-dihydroxyvitamin D3 (1,25(OH)2 D3) are steroid hormones with anti-inflammatory properties with enhanced effects when combined. We…”
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Genomic atlas of the human plasma proteome by Sun, Benjamin B., Maranville, Joseph C., Peters, James E., Stacey, David, Staley, James R., Blackshaw, James, Burgess, Stephen, Jiang, Tao, Paige, Ellie, Surendran, Praveen, Oliver-Williams, Clare, Kamat, Mihir A., Prins, Bram P., Wilcox, Sheri K., Zimmerman, Erik S., Chi, An, Bansal, Narinder, Spain, Sarah L., Wood, Angela M., Morrell, Nicholas W., Bradley, John R., Janjic, Nebojsa, Roberts, David J., Ouwehand, Willem H., Todd, John A., Soranzo, Nicole, Suhre, Karsten, Paul, Dirk S., Fox, Caroline S., Plenge, Robert M., Danesh, John, Runz, Heiko, Butterworth, Adam S.

“…Although plasma proteins have important roles in biological processes and are the direct targets of many drugs, the genetic factors that control…”
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Sequential immunotherapy: towards cures for autoimmunity by Ramírez-Valle, Francisco, Maranville, Joseph C., Roy, Sophie, Plenge, Robert M.

“…Despite major progress in the treatment of autoimmune diseases in the past two decades, most therapies do not cure disease and can be associated with increased…”
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Author Correction: Sequential immunotherapy: towards cures for autoimmunity by Ramírez-Valle, Francisco, Maranville, Joseph C., Roy, Sophie, Plenge, Robert M.

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New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries by Shrine, Nick, Guyatt, Anna L., Erzurumluoglu, A. Mesut, Jackson, Victoria E., Hobbs, Brian D., Melbourne, Carl A., Batini, Chiara, Fawcett, Katherine A., Song, Kijoung, Sakornsakolpat, Phuwanat, Boxall, Ruth, Reeve, Nicola F., Obeidat, Ma’en, Zhao, Jing Hua, Wielscher, Matthias, Weiss, Stefan, Kentistou, Katherine A., Cook, James P., Sun, Benjamin B., Zhou, Jian, Hui, Jennie, Karrasch, Stefan, Imboden, Medea, Harris, Sarah E, Marten, Jonathan, Enroth, Stefan, Kerr, Shona M., Surakka, Ida, Vitart, Veronique, Lehtimäki, Terho, Bakke, Per S., Beaty, Terri H., Bossé, Yohan, Brandsma, Corry-Anke, Chen, Zhengming, Crapo, James D., Danesh, John, DeMeo, Dawn L., Dudbridge, Frank, Gieger, Christian, Gulsvik, Amund, Hansell, Anna L., Hao, Ke, Hoffman, Joshua D., Hokanson, John E., Homuth, Georg, Joshi, Peter K., Joubert, Philippe, Langenberg, Claudia, Li, Xuan, Li, Liming, Lin, Kuang, Lind, Lars, Locantore, Nicholas, Luan, Jian’an, Mahajan, Anubha, Maranville, Joseph C., Murray, Alison, Packer, Richard, Parker, Margaret M., Paynton, Megan L., Porteous, David J., Prokopenko, Dmitry, Runz, Heiko, Sin, Don D, Smith, Blair H, Soler Artigas, María, Sparrow, David, Tal-Singer, Ruth, Timmers, Paul R. H. J., Whittaker, John C., Woodruff, Prescott G., Yerges-Armstrong, Laura M., Troyanskaya, Olga G., Raitakari, Olli T., Kähönen, Mika, Polašek, Ozren, Gyllensten, Ulf, Rudan, Igor, Deary, Ian J., Probst-Hensch, Nicole M., Schulz, Holger, James, Alan L, Wilson, James F., Stubbe, Beate, Zeggini, Eleftheria, Jarvelin, Marjo-Riitta, Wareham, Nick, Silverman, Edwin K., Hayward, Caroline, Morris, Andrew P., Butterworth, Adam S., Scott, Robert A., Walters, Robin G., Meyers, Deborah A., Cho, Michael H., Strachan, David P., Hall, Ian P., Tobin, Martin D., Wain, Louise V.

“…Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive pulmonary disease (COPD). In a genome-wide association study in…”
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HDL-cholesterol levels and risk of age-related macular degeneration: a multiethnic genetic study using Mendelian randomization by Fan, Qiao, Maranville, Joseph C, Fritsche, Lars, Sim, Xueling, Cheung, Chui Ming Gemmy, Chen, Li Jia, Gorski, Mathias, Yamashiro, Kenji, Ahn, Jeeyun, Laude, Augustinus, Dorajoo, Rajkumar, Lim, Tock Han, Teo, Yik-Ying, Blaustein, Robert O, Yoshimura, Nagahisa, Park, Kyu-Hyung, Pang, Chi Pui, Tai, E Shyong, Khor, Chiea Chuen, Wong, Tien Yin, Runz, Heiko, Cheng, Ching-Yu

“…Dyslipidemia, particularly high-density lipoprotein cholesterol (HDL-C), has recently been implicated in the pathogenesis of age-related macular degeneration…”
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Phenome-wide association studies across large population cohorts support drug target validation by Diogo, Dorothée, Tian, Chao, Franklin, Christopher S., Alanne-Kinnunen, Mervi, March, Michael, Spencer, Chris C. A., Vangjeli, Ciara, Weale, Michael E., Mattsson, Hannele, Kilpeläinen, Elina, Sleiman, Patrick M. A., Reilly, Dermot F., McElwee, Joshua, Maranville, Joseph C., Chatterjee, Arnaub K., Bhandari, Aman, Nguyen, Khanh-Dung H., Estrada, Karol, Reeve, Mary-Pat, Hutz, Janna, Bing, Nan, John, Sally, MacArthur, Daniel G., Salomaa, Veikko, Ripatti, Samuli, Hakonarson, Hakon, Daly, Mark J., Palotie, Aarno, Hinds, David A., Donnelly, Peter, Fox, Caroline S., Day-Williams, Aaron G., Plenge, Robert M., Runz, Heiko

“…Phenome-wide association studies (PheWAS) have been proposed as a possible aid in drug development through elucidating mechanisms of action, identifying…”
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Mapping gene-environment interactions at regulatory polymorphisms: Insights into mechanisms of phenotypic variation by Maranville, Joseph C., Luca, Francesca, Stephens, Matthew, Di Rienzo, Anna

“…Genetic effects on gene regulation make a substantial contribution to phenotypic diversity, yet their mechanisms remain elusive. Here, we discuss the potential…”
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Sa1244 In Vitro Sensitivity Assays and Clinical Response to Glucocorticoids in Patients With Inflammatory Bowel Disease by Maranville, Joseph C, Hanauer, Stephen B, DiRienzo, Anna, Kupfer, Sonia

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