Search Results - "Marani, Marina"

The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells by Giardina, Giorgio, Paone, Alessio, Tramonti, Angela, Lucchi, Roberta, Marani, Marina, Magnifico, Maria Chiara, Bouzidi, Amani, Pontecorvi, Valentino, Guiducci, Giulia, Zamparelli, Carlotta, Rinaldo, Serena, Paiardini, Alessandro, Contestabile, Roberto, Cutruzzolà, Francesca

“…Cancer cells reprogramme one‐carbon metabolism (OCM) to sustain growth and proliferation. Depending on cell demands, serine hydroxymethyltransferase (SHMT)…”
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How pyridoxal 5′‐phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state by Giardina, Giorgio, Brunotti, Paolo, Fiascarelli, Alessio, Cicalini, Alessandra, Costa, Mauricio G. S, Buckle, Ashley M, Salvo, Martino L, Giorgi, Alessandra, Marani, Marina, Paone, Alessio, Rinaldo, Serena, Paiardini, Alessandro, Contestabile, Roberto, Cutruzzolà, Francesca

“…Adaptive metabolic reprogramming gives cancer cells a proliferative advantage. Tumour cells extensively use glycolysis to sustain anabolism and produce serine,…”
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A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic serine hydroxymethyltransferase and induces cell death in lung cancer cells by Marani, Marina, Paone, Alessio, Fiascarelli, Alessio, Macone, Alberto, Gargano, Maurizio, Rinaldo, Serena, Giardina, Giorgio, Pontecorvi, Valentino, Koes, David, McDermott, Lee, Yang, Tianyi, Paiardini, Alessandro, Contestabile, Roberto, Cutruzzolà, Francesca

“…Serine hydroxymethyltransferase (SHMT) is a central enzyme in the metabolic reprogramming of cancer cells, providing activated one-carbon units in the…”
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MYC is activated by USP2a-mediated modulation of microRNAs in prostate cancer by Benassi, Barbara, Flavin, Richard, Marchionni, Luigi, Zanata, Silvio, Pan, Yunfeng, Chowdhury, Dipanjan, Marani, Marina, Strano, Sabrina, Muti, Paola, Blandino, Giovanni, Loda, Massimo

“…Ubiquitin-specific protease 2a (USP2a) is overexpressed in almost half of human prostate cancers and c-Myc is amplified in one third of these tumor types…”
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Screening and In Vitro Testing of Antifolate Inhibitors of Human Cytosolic Serine Hydroxymethyltransferase by Paiardini, Alessandro, Fiascarelli, Alessio, Rinaldo, Serena, Daidone, Frederick, Giardina, Giorgio, Koes, David R., Parroni, Alessia, Montini, Giulia, Marani, Marina, Paone, Alessio, McDermott, Lee A., Contestabile, Roberto, Cutruzzolà, Francesca

“…Metabolic reprogramming of tumor cells toward serine catabolism is now recognized as a hallmark of cancer. Serine hydroxymethyltransferase (SHMT), the enzyme…”
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Glucose Metabolism in the Progression of Prostate Cancer by Cutruzzolà, Francesca, Giardina, Giorgio, Marani, Marina, Macone, Alberto, Paiardini, Alessandro, Rinaldo, Serena, Paone, Alessio

“…Prostate cancer is one of the most common types of cancer in western country males but the mechanisms involved in the transformation processes have not been…”
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Blockage of melatonin receptors impairs p53-mediated prevention of DNA damage accumulation by Santoro, Raffaela, Mori, Federica, Marani, Marina, Grasso, Giuseppe, Cambria, Maria Anna, Blandino, Giovanni, Muti, Paola, Strano, Sabrina

“…Melatonin has been known to be a chemopreventive agent since its levels inversely correlate with the risk of developing cancer. We have recently shown that…”
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Linking Infection and Prostate Cancer Progression: Toll-like Receptor3 Stimulation Rewires Glucose Metabolism in Prostate Cells by MAGNIFICO, MARIA CHIARA, MACONE, ALBERTO, MARANI, MARINA, BOUZIDI, AMANI, GIARDINA, GIORGIO, RINALDO, SERENA, CUTRUZZOLÀ, FRANCESCA, PAONE, ALESSIO

“…Background/Aim: The connection between prostate cancer and inflammation has been proposed many years ago, but very little is known about the metabolic…”
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The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism by Guiducci, Giulia, Paone, Alessio, Tramonti, Angela, Giardina, Giorgio, Rinaldo, Serena, Bouzidi, Amani, Magnifico, Maria C, Marani, Marina, Menendez, Javier A, Fatica, Alessandro, Macone, Alberto, Armaos, Alexandros, Tartaglia, Gian G, Contestabile, Roberto, Paiardini, Alessandro, Cutruzzolà, Francesca

“…Abstract Enzymes of intermediary metabolism are often reported to have moonlighting functions as RNA-binding proteins and have regulatory roles beyond their…”
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