Search Results - "Marakovits, J T"

Structure-Assisted Design of Mechanism-Based Irreversible Inhibitors of Human Rhinovirus 3C Protease with Potent Antiviral Activity against Multiple Rhinovirus Serotypes by Matthews, D A, Dragovich, P S, Webber, S E, Fuhrman, S A, Patick, A K, Zalman, L S, Hendrickson, T F, Love, R A, Prins, T J, Marakovits, J T, Zhou, R, Tikhe, J, Ford, C E, Meador, J W, Ferre, R A, Brown, E L, Binford, S L, Brothers, M A, DeLisle, D M, Worland, S T

“…Human rhinoviruses, the most important etiologic agents of the common cold, are messenger-active single-stranded monocistronic RNA viruses that have evolved a…”
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Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 1. Michael Acceptor Structure−Activity Studies by Dragovich, Peter S, Webber, Stephen E, Babine, Robert E, Fuhrman, Shella A, Patick, Amy K, Matthews, David A, Lee, Caroline A, Reich, Siegfried H, Prins, Thomas J, Marakovits, Joseph T, Littlefield, Ethel S, Zhou, Ru, Tikhe, Jayashree, Ford, Clifford E, Wallace, Michael B, Meador, James W, Ferre, Rose Ann, Brown, Edward L, Binford, Susan L, Harr, James E. V, DeLisle, Dorothy M, Worland, Stephen T

“…The structure-based design, chemical synthesis, and biological evaluation of peptide-derived human rhinovirus (HRV) 3C protease (3CP) inhibitors are described…”
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Synthesis and Evaluation of Nitroheterocyclic Phosphoramidates as Hypoxia-Selective Alkylating Agents by Borch, Richard F, Liu, Jiwen, Schmidt, James P, Marakovits, Joseph T, Joswig, Carolyn, Gipp, Jerry J, Mulcahy, R. Timothy

“…A series of novel nitroheterocyclic phosphoramidates has been prepared, and the cytotoxicity of these compounds has been evaluated in clonogenic assays against…”
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Tricyclic Benzimidazoles as Potent Poly(ADP-ribose) Polymerase-1 Inhibitors by Skalitzky, Donald J, Marakovits, Joseph T, Maegley, Karen A, Ekker, Anne, Yu, Xiao-Hong, Hostomsky, Zdenek, Webber, Stephen E, Eastman, Brian W, Almassy, Robert, Li, Jianke, Curtin, Nicola J, Newell, David R, Calvert, A. Hilary, Griffin, Roger J, Golding, Bernard T

“…Novel tricyclic benzimidazole carboxamide poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors have been synthesized. Several compounds were found to be powerful…”
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Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 4. Incorporation of P1 Lactam Moieties as l-Glutamine Replacements by Dragovich, Peter S, Prins, Thomas J, Zhou, Ru, Webber, Stephen E, Marakovits, Joseph T, Fuhrman, Shella A, Patick, Amy K, Matthews, David A, Lee, Caroline A, Ford, Clifford E, Burke, Benjamin J, Rejto, Paul A, Hendrickson, Thomas F, Tuntland, Tove, Brown, Edward L, Meador, James W, Ferre, Rose Ann, Harr, James E. V, Kosa, Maha B, Worland, Stephen T

“…The structure-based design, chemical synthesis, and biological evaluation of various human rhinovirus (HRV) 3C protease (3CP) inhibitors which incorporate P1…”
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Structure-based design of irreversible, tripeptidyl human rhinovirus 3C protease inhibitors containing N-methyl amino acids by Dragovich, Peter S, Webber, Stephen E, Prins, Thomas J, Zhou, Ru, Marakovits, Joseph T, Tikhe, Jayashree G, Fuhrman, Shella A, Patick, Amy K, Matthews, David A, Ford, Clifford E, Brown, Edward L, Binford, Susan L, Meador, James W, Ferre, Rose Ann, Worland, Stephen T

“…Tripeptide-derived molecules incorporating N-methyl amino acid residues and C-terminal Michael acceptor moieties were evaluated as irreversible inhibitors of…”
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Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 2. Peptide Structure−Activity Studies by Dragovich, Peter S, Webber, Stephen E, Babine, Robert E, Fuhrman, Shella A, Patick, Amy K, Matthews, David A, Reich, Siegfried H, Marakovits, Joseph T, Prins, Thomas J, Zhou, Ru, Tikhe, Jayashree, Littlefield, Ethel S, Bleckman, Ted M, Wallace, Michael B, Little, Thomas L, Ford, Clifford E, Meador, James W, Ferre, Rose Ann, Brown, Edward L, Binford, Susan L, DeLisle, Dorothy M, Worland, Stephen T

“…The structure-based design, chemical synthesis, and biological evaluation of various peptide-derived human rhinovirus (HRV) 3C protease (3CP) inhibitors are…”
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Design and synthesis of irreversible depsipeptidyl human rhinovirus 3C protease inhibitors by Webber, Stephen E., Marakovits, Joseph T., Dragovich, Peter S., Prins, Thomas J., Zhou, Ru, Fuhrman, Shella A., Patick, Amy K., Matthews, David A., Lee, Caroline A., Srinivasan, Babu, Moran, Terry, Ford, Clifford E., Brothers, Mary A., Harr, James E.V., Meador, James W., Ferre, Rose Ann, Worland, Stephen T.

“…Novel tripeptidyl C-terminal Michael acceptors with an ester replacement of the P 2–P 3 amide bond were investigated as irreversible inhibitors of the human…”
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Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 4. Incorporation of P 1 Lactam Moieties as l -Glutamine Replacements by Dragovich, Peter S., Prins, Thomas J., Zhou, Ru, Webber, Stephen E., Marakovits, Joseph T., Fuhrman, Shella A., Patick, Amy K., Matthews, David A., Lee, Caroline A., Ford, Clifford E., Burke, Benjamin J., Rejto, Paul A., Hendrickson, Thomas F., Tuntland, Tove, Brown, Edward L., Meador, James W., Ferre, Rose Ann, Harr, James E. V., Kosa, Maha B., Worland, Stephen T.

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Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 4. Incorporation of P sub(1) Lactam Moieties as L-Glutamine Replacements by Dragovich, P S, Prins, T J, Zhou, Ru, Webber, SE, Marakovits, J T, Fuhrman, SA, Patick, A K, Matthews, DA, Lee, CA, d, CE, Burke, B J, Rejto, P A, Hendrickson, T F, Tuntland, T

“…The structure-based design, chemical synthesis, and biological evaluation of various human rhinovirus (HRV) 3C protease (3CP) inhibitors which incorporate P…”
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