Search Results - "Marais, A. David"

Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study by Cuchel, Marina, Dr, Meagher, Emma A, MD, du Toit Theron, Hendrik, Prof, Blom, Dirk J, PhD, Marais, A David, Prof, Hegele, Robert A, Prof, Averna, Maurizio R, Prof, Sirtori, Cesare R, Prof, Shah, Prediman K, Prof, Gaudet, Daniel, MD, Stefanutti, Claudia, MD, Vigna, Giovanni B, MD, Du Plessis, Anna ME, MMed, Propert, Kathleen J, Prof, Sasiela, William J, PhD, Bloedon, LeAnne T, MS, Rader, Daniel J, Prof

“…Summary Background Patients with homozygous familial hypercholesterolaemia respond inadequately to existing drugs. We aimed to assess the efficacy and safety…”
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Familial dysbetalipoproteinemia: an underdiagnosed lipid disorder by Koopal, Charlotte, Marais, A David, Visseren, Frank L J

“…To review pathophysiological, epidemiological and clinical aspects of familial dysbetalipoproteinemia; a model disease for remnant metabolism and…”
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Lomitapide and Mipomersen—Inhibiting Microsomal Triglyceride Transfer Protein (MTP) and apoB100 Synthesis by Blom, Dirk J., Raal, Frederick J., Santos, Raul D., Marais, A. David

“…Purpose of Review The goal of this review is to evaluate the role of inhibiting the synthesis of lipoproteins when there is no or little residual LDL-receptor…”
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Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial by Raal, Frederick J, Prof, Santos, Raul D, MD, Blom, Dirk J, MD, Marais, A David, Prof, Charng, Min-Ji, MD, Cromwell, William C, MD, Lachmann, Robin H, MRCP, Gaudet, Daniel, MD, Tan, Ju L, MB BS, Chasan-Taber, Scott, PhD, Tribble, Diane L, PhD, Flaim, JoAnn D, PhD, Crooke, Stanley T, MD

“…Summary Background Homozygous familial hypercholesterolaemia is a rare genetic disorder in which both LDL-receptor alleles are defective, resulting in very…”
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The C679X mutation in PCSK9 is present and lowers blood cholesterol in a Southern African population by Hooper, Amanda J, Marais, A. David, Tanyanyiwa, Donald M, Burnett, John R

“…Abstract Objective Missense mutations in the proprotein convertase subtilisin/kexin type 9 gene ( PCSK 9) can cause familial hypercholesterolemia. However, two…”
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Effect of adding bezafibrate to standard lipid-lowering therapy on post-fat load lipid levels in patients with familial dysbetalipoproteinemia. A randomized placebo-controlled crossover trial by Koopal, Charlotte, Marais, A. David, Westerink, Jan, van der Graaf, Yolanda, Visseren, Frank L.J.

“…Familial dysbetalipoproteinemia (FD) is a genetic disorder associated with impaired postprandial lipid clearance. The effect of adding bezafibrate to standard…”
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Dietary lipid modification for mild and severe dyslipidaemias by Marais, A. David

“…The aim of this review is to place a historical perspective on linking dyslipidaemia with atherosclerosis and emphasises previous knowledge about the impact on…”
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Apolipoprotein E in lipoprotein metabolism, health and cardiovascular disease by Marais, A.David

“…Apolipoprotein E (apoE), a 34 kDa circulating glycoprotein of 299 amino acids, predominantly synthesised in the liver, associates with triglyceride-rich…”
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Elevated Plasma PCSK9 Level Is Equally Detrimental for Patients With Nonfamilial Hypercholesterolemia and Heterozygous Familial Hypercholesterolemia, Irrespective of Low-Density Lipoprotein Receptor Defects by Lambert, Gilles, PhD, Petrides, Francine, BSc, Chatelais, Mathias, BSc, Blom, Dirk J., MD, PhD, Choque, Benjamin, PhD, Tabet, Fatiha, PhD, Wong, Gida, MD, Rye, Kerry-Anne, PhD, Hooper, Amanda J., PhD, Burnett, John R., MD, PhD, Barter, Philip J., MD, PhD, Marais, A. David, MD

“…Objectives Do elevated proprotein convertase subtilisin/kexin type 9 (PCSK9) levels constitute an even greater risk for patients who already have reduced…”
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Simvastatin enhances protection against Listeria monocytogenes infection in mice by counteracting Listeria-induced phagosomal escape by Parihar, Suraj P, Guler, Reto, Lang, Dirk M, Suzuki, Harukazu, Marais, A David, Brombacher, Frank

“…Statins are well-known cholesterol lowering drugs targeting HMG-CoA-reductase, reducing the risk of coronary disorders and hypercholesterolemia. Statins are…”
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Heterozygous familial hypercholesterolaemia in specialist centres in South Africa, Australia and Brazil: Importance of early detection and lifestyle advice by Pang, Jing, David Marais, A., Blom, Dirk J., Brice, Brigitte C., Silva, Pamela RS, Jannes, Cinthia E., Pereira, Alexandre C., Hooper, Amanda J., Ray, Kausik K., Santos, Raul D., Watts, Gerald F.

“…Familial hypercholesterolaemia (FH) is the commonest monogenic disorder that accelerates atherosclerotic cardiovascular disease. We compared and contrasted the…”
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Normalization of Low-Density Lipoprotein Receptor Expression in Receptor Defective Homozygous Familial Hypercholesterolemia by Inhibition of PCSK9 With Alirocumab by Lambert, Gilles, PhD, Chatelais, Mathias, BSc, Petrides, Francine, BSc, Passard, Maxime, BSc, Thedrez, Aurélie, PhD, Rye, Kerry-Anne, PhD, Schwahn, Uwe, PhD, Gusarova, Viktoria, PhD, Blom, Dirk J., MD, PhD, Sasiela, William, PhD, Marais, A. David, MD

“…Proprotein convertase subtilisin kexin type-9 (PCSK9) inhibition using monoclonal antibodies (mAbs) lowers low-density lipoprotein cholesterol (LDL-C) by >50%…”
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Autosomal dominant familial dysbetalipoproteinemia: A pathophysiological framework and practical approach to diagnosis and therapy by Koopal, Charlotte, MD, Marais, A. David, MD, Westerink, Jan, MD PhD, Visseren, Frank L.J., MD PhD

“…Abstract Familial dysbetalipoproteinemia (FD) is a genetic disorder of lipoprotein metabolism associated with an increased risk for premature cardiovascular…”
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Comparative aspects of the care of familial hypercholesterolemia in the “Ten Countries Study” by Pang, Jing, Chan, Dick C., Hu, Miao, Muir, Lauretta A., Kwok, See, Charng, Min-Ji, Florkowski, Christopher M., George, Peter M., Lin, Jie, Loi, Do Doan, Marais, A. David, Nawawi, Hapizah M., Gonzalez-Santos, Lourdes E., Su, Ta-Chen, Truong, Thanh Huong, Santos, Raul D., Soran, Handrean, Tomlinson, Brian, Yamashita, Shizuya, Ademi, Zanfina, Watts, Gerald F.

“…There is a lack of information on the health care of familial hypercholesterolemia (FH). The objective of this study was to compare the health care of FH in…”
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Colesevelam Hydrochloride: Efficacy and Safety in Pediatric Subjects with Heterozygous Familial Hypercholesterolemia by Stein, Evan A., MD, PhD, Marais, A. David, MD, Szamosi, Tamas, MD, PhD, Raal, Frederick J., MD, PhD, Schurr, Daniel, MD, Urbina, Elaine M., MD, Hopkins, Paul N., MD, MSPH, Karki, Sulekha, BAMS, Xu, Jianbo, MS, Misir, Soamnauth, PharmD, Melino, Michael, PhD

“…Objective Evaluate the efficacy and safety of colesevelam hydrochloride in children with heterozygous familial hypercholesterolemia (heFH). Study design This…”
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Translational Research for Improving the Care of Familial Hypercholesterolemia: The “Ten Countries Study” and Beyond by Watts, Gerald F, Ding, Phillip YA, George, Peter, Hagger, Martin S, Hu, Miao, Lin, Jie, Khoo, Kah Lin, Marais, A David, Miida, Takashi, Nawawi, Hapizah M, Pang, Jing, Park, Jeong Euy, Gonzalez-Santos, Lourdes B, Su, Ta-Chen, Truong, Thanh Huong, Santos, Raul D, Soran, Handrean, Yamashita, Shizuya, Tomlinson, Brian, for tha members of the "Ten countries Study"

“…Familial hypercholesterolemia (FH) is the most common and serious form of inherited hyperlipidaemia. Dominantly inherited with high penetrance, untreated FH…”
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Rodent nutritional model of non-alcoholic steatohepatitis: Species, strain and sex difference studies by KIRSCH, RICHARD, CLARKSON, VIVIAN, SHEPHARD, ENID G, MARAIS, DAVID A, JAFFER, MOHAMED A, WOODBURNE, VIVIENNE E, KIRSCH, RALPH E, HALL, PAULINE DE LA M

“…Background and Aim:  The methionine choline‐deficient (MCD) diet leads to steatohepatitis in rodents. The aim of the present study was to investigate species,…”
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Statin Therapy Reduces the Mycobacterium tuberculosis Burden in Human Macrophages and in Mice by Enhancing Autophagy and Phagosome Maturation by Parihar, Suraj P., Guler, Reto, Khutlang, Rethabile, Lang, Dirk M., Hurdayal, Ramona, Mhlanga, Musa M., Suzuki, Harukazu, Marais, A. David, Brombacher, Frank

“…Background. Statins are cholesterol-lowering drugs, targeting HMG-CoA reductase, thereby reducing the risk of coronary disorders and hypercholesterolemia…”
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Survival in homozygous familial hypercholesterolaemia is determined by the on-treatment level of serum cholesterol by Thompson, Gilbert R, Blom, Dirk J, Marais, A David, Seed, Mary, Pilcher, Gillian J, Raal, Frederick J

“…Abstract Aims Homozygous familial hypercholesterolaemia (FH) is a rare inherited disorder characterized by extreme hypercholesterolaemia from birth,…”
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Reduced Lipoprotein(a) Associated With the Apolipoprotein E2 Genotype Confers Cardiovascular Protection in Familial Hypercholesterolemia by Blanchard, Valentin, BS, Croyal, Mikaël, PhD, Khantalin, Ilya, MD, Ramin-Mangata, Stéphane, BS, Chemello, Kévin, BS, Nativel, Brice, PhD, Blom, Dirk. J., MD, PhD, Marais, A. David, MD, Lambert, Gilles, PhD

“…There are 3 isoforms of apolipoprotein E (apo E) in humans (ε2, ε3, and ε4). They differ by single amino acid substitutions that variably affect their affinity…”
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