Search Results - "Marais, A. D."

Management of hyperlipidaemia by Marais, A.D, Blom, D.J, Raal, F.J

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Efficacy criteria and cholesterol targets for LDL apheresis by Thompson, Gilbert R, Barbir, M, Davies, D, Dobral, P, Gesinde, M, Livingston, M, Mandry, P, Marais, A.D, Matthews, S, Neuwirth, C, Pottle, A, le Roux, C, Scullard, D, Tyler, C, Watkins, S

“…Abstract Low density lipoprotein (LDL) apheresis is now accepted as the treatment of choice for patients with homozygous familial hypercholesterolaemia and for…”
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Apolipoprotein E and Atherosclerosis by Marais, A. D.

“…Purpose of Review The functions, genetic variations and impact of apolipoprotein E on lipoprotein metabolism in general are placed in the context of clinical…”
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Marine and terrestrial foods as a source of brain-selective nutrients for early modern humans in the southwestern Cape, South Africa by Kyriacou, K., Blackhurst, D.M., Parkington, J.E., Marais, A.D.

“…Many attempts have been made to define and reconstruct the most plausible ecological and dietary niche of the earliest members of the human species. While…”
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Familial hypercholesterolaemia and its management in South Africa by Marais, A.D.

“…This issue of the Cardiovascular Journal of Africa has published two articles relevant to severe dyslipidaemias. A new therapeutic agent under review by the…”
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Identification of a single MPV17 nonsense‐associated altered splice variant in 24 South African infants with mitochondrial neurohepatopathy by Meldau, S., De Lacy, R.J., Riordan, G.T.M., Goddard, E.A., Pillay, K., Fieggen, K.J., Marais, A.D., Van der Watt, G.F.

“…MPV17‐related mitochondrial neurohepatopathy is a rare genetic disorder worldwide. We report on a novel pathogenic variant in the MPV17 gene in 24 unrelated…”
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The lipid-lowering effects of lomitapide are unaffected by adjunctive apheresis in patients with homozygous familial hypercholesterolaemia – A post-hoc analysis of a Phase 3, single-arm, open-label trial by Stefanutti, C, Blom, D.J, Averna, M.R, Meagher, E.A, Theron, H. dT, Marais, A.D, Hegele, R.A, Sirtori, C.R, Shah, P.K, Gaudet, D, Vigna, G.B, Sachais, B.S, Di Giacomo, S, du Plessis, A.M.E, Bloedon, L.T, Balser, J, Rader, D.J, Cuchel, M

“…Abstract Objective Lomitapide (a microsomal triglyceride transfer protein inhibitor) is an adjunctive treatment for homozygous familial hypercholesterolaemia…”
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Familial hypercholesterolaemia workshop for leveraging point-of-care testing and personalised medicine in association with the Lipid and Atherosclerosis Society of Southern Africa by Marais, A.D., Kotze, M.J, Raal, F.J., Khine, A.A., Humphries, S.E., Talmud, P.J.

“…Familial hypercholesterolaemia (FH) is a common autosomal dominantly inherited disorder in which impaired clearance of plasma low-density lipoprotein…”
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Management of hyperlipidaemia by Marais, A D, Blom, D J, Raal, F J

“…To the Editor: As physicians with expertise in the management of lipid disorders, we express our concern that the guideline for hyperlipidaemia published in…”
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Cerebrotendinous xanthomatosis without neurological involvement by Stelten, B. M. L., Raal, F. J., Marais, A. D., Riksen, N. P., Roeters van Lennep, J. E., Duell, P.B, Graaf, M., Kluijtmans, L. A. J., Wevers, R. A., Verrips, A.

“…Background Cerebrotendinous xanthomatosis (CTX) is an autosomal recessively inherited inborn error of metabolism. Neurological symptoms are considered to be a…”
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Discovering hypertriglyceridaemia by Marais, A D, Blom, D J

“…To the Editor: Hypertriglyceridaemia is a well-established, but occasionally overlooked, cause of pancreatitis despite mention in South African (SA) guidelines…”
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Hypertriglyceridaemia in adolescents may have serious complications by Korf, M, Zöllner, E W, Solomon, G E A, Zemlin, A E, Marais, A D

“…Acute pancreatitis is an often-overlooked cause of acute abdominal pain in children and adolescents. Severe hypertriglyceridaemia is an important cause of…”
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Severe hypercholesterolaemia with a high risk of atherosclerosis may be precipitated by a high-sterol diet by Marais, A.D., Segal, D.

“…To the Editor: Increasing dietary fat intake impacts variably on the plasma lipid profile, and the consequent dyslipidaemia influences cardiovascular risk from…”
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Familial hypercholesterolaemia in South Africa: A reminder by Marais, A D, Blom, D J, Raal, F J

“…It is ironic that South Africa (SA), known for the high prevalence of familial hypercholesterolaemia (FH)[1] in several population groups due to multiple…”
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The influence of glucocorticoids on lipid and lipoprotein metabolism and atherosclerosis by Ross, Ian L, Marais, A David

“…Glucocorticoids have multiple therapeutic uses, but their impact on lipid metabolism and cardiovascular disease risk is not always considered during long-term…”
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Dysbetalipoproteinaemia: Clinical and pathophysiological features by BLOM, D. J, BYRNES, P, JONES, S, MARAIS, A. D

“…Dysbetalipoproteinaemia (type III hyperlipidaemia, broad-beta disease) is a highly atherogenic genetic disorder of lipoprotein metabolism. It presents with a…”
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Effects of androgen manipulation on postprandial triglyceridaemia, low-density lipoprotein particle size and lipoprotein(a) in men by Hislop, M.S, St Clair Gibson, A, Lambert, M.I, Noakes, T.D, Marais, A.D

“…Although androgenic hormones decrease HDLC concentration, no direct evidence has linked them to atherosclerosis. The present study was undertaken to extend our…”
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Effects of anabolic-androgenic steroid use or gonadal testosterone suppression on serum leptin concentration in men by Hislop, MS, Ratanjee, BD, Soule, SG, Marais, AD

“…OBJECTIVE: Serum leptin concentration shows a sexual dimorphism that is not accounted for by gender differences in adiposity. A strong inverse association…”
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Plasma mevalonic acid, an index of cholesterol synthesis in vivo, and responsiveness to HMG-CoA reductase inhibitors in familial hypercholesterolaemia by Naoumova, R.P., Marais, A.D., Mountney, J., Firth, J.C., Rendell, N.B., Taylor, G.W., Thompson, G.R.

“…Fasting plasma mevalonic acid (MVA), an indicator of in vivo cholesterol synthesis, was measured in 35 patients with familial hypercholesterolaemia (FH) of…”
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Chylomicron remnant metabolism in familial dyslipidemias studied with a remnant-like emulsion breath test by Redgrave, T G, Watts, G F, Martins, I J, Barrett, P H, Mamo, J C, Dimmitt, S B, Marais, A D

“…We have developed a stable isotope breath test for the assessment of chylomicron remnant metabolism and report the results from the breath test in human…”
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