Search Results - "Marahatta, Anu"

An involvement of oxidative stress in endoplasmic reticulum stress and its associated diseases by Bhandary, Bidur, Marahatta, Anu, Kim, Hyung-Ryong, Chae, Han-Jung

“…The endoplasmic reticulum (ER) is the major site of calcium storage and protein folding. It has a unique oxidizing-folding environment due to the predominant…”
Get full text

High throughput and fully automated sample preparation for quantitative bioanalysis using LC/MS/MS by Marahatta, Anu, Abbondondolo, Sara, Roberts, Christopher, Strock, Christopher

Get full text

Water Extracts of Immature Rubus coreanus Regulate Lipid Metabolism in Liver Cells by Bhandary, Bidur, Lee, Geum-Hwa, Marahatta, Anu, Lee, Hak-Yong, Kim, Sun-Young, So, Byung-Ok, Kwon, Ji-Wung, Song, Ji-Young, Lee, Hee-Kwon, Kim, Hyung-Ryong, Chae, Soo-Wan, Chae, Han-Jung

“…Hyperlipidemia is a major contributor for atherosclerosis and hypolipidemic drugs such as statin are highly prescribed to treat elevated lipid level in plasma…”
Get full text

Hydroxyurea: Analytical techniques and quantitative analysis by Marahatta, Anu, Ware, Russell E.

“…Hydroxyurea is a potent disease-modifying therapeutic agent with efficacy for the treatment of sickle cell anemia. When administered at once-daily oral doses…”
Get full text

Hydroxyurea Exposure in Lactation: a Pharmacokinetics Study (HELPS) by Ware, Russell E., Marahatta, Anu, Ware, Julie L., McElhinney, Kathryn, Dong, Min, Vinks, Alexander A.

“…Lactation is contraindicated for women with sickle cell anemia receiving hydroxyurea therapy, despite sparse pharmacokinetics data. In 16 women who were…”
Get full text

Characterization of Salvia miltiorrhiza ethanol extract as an anti-osteoporotic agent by Cui, Yan, Bhandary, Bidur, Marahatta, Anu, Lee, Geum-Hwa, Li, Bo, Kim, Do-Sung, Chae, Soo-Wan, Kim, Hyung-Ryong, Chae, Han-Jung

“…Salvia miltiorrhiza (SM) has long been used as a traditional oriental medicine for cardiovascular disease. Accumulating evidence also indicates that SM has…”
Get full text

Hydroxyurea Exposure in Lactation—a Pharmacokinetics Study (HELPS) by Ware, Russell E., Marahatta, Anu, Ware, Julie L, McElhinney, Kathryn L, Dong, Min, Vinks, Alexander A.

“…Hydroxyurea is a potent and safe disease-modifying therapy for both children and adults with sickle cell anemia (SCA). Several decades of research data have…”
Get full text

Robust clinical and laboratory response to hydroxyurea using pharmacokinetically guided dosing for young children with sickle cell anemia by McGann, Patrick T., Niss, Omar, Dong, Min, Marahatta, Anu, Howard, Thad A., Mizuno, Tomoyuki, Lane, Adam, Kalfa, Theodosia A., Malik, Punam, Quinn, Charles T., Ware, Russell E., Vinks, Alexander A.

“…Hydroxyurea is FDA‐approved and now increasingly used for children with sickle cell anemia (SCA), but dosing strategies, pharmacokinetic (PK) profiles, and…”
Get full text

Stable-Isotope Dilution HPLC-Electrospray Ionization Tandem Mass Spectrometry Method for Quantifying Hydroxyurea in Dried Blood Samples by Marahatta, Anu, Megaraj, Vandana, McGann, Patrick T, Ware, Russell E, Setchell, Kenneth D R

“…Sickle cell anemia (SCA) is a life-threatening blood disorder characterized by the presence of sickle-shaped erythrocytes. Hydroxyurea is currently the only US…”
Get full text

Pharmacokinetics and Tissue Distribution of Hydroxyurea in a Mouse Model by Marahatta, Anu, McElhinney, Kathryn, Howard, Thad A., Ware, Russell E.

“…Background: Hydroxyurea is currently the only US FDA-approved treatment for patients with sickle cell anemia (SCA), and 30 years of research have documented…”
Get full text

4-Phenylbutyric acid regulates CCl4-induced acute hepatic dyslipidemia in a mouse model: A mechanism-based PK/PD study by Lee, Hwa Young, Marahatta, Anu, Bhandary, Bidur, Kim, Hyung-Ryong, Chae, Han-Jung

“…Endoplasmic reticulum (ER) stress and associated protein aggregation are closely associated with human diseases, including alterations in hepatic lipid…”
Get full text

Hydroxyurea Pharmacokinetic Profiles in Children Treated for Extreme Thrombocytosis after Total Pancreatectomy with Islet Cell Autotransplant Demonstrate Poor Absorption by Boucher, Alexander A, Dong, Min, Marahatta, Anu, Hausfeld, Adriane, Howard, Thad A., Nathan, Jaimie D, Vinks, Alexander A., McGann, Patrick T., Ware, Russell E., Luchtman-Jones, Lori

“…Background Total pancreatectomy with islet autotransplantation (TPIAT) is a surgical treatment for chronic recurrent pancreatitis that involves splenectomy,…”
Get full text

Novel Genetic Loci That Influence Fetal Hemoglobin Expression in Children with Sickle Cell Anemia by Marahatta, Anu, Howard, Thad A., Stuber, Susan E., McElhinney, Kathryn L, Tshilolo, Leon, Williams, Thomas N., Olupot-Olupot, Peter, Santos, Brigida, John, Chandy C., Opoka, Robert, Nieves, Rosa M., Mena, Rafael, Baker, Jasmine, Latham, Teresa, Flanagan, Jonathan M., Ware, Russell E.

“…Introduction: Elevated levels of fetal hemoglobin (HbF) are known to ameliorate both the morbidity and mortality of sickle cell anemia (SCA). Sustained…”
Get full text

Clinical and Laboratory Benefits of Early Initiation of Hydroxyurea with Pharmacokinetic Guided Dosing for Young Children with Sickle Cell Anemia by McGann, Patrick T., Niss, Omar, Dong, Min, Marahatta, Anu, Mizuno, Tomoyuki, Kalinyak, Karen, Kalfa, Theodosia A., Malik, Punam, Quinn, Charles T., Ware, Russell E., Vinks, Alexander A.

“…Background: Hydroxyurea is now the standard of care for children with sickle cell anemia (SCA). Results from the BABY HUG study and recommendations from the…”
Get full text

Mitochondria in relation to cancer metastasis by Bhandary, Bidur, Marahatta, Anu, Kim, Hyung-Ryong, Chae, Han-Jung

“…Mitochondria, also known as “Power House of cell,” are crucial organelles, regulating energy metabolism. Recently, an involvement of mitochondria in cancer…”
Get full text

Genetic Variants That Influence Fetal Hemoglobin Expression from Hydroxyurea Treatment by Marahatta, Anu, Flanagan, Jonathan M., Howard, Thad A., Mortier, Nicole, Schultz, William, McElhinney, Kathryn L, Tshilolo, Leon, Williams, Thomas N., Olupot-Olupot, Peter, Santos, Brigida, John, Chandy C., Opoka, Robert, Nieves, Rosa M., Mena, Rafael, Reid, Marvin E, Rankine-Mullings, Angela, Baker, Jasmine, McGann, Patrick T., Aygun, Banu, Lane, Adam, Tomlinson, George A., Latham, Teresa, Stuber, Susan E., Ware, Russell E.

“…Introduction: Hydroxyurea is a potent therapeutic agent for sickle cell anemia (SCA), and treatment at maximum tolerated dose (MTD) is becoming the standard of…”
Get full text

Hydroxyurea Pharmacokinetics in Pediatric Patients After Total Pancreatectomy With Islet Autotransplantation by Boucher, Alexander A., Dong, Min, Vinks, Alexander A., Marahatta, Anu, Howard, Thad A., Ware, Russell E., Nathan, Jaimie D., Abu‐El‐Haija, Maisam, Luchtman‐Jones, Lori

“…Total pancreatectomy with islet autotransplantation is a complex surgical approach for acute recurrent or chronic pancreatitis that frequently triggers extreme…”
Get full text

Pharmacokinetics of Hydroxyurea Therapy in African Children with Sickle Cell Anemia:Â Noharm Ancillary PK Study by Marahatta, Anu, Dong, Min, Opoka, Robert, McElhinney, Kathryn E., Latham, Teresa S., John, Chandy C., Vinks, Alexander A., Ware, Russell E.

“…▪ Background. Hydroxyurea is an important disease-modifying therapy for sickle cell anemia (SCA). Through induction of fetal hemoglobin and other mechanisms,…”
Get full text

PI3Kδ contributes to ER stress-associated asthma through ER-redox disturbances: the involvement of the RIDD–RIG-I–NF-κB axis by Kim, Hyun-Kyoung, Lee, Geum-Hwa, Bhattarai, Kashi Raj, Junjappa, Raghu Patil, Lee, Hwa-Young, Handigund, Mallikarjun, Marahatta, Anu, Bhandary, Bidur, Baek, In-Hwan, Pyo, Jae Sung, Kim, Hye-Kyung, Chai, Ok Hee, Kim, Hyung-Ryong, Lee, Yong-Chul, Chae, Han-Jung

“…Hyperactivation of phosphoinositol 3-kinase (PI3K) has been suggested to be a potential mechanism for endoplasmic reticulum (ER) stress-enhanced airway…”
Get full text

Soybean greatly reduces valproic acid plasma concentrations: A food–drug interaction study by Marahatta, Anu, Bhandary, Bidur, Jeong, Seul-Ki, Kim, Hyung-Ryong, Chae, Han-Jung

“…The aim of this study was to investigate the effects of soy on the pharmacokinetics and pharmacodynamics of valproic acid (VPA). In a preclinical study, rats…”
Get full text