Search Results - "Maragoudakis, E"

Thrombin's central role in angiogenesis and pathophysiological processes by Tsopanoglou, Nikos E, Maragoudakis, Michael E

“…A plethora of endogenous modulators of angiogenesis have been identified and their roles in the molecular and cellular events that mediate and regulate…”
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Blockade of angiogenesis by small molecule antagonists to protease-activated receptor-1: association with endothelial cell growth suppression and induction of apoptosis by Zania, Panagiota, Kritikou, Sosanna, Flordellis, Christodoulos S, Maragoudakis, Michael E, Tsopanoglou, Nikos E

“…Many studies support the notion that protease-activated receptor (PAR)-1 plays a pivotal role in angiogenesis. However, direct evidence and understanding the…”
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Parstatin, the cleaved peptide on proteinase-activated receptor 1 activation, is a potent inhibitor of angiogenesis by Zania, Panagiota, Gourni, Despina, Aplin, Alfred C, Nicosia, Roberto F, Flordellis, Christodoulos S, Maragoudakis, Michael E, Tsopanoglou, Nikos E

“…The proteolytic activation by thrombin of the proteinase-activated receptor 1 unveils the tethered peptide ligand and cleaves a 41-amino acid peptide. In this…”
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Mechanism of thrombin-induced angiogenesis by Maragoudakis, M E, Tsopanoglou, N E, Andriopoulou, P

“…Clinical, laboratory, histopathological and pharmacological evidence support the notion that a systemic activation of blood coagulation is often present in…”
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On the mechanism of thrombin-induced angiogenesis. Potentiation of vascular endothelial growth factor activity on endothelial cells by up-regulation of its receptors by Tsopanoglou, N E, Maragoudakis, M E

“…Many of the cellular actions of thrombin may contribute to the angiogenesis-promoting effect of thrombin reported previously. In this study, we investigated…”
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Inhibition of angiogenesis by small-molecule antagonists of protease-activated receptor-1 by Tsopanoglou, Nikos E, Maragoudakis, Michael E

“…Angiogenesis, the growth of new blood vessels from preexisting ones, is a necessary component of embryogenesis, wound healing, and the proliferative phase of…”
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Thrombin promotes endothelial cell alignment in Matrigel in vitro and angiogenesis in vivo by Haralabopoulos, G C, Grant, D S, Kleinman, H K, Maragoudakis, M E

“…We have tested the effect of thrombin on endothelial cell tube formation in vitro and angiogenesis in vivo. Thrombin induces the differentiation of endothelial…”
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Role of thrombin in angiogenesis and tumor progression by Tsopanoglou, Nikos E, Maragoudakis, Michael E

“…Clinical, laboratory, histopathological, and pharmacological evidence support the notion that the coagulation system, which is activated in most cancer…”
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Evidence that platelets promote tube formation by endothelial cells on matrigel by Pipili‐Synetos, E, Papadimitriou, E, Maragoudakis, M E

“…1 The involvement of platelets in neovascularization was investigated in the matrigel tube formation assay, an in vitro model of angiogenesis. 2 Platelets…”
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Thrombin Functions through Its RGD Sequence in a Non-canonical Conformation by Papaconstantinou, Matthew E, Carrell, Christopher J, Pineda, Agustin O, Bobofchak, Kevin M, Mathews, F Scott, Flordellis, Christodoulos S, Maragoudakis, Michael E, Tsopanoglou, Nikos E, Di Cera, Enrico

“…Previous studies have suggested that thrombin interacts with integrins in endothelial cells through its RGD (Arg-187, Gly-188, Asp-189) sequence. All existing…”
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Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase by Venema, Richard C, Venema, Virginia J, Ju, Hong, Harris, M Brennan, Snead, Connie, Jilling, Tamas, Dimitropoulou, Christiana, Maragoudakis, Michael E, Catravas, John D

“…Soluble guanylate cyclase (sGC) is an important downstream intracellular target of nitric oxide (NO) that is produced by endothelial NO synthase (eNOS) and…”
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Nitric oxide synthase expression, enzyme activity and NO production during angiogenesis in the chick chorioallantoic membrane by Pipili‐Synetos, Eva, Kritikou, Sosanna, Papadimitriou, Evangelia, Athanassiadou, Aglaia, Flordellis, C, Maragoudakis, M E

“…In order to elucidate further the role of nitric oxide (NO) as an endogenous antiangiogenic mediator, mRNA expression of inducible nitric oxide synthase…”
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Inhibition of angiogenesis, tumour growth and metastasis by the NO‐releasing vasodilators, isosorbide mononitrate and dinitrate by Pipili‐Synetos, Eva, Papageorgiou, A., Sakkoula, Eleni, Sotiropoulou, Georgia, Fotsis, T., Karakiulakis, G., Maragoudakis, M.E.

“…1 The effect of the nitric oxide (NO)‐producing nitrovasodilators isosorbide mononitrate (ISMN) and isosorbide dinitrate (ISDN) were assessed on (a) the in…”
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Evidence that nitric oxide is an endogenous antiangiogenic mediator by Pipili‐Synetos, Eva, Sakkoula, Eleni, Haralabopoulos, G., Andriopoulou, Paraskevi, Peristeris, P., Maragoudakis, M.E.

“…1 The involvement of nitric oxide (NO) in the regulation of angiogenesis was examined in the in vivo system of the chorioallantoic membrane (CAM) of the chick…”
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Thrombin promotes angiogenesis by a mechanism independent of fibrin formation by Tsopanoglou, N E, Pipili-Synetos, E, Maragoudakis, M E

“…The role of thrombin in angiogenesis was investigated in the chick chorioallantoic membrane (CAM) system. alpha-Thrombin promoted angiogenesis in a…”
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Boron–aluminide coatings applied by pack cementation method on low-alloy steels by Maragoudakis, N.E, Stergioudis, G, Omar, H, Paulidou, H, Tsipas, D.N

“…A simultaneous one-step boroaluminizing process has been performed on a 2.25Cr–Mo steel by means of pack cementation method using a B/Al boriding powder. Three…”
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Involvement of nitric oxide in the inhibition of angiogenesis by interleukin‐2 by Sakkoula, Eleni, Pipili‐Synetos, Eva, Maragoudakis, M. E.

“…Interleukin‐2 (IL‐2), an immunoregulatory cytokine possessing antitumour activity, is an inducer of nitric oxide (NO) synthesis in mice and man. In this study,…”
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Boro-nitriding of steel US 37-1 by Maragoudakis, N.E, Stergioudis, G, Omar, H, Pavlidou, E, Tsipas, D.N

“…In this paper, we present a novel duplex surface treatment carried out on steel US 37-1. The as-produced multi-layer coating was characterised by optical…”
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On the mechanism(s) of thrombin induced angiogenesis by Maragoudakis, M E, Tsopanoglou, N E

“…Promotion of tumour progression by thrombin is suggested by several clinical and laboratory observations. A plausible explanation for this effect of thrombin…”
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Nitric oxide is involved in the regulation of angiogenesis by Pipili‐Synetos, Eva, Sakkoula, Eleni, Maragoudakis, M.E.

“…The in vivo model of the chick embryo chorioallantoic membrane (CAM) was used to study the involvement of nitric oxide (NO) in angiogenesis. The…”
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