Search Results - "Marafie, Sulaiman K."

mTOR: Its Critical Role in Metabolic Diseases, Cancer, and the Aging Process by Marafie, Sulaiman K, Al-Mulla, Fahd, Abubaker, Jehad

“…The mammalian target of rapamycin (mTOR) is a pivotal regulator, integrating diverse environmental signals to control fundamental cellular functions, such as…”
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Higher binding affinity of furin for SARS-CoV-2 spike (S) protein D614G mutant could be associated with higher SARS-CoV-2 infectivity by Mohammad, Anwar, Alshawaf, Eman, Marafie, Sulaiman K., Abu-Farha, Mohamed, Abubaker, Jehad, Al-Mulla, Fahd

“…•The G clade 23403A>G mutation on the spike glycoprotein (S protein) encodes a virulent strain of SARS-CoV-2.•The D614G substitution causes the loss of a…”
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Notoginsenoside R1, a metabolite from Panax notoginseng (Burkill) F.H.Chen, stimulates insulin secretion through activation of phosphatidylinositol 3-kinase (PI3K)/Akt pathway by Al-Romaiyan, Altaf, Barakat, Ahmad, Marafie, Sulaiman K, Masocha, Willias

“…For ages, botanical medicine has been used in the treatment of diabetes mellitus (DM). Notoginsenoside R1 (NGR1), a Panax notoginseng (Burkill) F.H.Chen…”
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An Overview of the Role of Furin in Type 2 Diabetes by Marafie, Sulaiman K., Al-Mulla, Fahd

“…Post-translational modifications (PTMs) play important roles in regulating several human diseases, like cancer, neurodegenerative disorders, and metabolic…”
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Palmitic acid-induced lipotoxicity promotes a novel interplay between Akt-mTOR, IRS-1, and FFAR1 signaling in pancreatic β-cells by Marafie, Sulaiman K, Al-Shawaf, Eman M, Abubaker, Jehad, Arefanian, Hossein

“…Free fatty acid receptor 1 (FFAR1) is G-protein coupled receptor predominantly expressed in pancreatic β-cells that is activated by a variety of free fatty…”
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Comparative Proteomic Analysis Identifies EphA2 as a Specific Cell Surface Marker for Wharton's Jelly-Derived Mesenchymal Stem Cells by Al Madhoun, Ashraf, Marafie, Sulaiman K, Haddad, Dania, Melhem, Motasem, Abu-Farha, Mohamed, Ali, Hamad, Sindhu, Sardar, Atari, Maher, Al-Mulla, Fahd

“…Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) are a valuable tool in stem cell research due to their high proliferation rate, multi-lineage…”
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Targeting SARS-CoV-2 Macrodomain-1 to Restore the Innate Immune Response Using In Silico Screening of Medicinal Compounds and Free Energy Calculation Approaches by Mohammad, Anwar, Alshawaf, Eman, Arefanian, Hossein, Marafie, Sulaiman K, Khan, Abbas, Wei, Dong-Qing, Al-Mulla, Fahd, Abubaker, Jehad

“…Among the different drug targets of SARS-CoV-2, a multi-domain protein known as NSP3 is a critical element of the translational and replication machinery. The…”
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Molecular Simulation-Based Investigation of Highly Potent Natural Products to Abrogate Formation of the nsp10-nsp16 Complex of SARS-CoV-2 by Mohammad, Anwar, Alshawaf, Eman, Marafie, Sulaiman K, Abu-Farha, Mohamed, Al-Mulla, Fahd, Abubaker, Jehad

“…The SARS-CoV-2 non-structural protein (nsp) nsp10-nsp16 complex is essential for the 2'-O-methylation of viral mRNA, a crucial step for evading the innate…”
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Structural-Dynamics and Binding Analysis of RBD from SARS-CoV-2 Variants of Concern (VOCs) and GRP78 Receptor Revealed Basis for Higher Infectivity by Khan, Abbas, Mohammad, Anwar, Haq, Inamul, Nasar, Mohammad, Ahmad, Waqar, Yousafi, Qudsia, Suleman, Muhammad, Ahmad, Sajjad, Albutti, Aqel, Khan, Taimoor, Marafie, Sulaiman K, Alshawaf, Eman, Ali, Syed Shujait, Abubaker, Jehad, Wei, Dong-Qing

“…Glucose-regulated protein 78 (GRP78) might be a receptor for SARS-CoV-2 to bind and enter the host cell. Recently reported mutations in the spike glycoprotein…”
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Structural analysis of ACE2 variant N720D demonstrates a higher binding affinity to TMPRSS2 by Mohammad, Anwar, Marafie, Sulaiman K., Alshawaf, Eman, Abu-Farha, Mohamed, Abubaker, Jehad, Al-Mulla, Fahd

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel member of the betacoronaviruses family affecting the lower respiratory tract mainly…”
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Discovery of natural products to block SARS-CoV-2 S-protein interaction with Neuropilin-1 receptor: A molecular dynamics simulation approach by Alshawaf, Eman, Hammad, Maha M., Marafie, Sulaiman K., Ali, Hamad, Al-Mulla, Fahd, Abubaker, Jehad, Mohammad, Anwar

“…Neuropilin-1 (NRP1) is a widely expressed cell surface receptor protein characterized by its pleiotropic function. Recent reports highlighted NRP1 as an…”
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Commiphora myrrha stimulates insulin secretion from β-cells through activation of atypical protein kinase C and mitogen-activated protein kinase by Al-Romaiyan, Altaf, Masocha, Willias, Oyedemi, Sunday, Marafie, Sulaiman K., Huang, Guo-Cai, Jones, Peter M., Persaud, Shanta J.

“…Ayurvedic medicine has been used in the treatment of diabetes mellitus for centuries. In Arabia and some areas of Africa, Commiphora myrrha (CM) has been…”
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Outcomes of COVID-19: Disparities by ethnicity by Ali, Hamad, Alshukry, Abdullah, Marafie, Sulaiman K., AlRukhayes, Monera, Ali, Yaseen, Abbas, Mohammad Bu, Al-Taweel, Abdullah, Bukhamseen, Yousef, Dashti, Mohammad H., Al-Shammari, Abdullah A., Abu-Farha, Mohammad, AbuBakr, Jehad, Al-Mulla, Fahd

“…To investigate the role of ethnicity in COVID-19 outcome disparities in a cohort in Kuwait. This is a retrospective analysis of 405 individuals infected with…”
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Exploring the Binding Mechanism of NRG1–ERBB3 Complex and Discovery of Potent Natural Products to Reduce Diabetes-Assisted Breast Cancer Progression by Marafie, Sulaiman K., Alshawaf, Eman, Abu-Farha, Mohamed, Thanaraj, Thangavel Alphonse, Wei, Dong-Qing, Al-Mulla, Fahd, Khan, Abbas, Abubaker, Jehad, Mohammad, Anwar

“…Diabetes mellitus significantly contributes to breast cancer progression, where hyperglycemia upregulates specific genes, leading to more aggressive tumor…”
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Palmitic acid-induced lipotoxicity promotes a novel interplay between Akt-mTOR, IRS-1, and FFAR1 signaling in pancreatic [beta]-cells by Marafie, Sulaiman K, Al-Shawaf, Eman M, Abubaker, Jehad, Arefanian, Hossein

“…Free fatty acid receptor 1 (FFAR1) is G-protein coupled receptor predominantly expressed in pancreatic [beta]-cells that is activated by a variety of free…”
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TRIM7, a Novel Binding Protein of the mTORC2 Component Sin1 by Marafie, Sulaiman K

“…TRIM7 is a member of the TRIM (tripartite motif-containing) protein superfamily. This family has been implicated in many disorders such as genetic diseases,…”
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