Search Results - "Marín de Mas, Igor"

Model-driven discovery of long-chain fatty acid metabolic reprogramming in heterogeneous prostate cancer cells by Marín de Mas, Igor, Aguilar, Esther, Zodda, Erika, Balcells, Cristina, Marin, Silvia, Dallmann, Guido, Thomson, Timothy M, Papp, Balázs, Cascante, Marta

“…Epithelial-mesenchymal-transition promotes intra-tumoral heterogeneity, by enhancing tumor cell invasiveness and promoting drug resistance. We integrated…”
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Endothelial Cell Phenotypes Demonstrate Different Metabolic Patterns and Predict Mortality in Trauma Patients by Henriksen, Hanne H, Marín de Mas, Igor, Nielsen, Lars K, Krocker, Joseph, Stensballe, Jakob, Karvelsson, Sigurður T, Secher, Niels H, Rolfsson, Óttar, Wade, Charles E, Johansson, Pär I

“…In trauma patients, shock-induced endotheliopathy (SHINE) is associated with a poor prognosis. We have previously identified four metabolic phenotypes in a…”
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Unveiling the Metabolic Changes on Muscle Cell Metabolism Underlying p -Phenylenediamine Toxicity by Marín de Mas, Igor, Marín, Silvia, Pachón, Gisela, Rodríguez-Prados, Juan C, Vizán, Pedro, Centelles, Josep J, Tauler, Romà, Azqueta, Amaya, Selivanov, Vitaly, López de Ceraín, Adela, Cascante, Marta

“…Rhabdomyolysis is a disorder characterized by acute damage of the sarcolemma of the skeletal muscle leading to release of potentially toxic muscle cell…”
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Relevance of the MEK/ERK signaling pathway in the metabolism of activated macrophages: a metabolomic approach by Través, Paqui G, de Atauri, Pedro, Marín, Silvia, Pimentel-Santillana, María, Rodríguez-Prados, Juan-Carlos, Marín de Mas, Igor, Selivanov, Vitaly A, Martín-Sanz, Paloma, Boscá, Lisardo, Cascante, Marta

“…The activation of immune cells in response to a pathogen involves a succession of signaling events leading to gene and protein expression, which requires…”
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A Multi-Level Systems Biology Analysis of Aldrin's Metabolic Effects on Prostate Cancer Cells by Bedia, Carmen, Dalmau, Nuria, Nielsen, Lars K, Tauler, Romà, Marín de Mas, Igor

“…Although numerous studies support a dose-effect relationship between Endocrine disruptors (EDs) and the progression and malignancy of tumors, the impact of a…”
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Metabolic Modelling as a Framework for Metabolomics Data Integration and Analysis by Volkova, Svetlana, Matos, Marta R A, Mattanovich, Matthias, Marín de Mas, Igor

“…Metabolic networks are regulated to ensure the dynamic adaptation of biochemical reaction fluxes to maintain cell homeostasis and optimal metabolic fitness in…”
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Chronic Obstructive Pulmonary Disease heterogeneity: challenges for health risk assessment, stratification and management by Roca, Josep, Vargas, Claudia, Cano, Isaac, Selivanov, Vitaly, Barreiro, Esther, Maier, Dieter, Falciani, Francesco, Wagner, Peter, Cascante, Marta, Garcia-Aymerich, Judith, Kalko, Susana, De Mas, Igor, Tegnér, Jesper, Escarrabill, Joan, Agustí, Alvar, Gomez-Cabrero, David

“…Heterogeneity in clinical manifestations and disease progression in Chronic Obstructive Pulmonary Disease (COPD) lead to consequences for patient health risk…”
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Systems Medicine: from molecular features and models to the clinic in COPD by Gomez-Cabrero, David, Menche, Jörg, Cano, Isaac, Abugessaisa, Imad, Huertas-Migueláñez, Mercedes, Tenyi, Akos, Marin de Mas, Igor, Kiani, Narsis A, Marabita, Francesco, Falciani, Francesco, Burrowes, Kelly, Maier, Dieter, Wagner, Peter, Selivanov, Vitaly, Cascante, Marta, Roca, Josep, Barabási, Albert-László, Tegnér, Jesper

“…Chronic Obstructive Pulmonary Disease (COPD) patients are characterized by heterogeneous clinical manifestations and patterns of disease progression. Two major…”
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Cancer cell metabolism as new targets for novel designed therapies by Marín de Mas, Igor, Aguilar, Esther, Jayaraman, Anusha, Polat, Ibrahim H, Martín-Bernabé, Alfonso, Bharat, Rohit, Foguet, Carles, Milà, Enric, Papp, Balázs, Centelles, Josep J, Cascante, Marta

“…Metabolic processes are altered in cancer cells, which obtain advantages from this metabolic reprogramming in terms of energy production and synthesis of…”
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Soft‐sensors application for automated feeding control in high‐throughput mammalian cell cultures by Martínez‐Monge, Iván, Martínez, Carlos, Decker, Marianne, Udugama, Isuru A., Marín de Mas, Igor, Gernaey, Krist V., Nielsen, Lars K.

“…The ever‐increasing demand for biopharmaceuticals has created the need for improving the overall productivity of culture processes. One such operational…”
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Integrating Genome-Scale Metabolic Models with Patient Plasma Metabolome to Study Endothelial Metabolism In Situ by Silva-Lance, Fernando, Montejano-Montelongo, Isabel, Bautista, Eric, Nielsen, Lars K, Johansson, Pär I, Marin de Mas, Igor

“…Patient blood samples are invaluable in clinical omics databases, yet current methodologies often fail to fully uncover the molecular mechanisms driving…”
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Stoichiometric gene-to-reaction associations enhance model-driven analysis performance: Metabolic response to chronic exposure to Aldrin in prostate cancer by Marín de Mas, Igor, Torrents, Laura, Bedia, Carmen, Nielsen, Lars K, Cascante, Marta, Tauler, Romà

“…Genome-scale metabolic models (GSMM) integrating transcriptomics have been widely used to study cancer metabolism. This integration is achieved through logical…”
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Molecular mechanisms underlying COPD-muscle dysfunction unveiled through a systems medicine approach by Marín de Mas, Igor, Fanchon, Eric, Papp, Balázs, Kalko, Susana, Roca, Josep, Cascante, Marta

“…Skeletal muscle dysfunction is a systemic effect in one-third of patients with chronic obstructive pulmonary disease (COPD), characterized by high…”
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Enhancing control systems of higher plant culture chambers via multilevel structural mechanistic modelling by Ciurans, Carles, Guerrero, Josep M., Martínez-Mongue, Ivan, Dussap, Claude G., Marin de Mas, Igor, Gòdia, Francesc

“…Modelling higher plant growth is of strategic interest for modern agriculture as well as for the development of bioregenerative life support systems for space…”
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A Protocol for the Automatic Construction of Highly Curated Genome-Scale Models of Human Metabolism by Marin de Mas, Igor, Herand, Helena, Carrasco, Jorge, Nielsen, Lars K, Johansson, Pär I

“…Genome-scale metabolic models (GEMs) have emerged as a tool to understand human metabolism from a holistic perspective with high relevance in the study of many…”
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Metabolic systems analysis identifies a novel mechanism contributing to shock in patients with endotheliopathy of trauma (EoT) involving thromboxane A2 and LTC4 by Henriksen, Hanne H., Marín de Mas, Igor, Herand, Helena, Krocker, Joseph, Wade, Charles E., Johansson, Pär I.

“…•Endotheliopathy of Trauma (EoT) defined by an admission syndecan-1 level ≥ 40 ng/mL has been reported to be associated with significantly increased…”
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Workforce preparation: the Biohealth computing model for Master and PhD students by Cascante, Marta, de Atauri, Pedro, Gomez-Cabrero, David, Wagner, Peter, Centelles, Josep J, Marin, Silvia, Cano, Isaac, Velickovski, Filip, Marin de Mas, Igor, Maier, Dieter, Roca, Josep, Sabatier, Philippe

“…The article addresses the strategic role of workforce preparation in the process of adoption of Systems Medicine as a driver of biomedical research in the new…”
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Compartmentation of glycogen metabolism revealed from 13C isotopologue distributions by de Mas, Igor Marin, Selivanov, Vitaly A, Marin, Silvia, Roca, Josep, Orešič, Matej, Agius, Loranne, Cascante, Marta

“…Stable isotope tracers are used to assess metabolic flux profiles in living cells. The existing methods of measurement average out the isotopic isomer…”
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Metabolic Reprogramming and Dependencies Associated with Epithelial Cancer Stem Cells Independent of the Epithelial‐Mesenchymal Transition Program by Aguilar, Esther, Marin de Mas, Igor, Zodda, Erika, Marin, Silvia, Morrish, Fionnuala, Selivanov, Vitaly, Meca‐Cortés, Óscar, Delowar, Hossain, Pons, Mònica, Izquierdo, Inés, Celià‐Terrassa, Toni, de Atauri, Pedro, Centelles, Josep J., Hockenbery, David, Thomson, Timothy M., Cascante, Marta

“…In solid tumors, cancer stem cells (CSCs) can arise independently of epithelial‐mesenchymal transition (EMT). In spite of recent efforts, the metabolic…”
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Minimizing Clonal Variation during Mammalian Cell Line Engineering for Improved Systems Biology Data Generation by Grav, Lise Marie, Sergeeva, Daria, Lee, Jae Seong, Marin de Mas, Igor, Lewis, Nathan E, Andersen, Mikael Rørdam, Nielsen, Lars Keld, Lee, Gyun Min, Kildegaard, Helene Faustrup

“…Mammalian cells are widely used to express genes for basic biology studies and biopharmaceuticals. Current methods for generation of engineered cell lines…”
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