Search Results - "Marín‐Hernández, Alvaro"

Energy metabolism in tumor cells by Moreno‐Sánchez, Rafael, Rodríguez‐Enríquez, Sara, Marín‐Hernández, Alvaro, Saavedra, Emma

“…In early studies on energy metabolism of tumor cells, it was proposed that the enhanced glycolysis was induced by a decreased oxidative phosphorylation. Since…”
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Reactive oxygen species are generated by the respiratory complex II – evidence for lack of contribution of the reverse electron flow in complex I by Moreno‐Sánchez, Rafael, Hernández‐Esquivel, Luz, Rivero‐Segura, Nadia A., Marín‐Hernández, Alvaro, Neuzil, Jiri, Ralph, Stephen J., Rodríguez‐Enríquez, Sara

“…Succinate‐driven oxidation via complex II (CII) may have a significant contribution towards the high rates of production of reactive oxygen species (ROS) by…”
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Modeling cancer glycolysis under hypoglycemia, and the role played by the differential expression of glycolytic isoforms by Marín‐Hernández, Alvaro, López‐Ramírez, Sayra Y., Del Mazo‐Monsalvo, Isis, Gallardo‐Pérez, Juan C., Rodríguez‐Enríquez, Sara, Moreno‐Sánchez, Rafael, Saavedra, Emma

“…The effect of hypoglycemia on the contents of glycolytic proteins, activities of enzymes/transporters and flux of HeLa and MCF‐7 tumor cells was experimentally…”
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Kinetics of transport and phosphorylation of glucose in cancer cells by Rodríguez-Enríquez, Sara, Marín-Hernández, Alvaro, Gallardo-Pérez, Juan Carlos, Moreno-Sánchez, Rafael

“…Metabolic control analysis of tumor glycolysis has indicated that hexokinase (HK) and glucose transporter (GLUT) exert the main flux control (71%). To…”
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Targeting of cancer energy metabolism by Rodríguez-Enríquez, Sara, Marín-Hernández, Alvaro, Gallardo-Pérez, Juan Carlos, Carreño-Fuentes, Liliana, Moreno-Sánchez, Rafael

“…The main purpose of this review is to update and analyze the effect of several antineoplastic drugs (adriamycin, apoptodilin, casiopeinas, cisplatin,…”
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Phosphofructokinase type 1 kinetics, isoform expression, and gene polymorphisms in cancer cells by Moreno-Sánchez, Rafael, Marín-Hernández, Alvaro, Gallardo-Pérez, Juan Carlos, Quezada, Héctor, Encalada, Rusely, Rodríguez-Enríquez, Sara, Saavedra, Emma

“…Kinetic analysis of PFK‐1 from rodent AS‐30D, and human HeLa and MCF‐7 carcinomas revealed sigmoidal [fructose 6‐phosphate, Fru6P]‐rate curves with different…”
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Energy metabolism transition in multi-cellular human tumor spheroids by Rodríguez-Enríquez, Sara, Gallardo-Pérez, Juan Carlos, Avilés-Salas, Alejandro, Marín-Hernández, Alvaro, Carreño-Fuentes, Liliana, Maldonado-Lagunas, Vilma, Moreno-Sánchez, Rafael

“…It is thought that glycolysis is the predominant energy pathway in cancer, particularly in solid and poorly vascularized tumors where hypoxic regions develop…”
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Oxidative phosphorylation is impaired by prolonged hypoxia in breast and possibly in cervix carcinoma by Rodríguez-Enríquez, Sara, Carreño-Fuentes, Liliana, Gallardo-Pérez, Juan Carlos, Saavedra, Emma, Quezada, Héctor, Vega, Alicia, Marín-Hernández, Alvaro, Olín-Sandoval, Viridiana, Torres-Márquez, M. Eugenia, Moreno-Sánchez, Rafael

“…It has been assumed that oxidative phosphorylation (OxPhos) in solid tumors is severely reduced due to cytochrome c oxidase substrate restriction, although the…”
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The bioenergetics of cancer: Is glycolysis the main ATP supplier in all tumor cells? by Moreno-Sánchez, Rafael, Rodríguez-Enríquez, Sara, Saavedra, Emma, Marín-Hernández, Alvaro, Gallardo-Pérez, Juan Carlos

“…The molecular mechanisms by which tumor cells achieve an enhanced glycolytic flux and, presumably, a decreased oxidative phosphorylation are analyzed. As the…”
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The nutritional status of Methanosarcina acetivorans regulates glycogen metabolism and gluconeogenesis and glycolysis fluxes by Santiago‐Martínez, Michel Geovanni, Encalada, Rusely, Lira‐Silva, Elizabeth, Pineda, Erika, Gallardo‐Pérez, Juan Carlos, Reyes‐García, Marco Antonio, Saavedra, Emma, Moreno‐Sánchez, Rafael, Marín‐Hernández, Alvaro, Jasso‐Chávez, Ricardo

“…Gluconeogenesis is an essential pathway in methanogens because they are unable to use exogenous hexoses as carbon source for cell growth. With the aim of…”
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NAC Pre-Administration Prevents Cardiac Mitochondrial Bioenergetics, Dynamics, Biogenesis, and Redox Alteration in Folic Acid-AKI-Induced Cardio-Renal Syndrome Type 3 by Cuevas-López, Belén, Romero-Ramirez, Edgar Ignacio, García-Arroyo, Fernando E, Tapia, Edilia, León-Contreras, Juan Carlos, Silva-Palacios, Alejandro, Roldán, Francisco-Javier, Campos, Omar Noel Medina, Hernandez-Esquivel, Luz, Marín-Hernández, Alvaro, Gonzaga-Sánchez, José Guillermo, Hernández-Pando, Rogelio, Pedraza-Chaverri, José, Sánchez-Lozada, Laura Gabriela, Aparicio-Trejo, Omar Emiliano

“…The incidence of kidney disease is increasing worldwide. Acute kidney injury (AKI) can strongly favor cardio-renal syndrome (CRS) type 3 development. However,…”
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The 2‐oxoglutarate supply exerts significant control on the lysine synthesis flux in Saccharomyces cerevisiae by Quezada, Héctor, Marín‐Hernández, Alvaro, Arreguín‐Espinosa, Roberto, Rumjanek, Franklin D., Moreno‐Sánchez, Rafael, Saavedra, Emma

“…To determine the extent to which the supply of the precursor 2‐oxoglutarate (2‐OG) controls the synthesis of lysine in Saccharomyces cerevisiae growing…”
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Canonical and new generation anticancer drugs also target energy metabolism by Rodríguez-Enríquez, Sara, Gallardo-Pérez, Juan Carlos, Hernández-Reséndiz, Ileana, Marín-Hernández, Alvaro, Pacheco-Velázquez, Silvia C., López-Ramírez, Sayra Y., Rumjanek, Franklin D., Moreno-Sánchez, Rafael

“…Significant efforts have been made for the development of new anticancer drugs (protein kinase or proteasome inhibitors, monoclonal humanized antibodies) with…”
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Kinetic modeling can describe in vivo glycolysis in Entamoeba histolytica by Saavedra, Emma, Marín-Hernández, Alvaro, Encalada, Rusely, Olivos, Alfonso, Mendoza-Hernández, Guillermo, Moreno-Sánchez, Rafael

“…Glycolysis in the human parasite Entamoeba histolytica is characterized by the absence of cooperative modulation and the prevalence of pyrophosphate-dependent…”
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Experimental validation of metabolic pathway modeling: An illustration with glycolytic segments from Entamoeba histolytica by Moreno‐Sánchez, Rafael, Encalada, Rusely, Marín‐Hernández, Alvaro, Saavedra, Emma

“…In the search for new drug targets in the human parasite Entamoeba histolytica , metabolic control analysis was applied to determine, experimentally, flux…”
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The Lys20 homocitrate synthase isoform exerts most of the flux control over the lysine synthesis pathway in Saccharomyces cerevisiae by Quezada, Héctor, Marín‐Hernández, Alvaro, Aguilar, Diana, López, Geovani, Gallardo‐Pérez, Juan Carlos, Jasso‐Chávez, Ricardo, González, Alicia, Saavedra, Emma, Moreno‐Sánchez, Rafael

“…Summary In Saccharomyces cerevisiae, the first committed step in the lysine (Lys) biosynthetic pathway is catalysed by the Lys20 and Lys21 homocitrate synthase…”
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Multi-biomarker pattern for tumor identification and prognosis by Rodríguez-Enríquez, Sara, Pacheco-Velázquez, Silvia Cecilia, Gallardo-Pérez, Juan Carlos, Marín-Hernández, Alvaro, Aguilar-Ponce, José Luis, Ruiz-García, Erika, RuizGodoy-Rivera, Luz María, Meneses-García, Abelardo, Moreno-Sánchez, Rafael

“…In last decades, the basic, clinical, and translational research efforts have been directed to the identification of standard biomarkers associated with the…”
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Cd2+ resistance mechanisms in Methanosarcina acetivorans involve the increase in the coenzyme M content and induction of biofilm synthesis by Lira-Silva, Elizabeth, Santiago-Martínez, M. Geovanni, García-Contreras, Rodolfo, Zepeda-Rodríguez, Armando, Marín-Hernández, Alvaro, Moreno-Sánchez, Rafael, Jasso-Chávez, Ricardo

“…Summary To assess what defence mechanisms are triggered by Cd2+ stress in Methanosarcina acetivorans, cells were cultured at different cadmium concentrations…”
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Activation of ALDH1A1 by omeprazole reduces cell oxidative stress damage by Calleja, Luis Francisco, Yoval‐Sánchez, Belem, Hernández‐Esquivel, Luz, Gallardo‐Pérez, Juan Carlos, Sosa‐Garrocho, Marcela, Marín‐Hernández, Álvaro, Jasso‐Chávez, Ricardo, Macías‐Silva, Marina, Salud Rodríguez‐Zavala, José

“…Under physiological conditions, cells produce low basal levels of reactive oxygen species (ROS); however, in pathologic conditions ROS production increases…”
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Hypoglycemia Enhances Epithelial‐Mesenchymal Transition and Invasiveness, and Restrains the Warburg Phenotype, in Hypoxic HeLa Cell Cultures and Microspheroids by Marín‐Hernández, Álvaro, Gallardo‐Pérez, Juan Carlos, Hernández‐Reséndiz, Ileana, Del Mazo‐Monsalvo, Isis, Robledo‐Cadena, Diana Xochiquetzal, Moreno‐Sánchez, Rafael, Rodríguez‐Enríquez, Sara

“…The accelerated growth of solid tumors leads to episodes of both hypoxia and hypoglycemia (HH) affecting their intermediary metabolism, signal transduction,…”
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