Search Results - "Marín, Ana V."

MYC directly transactivates CR2/CD21, the receptor of the Epstein–Barr virus, enhancing the viral infection of Burkitt lymphoma cells by Molina, Ester, García-Gutiérrez, Lucía, Junco, Vanessa, Perez-Olivares, Mercedes, de Yébenes, Virginia G., Blanco, Rosa, Quevedo, Laura, Acosta, Juan C., Marín, Ana V., Ulgiati, Daniela, Merino, Ramon, Delgado, M. Dolores, Varela, Ignacio, Regueiro, José R., Moreno de Alborán, Ignacio, Ramiro, Almudena R., León, Javier

“…MYC is an oncogenic transcription factor dysregulated in about half of total human tumors. While transcriptomic studies reveal more than 1000 genes regulated…”
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Natural killer cell hyporesponsiveness and impaired development in a CD247-deficient patient by Valés-Gómez, Mar, PhD, Esteso, Gloria, PhD, Aydogmus, Cigdem, MD, Blázquez-Moreno, Alfonso, BSc, Marín, Ana V., BSc, Briones, Alejandro C., BSc, Garcillán, Beatriz, PhD, García-Cuesta, Eva-María, BSc, López Cobo, Sheila, BSc, Haskologlu, Sule, MD, Moraru, Manuela, MD, Cipe, Funda, MD, Dobbs, Kerry, BS, Dogu, Figen, MD, Parolini, Silvia, PhD, Notarangelo, Luigi D., MD, Vilches, Carlos, MD, PhD, Recio, Maria J., PhD, Regueiro, José R., PhD, Ikinciogullari, Aydan, MD, Reyburn, Hugh T., PhD

“…To the Editor: The analysis of single gene defects in patients with primary immunodeficiency has provided important insights into the normal physiology of the…”
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Role of Ras isoforms in γδ T-cell development by Marín-Marín, Ana V, Pérez, Eva Jiménez, Santos, Eugenio, Fernández-Malavé, Edgar

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The CD38/NAD/SIRTUIN1/EZH2 Axis Mitigates Cytotoxic CD8 T Cell Function and Identifies Patients with SLE Prone to Infections by Katsuyama, Eri, Suarez-Fueyo, Abel, Bradley, Sean J., Mizui, Masayuki, Marin, Ana V., Mulki, Lama, Krishfield, Suzanne, Malavasi, Fabio, Yoon, Joon, Sui, Shannan J. Ho, Kyttaris, Vasileios C., Tsokos, George C.

“…Patients with systemic lupus erythematosus (SLE) suffer frequent infections that account for significant morbidity and mortality. T cell cytotoxic responses…”
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Inherited human ezrin deficiency impairs adaptive immunity by García-Solís, Blanca, Van Den Rym, Ana, Martinez-Martínez, Laura, Franco, Teresa, Pérez-Caraballo, Jareb J., Markle, Janet, Cubillos-Zapata, Carolina, Marín, Ana V., Recio, María J., Regueiro, José R., Navarro-Zapata, Alfonso, Mestre-Durán, Carmen, Ferreras, Cristina, Martín Cotázar, Carla, Mena, Roció, de la Calle-Fabregat, Carlos, López-Lera, Alberto, Fernández Arquero, Miguel, Pérez-Martínez, Antonio, López-Collazo, Eduardo, Sánchez-Ramón, Silvia, Casanova, Jean-Laurent, Martínez-Barricarte, Rubén, de la Calle-Martín, Oscar, Pérez de Diego, Rebeca

“…Inborn errors of immunity (IEI) are a group of monogenic diseases that confer susceptibility to infection, autoimmunity, and cancer. Despite the…”
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T-cell receptor signaling in Schimke immuno-osseous dysplasia is SMARCAL1-independent by Marin, Ana V, Jiménez-Reinoso, Anaïs, Mazariegos, Marina S, Román-Ortiz, Elena, Regueiro, José R

“…Schimke immuno-osseous dysplasia (SIOD) caused by mutations in is an ultra-rare disease characterized by specific facial features, skeletal dysplasia, and…”
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The role of the different CD3γ domains in TCR expression and signaling by Garcillán, Beatriz, Megino, Rebeca F., Herrero-Alonso, Marta, Guardo, Alberto C., Perez-Flores, Veronica, Juraske, Claudia, Idstein, Vincent, Martin-Fernandez, Jose M., Geisler, Carsten, Schamel, Wolfgang W. A., Marin, Ana V., Regueiro, Jose R.

“…The CD3 subunits of the T-cell antigen receptor (TCR) play a central role in regulation of surface TCR expression levels. Humans who lack CD3γ (γ — ) show…”
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CD3G or CD3D Knockdown in Mature, but Not Immature, T Lymphocytes Similarly Cripples the Human TCRαβ Complex by Garcillán, Beatriz, Fuentes, Patricia, Marin, Ana V., Megino, Rebeca F., Chacon-Arguedas, Daniel, Mazariegos, Marina S., Jiménez-Reinoso, Anaïs, Muñoz-Ruiz, Miguel, Laborda, Raquel G., Cárdenas, Paula P., Fernández-Malavé, Edgar, Toribio, Maria L., Regueiro, José R.

“…The human αβ T-cell receptor (TCR) is composed of a variable heterodimer (TCRαβ) and three invariant dimers (CD3γε, CD3δε, and ζζ/CD247 2 ). The role of each…”
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Nonsense CD247 mutations show dominant-negative features in T-cell receptor expression and function by Briones, Alejandro C., Megino, Rebeca F., Marin, Ana V., Chacón-Arguedas, Daniel, García-Martinez, Elena, Balastegui-Martín, Héctor, Reyburn, Hugh T., Henrickson, Sarah E., Rodríguez-Sainz, Carmen, Seoane-Reula, Elena, Sanchez-Mateos, Paloma, Cardenas, Paula P., Regueiro, Jose R.

“…[Display omitted] The invariant TCR ζ/CD247 homodimer is crucial for TCR/CD3 expression and signaling through its 3 immunoreceptor tyrosine-based activation…”
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Complement in basic processes of the cell by Jiménez-Reinoso, Anaïs, Marin, Ana V., Regueiro, José R.

“…•Extrahepatic and autocrine complement influence their local behavior.•Complotypes can tilt complement activation toward inflammation.•Extracellular complement…”
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Human plasma C3 is essential for the development of memory B, but not T, lymphocytes by Jiménez-Reinoso, Anaïs, Marin, Ana V., Subias, Marta, López-Lera, Alberto, Román-Ortiz, Elena, Payne, Kathryn, Ma, Cindy S., Arbore, Giuseppina, Kolev, Martin, Freeley, Simon J., Kemper, Claudia, Tangye, Stuart G., Fernández-Malavé, Edgar, Rodríguez de Córdoba, Santiago, López-Trascasa, Margarita, Regueiro, José R.

“…[...]we generated pure T- and B-cell lines from our cohort and analyzed their intracellular C3 content by flow cytometry using specific mAb against 2…”
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Lymphocyte integration of complement cues by Marin, Ana V., Cárdenas, Paula P., Jiménez-Reinoso, Anaïs, Muñoz-Ruiz, Miguel, Regueiro, Jose R.

“…We address current data, views and puzzles on the emerging topic of regulation of lymphocytes by complement proteins or fragments. Such regulation is believed…”
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Role of Ras isoforms in [gamma delta] T-cell development by Marín-Marín, Ana V, Pérez, Eva Jiménez, Santos, Eugenio, Fernández-Malavé, Edgar

“…Doc number: O6…”
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γδ T Lymphocytes in the Diagnosis of Human T Cell Receptor Immunodeficiencies by Garcillán, Beatriz, Marin, Ana V M, Jiménez-Reinoso, Anaïs, Briones, Alejandro C, Muñoz-Ruiz, Miguel, García-León, María J, Gil, Juana, Allende, Luis M, Martínez-Naves, Eduardo, Toribio, María L, Regueiro, José R

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Crystal Structure of Glyceraldehyde-3-Phosphate Dehydrogenase from the Gram-Positive Bacterial Pathogen A. vaginae , an Immunoevasive Factor that Interacts with the Human C5a Anaphylatoxin by Querol-García, Javier, Fernández, Francisco J, Marin, Ana V, Gómez, Sara, Fullà, Daniel, Melchor-Tafur, Cecilia, Franco-Hidalgo, Virginia, Albertí, Sebastián, Juanhuix, Jordi, Rodríguez de Córdoba, Santiago, Regueiro, José R, Vega, M Cristina

“…The Gram-positive anaerobic human pathogenic bacterium causes most diagnosed cases of bacterial vaginosis as well as opportunistic infections in…”
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Primary T-cell immunodeficiency with functional revertant somatic mosaicism in CD247 by Marin, Ana V., MSc, Jiménez-Reinoso, Anaïs, MSc, Briones, Alejandro C., MSc, Muñoz-Ruiz, Miguel, MSc, Aydogmus, Cigdem, MD, Pasick, Luke J., BSc, Couso, Jorge, MSc, Mazariegos, Marina S., MSc, Alvarez-Prado, Angel F., MSc, Blázquez-Moreno, Alfonso, MSc, Cipe, Funda E., MD, Haskologlu, Sule, MD, Dogu, Figen, MD, Morín, Matías, PhD, Moreno-Pelayo, Miguel A., PhD, García-Sánchez, Félix, PhD, Gil-Herrera, Juana, MD, PhD, Fernández-Malavé, Edgar, PhD, Reyburn, Hugh T., PhD, Ramiro, Almudena R., PhD, Ikinciogullari, Aydan, MD, Recio, Maria J., PhD, Regueiro, Jose R., PhD, Garcillán, Beatriz, PhD

“…[...]TCR immunodeficiencies display a range of phenotypes and careful differential diagnosis is essential for appropriate therapy. [...]mild lymphopenia and…”
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The C3-R735W variant results in a hyperactive C3 that associates with atypical haemolytic uremic syndrome and C3-glomerulopathy by Tortajada, Agustín, Marín, Ana V., Arjona, Emilia, Chacón, Daniel, Sabúz, Ùscar, Merinero, Héctor Martín, Regueiro, José R., Córdoba, Santiago Rodríguez de

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74 αβ T cells and complement meet again: TCR crosstalk with surface complement regulators by Chacon-Arguedas, Daniel, Benito, Iván E., Fernández-Boraita, Julia, Jimenez, Diego J., Tortajada, Agustín, Marin, Ana V., Regueiro, José R.

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New syndromic combined immunodeficiency with severe neurodevelopmental defects caused by biallelic null variants in the PPM1D gene by Esteve-Sole, Ana, González-Granado, Luis Ignacio, Pias, Leticia, Marin, Ana V, Brown, Kate, Abraham, Roshini, Hickey, Scott E, Sweeney, Colin L, Haigh, Cathryn L, Rosenzweig, Sergio

“…PPM1D (protein phosphatase Mn2+/Mg2+-dependent 1D) is a phosphatase that targets proteins related to the DNA damage repair system. C-terminal variants in PPM1D…”
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211 Biallelic null mutations in PPM1D cause a novel combined immunodeficiency with severe neurodevelopmental defects by Sole, Ana Esteve, González-Granado, Luis Ignacio, Boast, Brigette, Niemela, Julie E., Stoddart, Jennifer L., Silva, Agustin G., Pias, Leticia, Bolasell, Merce, Marin, Ana V., Regueiro, Jose R, Alsina, Laia, Martine, Pierre, Brown, Kate, Apella, Ettore, Quesada, Juan Francisco, Sweeney, Colin L, Malech, Harry, Haigh, Cathryn L, Kueh, HyeSun, Rosenzweig, Sergio

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