Search Results - "María Hernández‐Rivas, Jesús"

Single agent subcutaneous blinatumomab for advanced acute lymphoblastic leukemia by Jabbour, Elias, Zugmaier, Gerhard, Agrawal, Vaibhav, Martínez‐Sánchez, Pilar, Rifón Roca, José J., Cassaday, Ryan D., Böll, Boris, Rijneveld, Anita, Abdul‐Hay, Maher, Huguet, Françoise, Cluzeau, Thomas, Díaz, Mar Tormo, Vucinic, Vladan, González‐Campos, José, Rambaldi, Alessandro, Schwartz, Stefan, Berthon, Céline, Hernández‐Rivas, Jesús María, Gordon, Paul R., Brüggemann, Monika, Hamidi, Ali, Chen, Yuqi, Wong, Hansen L., Panwar, Bharat, Katlinskaya, Yuliya, Markovic, Ana, Kantarjian, Hagop

“…Blinatumomab is a BiTE® (bispecific T‐cell engager) molecule that redirects CD3+ T‐cells to engage and lyse CD19+ target cells. Here we demonstrate that…”
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Results of the compassionate program of inotuzumab ozogamicin for adult patients with relapsed or refractory acute lymphoblastic leukemia in Spain by Torrent, Anna, Morgades, Mireia, García‐Calduch, Olga, Llano, María Paz Queipo, Montesinos, Pau, Navarro, Irene, Hernández‐Rivas, Jesús María, Bárez‐García, Abelardo, González‐Campos, José, Oiartzabal, Itziar, Valero, Marta, Cervera, Marta, Zudaire, Teresa, Albors‐Ferreiro, Manuel, López‐Godino, Oriana, Gil‐Cortés, Cristina, Villalón, Lucía, Saldaña, Raquel, Ribera, Josep‐María

“…Introduction The prognosis of relapsed B cell precursor acute lymphoblastic leukemia (B‐ALL) is poor and few patients can be successfully rescued with…”
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Treatment of young patients with Philadelphia chromosome-positive acute lymphoblastic leukaemia using increased dose of imatinib and deintensified chemotherapy before allogeneic stem cell transplantation by Ribera, Josep-María, García, Olga, Montesinos, Pau, Brunet, Salut, Abella, Eugenia, Barrios, Manuel, González-Campos, José, Bravo, Pilar, Amigo, Maria-Luz, Hernández-Rivas, Jesús-María

“…Summary The main outcomes of the Programa Español para Tratamiento de Hemopatías (PETHEMA)‐acute lymphoblastic leukaemia (ALL)‐Ph‐08 trial were described and…”
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Biological significance of monoallelic and biallelic BIRC3 loss in del(11q) chronic lymphocytic leukemia progression by Quijada-Álamo, Miguel, Hernández-Sánchez, María, Rodríguez-Vicente, Ana-Eugenia, Pérez-Carretero, Claudia, Rodríguez-Sánchez, Alberto, Martín-Izquierdo, Marta, Alonso-Pérez, Verónica, García-Tuñón, Ignacio, Bastida, José María, Vidal-Manceñido, María Jesús, Galende, Josefina, Aguilar, Carlos, Queizán, José Antonio, González-Gascón y Marín, Isabel, Hernández-Rivas, José-Ángel, Benito, Rocío, Ordóñez, José Luis, Hernández-Rivas, Jesús-María

“…BIRC3 is monoallelically deleted in up to 80% of chronic lymphocytic leukemia (CLL) cases harboring del(11q). In addition, truncating mutations in the…”
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Hematopoietic stem cells with granulo-monocytic differentiation state overcome venetoclax sensitivity in patients with myelodysplastic syndromes by Rodriguez-Sevilla, Juan Jose, Ganan-Gomez, Irene, Ma, Feiyang, Chien, Kelly, Del Rey, Monica, Loghavi, Sanam, Montalban-Bravo, Guillermo, Adema, Vera, Wildeman, Bethany, Kanagal-Shamanna, Rashmi, Bazinet, Alexandre, Chifotides, Helen T., Thongon, Natthakan, Calvo, Xavier, Hernández-Rivas, Jesús María, Díez-Campelo, Maria, Garcia-Manero, Guillermo, Colla, Simona

“…The molecular mechanisms of venetoclax-based therapy failure in patients with acute myeloid leukemia were recently clarified, but the mechanisms by which…”
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Covering Hierarchical Dirichlet Mixture Models on binary data to enhance genomic stratifications in onco-hematology by Dall'Olio, Daniele, Sträng, Eric, Turki, Amin T, Tettero, Jesse M, Barbus, Martje, Schulze-Rath, Renate, Elicegui, Javier Martinez, Matteuzzi, Tommaso, Merlotti, Alessandra, Carota, Luciana, Sala, Claudia, Della Porta, Matteo G, Giampieri, Enrico, Hernández-Rivas, Jesús María, Bullinger, Lars, Castellani, Gastone

“…Onco-hematological studies are increasingly adopting statistical mixture models to support the advancement of the genomically-driven classification systems for…”
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Molecular profiling of pre- and post- 5-azacytidine myelodysplastic syndrome samples identifies predictors of response by González, Mónica Del Rey, Chakraborty, Sohini, Hernández-Sánchez, Jesús María, Diez Campelo, María, Park, Christopher Y, Hernández Rivas, Jesús María

“…Treatment with the hypomethylating agent 5-azacytidine (AZA) increases survival in high-risk (HR) myelodysplastic syndrome (MDS) patients, but predicting…”
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Transcriptomic analysis of patients with immune thrombocytopenia treated with eltrombopag by Hernández-Sánchez, Jesús María, Bastida, José María, Alonso-López, Diego, Benito, Rocío, González-Porras, José Ramón, De Las Rivas, Javier, Hernández Rivas, Jesús María, Rodríguez-Vicente, Ana Eugenia

“…In the last years, the use of thrombopoietin receptor agonists (TPO-RA), eltrombopag and romiplostim, has improved the management of immune thrombocytopenia…”
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Clinical, biological, and prognostic implications of SF3B1 co-occurrence mutations in very low/low- and intermediate-risk MDS patients by Janusz, Kamila, Izquierdo, Marta Martín, Cadenas, Félix López, Ramos, Fernando, Sánchez, Jesús María Hernández, Lumbreras, Eva, Robledo, Cristina, del Real, Javier Sánchez, Caballero, Juan Carlos, Collado, Rosa, Bernal, Teresa, Pedro, Carme, Insunza, Andrés, de Paz, Raquel, Xicoy, Blanca, Salido, Eduardo, García, Joaquín Sánchez, Mínguez, Sandra Santos, García, Cristina Miguel, Muñoz, Ana María Simón, Barba, Mercedes Sánchez, Rivas, Jesús María Hernández, Abáigar, María, Campelo, María Díez

“…SF3B1 is a highly mutated gene in myelodysplastic syndrome (MDS) patients, related to a specific subtype and parameters of good prognosis in MDS without excess…”
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Expert consensus on the use of systemic glucocorticoids for managing eosinophil-related diseases by Del Pozo, Victoria, Bobolea, Irina, Rial, Manuel J, Espigol-Frigolé, Georgina, Solans Laqué, Roser, Hernández-Rivas, Jesús María, Mora, Elvira, Crespo-Lessmann, Astrid, Izquierdo Alonso, José Luis, Domínguez Sosa, María Sandra, Maza-Solano, Juan, Atienza-Mateo, Belén, Bañas-Conejero, David, Moure, Abraham L, Rúa-Figueroa, Íñigo

“…Eosinophil-related diseases represent a group of pathologic conditions with highly heterogeneous clinical presentation and symptoms ranging from mild to…”
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The Evolving Landscape of Chronic Lymphocytic Leukemia on Diagnosis, Prognosis and Treatment by Pérez-Carretero, Claudia, González-Gascón-y-Marín, Isabel, Rodríguez-Vicente, Ana E., Quijada-Álamo, Miguel, Hernández-Rivas, José-Ángel, Hernández-Sánchez, María, Hernández-Rivas, Jesús María

“…The knowledge of chronic lymphocytic leukemia (CLL) has progressively deepened during the last forty years. Research activities and clinical studies have been…”
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Outcomes and effect of somatic mutations after erythropoiesis stimulating agents in patients with lower-risk myelodysplastic syndromes by Caballero, Juan Carlos, Dávila, Julio, López-Pavía, María, Such, Esperanza, Bernal, Teresa, Ramos, Fernando, Calabuig, Marisa, Hernández Sánchez, Jesús María, Pomares, Helena, Sánchez Barba, Mercedes, Abáigar, María, González, Bernardo, Merchán, Brayan, Sancho-Tello, Reyes, Callejas, Marta, Muñoz-Novas, Carolina, Cerveró, Carlos, Sanz, Guillermo, Hernández Rivas, Jesús María, Díez Campelo, María

“…Erythropoiesis stimulating agents (ESAs) are the first-line therapy in patients with lower-risk myelodysplastic syndromes (LR-MDS). Some predictive factors for…”
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ETV6 / RUNX1 Fusion Gene Abrogation Decreases the Oncogenicity of Tumour Cells in a Preclinical Model of Acute Lymphoblastic Leukaemia by Montaño, Adrián, Ordoñez, Jose Luis, Alonso-Pérez, Verónica, Hernández-Sánchez, Jesús, Santos, Sandra, González, Teresa, Benito, Rocío, García-Tuñón, Ignacio, Hernández-Rivas, Jesús María

“…The t(12;21)(p13;q22), which fuses and genes, is the most common genetic abnormality in children with B-cell precursor acute lymphoblastic leukaemia. The…”
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NEMHESYS—European Perspective on the Implementation of Next‐generation Sequencing Into Clinical Diagnostics by Serramito‐Gómez, Inmaculada, Clarke, Kathryn M., Rodríguez‐Vicente, Ana Eugenia, McGimpsey, Julie E., Abáigar, María, Díez, Carlos Barranquero, Benito, Rocío, Bullinger, Lars, Mills, Ken I., Hernández Rivas, Jesús María

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Second Revision of the International Staging System (R2-ISS) for Overall Survival in Multiple Myeloma: A European Myeloma Network (EMN) Report Within the HARMONY Project by D'Agostino, Mattia, Cairns, David A, Lahuerta, Juan José, Wester, Ruth, Bertsch, Uta, Waage, Anders, Zamagni, Elena, Mateos, María-Victoria, Dall'Olio, Daniele, van de Donk, Niels W C J, Jackson, Graham, Rocchi, Serena, Salwender, Hans, Bladé Creixenti, Joan, van der Holt, Bronno, Castellani, Gastone, Bonello, Francesca, Capra, Andrea, Mai, Elias K, Dürig, Jan, Gay, Francesca, Zweegman, Sonja, Cavo, Michele, Kaiser, Martin F, Goldschmidt, Hartmut, Hernández Rivas, Jesús María, Larocca, Alessandra, Cook, Gordon, San-Miguel, Jesús F, Boccadoro, Mario, Sonneveld, Pieter

“…Patients with newly diagnosed multiple myeloma (NDMM) show heterogeneous outcomes, and approximately 60% of them are at intermediate-risk according to the…”
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Prognostic significance of complex karyotype and monosomal karyotype in adult patients with acute lymphoblastic leukemia treated with risk‐adapted protocols by Motlló, Cristina, Ribera, Josep‐María, Morgades, Mireia, Granada, Isabel, Montesinos, Pau, González‐Campos, José, Fernández‐Abellán, Pascual, Tormo, Mar, Bethencourt, Concepción, Brunet, Salut, Hernández‐Rivas, Jesús‐María, Moreno, María‐José, Sarrà, Josep, del Potro, Eloy, Barba, Pere, Bernal, Teresa, Grande, Carlos, Grau, Javier, Cervera, José, Feliu, Evarist

“…BACKGROUND The karyotype is a predictor of outcomes in adults with acute lymphoblastic leukemia (ALL). The unfavorable prognostic significance of complex…”
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Alteration in endoglin-related angiogenesis in refractory cytopenia with multilineage dysplasia by del Rey, Mónica, Pericacho, Miguel, Velasco, Soraya, Lumbreras, Eva, López-Novoa, José Miguel, Hernández-Rivas, Jesús María, Rodríguez-Barbero, Alicia

“…The functional mechanisms involved in angiogenesis and the potential role of endoglin (ENG), recently described as a new marker for this process, have not been…”
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Novel variants in GALE cause syndromic macrothrombocytopenia by disrupting glycosylation and thrombopoiesis by Marín-Quílez, Ana, Di Buduo, Christian Andrea, Díaz-Ajenjo, Lorena, Abbonante, Vittorio, Vuelta, Elena, Soprano, Paolo Maria, Miguel-García, Cristina, Santos-Mínguez, Sandra, Serramito-Gómez, Inmaculada, Ruiz-Sala, Pedro, Peñarrubia, María Jesús, Pardal, Emilia, Hernández-Rivas, Jesús María, González-Porras, José Ramón, García-Tuñón, Ignacio, Benito, Rocío, Rivera, José, Balduini, Alessandra, Bastida, José María

“…•GALE is expressed during late-stage megakaryopoiesis, regulating the glycosylation and surface exposure of GPIbα and β1 integrin.•Novel GALE variants cause…”
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Sitosterolemia: Diagnosis, Metabolic and Hematological Abnormalities, Cardiovascular Disease and Management by Bastida, Jose María, Girós, María Luisa, Benito, Rocío, Janusz, Kamila, Hernández-Rivas, Jesús María, González-Porras, José Ramón

“…Sitosterolemia is a recessive inherited metabolic disorder of unknown prevalence, characterized by increased levels of plasma plant sterols. It is caused by 28…”
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Rearrangements involving 11q23.3/KMT2A in adult AML: mutational landscape and prognostic implications – a HARMONY study by Hernández-Sánchez, Alberto, González, Teresa, Sobas, Marta, Sträng, Eric, Castellani, Gastone, Abáigar, María, Valk, Peter J. M., Villaverde Ramiro, Ángela, Benner, Axel, Metzeler, Klaus H., Azibeiro, Raúl, Tettero, Jesse M., Martínez-López, Joaquín, Pratcorona, Marta, Martínez Elicegui, Javier, Mills, Ken I., Thiede, Christian, Sanz, Guillermo, Döhner, Konstanze, Heuser, Michael, Haferlach, Torsten, Turki, Amin T., Reinhardt, Dirk, Schulze-Rath, Renate, Barbus, Martje, Hernández-Rivas, Jesús María, Huntly, Brian, Ossenkoppele, Gert, Döhner, Hartmut, Bullinger, Lars

“…Balanced rearrangements involving the KMT2A gene ( KMT2A r) are recurrent genetic abnormalities in acute myeloid leukemia (AML), but there is lack of consensus…”
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