Search Results - "Maples, P"

Granulocyte-macrophage colony-stimulating factor gene-modified autologous tumor vaccines in non-small-cell lung cancer by NEMUNAITIS, John, STERNUM, Daniel, HEGE, Kristen, JABLONS, David, SMITH, John W, FOX, Bernard, MAPLES, Phil, HAMILTON, Scott, BORELLINI, Flavia, LIN, Andy, MORALI, Sayeh

“…To evaluate the feasibility, safety, and efficacy of vaccination with autologous tumor cells genetically modified with an adenoviral vector (Ad-GM) to secrete…”
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Phase II trial of Belagenpumatucel-L, a TGF-β2 antisense gene modified allogeneic tumor vaccine in advanced non small cell lung cancer (NSCLC) patients by Nemunaitis, J, Nemunaitis, M, Senzer, N, Snitz, P, Bedell, C, Kumar, P, Pappen, B, Maples, P B, Shawler, D, Fakhrai, H

“…In a previous dose escalation trial we demonstrated dose related survival correlation to Belagenpumatucel-L. In order to further evaluate safety and response…”
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A phase I trial of intravenous infusion of ONYX-015 and enbrel in solid tumor patients by Nemunaitis, J, Senzer, N, Sarmiento, S, Zhang, Y-A, Arzaga, R, Sands, B, Maples, P, Tong, A W

“…ONYX-015 is an attenuated chimeric human group C adenovirus, which preferentially replicates in and lyses tumor cells that are p53 negative. The purpose of…”
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Intravenous infusion of a replication-selective adenovirus (ONYX-015) in cancer patients: safety, feasibility and biological activity by NEMUNAITIS, J, CUNNINGHAM, C, KIRN, D, BUCHANAN, A, BLACKBURN, A, EDELMAN, G, MAPLES, P, NETTO, G, TONG, A, RANDLEV, B, OLSON, S

“…Although genetically engineered adenoviruses hold promise for the treatment of cancer, clinical trial reports have utilized intratumoral injection to date. To…”
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Vertically integrated translational studies of PDX1 as a therapeutic target for pancreatic cancer via a novel bifunctional RNAi platform by Wu, J, Liu, S, Yu, J, Zhou, G, Rao, D, Jay, C M, Kumar, P, Sanchez, R, Templeton, N, Senzer, N, Maples, P, Nemunaitis, J, Brunicardi, F C

“…RNA interference (RNAi) represents a powerful, new tool for scientific investigation as well as a promising new form of targeted gene therapy, with…”
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Immune response and survival of refractory cancer patients who received TGF- beta 2 antisense/GM-CSF gene modified autologous tumor cell (TAG) vaccine by Nemunaitis, J, Senzer, N, Olivares, J, Kumar, P, Barve, M, Kuhn, J, Nemunaitis, T, Magee, M, Yu, Y, Wallraven, G, Pappen, B O, Maples, P B

“…TAG vaccine is a novel 'triad vaccine' that involves transfection of autologous tumor with a dual plasmid, TGF beta 2 antisense gene and GM-CSF gene. Patients…”
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Immune response and survival of refractory cancer patients who received TGF-β2 antisense/GM-CSF gene modified autologous tumor cell (TAG) vaccine by Nemunaitis, J, Senzer, N, Olivares, J, Kumar, P, Barve, M, Kuhn, J, Nemunaitis, T, Magee, M, Yu, Y, Wallraven, G, Pappen, B O, Maples, P B

“…TAG vaccine is a novel ‘triad vaccine’ that involves transfection of autologous tumor with a dual plasmid, TGFβ2 antisense gene and GM-CSF gene. Patients with…”
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Enhanced target gene knockdown by a bifunctional shRNA: a novel approach of RNA interference by Rao, D D, Maples, P B, Senzer, N, Kumar, P, Wang, Z, Pappen, B O, Yu, Y, Haddock, C, Jay, C, Phadke, A P, Chen, S, Kuhn, J, Dylewski, D, Scott, S, Monsma, D, Webb, C, Tong, A, Shanahan, D, Nemunaitis, J

“…RNA interference (RNAi) is a natural cellular regulatory process that inhibits gene expression by transcriptional, post-transcriptional and translational…”
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Assessment of intravenous pbi-shRNA PDX1 nanoparticle (OFHIRNA-PDX1) in yucatan swine by Jay, C M, Ruoff, C, Kumar, P, Maass, H, Spanhel, B, Miller, M, Arrington, A, Montalvo, N, Gresham, V, Rao, D D, Evans, C, Wang, Z, Brunicardi, F C, Liu, S-H, Zhou, G, Senzer, N, Nemunaitis, J, King, L, Weeks, B, Clubb, F J, Fossum, T W, Maples, P B

“…PDX1 (pancreatic and duodenal homeobox 1) is overexpressed in pancreatic cancer, and its reduction results in tumor regression. Bi-functional pbi-shRNA PDX1…”
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P2.09 A non-viral, GNE -lipoplex treatment to correct sialylation defects in hereditary inclusion body myopathy (HIBM) by Yardeni, T, Manoli, I, Ciccone, C, Hoogstraten-Miller, S, Darvish, D, Anikster, Y, Maples, P, Jay, C.M, Gahl, W.A, Nemunaitis, J, Huizing, M

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Cellular immune profile of patients with advanced cancer before and after taxane treatment by TONG, A. W, SEAMOUR, B, LAWSON, J. M, ORDONEZ, G, VUKELJA, S, HYMAN, W, RICHARDS, D, STEIN, L, MAPLES, P. B, NEMUNAITIS, J

“…The purpose of this study is to determine immune recovery and function after treatment with docetaxel or paclitaxel. Peripheral blood mononuclear cells were…”
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Proof concept for clinical justification of network mapping for personalized cancer therapeutics by Nemunaitis, J, Senzer, N, Khalil, I, Shen, Y, Kumar, P, Tong, A, Kuhn, J, Lamont, J, Nemunaitis, M, Rao, D, Zhang, Y-A, Zhou, Y, Vorhies, J, Maples, P, Hill, C, Shanahan, D

“…To identify signature targets associated with patient-specific cancer lesions based on tumor versus normal tissue differential protein and mRNA coexpression…”
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The Bloxsom Air Lock: A Historical Perspective by Kendig, James W, Maples, Philip G, Maisels, M. Jeffrey

“…In 1950, Allan P. Bloxsom (1901-1991), a pediatrician at the St Joseph Hospital in Houston, introduced his positive pressure oxygen air lock (AL) for the…”
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Expansion of neutrophil precursors and progenitors in suspension cultures of CD34+ cells enriched from human bone marrow by Smith, S L, Bender, J G, Maples, P B, Unverzagt, K, Schilling, M, Lum, L, Williams, S, Van Epps, D E

“…The growth and differentiation of selected bone marrow CD34+ cells stimulated with hematopoietic growth factors in lipid cultures were evaluated to determine…”
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Potential Clinical Application of Antioncogene Ribozymes for Human Lung Cancer by Tong, Alex W., Zhang, Yu-An, Cunningham, Casey, Maples, Phillip, Nemunaitis, John

“…Non–small-cell lung cancer frequently contains oncogenetic defects (mutations in ras, retinoblastoma, and p53 genes) that contribute to disease…”
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Development and validation of a low-literacy Chronic Obstructive Pulmonary Disease knowledge Questionnaire (COPD-Q) by Maples, Paula, Franks, Andrea, Ray, Shaunta, Stevens, Amy Barger, Wallace, Lorraine S

“…Abstract Objective The objective of this study was to develop a content valid, understandable, readable, and reliable Chronic Obstructive Pulmonary Disease…”
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Selective replication and oncolysis in p53 mutant tumors with ONYX-015, an E1B-55kD gene-deleted adenovirus, in patients with advanced head and neck cancer : A phase II trial by NEMUNAITIS, John, GANLY, Ian, REID, Tony, KAYE, Sam, KIRN, David, KHURI, Fadlo, ARSENEAU, James, KUHN, Joseph, MCCARTY, Todd, LANDERS, Stephen, MAPLES, Phillip, ROMEL, Larry, RANDLEV, Britta

“…ONYX-015 is an E1B-55kDa gene-deleted adenovirus engineered to selectively replicate in and lyse p53-deficient cancer cells. To evaluate the selectivity of…”
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Hereditary inclusion body myopathy: single patient response to intravenous dosing of GNE gene lipoplex by Nemunaitis, Gregory, Jay, Chris M, Maples, Phillip B, Gahl, William A, Huizing, Marjan, Yardeni, Tal, Tong, Alex W, Phadke, Anagha P, Pappen, Beena O, Bedell, Cynthia, Allen, Henry, Hernandez, Cathy, Templeton, Nancy S, Kuhn, Joseph, Senzer, Neil, Nemunaitis, John

“…Hereditary inclusion body myopathy (HIBM) is an autosomal recessive adult-onset myopathy due to mutations in the GNE (UDP-N-acetylglucosamine…”
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Immune response and survival of refractory cancer patients who received TGF-[beta]2 antisense/GM-CSF gene modified autologous tumor cell (TAG) vaccine by Nemunaitis, J, Senzer, N, Olivares, J, Kumar, P, Barve, M, Kuhn, J, Nemunaitis, T, Magee, M, Yu, Y, Wallraven, G, Pappen, B O, Maples, P B

“…TAG vaccine is a novel 'triad vaccine' that involves transfection of autologous tumor with a dual plasmid, TGF[beta]2 antisense gene and GM-CSF gene. Patients…”
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Differential expression of alpha- and beta-globin genes in erythroleukemic cell lines by BERU, N, MAPLES, P. B, HERMINE, O, GOLDWASSER, E

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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