Search Results - "Mapara, M"

The Association between Pneumococcal Pneumonia and Acute Cardiac Events by Musher, Daniel M., Rueda, Adriana M., Kaka, Anjum S., Mapara, Sulaiman M.

“…Background. Increased cardiac stress, hypoxemia, and inflammation may contribute to acute cardiac events, such as myocardial infarction (MI), arrhythmia,…”
Get full text

Lenalidomide-induced upregulation of CXCR4 in CD34+ hematopoietic cells, a potential mechanism of decreased hematopoietic progenitor mobilization by Li, S, Fu, J, Ma, H, Mapara, M Y, Lentzsch, S

Get full text

Time-intensified dexamethasone/cisplatin/cytarabine: an effective salvage therapy with low toxicity in patients with relapsed and refractory Hodgkin’s disease by Josting, A., Rudolph, C., Reiser, M., Mapara, M., Sieber, M., Kirchner, H. H., Dörken, B., Hossfeld, D. K., Diehl, V., Engert, A.

“…Background: An important variable affecting outcome in relapsed and refractory Hodgkin’s disease (HD) is the potential of conventional salvage chemotherapy to…”
Get full text

Anti-CD20- and B-cell receptor-mediated apoptosis : Evidence for shared intracellular signaling pathways by MATHAS, Stephan, RICKERS, Anke, BOMMERT, Kurt, DÖRKEN, Bernd, MAPARA, Markus Y

“…Clinical administration of the anti-CD20 antibody IDEC-C2B8 can induce remission of low-grade B-cell lymphoma. Whereas it has been suggested that the main…”
Get full text

Cologne high-dose sequential chemotherapy in relapsed and refractory Hodgkin lymphoma: results of a large multicenter study of the German Hodgkin Lymphoma Study Group (GHSG) by Josting, A., Rudolph, C., Mapara, M., Glossmann, J.-P., Sienawski, M., Sieber, M., Kirchner, H. H., Dörken, B., Hossfeld, D. K., Kisro, J., Metzner, B., Berdel, W. E., Diehl, V., Engert, A.

“…Background: We designed a dose- and time-intensified high-dose sequential chemotherapy regimen for patients with relapsed and refractory Hodgkin lymphoma (HD)…”
Get full text

Infectious complications after high-dose chemotherapy and autologous stem cell transplantation: comparison between patients with lymphoma or multiple myeloma and patients with solid tumors by REICH, G, MAPARA, M. Y, REICHARDT, P, DÖRKEN, B, MASCHMEYER, G

“…From November 1994 to May 1998, 117 patients (66 with solid tumor, 36 with lymphoma, 14 with multiple myeloma, one with acute leukemia) underwent 178 cycles of…”
Get full text

High-dose sequential chemotherapy followed by autologous stem cell transplantation in relapsed and refractory aggressive non-Hodgkin's lymphoma: results of a multicenter phase II study by Josting, A., Sieniawski, M., Glossmann, J.-P., Staak, O., Nogova, L., Peters, N., Mapara, M., Dörken, B., Ko, Y., Metzner, B., Kisro, J., Diehl, V., Engert, A.

“…Background: Combination chemotherapy can cure patients with non-Hodgkin's lymphoma (NHL), but those who suffer treatment failure or relapse still have a poor…”
Get full text

Nonmyeloablative stem cell transplantation in metastatic renal cell carcinoma: delayed graft-versus-tumor effect is associated with chimerism conversion but transplantation has high toxicity by MASSENKEIL, G, ROIGAS, J, NAGY, M, WILLE, A, STROSZCZYNSKI, C, MAPARA, M. Y, LOENING, S, DÖRKEN, B, ARNOLD, R

“…Seven out of 29 patients with metastatic renal cell carcinoma (RCC) considered eligible for allogeneic stem cell transplantation underwent nonmyeloablative…”
Get full text

High-Level Nuclear NF-κB and Oct-2 Is a Common Feature of Cultured Hodgkin/Reed-Sternberg Cells by Bargou, Ralf C., Leng, Corinna, Krappmann, Daniel, Emmerich, Florian, Mapara, Markus Y., Bommert, Kurt, Royer, Hans-Dieter, Scheidereit, Claus, Dorken, Bemd

“…There is a considerable lack of understanding about the common molecular defects that form the basis for the occurrence of Hodgkin's lymphoma. Despite a number…”
Get full text

Expression of the bcl-2 gene family in normal and malignant breast tissue: low bax-alpha expression in tumor cells correlates with resistance towards apoptosis by Bargou, R C, Daniel, P T, Mapara, M Y, Bommert, K, Wagener, C, Kallinich, B, Royer, H D, Dörken, B

“…We have studied the expression of the apoptosis-regulating genes bcl-2, bcl-x, bax and APO-1/fas (CD95) in human breast cancer. The expression pattern of these…”
Get more information

APO-1 mediated apoptosis or proliferation in human chronic B lymphocytic leukemia: correlation with bcl-2 oncogene expression by Mapara, M Y, Bargou, R, Zugck, C, Döhner, H, Ustaoglu, F, Jonker, R R, Krammer, P H, Dörken, B

“…We studied induction of apoptosis in several human malignant B cells from chronic lymphocytic leukemias (BCLL) by triggering the APO-1 antigen. The APO-1…”
Get more information

Overexpression of the death-promoting gene bax-alpha which is downregulated in breast cancer restores sensitivity to different apoptotic stimuli and reduces tumor growth in SCID mice by Bargou, R C, Wagener, C, Bommert, K, Mapara, M Y, Daniel, P T, Arnold, W, Dietel, M, Guski, H, Feller, A, Royer, H D, Dörken, B

“…We have studied the expression of members of the bcl-2 family in human breast cancer. The expression pattern of these genes in breast cancer tissue samples was…”
Get full text

Successful peripheral blood stem cell mobilization with etoposide (VP-16) in patients with relapsed or resistant lymphoma who failed cyclophosphamide mobilization by REISER, M, JOSTING, A, ENGERT, A, DRAUBE, A, MAPARA, M, SCHEID, C, CHEMNITZ, J, TESCH, H, WOLF, J, DIEHL, V, SÖHNGEN, D

“…High-dose chemotherapy (HDCT) followed by autologous blood stem cell transplantation is considered the treatment of choice for patients with relapsed or…”
Get full text

Induction of the death-promoting gene bax-α sensitizes cultured breast-cancer cells to drug-induced apoptosis by WAGENER, C, BARGOU, R, DANIEL, P. T, BOMMERTY, K, MAPARA, M. Y, ROYER, H. D, DÖRKEN, B

“…Resistance to apoptosis plays an important role in malignancies that are refractory to chemotherapy treatment. Recently we have shown that the expression of…”
Get full text

1.7 year follow-up after bortezomib therapy for refractory antibody mediated rejection by Shapiro, R, Lunz, J, Zeevi, A, Basu, A, Mapara, M, Randhawa, P, Tan, H P, Sharma, V, Humar, A

“…In summary, 1.7 years after transplantation, bortezomib rescue has been durably effective in salvaging our patient with refractory antibody mediated rejection…”
Get more information

Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression by Bargou, Ralf C, Jürchott, Karsten, Wagener, Christian, Bergmann, Stephan, Metzner, Sylvia, Bommert, Kurt, Mapara, Markus Y, Winzer, Klaus-Jürgen, Dietel, Manfred, Dörken, Bernd, Royer, Hans-Dieter

“…Breast cancers are either primarily resistant to chemotherapy (intrinsic resistance), or respond to chemotherapy but later recur with a multidrug-resistant…”
Get full text

CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia by Frangoul, Haydar, Altshuler, David, Cappellini, M. Domenica, Chen, Yi-Shan, Domm, Jennifer, Eustace, Brenda K, Foell, Juergen, de la Fuente, Josu, Grupp, Stephan, Handgretinger, Rupert, Ho, Tony W, Kattamis, Antonis, Kernytsky, Andrew, Lekstrom-Himes, Julie, Li, Amanda M, Locatelli, Franco, Mapara, Markus Y, de Montalembert, Mariane, Rondelli, Damiano, Sharma, Akshay, Sheth, Sujit, Soni, Sandeep, Steinberg, Martin H, Wall, Donna, Yen, Angela, Corbacioglu, Selim

“…Two patients, one with transfusion-dependent β-thalassemia and the other with sickle cell disease, received autologous CD34+ cells edited with CRISPR-Cas9…”
Get full text

Detection of tumor cells in peripheral blood samples from patients with germ cell tumors using immunocytochemical and reverse transcriptase-polymerase chain reaction techniques by HILDEBRANDT, M. O, BLÄSER, F, BEYER, J, SIEGERT, W, MAPARA, M. Y, HUHN, D, SALAMA, A

“…The aim of this study was to establish sensitive techniques for the detection of residual germ cell tumor cells in peripheral blood and progenitor cell…”
Get full text

Autologous peripheral blood stem cell transplantation of stem cells harvested in imatinib-induced complete cytogenetic remission: an example of in vivo purging in CML by le Coutre, P, Kreuzer, K A, Massenkeil, G, Baskaynak, G, Zschieschang, P, Genvresse, I, Lupberger, J, Mapara, M, Dörken, B, Arnold, R

Get full text

Exagamglogene Autotemcel for Severe Sickle Cell Disease by Frangoul, Haydar, Locatelli, Franco, Sharma, Akshay, Bhatia, Monica, Mapara, Markus, Molinari, Lyndsay, Wall, Donna, Liem, Robert I., Telfer, Paul, Shah, Ami J., Cavazzana, Marina, Corbacioglu, Selim, Rondelli, Damiano, Meisel, Roland, Dedeken, Laurence, Lobitz, Stephan, de Montalembert, Mariane, Steinberg, Martin H., Walters, Mark C., Eckrich, Michael J., Imren, Suzan, Bower, Laura, Simard, Christopher, Zhou, Weiyu, Xuan, Fengjuan, Morrow, Phuong Khanh, Hobbs, William E., Grupp, Stephan A.

“…Of 30 patients with severe sickle cell disease who were treated with gene-edited autologous hematopoietic stem and progenitor cells, 29 were free from…”
Get full text