Diagnosis and evaluation of hepatitis C virus among haemodialysis patients/ Diagnostic et evaluation de l'hepatite virale C chez l'hemodialyse

Hepatitis C is a health problem worldwide. The World Health Organization estimates that 3% of world's population is infected with hepatitis C virus (HCV). In haemodialysis patients, the prevalence reaches 80% in some countries. In Morocco, HCV prevalence is 32% according to the Moroccan registe...

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Bibliographic Details
Published in:	Eastern Mediterranean health journal Vol. 19; no. 2; pp. 192 - 199
Main Authors:	Bahadi, A, Maoujoud, Y, Zejjari, Y, Alayoud, A, Hassani, K, Elkabbaj, D, Benyahia, M
Format:	Journal Article
Language:	English
Published:	World Health Organization 01-02-2013
Subjects:	Analysis Care and treatment Diagnosis Health aspects Hemodialysis patients Hepatitis C virus Prevalence studies (Epidemiology) Risk factors
Online Access:	Get full text
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Summary:	Hepatitis C is a health problem worldwide. The World Health Organization estimates that 3% of world's population is infected with hepatitis C virus (HCV). In haemodialysis patients, the prevalence reaches 80% in some countries. In Morocco, HCV prevalence is 32% according to the Moroccan register of dialysis. The natural history of hepatitis C infection in chronic haemodialysis patients is characterized by a silent evolution. There are different methods to diagnose HCV and they are becoming increasingly sensitive. There are indirect tests for antibodies to HCV: these are reproducible but false negatives are common and there is direct testing of viral RNA: this is more sensitive but not always available and is more expensive. The use of these tests has been categorized through new recommendations from learned societies. However, the evaluation of liver disease is still controversial and liver biopsy remains the gold standard. This paper reviews the approaches for diagnosing and evaluating hepatitis C in haemodialysis patients. L'hepatite virale C constitue un probleme de sante a l'echelle mondiale. L'Organisation mondiale de la Sante estime que 3 % de la population mondiale est infectee par le virus de l'hepatite C (VHC). Chez les hemodialyses, la prevalence atteint 80 % dans certains pays. Au Maroc, la prevalence est de 32 % selon le registre marocain de dialyse. L'histoire naturelle de l'infection par le virus de l'hepatite C chez l'hemodialyse chronique est caracterisee par une evolution silencieuse. Les moyens de diagnostic du VHC sont divers et de plus en plus sensibles : les tests indirects a la recherche des anticorps anti-VHC qui sont reproductibles mais les cas de faux negatifs sont tres frequents, et les tests directs recherchant l'ARN viral qui sont de plus en plus sensibles mais ne sont pas toujours disponibles et ont un cout eleve. L'utilisation de ces tests a ete codifiee grace aux nouvelles recommandations des societes savantes. Cependant, l'evaluation de l'atteinte hepatique demeure controversee et la ponction-biopsie hepatique reste la methode de reference. Le present article passe en revue les approches pour le diagnostic et l'evaluation de l'hepatite C chez l'hemodialyse.
ISSN:	1020-3397 1020-3397