Search Results - "Maoileidigh, Daibhid O"
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Control of a hair bundle’s mechanosensory function by its mechanical load
Published in Proceedings of the National Academy of Sciences - PNAS (03-03-2015)“…Hair cells, the sensory receptors of the internal ear, subserve different functions in various receptor organs: they detect oscillatory stimuli in the auditory…”
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2
A Unified Model of Transcription Elongation: What Have We Learned from Single-Molecule Experiments?
Published in Biophysical journal (02-03-2011)“…The transcription of the genetic information encoded in DNA into RNA is performed by RNA polymerase (RNAP), a complex molecular motor, highly conserved across…”
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3
Frequency-selective exocytosis by ribbon synapses of hair cells in the bullfrog's amphibian papilla
Published in The Journal of neuroscience (26-09-2012)“…The activity of auditory afferent fibers depends strongly on the frequency of stimulation. Although the bullfrog's amphibian papilla lacks the flexible basilar…”
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4
The functional role of connectors in outer-hair-cell hair bundles
Published in Biophysical journal (11-02-2022)Get full text
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Motile Hair Cells Distinguish Mechanical Signals from Noise Best When They Operate on the Brink of Spontaneous Oscillation
Published in Biophysical journal (02-02-2018)Get full text
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An Active Mechanism for Signal Detection in the Mammalian Ear
Published in Biophysical journal (31-01-2012)Get full text
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7
A Bundle of Mechanisms: Inner-Ear Hair-Cell Mechanotransduction
Published in Trends in neurosciences (Regular ed.) (01-03-2019)“…In the inner ear, the deflection of hair bundles, the sensory organelles of hair cells, activates mechanically-gated channels (MGCs). Hair bundles monitor…”
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Coupling between the Stereocilia of Rat Sensory Inner-Hair-Cell Hair Bundles Is Weak, Shaping Their Sensitivity to Stimulation
Published in The Journal of neuroscience (22-03-2023)“…The hair bundle is the universal mechanosensory organelle of auditory, vestibular, and lateral-line systems. A bundle comprises mechanically coupled…”
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9
Effects of cochlear loading on the motility of active outer hair cells
Published in Proceedings of the National Academy of Sciences - PNAS (02-04-2013)“…Outer hair cells (OHCs) power the amplification of sound-induced vibrations in the mammalian inner ear through an active process that involves hair-bundle…”
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10
Identification of Bifurcations from Observations of Noisy Biological Oscillators
Published in Biophysical journal (23-08-2016)“…Hair bundles are biological oscillators that actively transduce mechanical stimuli into electrical signals in the auditory, vestibular, and lateral-line…”
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The interplay between active hair bundle motility and electromotility in the cochlea
Published in The Journal of the Acoustical Society of America (01-09-2010)“…The cochlear amplifier is a nonlinear active process providing the mammalian ear with its extraordinary sensitivity, large dynamic range and sharp frequency…”
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12
Homeostatic enhancement of sensory transduction
Published in Proceedings of the National Academy of Sciences - PNAS (15-08-2017)“…Our sense of hearing boasts exquisite sensitivity, precise frequency discrimination, and a broad dynamic range. Experiments and modeling imply, however, that…”
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13
diverse effects of mechanical loading on active hair bundles
Published in Proceedings of the National Academy of Sciences - PNAS (07-02-2012)“…Hair cells in the auditory, vestibular, and lateral-line systems of vertebrates receive inputs through a remarkable variety of accessory structures that impose…”
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14
Thermodynamic and Kinetic Modeling of Transcriptional Pausing
Published in Proceedings of the National Academy of Sciences - PNAS (21-03-2006)“…We present a statistical mechanics approach for the prediction of backtracked pauses in bacterial transcription elongation derived from structural models of…”
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15
Comparison of nonlinear mammalian cochlear-partition models
Published in The Journal of the Acoustical Society of America (01-01-2013)“…Various simple mathematical models of the dynamics of the organ of Corti in the mammalian cochlea are analyzed and their dynamics compared. The specific models…”
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16
Bilateral Spontaneous Otoacoustic Emissions Show Coupling between Active Oscillators in the Two Ears
Published in Biophysical journal (21-05-2019)“…Spontaneous otoacoustic emissions (SOAEs) are weak sounds that emanate from the ears of tetrapods in the absence of acoustic stimulation. These emissions are…”
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17
Sinusoidal-signal detection by active, noisy oscillators on the brink of self-oscillation
Published in Physica. D (01-09-2018)“…Determining the conditions under which an active system best detects sinusoidal signals is important for numerous fields. It is known that a quiescent,…”
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18
The kinetics of transcription elongation
Published 2006“…Transcription is the first step in gene expression and as such it is the most highly regulated. In particular, regulation of the elongation phase of…”
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Dissertation -
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Control of a hair bundle's mechanosensory function by its mechanical load
Published 28-03-2017“…Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):E1000-9 Hair cells, the sensory receptors of the internal ear, subserve different functions in various receptor…”
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Dimensions of a Living Cochlear Hair Bundle
Published in Frontiers in cell and developmental biology (25-11-2021)“…The hair bundle is the mechanosensory organelle of hair cells that detects mechanical stimuli caused by sounds, head motions, and fluid flows. Each hair bundle…”
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