Search Results - "Mao, Tiebo"

Single-cell analysis of pancreatic ductal adenocarcinoma identifies a novel fibroblast subtype associated with poor prognosis but better immunotherapy response by Wang, Yu, Liang, Yiyi, Xu, Haiyan, Zhang, Xiao, Mao, Tiebo, Cui, Jiujie, Yao, Jiayu, Wang, Yongchao, Jiao, Feng, Xiao, Xiuying, Hu, Jiong, Xia, Qing, Zhang, Xiaofei, Wang, Xujun, Sun, Yongwei, Fu, Deliang, Shen, Lei, Xu, Xiaojiang, Xue, Jing, Wang, Liwei

“…The current pathological and molecular classification of pancreatic ductal adenocarcinoma (PDAC) provides limited guidance for treatment options, especially…”
Get full text

Activation of the PI3K/AKT signaling pathway by ARNTL2 enhances cellular glycolysis and sensitizes pancreatic adenocarcinoma to erlotinib by Ge, Weiyu, Wang, Yanling, Quan, Ming, Mao, Tiebo, Bischof, Evelyne Y, Xu, Haiyan, Zhang, Xiaofei, Li, Shumin, Yue, Ming, Ma, Jingyu, Yang, Haiyan, Wang, Lei, Yu, Zhengyuan, Wang, Liwei, Cui, Jiujie

“…Pancreatic adenocarcinoma (PC) is an aggressive malignancy with limited treatment options. The poor prognosis primarily stems from late-stage diagnosis and…”
Get full text

A Novel Molecular Signature of Cancer-Associated Fibroblasts Predicts Prognosis and Immunotherapy Response in Pancreatic Cancer by Ge, Weiyu, Yue, Ming, Wang, Yanling, Wang, Yongchao, Xue, Shengbai, Shentu, Daiyuan, Mao, Tiebo, Zhang, Xiaofei, Xu, Haiyan, Li, Shumin, Ma, Jingyu, Wang, Liwei, Cui, Jiujie

“…Cancer-associated fibroblasts (CAFs), a prominent population of stromal cells, play a crucial role in tumor progression, prognosis, and treatment response…”
Get full text

Characterization of the genomic landscape in large-scale Chinese patients with pancreatic cancer by Zhang, Xiaofei, Mao, Tiebo, Zhang, Bei, Xu, Haiyan, Cui, Jiujie, Jiao, Feng, Chen, Dongqin, Wang, Yu, Hu, Jiong, Xia, Qing, Ge, Weiyu, Li, Shumin, Yue, Ming, Ma, Jingyu, Yao, Jiayu, Wang, Yongchao, Wang, Yanling, Shentu, Daiyuan, Zhang, Xiao, Chen, Shiqing, Bai, Yuezong, Wang, Yuexiang, Zhang, Xuebin, Liu, Qiang, Sun, Yongwei, Fu, Deliang, Liu, Yingbin, Xiong, Lei, Wang, Liwei

“…Pancreatic ductal adenocarcinoma (PDAC) is a malignant tumor with an extremely poor prognosis. Effective targets for anticancer therapy confirmed in PDAC are…”
Get full text

Cuproptosis‐related lncRNAs are correlated with tumour metabolism and immune microenvironment and predict prognosis in pancreatic cancer patients by Wang, Yanling, Ge, Weiyu, Xue, Shengbai, Cui, Jiujie, Zhang, Xiaofei, Mao, Tiebo, Xu, Haiyan, Li, Shumin, Ma, Jingyu, Yue, Ming, Shentu, Daiyuan, Wang, Liwei

“…Cuproptosis is a novel cell death pathway, and the regulatory mechanism in pancreatic cancer (PC) is unclear. The authors aimed to figure out whether…”
Get full text

A phase I study of the safety and activity of K-001 in patients with advanced pancreatic ductal adenocarcinoma by Cui, Jiujie, Yang, Haiyan, Liu, Jue, Chen, Donghui, Hu, Jiong, Zhang, Haiyan, Wang, Yu, Han, Ting, Mao, Tiebo, Jiao, Feng, Biskup, Ewelina, Pan, Yaotian, Liu, Min, Wang, Liwei

“…Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease that lack of effective therapeutic drugs. K-001 is an oral antitumor drug made…”
Get full text

HDACs/mTOR inhibitor synergizes with pyrotinib in HER2-positive pancreatic cancer through degradation of mutant P53 by Mao, Tiebo, Zhang, Xiaofei, Xu, Haiyan, Zhang, Xiao, Ge, Weiyu, Li, Shumin, Ma, Jingyu, Yue, Ming, Xue, Shengbai, Cui, Jiujie, Wang, Liwei

“…Pancreatic ductal adenocarcinoma (PDAC), as a highly lethal malignancy with high mortality, lacks of effective treatment. Canonical therapeutic targets in PDAC…”
Get full text

Distinguishable Prognostic Signatures and Tumor Immunogenicity Between Pancreatic Head Cancer and Pancreatic Body/Tail Cancer by Ge, Weiyu, Ma, Jingyu, Mao, Tiebo, Xu, Haiyan, Zhang, Xiaofei, Li, Shumin, Wang, Yongchao, Yao, Jiayu, Yue, Ming, Jiao, Feng, Wang, Yu, Zhuo, Meng, Han, Ting, Hu, Jiong, Zhang, Xiao, Cui, Jiujie, Wang, Liwei

“…Background Pancreatic head cancer and pancreatic body/tail cancer are considered to have different clinical presentations and to have altered outcomes. Methods…”
Get full text

A novel angiogenesis-based molecular signature related to prognosis and tumor immune interactions of pancreatic cancer by Ge, Weiyu, Shentu, Daiyuan, Wang, Yongchao, Wang, Yanling, Xue, Shengbai, Yue, Ming, Mao, Tiebo, Zhang, Xiaofei, Xu, Haiyan, Li, Shumin, Ma, Jingyu, Yao, Jiayu, Cui, Jiujie, Wang, Liwei

“…Angiogenesis, a hallmark of cancer, is related to prognosis, tumor progression, and treatment response. Nevertheless, the correlation of angiogenesis-based…”
Get full text

Association of aging-related genes with prognosis and immune infiltration in pancreatic adenocarcinoma by Xue, Shengbai, Ge, Weiyu, Wang, Kexuan, Mao, Tiebo, Zhang, Xiaofei, Xu, Haiyan, Wang, Yongchao, Yao, Jiayu, Li, Shumin, Yue, Ming, Ma, Jingyu, Wang, Yanling, Shentu, Daiyuan, Cui, Jiujie, Wang, Liwei

“…Pancreatic adenocarcinoma (PAAD) is one of the deadliest malignancies. Aging is described as the degeneration of physiological function, which is complexly…”
Get full text

Characterization of DNA damage response deficiency in pancreatic cancer patients from China by Zhang, Xiaofei, Mao, Tiebo, Zhang, Bei, Xu, Haiyan, Cui, Jiujie, Jiao, Feng, Chen, Dongqin, Wang, Yu, Hu, Jiong, Xia, Qing, Li, Shumin, Yue, Ming, Ma, Jingyu, Yao, Jiayu, Wang, Yongchao, Zhang, Xiao, Chen, Shiqing, Bai, Yuezong, Wang, Yuexiang, Zhang, Xuebin, Liu, Qiang, Sun, Yongwei, Fu, Deliang, Liu, Yingbin, Xiong, Lei, Wang, Liwei

“…Abbreviations ATM ataxia telangiectasia mutated BER base excision repair BRCA breast cancer susceptibility gene DDR DNA damage response DR direct repair ERCC6…”
Get full text

Chemotherapeutic drugs-induced pyroptosis mediated by gasdermin E promotes the progression and chemoresistance of pancreatic cancer by Li, Shumin, Yue, Ming, Xu, Haiyan, Zhang, Xiaofei, Mao, Tiebo, Quan, Ming, Ma, Jingyu, Wang, Yanling, Ge, Weiyu, Wang, Yongchao, Xue, Shengbai, Shentu, Daiyuan, Cui, Jiujie, Wang, Liwei

“…Pyroptosis is closely associated with cancer development; however, the role of pyroptosis in pancreatic ductal adenocarcinoma (PDAC), a fatal malignant tumour…”
Get full text

PLA2G2A+ cancer-associated fibroblasts mediate pancreatic cancer immune escape via impeding antitumor immune response of CD8+ cytotoxic T cells by Ge, Weiyu, Yue, Ming, Lin, Ruirong, Zhou, Tianhao, Xu, Haiyan, Wang, Yu, Mao, Tiebo, Li, Shumin, Wu, Xiuqi, Zhang, Xiaofei, Wang, Yongchao, Ma, Jingyu, Wang, Yanling, Xue, Shengbai, Shentu, Daiyuan, Cui, Jiujie, Wang, Liwei

“…Our previous research defined a novel metabolic cancer associated fibroblasts subset (meCAFs) enriched in loose-type pancreatic ductal adenocarcinoma (PDAC)…”
Get full text

CSE1L, as a novel prognostic marker, promotes pancreatic cancer proliferation by regulating the AKT/mTOR signaling pathway by Zhang, Xiao, Zhang, Xiaofei, Mao, Tiebo, Xu, Haiyan, Cui, Jiujie, Lin, Hechun, Wang, Liwei

“…Pancreatic cancer is one of the most aggressive tumors with poor prognosis and new targetable therapies are urgently required. CSE1L (chromosome segregation 1…”
Get full text

PD-1 antibody combined with paclitaxel (albumin bound) and gemcitabine as first-line therapy in patients with metastatic pancreatic cancer by Cui, Jiujie, Yao, Jiayu, Wang, Yu, Liang, Yiyi, Wang, Yongchao, Jiao, Feng, Zhang, Xiao, Han, Ting, Mao, Tiebo, Xia, Qing, Xiao, Xiuying, Yang, Haiyan, Wang, Li-Wei

“…Abstract only TPS4665 Background: Pancreatic cancer is a malignant tumor with limited therapeutic strategies and poor prognosis. About 60% of the patients have…”
Get full text

Synergistic blocking of RAS downstream signaling and epigenetic pathway in KRAS mutant pancreatic cancer by Zhang, Xiaofei, Mao, Tiebo, Xu, Haiyan, Li, Shumin, Yue, Ming, Ma, Jingyu, Yao, Jiayu, Wang, Yongchao, Zhang, Xiao, Ge, Weiyu, Wang, Yanling, Shentu, Daiyuan, Wang, Liwei

“…Pancreatic ductal adenocarcinoma (PDAC) is a highly fatal malignancy and lacks effective therapeutic targets. Trametinib is considered to be a promising…”
Get full text

Anti-PD-1 antibody combined with albumin-bound paclitaxel and gemcitabine (AG) as first-line therapy and Anti-PD-1 monotherapy as maintenance in metastatic pancreatic ductal adenocarcinoma (PDAC) by Cui, Jiujie, Yang, Haiyan, Hu, Jiong, Yao, Jiayu, Wang, Yu, Liang, Yiyi, Wang, Yongchao, Jiao, Feng, Zhang, Xiaofei, Zhang, Xiao, Han, Ting, Mao, Tiebo, Xia, Qing, Xiao, Xiuying, Wang, Li-Wei

“…Abstract only e16218 Background: Two studies in ASCO 2018 showed the preliminary efficacy of PD-1 inhibitor and AG as first-line therapy for advanced…”
Get full text

Upregulation of KSRP by miR-27b provides IFN-γ-induced post-transcriptional regulation of CX3CL1 in liver epithelial cells by Xia, Zijie, Lu, Yajing, Li, Xiaoqing, Mao, Tiebo, Chen, Xian-Ming, Zhou, Rui

“…Aberrant cellular responses to pro-inflammatory cytokines, such as IFN-γ, are pathogenic features in many chronic inflammatory diseases. A variety of feedback…”
Get full text

Prediction of Survival and Tumor Microenvironment Infiltration Based on Pyroptosis-Related lncRNAs in Pancreatic Cancer by Xue, Shengbai, Shen, Kangjie, Wang, Kexuan, Ge, Weiyu, Mao, Tiebo, Li, Shumin, Zhang, Xiaofei, Xu, Haiyan, Wang, Yongchao, Yao, Jiayu, Yue, Ming, Ma, Jingyu, Wang, Yanling, Shentu, Daiyuan, Cui, Jiujie, Wang, Liwei

“…Pancreatic cancer (PC) is a fatal tumor with high mortality. Pyroptosis plays a tumor suppressor role as a novel cell death. However, the influences of the…”
Get full text

A narrative review of Safety management of 1 L platinum-based chemotherapy and maintenance olaparib in BRCA mutated advanced pancreatic cancer by Yao, Jiayu, Wang, Yongchao, Mao, Tiebo, Liang, Yiyi, Zhang, Xiao, Yang, Haiyan, Hu, Jiong, Jiao, Feng, Cui, Jiujie, Wang, Liwei

“…We aimed to review the safety management and efficacy of a modified FOLFIRINOX regimen to help clinicians improve first-line platinum-based chemotherapy and…”
Get full text