Search Results - "Mao, Qinwen"

Role of neuroinflammation in neurodegeneration development by Zhang, Weifeng, Xiao, Dan, Mao, Qinwen, Xia, Haibin

“…Studies in neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease and Amyotrophic lateral sclerosis, Huntington’s disease, and so on,…”
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FAM76B regulates NF-κB-mediated inflammatory pathway by influencing the translocation of hnRNPA2B1 by Wang, Dongyang, Zheng, Xiaojing, Chai, Lihong, Zhao, Junli, Zhu, Jiuling, Li, Yanqing, Yang, Peiyan, Mao, Qinwen, Xia, Haibin

“…FAM76B has been reported to be a nuclear speckle-localized protein with unknown function. In this study, FAM76B was first demonstrated to inhibit the…”
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MCP1-CCR2 and neuroinflammation in the ALS motor cortex with TDP-43 pathology by Jara, Javier H, Gautam, Mukesh, Kocak, Nuran, Xie, Edward F, Mao, Qinwen, Bigio, Eileen H, Özdinler, P Hande

“…The involvement of non-neuronal cells and the cells of innate immunity has been attributed to the initiation and progression of ALS. TDP-43 pathology is…”
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The Role of Macrophages in the Response to TNF Inhibition in Experimental Arthritis by Huang, Qi-Quan, Birkett, Robert, Doyle, Renee, Shi, Bo, Roberts, Elyssa L, Mao, Qinwen, Pope, Richard M

“…The reduction of synovial tissue macrophages is a reliable biomarker for clinical improvement in patients with rheumatoid arthritis (RA), and macrophages are…”
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Cortical and subcortical pathological burden and neuronal loss in an autopsy series of FTLD-TDP-type C by Kawles, Allegra, Nishihira, Yasushi, Feldman, Alex, Gill, Nathan, Minogue, Grace, Keszycki, Rachel, Coventry, Christina, Spencer, Callen, Lilek, Jaclyn, Ajroud, Kaouther, Coppola, Giovanni, Rademakers, Rosa, Rogalski, Emily, Weintraub, Sandra, Zhang, Hui, Flanagan, Margaret E, Bigio, Eileen H, Mesulam, M-Marsel, Geula, Changiz, Mao, Qinwen, Gefen, Tamar

“…The TDP-43 type C pathological form of frontotemporal lobar degeneration is characterized by the presence of immunoreactive TDP-43 short and long dystrophic…”
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A novel TanCAR targeting IL13Rα2 and EphA2 for enhanced glioblastoma therapy by Muhammad, Niaz, Wang, Rong, Li, Wenyan, Zhang, Zihan, Chang, Yongxing, Hu, Yitao, Zhao, Junli, Zheng, Xiaojing, Mao, Qinwen, Xia, Haibin

“…Chimeric antigen receptor T cell (CAR-T) therapy has been shown to be an effective strategy for combatting non-solid tumors; however, CAR-T therapy is still a…”
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Lycium barbarum polysaccharide alleviates dextran sodium sulfate-induced inflammatory bowel disease by regulating M1/M2 macrophage polarization via the STAT1 and STAT6 pathways by Wang, Juan, Gao, Huiying, Xie, Yuan, Wang, Peng, Li, Yu, Zhao, Junli, Wang, Chunlin, Ma, Xin, Wang, Yuwen, Mao, Qinwen, Xia, Haibin

“…Disruption of colonic homeostasis caused by aberrant M1/M2 macrophage polarization contributes to the development of inflammatory bowel disease (IBD). Lycium…”
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Morphological and ultrastructural investigation of the posterior atlanto-occipital membrane: Comparing children with Chiari malformation type I and controls by Ravindra, Vijay M, Robinson, Lorraina, Jensen, Hailey, Kurudza, Elena, Joyce, Evan, Ludwick, Allison, Telford, Russell, Youssef, Osama, Ryan, Justin, Bollo, Robert J, Iyer, Rajiv R, Kestle, John R W, Cheshier, Samuel H, Ikeda, Daniel S, Mao, Qinwen, Brockmeyer, Douglas L

“…The fibrous posterior atlanto-occipital membrane (PAOM) at the craniocervical junction is typically removed during decompression surgery for Chiari…”
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Establishment of a HEK293 cell line by CRISPR/Cas9-mediated luciferase knock-in to study transcriptional regulation of the human SREBP1 gene by Li, Zihang, Zhao, Junli, Muhammad, Niaz, Wang, Dongyang, Mao, Qinwen, Xia, Haibin

“…Objectives To establish a HEK293 cell line with a luciferase knock-in reporter controlled by the endogenous SREBP1 promoter for investigating transcriptional…”
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RNA Interference Improves Motor and Neuropathological Abnormalities in a Huntington's Disease Mouse Model by Harper, Scott Q., Staber, Patrick D., He, Xiaohua, Eliason, Steven L., Martins, Inês H., Mao, Qinwen, Yang, Linda, Kotin, Robert M., Paulson, Henry L., Davidson, Beverly L., Welsh, Michael J.

“…Huntington's disease (HD) is a fatal, dominant neurogenetic disorder. HD results from polyglutamine repeat expansion (CAG codon, Q) in exon 1 of HD, conferring…”
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Revisiting the utility of TDP-43 immunoreactive (TDP-43-ir) pathology to classify FTLD-TDP subtypes by Nishihira, Yasushi, Gefen, Tamar, Mao, Qinwen, Appin, Christina, Kohler, Missia, Walker, Jamie, Rademakers, Rosa, Rademaker, Alfred, Rogalski, Emily, Weintraub, Sandra, Geula, Changiz, Mesulam, M-Marsel, Bigio, Eileen H.

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Disease and Region Specificity of Granulin Immunopositivities in Alzheimer Disease and Frontotemporal Lobar Degeneration by Mao, Qinwen, Wang, Dongyang, Li, Yanqing, Kohler, Missia, Wilson, Jayson, Parton, Zachary, Shmaltsuyeva, Bella, Gursel, Demirkan, Rademakers, Rosa, Weintraub, Sandra, Mesulam, Marek-Marsel, Xia, Haibin, Bigio, Eileen H.

“…Abstract Heterozygous loss-of-function mutations in GRN, the progranulin gene, which result in progranulin (PGRN) protein haploinsufficiency, are a major cause…”
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Diagnostic and Therapeutic Challenges of Rare Concurrent Intracranial Meningioma and Oligodendroglioma by Shoushtari, Ali, Robinson, Lorraina, Mao, Qinwen, Shah, Lubdha M, Salzman, Karen L, Menacho, Sarah T

“…Concurrent primary brain tumors are rare clinical entities, with a prevalence ranging from 0.1 to 0.5% of all diagnosed brain tumors. The co-occurrence of…”
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Predictors of recurrence in the management of chordoid meningioma by Choy, Winward, Ampie, Leonel, Lamano, Jonathan B., Kesavabhotla, Kartik, Mao, Qinwen, Parsa, Andrew T., Bloch, Orin

“…Management of chordoid meningiomas (CMs) is complicated by high rates of recurrence, particularly following subtotal resection. Optimal management is not…”
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Prognostic factors for recurrence and complications in the surgical management of primary chordoid gliomas: A systematic review of literature by Ampie, Leonel, Choy, Winward, Lamano, Jonathan B, Kesavabhotla, Kartik, Mao, Qinwen, Parsa, Andrew T, Bloch, Orin

“…Highlights • Chordoid glioma is a rare subtype of low grade glioma typically located within the 3rd ventricle. • Gross total resection is associated with…”
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Production and Characterization of Monoclonal Antibodies against Human Nuclear Protein FAM76B by Zheng, Xiaojing, Li, Yanqing, Zhao, Junli, Wang, Dongyang, Xia, Haibin, Mao, Qinwen

“…Human FAM76B (hFAM76B) is a 39 kDa protein that contains homopolymeric histidine tracts, a targeting signal for nuclear speckles. FAM76B is highly conserved…”
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Generation of a novel HEK293 luciferase reporter cell line by CRISPR/Cas9-mediated site-specific integration in the genome to explore the transcriptional regulation of the PGRN gene by Li, Yanqing, Li, Sai, Li, Yan, Xia, Haibin, Mao, Qinwen

“…Progranulin has multiple functions in several physiological and pathological processes, including embryonic development, wound repair, tumorigenesis,…”
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The luciferase reporter system of the MMP12 endogenous promoter for investigating transcriptional regulation of the human MMP12 gene by Du, Chunhua, Wu, Yanqiu, Ju, Yurong, Zhao, Junli, Yang, Peiyan, Mao, Qinwen, Xia, Haibin

“…Matrix metalloproteinase 12 (MMP12), a member of MMPs, can take lots of roles including extracellular matrix component degradation, viral infection,…”
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Mechanisms regulating the loss of Tregs in HUPO mice that develop spontaneous inflammatory arthritis by Huang, Qi-Quan, Hang, Yiwei, Doyle, Renee, Mao, Qinwen, Fang, Deyu, Pope, Richard M.

“…T regulatory cells (Tregs) are a potential therapeutic target in many autoimmune diseases including rheumatoid arthritis (RA). The mechanisms responsible for…”
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Phenotypically concordant distribution of pick bodies in aphasic versus behavioral dementias by Kawles, Allegra, Keszycki, Rachel, Minogue, Grace, Zouridakis, Antonia, Ayala, Ivan, Gill, Nathan, Macomber, Alyssa, Lubbat, Vivienne, Coventry, Christina, Rogalski, Emily, Weintraub, Sandra, Mao, Qinwen, Flanagan, Margaret E, Zhang, Hui, Castellani, Rudolph, Bigio, Eileen H, Mesulam, M-Marsel, Geula, Changiz, Gefen, Tamar

“…Pick's disease (PiD) is a subtype of the tauopathy form of frontotemporal lobar degeneration (FTLD-tau) characterized by intraneuronal 3R-tau inclusions. PiD…”
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