Antibiotic Resistance of Helicobacter Pylori Isolated in the Southeast Coastal Region of China

Background The resistance of Helicobacter pylori (H. pylori) to antibiotics is increasing worldwide, lowering its efficacy in current eradication therapies. This study evaluated H. pylori resistance to antibiotics in the southeast coastal region of China and suggests appropriate alternatives. Materi...

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Published in:	Helicobacter (Cambridge, Mass.) Vol. 18; no. 4; pp. 274 - 279
Main Authors:	Su, Peng, Li, Youming, Li, Hongzhang, Zhang, Jiakun, Lin, Lang, Wang, Qunying, Guo, Feng, Ji, Zizhong, Mao, Jibo, Tang, Wuheng, Shi, Zhengchao, Shao, Wei, Mao, Junliang, Zhu, Xinjian, Zhang, Xiaofeng, Tong, Yuefeng, Tu, Huimin, Jiang, Mizu, Wang, Zhiyong, Jin, Fengzhe, Yang, Ningmin, Zhang, Jianzhong
Format:	Journal Article
Language:	English
Published:	England Blackwell Publishing Ltd 01-08-2013
Subjects:	amoxicillin Anti-Bacterial Agents - pharmacology antibiotic resistance China - epidemiology clarithromycin Drug Resistance, Bacterial Helicobacter Infections - epidemiology Helicobacter Infections - microbiology Helicobacter pylori Helicobacter pylori - drug effects Helicobacter pylori - isolation & purification Humans levofloxacin metronidazole Microbial Sensitivity Tests Prevalence China
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Summary:	Background The resistance of Helicobacter pylori (H. pylori) to antibiotics is increasing worldwide, lowering its efficacy in current eradication therapies. This study evaluated H. pylori resistance to antibiotics in the southeast coastal region of China and suggests appropriate alternatives. Materials and Methods Seventeen thousand seven hundred and thirty one H. pylori strains were collected from eight areas of two provinces in coastal southeast China from 2010 to 2012. The resistance of these strains to six antibiotics was tested using the agar dilution method. Results The resistance rates to clarithromycin, metronidazole, levofloxacin, amoxicillin, gentamicin and furazolidone were 21.5, 95.4, 20.6, 0.1, 0.1 and 0.1%, respectively. Double, triple and quadruple antibacterial resistant percentages were 25.5, 7.5 and 0.1%, respectively. A positive association between the resistance to levofloxacin and to clarithromycin was found, but there was a negative correlation in the resistances to levofloxacin and to metronidazole. Conclusions The prevalence of H. pylori resistance to clarithromycin, metronidazole, levofloxacin and multiple antibiotics in coastal southeast China is high. Choice of therapy should be individualized based on a susceptibility test in this region of the country.
Bibliography:	National Key Program for Infectious Diseases of China - No. 2008ZX1004-002 Science and Technology Project of Zhejiang province - No. 2011C23140 National Technology R&D Program in the 12th Five-Year Plan of China - No. 2012BAI06B02 istex:F2F5446BDF599E8327C0973A79C7B55BBA278AF6 ArticleID:HEL12046 ark:/67375/WNG-MGDCJ5L2-1 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	1083-4389 1523-5378
DOI:	10.1111/hel.12046