Search Results - "Mao, Guogen"

The miR-15/107 Group of MicroRNA Genes: Evolutionary Biology, Cellular Functions, and Roles in Human Diseases by Finnerty, John R., Wang, Wang-Xia, Hébert, Sébastien S., Wilfred, Bernard R., Mao, Guogen, Nelson, Peter T.

“…The miR-15/107 group of microRNA (miRNA) gene is increasingly appreciated to serve key functions in humans. These miRNAs regulate gene expression involved in…”
Get full text

Effects of diet and hyperlipidemia on levels and distribution of circulating lysophosphatidic acid by Kraemer, Maria P., Mao, Guogen, Hammill, Courtney, Yan, Baoxiang, Li, Yu, Onono, Fredrick, Smyth, Susan S., Morris, Andrew J.

“…Lysophosphatidic acids (LPAs) are bioactive radyl hydrocarbon-substituted derivatives of glycerol 3-phosphate. LPA metabolism and signaling are implicated in…”
Get full text

Rad5 and Its Human Homologs, HLTF and SHPRH, Are Novel Interactors of Mismatch Repair by Miller, Anna K, Mao, Guogen, Knicely, Breanna G, Daniels, Hannah G, Rahal, Christine, Putnam, Christopher D, Kolodner, Richard D, Goellner, Eva M

“…DNA mismatch repair (MMR) repairs replication errors, and MMR defects play a role in both inherited cancer predisposition syndromes and in sporadic cancers…”
Get full text

Author Correction: Identification of novel genetic variants predisposing to familial oral squamous cell carcinomas by Huang, Yaping, Zhao, Jizhi, Mao, Guogen, Lee, Grace Sanghee, Zhang, Jia, Bi, Lijun, Gu, Liya, Chang, Zhijie, Valentino, Joseph, Li, Guo-Min

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
Get full text

The Histone Mark H3K36me3 Regulates Human DNA Mismatch Repair through Its Interaction with MutSα by Li, Feng, Mao, Guogen, Tong, Dan, Huang, Jian, Gu, Liya, Yang, Wei, Li, Guo-Min

“…DNA mismatch repair (MMR) ensures replication fidelity by correcting mismatches generated during DNA replication. Although human MMR has been reconstituted…”
Get full text

Cancer-driving H3G34V/R/D mutations block H3K36 methylation and H3K36me3–MutSα interaction by Fang, Jun, Huang, Yaping, Mao, Guogen, Yang, Shuang, Rennert, Gadi, Gu, Liya, Li, Haitao, Li, Guo-Min

“…Somatic mutations on glycine 34 of histone H3 (H3G34) cause pediatric cancers, but the underlying oncogenic mechanism remains unknown. We demonstrate that…”
Get full text

Regulation of PLPP3 gene expression by NF-κB family transcription factors by Mao, Guogen, Smyth, Susan S., Morris, Andrew J.

“…Lipid phosphate phosphatase 3 (LPP3), encoded by the PLPP3 gene, is an integral membrane enzyme that dephosphorylates phosphate esters of glycero- and…”
Get full text

Coronary Artery Disease Risk-Associated Plpp3 Gene and Its Product Lipid Phosphate Phosphatase 3 Regulate Experimental Atherosclerosis by Mueller, Paul A, Yang, Liping, Ubele, Margo, Mao, Guogen, Brandon, Jason, Vandra, Julia, Nichols, Timothy C, Escalante-Alcalde, Diana, Morris, Andrew J, Smyth, Susan S

“…OBJECTIVE:Genome-wide association studies identified novel loci in PLPP3(phospholipid phosphatase 3) that associate with coronary artery disease risk…”
Get full text

Cancer-driving H3G34V/R/D mutations block H3K36 methylation and H3K36me3–MutSa interaction by Fang, Jun, Huang, Yaping, Mao, Guogen, Yang, Shuang, Rennert, Gadi, Gu, Liya, Li, Haitao, Li, Guo-Min

“…Somatic mutations on glycine 34 of histone H3 (H3G34) cause pediatric cancers, but the underlying oncogenic mechanism remains unknown. We demonstrate that…”
Get full text

Modulation of microRNA processing by mismatch repair protein MutLα by Mao, Guogen, Lee, Sanghee, Ortega, Janice, Gu, Liya, Li, Guo-Min

“…MicroRNAs (miRNAs) are critical post-transcriptional regulators and are derived from hairpin-shaped primary transcripts via a series of processing steps…”
Get full text

Abstract 799: HLTF and SHPRH in mismatch repair and cancer by Miller, Anna Kristin, Mao, Guogen, Rahal, Christine, Putnam, Christopher, Goellner, Eva

“…Abstract Colorectal cancer (CRC) is one of the leading causes of cancer deaths, with an increasing rate of CRC diagnosis in younger individuals. MMR is the DNA…”
Get full text

Evidence That a Mutation in the MLH1 3′-Untranslated Region Confers a Mutator Phenotype and Mismatch Repair Deficiency in Patients with Relapsed Leukemia by Mao, Guogen, Pan, Xiaoyu, Gu, Liya

“…Defects in DNA mismatch repair (MMR) are the molecular basis of certain cancers, including hematological malignancies. The defects are often caused by…”
Get full text

Down‐regulation of MLH1 in a relapsed leukemia patient is associated with a three‐nucleotide deletion in the MLH1 3′ untranslated region by Gu, Liya, Mao, Guogen

“…Abstract only Defects in DNA mismatch repair (MMR) are the molecular basis of certain cancers, including hematological malignancies. These defects are often…”
Get full text

Specific sequence determinants of miR-15/107 microRNA gene group targets by Nelson, Peter T., Wang, Wang-Xia, Mao, Guogen, Wilfred, Bernard R., Xie, Kevin, Jennings, Mary H., Gao, Zhen, Wang, Xiaowei

“…MicroRNAs (miRNAs) target mRNAs in human cells via complex mechanisms that are still incompletely understood. Using anti-Argonaute (anti-AGO) antibody…”
Get full text

Identification of novel genetic variants predisposing to familial oral squamous cell carcinomas by Huang, Yaping, Zhao, Jizhi, Mao, Guogen, Lee, Grace Sanghee, Zhang, Jia, Bi, Lijun, Gu, Liya, Chang, Zhijie, Valentino, Joseph, Li, Guo-Min

“…Oral squamous cell carcinoma (OSCC) is a common subtype of head and neck squamous cell carcinoma (HNSCC), but the pathogenesis underlying familial OSCCs is…”
Get full text

Coordinated Processing of 3′ Slipped (CAG)n/(CTG)n Hairpins by DNA Polymerases β and δ Preferentially Induces Repeat Expansions by Chan, Nelson L.S., Guo, Jinzhen, Zhang, Tianyi, Mao, Guogen, Hou, Caixia, Yuan, Fenghua, Huang, Jian, Zhang, Yanbin, Wu, Jianxin, Gu, Liya, Li, Guo-Min

“…Expansion of CAG/CTG trinucleotide repeats causes certain familial neurological disorders. Hairpin formation in the nascent strand during DNA synthesis is…”
Get full text

Identification and characterization of OGG1 mutations in patients with Alzheimer's disease by Mao, Guogen, Pan, Xiaoyu, Zhu, Bei-Bei, Zhang, Yanbin, Yuan, Fenghua, Huang, Jian, Lovell, Mark A, Lee, Maxwell P, Markesbery, William R, Li, Guo-Min, Gu, Liya

“…Patients with Alzheimer's disease (AD) exhibit higher levels of 8-oxo-guanine (8-oxoG) DNA lesions in their brain, suggesting a reduced or defective 8-oxoG…”
Get full text

Erratum: Author Correction: Identification of novel genetic variants predisposing to familial oral squamous cell carcinomas by Huang, Yaping, Zhao, Jizhi, Mao, Guogen, Lee, Grace Sanghee, Zhang, Jia, Bi, Lijun, Gu, Liya, Chang, Zhijie, Valentino, Joseph, Li, Guo-Min

“…[This corrects the article DOI: 10.1038/s41421-019-0126-6.]…”
Get full text

Modulation of microRNA processing by mismatch repair protein MutL[alpha] by Mao, Guogen, Lee, Sanghee, Ortega, Janice, Gu, Liya, Li, Guo-min

“…MicroRNAs (miRNAs) are critical post-transcriptional regulators and are derived from hairpin-shaped primary transcripts via a series of processing steps…”
Get full text

Evidence That a Mutation in the MLH1 3′-Untranslated Region Confers a Mutator Phenotype and Mismatch Repair Deficiency in Patients with Relapsed Leukemia by Guogen Mao, Xiaoyu Pan, Liya Gu

“…Defects in DNA mismatch repair (MMR) are the molecular basis of certain cancers, including hematological malignancies. The defects are often caused by…”
Get full text