Search Results - "Mao, Angelo"

Regenerative medicine: Current therapies and future directions by Mao, Angelo S, David J. Mooney

“…Organ and tissue loss through disease and injury motivate the development of therapies that can regenerate tissues and decrease reliance on transplantations…”
Get full text

Effects of substrate stiffness and cell-cell contact on mesenchymal stem cell differentiation by Mao, Angelo S, Shin, Jae-Won, Mooney, David J

“…Abstract The mechanical properties of the microenvironment and direct contact-mediated cell-cell interactions are two variables known to be important in the…”
Get full text

Programmable CRISPR-responsive smart materials by English, Max A, Soenksen, Luis R, Gayet, Raphael V, de Puig, Helena, Angenent-Mari, Nicolaas M, Mao, Angelo S, Nguyen, Peter Q, Collins, James J

“…Stimuli-responsive materials activated by biological signals play an increasingly important role in biotechnology applications. We exploit the programmability…”
Get full text

Deterministic encapsulation of single cells in thin tunable microgels for niche modelling and therapeutic delivery by Mao, Angelo S., Shin, Jae-Won, Utech, Stefanie, Wang, Huanan, Uzun, Oktay, Li, Weiwei, Cooper, Madeline, Hu, Yuebi, Zhang, Liyuan, Weitz, David A., Mooney, David J.

“…Single cells encapsulated in a layer of alginate and injected intravenously delay clearance kinetics and sustain donor-derived soluble factors in vivo …”
Get full text

Microfluidic Templated Multicompartment Microgels for 3D Encapsulation and Pairing of Single Cells by Zhang, Liyuan, Chen, Kaiwen, Zhang, Haoyue, Pang, Bo, Choi, Chang‐Hyung, Mao, Angelo S., Liao, Hongbing, Utech, Stefanie, Mooney, David J., Wang, Huanan, Weitz, David A.

“…Controlled encapsulation and pairing of single cells within a confined 3D matrix can enable the replication of the highly ordered cellular structure of human…”
Get full text

Microfluidic Generation of Monodisperse, Structurally Homogeneous Alginate Microgels for Cell Encapsulation and 3D Cell Culture by Utech, Stefanie, Prodanovic, Radivoje, Mao, Angelo S., Ostafe, Raluca, Mooney, David J., Weitz, David A.

“…Monodisperse alginate microgels (10–50 μm) are created via droplet‐based microfluidics by a novel crosslinking procedure. Ionic crosslinking of alginate is…”
Get full text

Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate by Mooney, David J, Huebsch, Nathaniel, Arany, Praveen R, Mao, Angelo S, Shvartsman, Dmitry, Ali, Omar A, Bencherif, Sidi A, Rivera-Feliciano, José

“…Stem cells sense and respond to the mechanical properties of the extracellular matrix. However, both the extent to which extracellular-matrix mechanics affect…”
Get full text

Programmable microencapsulation for enhanced mesenchymal stem cell persistence and immunomodulation by Mao, Angelo S., Özkale, Berna, Shah, Nisarg J., Vining, Kyle H., Descombes, Tiphaine, Zhang, Liyuan, Tringides, Christina M., Wong, Sing-Wan, Shin, Jae-Won, Scadden, David T., Weitz, David A., Mooney, David J.

“…Mesenchymal stem cell (MSC) therapies demonstrate particular promise in ameliorating diseases of immune dysregulation but are hampered by short in vivo cell…”
Get full text

Cell volume change through water efflux impacts cell stiffness and stem cell fate by Guo, Ming, Pegoraro, Adrian F., Mao, Angelo, Zhou, Enhua H., Arany, Praveen R., Han, Yulong, Burnette, Dylan T., Jensen, Mikkel H., Kasza, Karen E., Moore, Jeffrey R., Mackintosh, Frederick C., Fredberg, Jeffrey J., Mooney, David J., Lippincott-Schwartz, Jennifer, Weitz, David A.

“…Cells alter their mechanical properties in response to their local microenvironment; this plays a role in determining cell function and can even influence stem…”
Get full text

Material microenvironmental properties couple to induce distinct transcriptional programs in mammalian stem cells by Darnell, Max, O’Neil, Alison, Mao, Angelo, Gu, Luo, Rubin, Lee L., Mooney, David J.

“…Variations in a multitude of material microenvironmental properties have been observed across tissues in vivo, and these have profound effects on cell…”
Get full text

An Integrated Microrobotic Platform for On-Demand, Targeted Therapeutic Interventions by Fusco, Stefano, Sakar, Mahmut Selman, Kennedy, Stephen, Peters, Christian, Bottani, Rocco, Starsich, Fabian, Mao, Angelo, Sotiriou, Georgios A., Pané, Salvador, Pratsinis, Sotiris E., Mooney, David, Nelson, Bradley J.

“…The presented microrobotic platform combines together the advantages of self‐folding NIR light sensitive polymer bilayers, magnetic alginate microbeads, and a…”
Get full text

3D Printed Microtransporters: Compound Micromachines for Spatiotemporally Controlled Delivery of Therapeutic Agents by Huang, Tian-Yun, Sakar, Mahmut Selman, Mao, Angelo, Petruska, Andrew J., Qiu, Famin, Chen, Xue-Bo, Kennedy, Stephen, Mooney, David, Nelson, Bradley J.

“…Functional compound micromachines are fabricated by a design methodology using 3D direct laser writing and selective physical vapor deposition of magnetic…”
Get full text

Minimally instrumented SHERLOCK (miSHERLOCK) for CRISPR-based point-of-care diagnosis of SARS-CoV-2 and emerging variants by de Puig, Helena, Lee, Rose A., Najjar, Devora, Tan, Xiao, Soenksen, Luis R., Angenent-Mari, Nicolaas M., Donghia, Nina M., Weckman, Nicole E., Ory, Audrey, Ng, Carlos F., Nguyen, Peter Q., Mao, Angelo S., Ferrante, Thomas C., Lansberry, Geoffrey, Sallum, Hani, Niemi, James, Collins, James J.

“…An integrated, low-cost, sample-to-answer, CRISPR-based diagnostic detects SARS-CoV-2 and variants from unprocessed saliva. The COVID-19 pandemic highlights…”
Get full text

An injectable bone marrow–like scaffold enhances T cell immunity after hematopoietic stem cell transplantation by Shah, Nisarg J., Mao, Angelo S., Shih, Ting-Yu, Kerr, Matthew D., Sharda, Azeem, Raimondo, Theresa M., Weaver, James C., Vrbanac, Vladimir D., Deruaz, Maud, Tager, Andrew M., Mooney, David J., Scadden, David T.

“…Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment for multiple disorders, but deficiency and dysregulation of T cells limit its…”
Get full text

Creating CRISPR-responsive smart materials for diagnostics and programmable cargo release by Gayet, Raphael V., de Puig, Helena, English, Max A., Soenksen, Luis R., Nguyen, Peter Q., Mao, Angelo S., Angenent-Mari, Nicolaas M., Collins, James J.

“…Materials that sense and respond to biological signals in their environment have a broad range of potential applications in drug delivery, medical devices and…”
Get full text

Single cell-laden protease-sensitive microniches for long-term culture in 3D by Lienemann, Philipp S, Rossow, Torsten, Mao, Angelo S, Vallmajo-Martin, Queralt, Ehrbar, Martin, Mooney, David J

“…Single cell-laden three-dimensional (3D) microgels that can serve to mimic stem cell niches in vitro, and are therefore termed microniches, can be efficiently…”
Get more information

RNA-responsive elements for eukaryotic translational control by Zhao, Evan M., Mao, Angelo S., de Puig, Helena, Zhang, Kehan, Tippens, Nathaniel D., Tan, Xiao, Ran, F. Ann, Han, Isaac, Nguyen, Peter Q., Chory, Emma J., Hua, Tiffany Y., Ramesh, Pradeep, Thompson, David B., Oh, Crystal Yuri, Zigon, Eric S., English, Max A., Collins, James J.

“…The ability to control translation of endogenous or exogenous RNAs in eukaryotic cells would facilitate a variety of biotechnological applications. Current…”
Get full text

Actuated 3D microgels for single cell mechanobiology by Özkale, Berna, Lou, Junzhe, Özelçi, Ece, Elosegui-Artola, Alberto, Tringides, Christina M, Mao, Angelo S, Sakar, Mahmut Selman, Mooney, David J

“…We present a new cell culture technology for large-scale mechanobiology studies capable of generating and applying optically controlled uniform compression on…”
Get more information

Acetalated Dextran Nanoparticles Loaded into an Injectable Alginate Cryogel for Combined Chemotherapy and Cancer Vaccination by Bauleth‐Ramos, Tomás, Shih, Ting‐Yu, Shahbazi, Mohammad‐Ali, Najibi, Alexander J., Mao, Angelo S., Liu, Dongfei, Granja, Pedro, Santos, Hélder A., Sarmento, Bruno, Mooney, David J.

“…Vaccination represents a promising strategy for cancer therapy due to its ability to efficiently eliminate tumors from the host body and prevent their…”
Get full text

Controlled self-assembly of alginate microgels by rapidly binding molecule pairs by Hu, Yuebi, Mao, Angelo S, Desai, Rajiv M, Wang, Huanan, Weitz, David A, Mooney, David J

“…Controlled self-assembly of cell-encapsulating microscale polymeric hydrogels (microgels) could be advantageous in a variety of tissue engineering and…”
Get more information