Search Results - "Manzoni, Olivier J. J."

Synaptic functions of endocannabinoid signaling in health and disease by Araque, Alfonso, Castillo, Pablo E., Manzoni, Olivier J., Tonini, Raffaella

“…Endocannabinoids (eCBs) are a family of lipid molecules that act as key regulators of synaptic transmission and plasticity. They are synthetized “on demand”…”
Get full text

Endocannabinoid-Mediated Plasticity in Nucleus Accumbens Controls Vulnerability to Anxiety after Social Defeat Stress by Bosch-Bouju, Clémentine, Larrieu, Thomas, Linders, Louisa, Manzoni, Olivier J., Layé, Sophie

“…Chronic social defeat stress (CSDS) is a clinically relevant model of mood disorders. The relationship between the CSDS model and a physiologically pertinent…”
Get full text

Cell-Type- and Endocannabinoid-Specific Synapse Connectivity in the Adult Nucleus Accumbens Core by Deroche, Marion A, Lassalle, Olivier, Castell, Laia, Valjent, Emmanuel, Manzoni, Olivier J

“…The nucleus accumbens (NAc) is a mesocorticolimbic structure that integrates cognitive, emotional and motor functions. Although its role in psychiatric…”
Get full text

Neuronal circuits underlying acute morphine action on dopamine neurons by Jalabert, Marion, Bourdy, Romain, Courtin, Julien, Veinante, Pierre, Manzoni, Olivier J, Barrot, Michel, Georges, François

“…Morphine is a highly potent analgesic with high addictive potential in specific contexts. Although dopamine neurons of the ventral tegmental area (VTA) are…”
Get full text

Glutamatergic synaptic deficits in the prefrontal cortex of the Ts65Dn mouse model for Down syndrome by Thomazeau, Aurore, Lassalle, Olivier, Manzoni, Olivier J.

“…Down syndrome (DS), the most prevalent cause of intellectual disability, stems from a chromosomal anomaly resulting in an entire or partial extra copy of…”
Get full text

In utero exposure to cannabidiol disrupts select early-life behaviors in a sex-specific manner by Iezzi, Daniela, Caceres-Rodriguez, Alba, Chavis, Pascale, Manzoni, Olivier J. J.

“…Cannabidiol (CBD), one of the main components of cannabis, is generally considered safe. CBD crosses the placenta and its use during pregnancy is steadily…”
Get full text

Molecular components and functions of the endocannabinoid system in mouse prefrontal cortex by Lafourcade, Mathieu, Elezgarai, Izaskun, Mato, Susana, Bakiri, Yamina, Grandes, Pedro, Manzoni, Olivier J

“…Cannabinoids have deleterious effects on prefrontal cortex (PFC)-mediated functions and multiple evidences link the endogenous cannabinoid (endocannabinoid)…”
Get full text

Polymodal activation of the endocannabinoid system in the extended amygdala by Puente, Nagore, Cui, Yihui, Lassalle, Olivier, Lafourcade, Mathieu, Georges, François, Venance, Laurent, Grandes, Pedro, Manzoni, Olivier J

“…The authors report that, in the extended amygdala, 2-arachidonoylglycerol and anandamide mediate retrograde short-term depression and long-term depression,…”
Get full text

Perinatal THC exposure via lactation induces lasting alterations to social behavior and prefrontal cortex function in rats at adulthood by Scheyer, Andrew F, Borsoi, Milene, Pelissier-Alicot, Anne-Laure, Manzoni, Olivier J J

“…Cannabis is the world's most widely abused illicit drug and consumption amongst women during and surrounding the period of pregnancy is increasing. Previously,…”
Get full text

Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions by Layé, Sophie, Manzoni, Olivier J, Lafourcade, Mathieu, Larrieu, Thomas, Mato, Susana, Duffaud, Anais, Sepers, Marja, Matias, Isabelle, De Smedt-Peyrusse, Veronique, Labrousse, Virginie F, Bretillon, Lionel, Matute, Carlos, Rodríguez-Puertas, Rafael

“…Lafourcade et al . find that a lifelong insufficiency in dietary n-3 polyunsaturated fatty acids leads to a specific loss of long-term synaptic depression…”
Get full text

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors by Marrs, William R, Blankman, Jacqueline L, Horne, Eric A, Thomazeau, Aurore, Lin, Yi Hsing, Coy, Jonathan, Bodor, Agnes L, Muccioli, Giulio G, Hu, Sherry Shu-Jung, Woodruff, Grace, Fung, Susan, Lafourcade, Mathieu, Alexander, Jessica P, Long, Jonathan Z, Li, Weiwei, Xu, Cong, Möller, Thomas, Mackie, Ken, Manzoni, Olivier J, Cravatt, Benjamin F, Stella, Nephi

“…Marrs et al . show that the serine hydrolase α/β-hydrolase domain 6 (ABHD6) controls the accumulation and efficacy of the endocannabinoid…”
Get full text

Sex-dependent effects of in utero cannabinoid exposure on cortical function by Bara, Anissa, Manduca, Antonia, Bernabeu, Axel, Borsoi, Milene, Serviado, Michela, Lassalle, Olivier, Murphy, Michelle, Wager-Miller, Jim, Mackie, Ken, Pelissier-Alicot, Anne-Laure, Trezza, Viviana, Manzoni, Olivier J

“…Cannabinoids can cross the placenta, thus may interfere with fetal endocannabinoid signaling during neurodevelopment, causing long-lasting deficits. Despite…”
Get full text

NMDA Receptor Surface Trafficking and Synaptic Subunit Composition Are Developmentally Regulated by the Extracellular Matrix Protein Reelin by Groc, Laurent, Choquet, Daniel, Stephenson, F. Anne, Verrier, Daniele, Manzoni, Olivier J, Chavis, Pascale

“…During postnatal development, changes in the subunit composition of glutamate receptors of the NMDA subtype (NMDARs) are key to the refinement of excitatory…”
Get full text

Muscarinic M1 Receptor Modulation of Synaptic Plasticity in Nucleus Accumbens of Wild-Type and Fragile X Mice by Neuhofer, Daniela, Lassalle, Olivier, Manzoni, Olivier J

“…We investigated how metabotropic acetylcholine receptors control excitatory synaptic plasticity in the mouse nucleus accumbens core. Pharmacological and…”
Get full text

Sexual differences in neuronal and synaptic properties across subregions of the mouse insular cortex by Iezzi, Daniela, Cáceres-Rodríguez, Alba, Strauss, Benjamin, Chavis, Pascale, Manzoni, Olivier J

“…The insular cortex (IC) plays a pivotal role in processing interoceptive and emotional information, offering insights into sex differences in behavior and…”
Get full text

Sex-specific modulation of early life vocalization and cognition by Fmr1 gene dosage in a mouse model of Fragile X Syndrome by Giua, Gabriele, Iezzi, Daniela, Caceres-Rodriguez, Alba, Strauss, Benjamin, Chavis, Pascale, Manzoni, Olivier J

“…Pup-dam ultrasonic vocalizations (USVs) are essential to cognitive and socio-emotional development. In autism and Fragile X Syndrome (FXS), disruptions in…”
Get full text

Endogenous Cannabinoids Mediate Long-Term Synaptic Depression in the Nucleus Accumbens by Robbe, David, Kopf, Manfred, Remaury, Anne, Bockaert, Joel, Manzoni, Olivier J.

“…Do endocannabinoids (eCBs) participate in long-term synaptic plasticity in the brain? Using pharmacological approaches and genetically altered mice, we show…”
Get full text

Sex-specific divergent maturational trajectories in the postnatal rat basolateral amygdala by Guily, Pauline, Lassalle, Olivier, Chavis, Pascale, Manzoni, Olivier J.

“…In rodents and humans, the basolateral amygdala (BLA), essential for emotional behaviors, is profoundly reorganized during adolescence. We compared in both…”
Get full text

Sex Differences in the Behavioral and Synaptic Consequences of a Single in vivo Exposure to the Synthetic Cannabimimetic WIN55,212-2 at Puberty and Adulthood by Borsoi, Milene, Manduca, Antonia, Bara, Anissa, Lassalle, Olivier, Pelissier-Alicot, Anne-Laure, Manzoni, Olivier J

“…Heavy cannabis consumption among adolescents is associated with significant and lasting neurobiological, psychological and health consequences that depend on…”
Get full text

Altered surface trafficking of presynaptic cannabinoid type 1 receptor in and out synaptic terminals parallels receptor desensitization by Mikasova, Lenka, Groc, Laurent, Choquet, Daniel, Manzoni, Olivier J

“…Presynaptic cannabinoid type 1 receptors (CB1Rs) are major mediators of retrograde synaptic plasticity at both excitatory and inhibitory synapses and…”
Get full text