Search Results - "Manzella, M."

Mapping lumbar efferent and afferent spinal circuitries via paddle array in a porcine model by Steele, A.G., Taccola, G., Frazier, A.M., Manzella, M., Hogan, M., Horner, P.J., Faraji, A.H., Sayenko, D.G.

“…Preclinical models are essential for identifying changes occurring after neurologic injury and assessing therapeutic interventions. Yucatan miniature pigs…”
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Further Evidence that Inhibition of Neuronal Voltage-Gated Calcium Channels Contributes to the Hypnotic Effect of Neurosteroid Analogue, 3β-OH by Timic Stamenic, Tamara, Manzella, Francesca M, Maksimovic, Stefan, Krishnan, Kathiresan, Covey, Douglas F, Jevtovic-Todorovic, Vesna, Todorovic, Slobodan M

“…We recently reported that a neurosteroid analogue with T-channel-blocking properties (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile (3β-OH), induced hypnosis…”
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Neonatal Isoflurane Does Not Affect Sleep Architecture and Minimally Alters Neuronal Beta Oscillations in Adolescent Rats by Manzella, Francesca M, Gulvezan, Bethany F, Maksimovic, Stefan, Useinovic, Nemanja, Raol, Yogendra H, Joksimovic, Srdjan M, Jevtovic-Todorovic, Vesna, Todorovic, Slobodan M

“…General anesthetics are neurotoxic to the developing rodent and primate brains leading to neurocognitive and socio-affective impairment later in life. In…”
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Neonatal Ketamine Alters High-Frequency Oscillations and Synaptic Plasticity in the Subiculum But Does not Affect Sleep Macrostructure in Adolescent Rats by Manzella, Francesca M, Joksimovic, Srdjan M, Orfila, James E, Fine, Brier R, Dietz, Robert M, Sampath, Dayalan, Fiedler, Hanna K, Tesic, Vesna, Atluri, Navya, Raol, Yogendra H, Jevtovic-Todorovic, Vesna, Herson, Paco S, Todorovic, Slobodan M

“…Exposure to sedative/hypnotic and anesthetic drugs, such as ketamine, during the critical period of synaptogenesis, causes profound neurotoxicity in the…”
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Rapid Clearance of Sialylated Glycoproteins by the Asialoglycoprotein Receptor by Park, Eric I, Manzella, Stephen M, Baenziger, Jacques U

“…The asialoglycoprotein-receptor (ASGP-R) located on liver parenchymal cells was originally identified and characterized on the basis of its ability to bind…”
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Expression Cloning of a New Member of the ABO Blood Group Glycosyltransferases, iGb3 Synthase, That Directs the Synthesis of Isoglobo-glycosphingolipids by Keusch, Jeremy J., Manzella, Stephen M., Nyame, Kwame A., Cummings, Richard D., Baenziger, Jacques U.

“…The large array of different glycolipids described in mammalian tissues is a reflection, in part, of diverse glycosyltransferase expression. Herein, we…”
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Short communication: Y-STR sample haplotypes from five United States of America population groups by Pignone, Michelle L., Manzella, April M., Galusha, Michelle, Le, Jennifer, Moreno, Lilliana I.

“…Y-STR haplotype data from five relevant United States population groups are provided. These data have been shared with the Y-Chromosome Haplotype Reference…”
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Isoflurane exposure for three hours triggers apoptotic cell death in neonatal macaque brain by Noguchi, K.K., Johnson, S.A., Dissen, G.A., Martin, L.D., Manzella, F.M., Schenning, K.J., Olney, J.W., Brambrink, A.M.

“…Retrospective clinical studies suggest there is a risk for neurodevelopmental impairment following early childhood exposure to anaesthesia. In the developing…”
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Synthetic neuroactive steroids as new sedatives and anaesthetics: Back to the future by Manzella, Francesca M., Covey, Douglas F., Jevtovic‐Todorovic, Vesna, Todorovic, Slobodan M.

“…Since the 1990s, there has been waning interest in researching general anaesthetics (anaesthetics). Although currently used anaesthetics are mostly safe and…”
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Sex-specific hypnotic effects of the neuroactive steroid (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile are mediated by peripheral metabolism into an active hypnotic steroid by Manzella, Francesca M, Cabrera, Omar H, Wilkey, Davis, Fine-Raquet, Brier, Klawitter, Jelena, Krishnan, Kathiresan, Covey, Douglas F, Jevtovic-Todorovic, Vesna, Todorovic, Slobodan M

“…The novel synthetic neuroactive steroid (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile (3β-OH) blocks T-type calcium channels but does not directly modulate…”
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Isoflurane exposure leads to apoptosis of neurons and oligodendrocytes in 20- and 40-day old rhesus macaques by Schenning, Katie J, Noguchi, Kevin K, Martin, Lauren Drew, Manzella, Francesca M, Cabrera, Omar H, Dissen, Gregory A, Brambrink, Ansgar M

“…Abstract Previously we reported that a 5-hour exposure of 6-day-old (P6) rhesus macaques to isoflurane triggers robust neuron and oligodendrocyte apoptosis. In…”
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Eliciting Facial Affect, Motivation, and Expectancies in Transference: Significant-Other Representations in Social Relations by Andersen, Susan M, Reznik, Inga, Manzella, Lenora M

“…Recent research has demonstrated transference in social perception, defined in terms of memory and schema-triggered evaluation in relation to a new person ( S…”
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Cloning of Gb3 Synthase, the Key Enzyme in Globo-series Glycosphingolipid Synthesis, Predicts a Family of α1,4-Glycosyltransferases Conserved in Plants, Insects, and Mammals by Keusch, Jeremy J., Manzella, Stephen M., Nyame, Kwame A., Cummings, Richard D., Baenziger, Jacques U.

“…We have cloned Gb3synthase, the key α1,4-galactosyltransferase in globo-series glycosphingolipid (GSL) synthesis, via a phenotypic screen, which previously…”
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Assessing the impact of using conventional swabs on the ANDE 6C arrestee biochip by Manzella, April M., Moreno, Lilliana I.

“…•A significant decrease in success rate was observed when using conventional cotton reference swabs with the ANDE 6C Arrestee cartridge.•Expert system failed…”
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Assessment of the ANDE 6C Rapid DNA system and investigative biochip for the processing of calcified and muscle tissue by Manzella, April M., Carte, Kathryn M., King, Sheria L., Moreno, Lilliana I.

“…The ANDE 6C Rapid DNA system could offer a potential alternative for the processing of calcified and soft tissue samples, often encountered in mass disaster…”
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Novel neuroactive steroid with hypnotic and T‐type calcium channel blocking properties exerts effective analgesia in a rodent model of post‐surgical pain by Joksimovic, Sonja Lj, Joksimovic, Srdjan M., Manzella, Francesca M., Asnake, Betelehem, Orestes, Peihan, Raol, Yogendra H., Krishnan, Kathiresan, Covey, Douglas F., Jevtovic‐Todorovic, Vesna, Todorovic, Slobodan M.

“…Background and Purpose Neuroactive steroid (3β,5β,17β)‐3‐hydroxyandrostane‐17‐carbonitrile (3β‐OH) is a novel hypnotic and voltage‐dependent blocker of T‐type…”
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Neonatal exposure to a neuroactive steroid alters low-frequency oscillations in the subiculum by Fine-Raquet, Brier, Manzella, Francesca M, Joksimovic, Srdjan M, Dietz, Robert M, Orfila, James E, Sampath, Dayalan, Tesic, Vesna, Atluri, Navya, Covey, Douglas F, Raol, Yogendra H, Jevtovic-Todorovic, Vesna, Herson, Paco S, Todorovic, Slobodan M

“…Preclinical studies have established that neonatal exposure to contemporary sedative/hypnotic drugs causes neurotoxicity in the developing rodent and primate…”
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Editorial "Earth and Space Science Informatics: informatics in oceanography" by Manzella, G. M. R, Iona, S, Nativi, S

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Cognition in female rats after blocking conversion of androgens to estrogens by Taylor, George T., Manzella, Francesca M., Huffman, Jacob, Cabrera, Omar H., Hoffman, Jessica

“…Women and non-human females have surprisingly high levels of circulating testosterone, yet the effects of androgens on non-reproductive behaviors, including…”
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RNA-sequencing and behavioral testing reveals inherited physical inactivity co-selects for anxiogenic behavior without altering depressive-like behavior in Wistar rats by Kelty, Taylor J., Brown, Jacob D., Kerr, Nathan R., Roberts, Michael D., Childs, Tom E., Cabrera, Omar H., Manzella, Francesca M., Miller, Dennis K., Taylor, George T., Booth, Frank W.

“…•Selective breeding rats for low voluntary running (LVR) distance co-selected for anxiogenic behavior, without altering depressive-like behavior in LVR…”
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