Search Results - "Manzano, JL"

Thiourea, triazole and thiadiazine compounds and their metal complexes as antifungal agents by Rodríguez-Fernández, E., Manzano, Juan L., Benito, Juan J., Hermosa, Rosa, Monte, Enrique, Criado, Julio J.

“…Many currently available antifungal and antibacterial agents have undesirable toxic effects, and a wide spread use of these drugs has lead to rapid development…”
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Thiourea derivatives and their nickel(II) and platinum(II) complexes: antifungal activity by del Campo, Rafael, Criado, Julio J., Garcı́a, Eva, Hermosa, Marı́a R., Jiménez-Sánchez, A., Manzano, Juan L., Monte, Enrique, Rodrı́guez-Fernández, E., Sanz, Francisca

“…We have synthesized two thiourea derivatives of methyl anthranilate ( 1, 2) and their complexes with nickel ( 3) and platinum(II) ( 4). We have also prepared…”
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PO-447 CDK5 as a prognostic and predictive factor in colorectal cancer patients by Cabrero, S, Bystrup, S, Ruiz de Porras, V, Musulén, E, Subirats, JL, Queralt, C, Manzano, JL, Martinez-Balibrea, E

“…IntroductionCdk5 has been related to cancer progression and metastasis and to response to DNA damage in cancer. In colorectal cancer (CRC), our previous…”
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Methylation patterns and K-ras mutations in tumor and paired serum of resected non-small-cell lung cancer patients by Ramirez, Jose Luis, Sarries, Carme, de Castro, Pedro Lopez, Roig, Barbara, Queralt, Cristina, Escuin, Daniel, de Aguirre, Itziar, Sanchez, Jose Miguel, Manzano, Jose Luis, Margelı́, Mireia, Sanchez, Jose Javier, Astudillo, Julio, Taron, Miquel, Rosell, Rafael

“…Gene methylation and K-ras mutations were examined in tumor and paired serum DNA of 50 resected non-small-cell lung cancer patients. RASSF1A, death associated…”
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New organotropic compounds: Synthesis, characterization and reactivity of Pt(II) and Au(III) complexes with bile acids: DNA interactions and ‘in vitro’ anticancer activity by Criado, Julio J., Manzano, Juan L., Rodrı́guez-Fernández, E.

“…Based on the ability of bile acids to vectorialize the cytostatic activity of other agents, we have designed and synthesized a new series of platinum and gold…”
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Weekly regimen of irinotecan/docetaxel in previously treated non-small cell lung cancer patients and correlation with uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) polymorphism by FONT, Albert, SANCHEZ, José Miguel, ROSELL, Rafael, TARON, Miquel, MARTINEZ-BALIBREA, Eva, SANCHEZ, José Javier, MANZANO, José Luis, MARGELI, Mireia, RICHARDET, Martin, BARNADAS, Agusti, ABAD, Albert

“…Inherited variations in drug metabolizing enzymes may influence drug efficacy. This phase II study assesses the impact of second-line weekly irinotecan…”
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Prognostic value of K-ras mutations and allelic imbalance on chromosome 18q in patients with resected colorectal cancer by Font, A, Abad, A, Monzó, M, Sanchez, J J, Guillot, M, Manzano, J L, Piñol, M, Ojanguren, I, Rosell, R

“…We designed this study to assess the frequency of K-ras mutations in patients with resected colorectal tumors and their association with survival. A second…”
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Intrinsically Fluorescent Cytotoxic Cisplatin Analogues as DNA Marker Molecules by Criado, Julio J, Fernández, Emilio R, Manzano, Juan L, Alonso, Angel, Barrena, Susana, Medarde, Manuel, Pelaez, Rafael, Tabernero, M. Dolores, Orfao, Alberto

“…Two square planar derivatives of Pt(en)Cl2 with intrinsic fluorescence in aqueous solution at room temperature, with quantum yields (Φ) 0.11 and 0.10,…”
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A phase II study of cisplatin, etoposide and gemcitabine in an unfavourable group of patients with carcinoma of unknown primary site by Balaña, C., Manzano, J.-L., Moreno, I., Cirauqui, B., Abad, A., Font, A., Mate, J.-L., Rosell, R.

“…Background: The aim of this phase II study was to determine toxicity, response rate, time to progression, and overall survival of cisplatin, etoposide and…”
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Osteopenia assessed by body composition analysis is related to malnutrition in alcoholic patients by Santolaria, Francisco, González-Reimers, Emilio, Pérez-Manzano, José Luis, Milena, Antonio, Gómez-Rodrı́guez, Marı́a Angeles, González-Dı́az, Antonia, de la Vega, Marı́a José, Martı́nez-Riera, Antonio

“…Osteopenia is frequent among alcoholics. Its pathogenesis seems to be multifactorial, including ethanol intake, hormonal changes, liver cirrhosis, and…”
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Bedside sonographic-guided versus blind nasoenteric feeding tube placement in critically ill patients by Hernandez-Socorro, Carmen Rosa, Marin, Jose, Ruiz-Santana, Sergio, Santana, Luciano, Manzano, Jose Luis

“…OBJECTIVETo compare a blind manual bedside method for placing feeding tubes into the small bowel vs. a sonographic bedside technique in critically ill…”
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The role of chemotherapy in early non-small-cell lung cancer management by Rosell, Rafael, Felip, Enriqueta, Maestre, Jose, Sanchez, Jose Miguel, Sanchez, Jose Javier, Manzano, Jose Luis, Astudillo, Julio, Taron, Miquel, Monzo, Mariano

“…Great advances have been made in chemotherapy in advanced and metastatic non-small-cell lung cancer (NSCLC), and a major milestone was reached with the…”
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Nutritional assessment in alcoholic patients. Its relationship with alcoholic intake, feeding habits, organic complications and social problems by Santolaria, Francisco, Pérez-Manzano, José Luis, Milena, Antonio, González-Reimers, Emilio, Gómez-Rodrı́guez, Marı́a Angeles, Martı́nez-Riera, Antonio, Alemán-Valls, Marı́a Remedios, de la Vega-Prieto, Marı́a José

“…To establish their ability to predict malnutrition, irregular feeding, alcoholic intake, derangement of social and familial links and organic complications…”
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Determinants of response and resistance to cytotoxics by Rosell, Rafael, Monzó, Mariano, Alberola, Vicente, Taron, Miquel, Barnadas, Agustin, Sánchez, Jose Miguel, Manzano, Jose Luis, Sanchez, José Javier

“…There is an underlying feeling in the oncology community that chemotherapy has reached a therapeutic “glass ceiling” in non–small cell lung cancer, and that we…”
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Phase I study of weekly CPT-11 (irinotecan)/docetaxel in patients with advanced solid tumors by Font, A, Sanchez, J.M, Rosell, R, Taron, M, Martinez, E, Guillot, M, Manzano, J.L, Margeli, M, Barnadas, A, Abad, A

“…Based on the synergistic cytotoxicity demonstrated in vitro by topoisomerase I inhibitors followed by docetaxel and the feasibility of giving both drugs on a…”
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Phase II non-randomized study of three different sequences of docetaxel and vinorelbine in patients with advanced non-small cell lung cancer by Sánchez, José Miguel, Balañá, Carme, Font, Albert, Sánchez, José Javier, Manzano, José Luis, Guillot, Mónica, Margelı́, Mireia, Richardet, Martin, Rosell, Rafael

“…Docetaxel and vinorelbine as single agents and in combination with cisplatin have shown significant activity in advanced non-small cell lung cancer (NSCLC)…”
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Phase I study of the combination of oxaliplatin, irinotecan and continuous infusion 5-fluorouracil in digestive tumors by Abad, Albert, Massutí, Bartomeu, Gallego, Javier, Yuste, Ana L, Manzano, José Luis, Carrato, Alfredo, Antón, Antonio, Marfa, Xavier, Diaz-Rubio, Eduardo

“…Oxaliplatin (L-OHP), irinotecan (CPT-11) and 5-fluorouracil (5-FU) have shown their efficacy in metastatic colorectal cancer. The synergism of these drugs has…”
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Structural characterization and cytostatic activity of chlorobischolylglycinatogold(III) by Carrasco, Joaquı́n, Criado, Julio J., Macı́as, Rocı́o I.R., Manzano, Juan L., Marı́n, José J.G., Medarde, Manuel, Rodrı́guez, Emilio

“…Based on the ability of bile acids for vectorializing the cytostatic activity of other agents, we have designed and synthesized a new bile acid cholylglycinato…”
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Prevention of Dexamethasone-Induced Lymphocytic Apoptosis in the Intestine and in Peyer Patches by Enteral Nutrition by Ruiz-Santana, Sergio, López, Antonio, Torres, Santiago, Rey, Agustin, Losada, Antonio, Latasa, Leonor, Manzano, José L., Díaz-Chico, Bonifacio N.

“…Background: Apoptosis is a programmed cell death, genetically controlled, that can be activated by physiological and pathophysiological events and by the…”
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Stress-induced gastroduodenal lesions and total parenteral nutrition in critically ill patients: frequency, complications, and the value of prophylactic treatment. A prospective, randomized study by Ruiz-Santana, S, Ortiz, E, Gonzalez, B, Bolaños, J, Ruiz-Santana, A J, Manzano, J L

“…To assess the frequency, complications, and value of prophylactic treatment of stress-induced gastroduodenal lesions. Patients were prospectively randomized to…”
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