Search Results - "Manz, Rudolf Armin"

Targeting B Cells and Plasma Cells in Autoimmune Diseases by Hofmann, Katharina, Clauder, Ann-Katrin, Manz, Rudolf Armin

“…Success with B cell depletion using rituximab has proven the concept that B lineage cells represent a valid target for the treatment of autoimmune diseases,…”
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IL-10 revisited in systemic lupus erythematosus by Biswas, Swayanka, Bieber, Katja, Manz, Rudolf Armin

“…IL-10 is a cytokine with pleiotropic functions, particularly known for its suppressive effects on various immune cells. Consequently, it can limit the…”
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Bone Marrow Plasma Cells Modulate Local Myeloid-Lineage Differentiation via IL-10 by Meng, Lingzhang, Almeida, Larissa Nogueira, Clauder, Ann-Katrin, Lindemann, Timo, Luther, Julia, Link, Christopher, Hofmann, Katharina, Kulkarni, Upasana, Wong, David Ming, David, Jean-Pierre, Manz, Rudolf Armin

“…Bone marrow plasma cells have been reported to represent a major source of IL-10; however, the impact of plasma cell derived IL-10 in that tissue remains…”
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IL-10 mediates plasmacytosis-associated immunodeficiency by inhibiting complement-mediated neutrophil migration by Kulkarni, Upasana, PhD, Karsten, Christian M., PhD, Kohler, Thomas, PhD, Hammerschmidt, Sven, PhD, Bommert, Kurt, PhD, Tiburzy, Benjamin, MS, Meng, Lingzhang, MS, Thieme, Lara, MS, Recke, Andreas, MD, Ludwig, Ralf J., MD, Pollok, Karolin, MS, Kalies, Kathrin, PhD, Bogen, Bjarne, MD, PhD, Boettcher, Martin, PhD, Kamradt, Thomas, MD, Hauser, Anja E., PhD, Langer, Christian, MD, Huber-Lang, Markus, MD, Finkelman, Fred D., MD, Köhl, Jörg, MD, Wong, David M., PhD, Manz, Rudolf Armin, PhD

“…Background Plasmacytosis (ie, an expansion of plasma cell populations to much greater than the homeostatic level) occurs in the context of various immune…”
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Plasma cells in immunopathology: concepts and therapeutic strategies by Tiburzy, Benjamin, Kulkarni, Upasana, Hauser, Anja Erika, Abram, Melanie, Manz, Rudolf Armin

“…Plasma cells are terminally differentiated B cells that secrete antibodies, important for immune protection, but also contribute to any allergic and autoimmune…”
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Eosinophils and megakaryocytes support the early growth of murine MOPC315 myeloma cells in their bone marrow niches by Wong, David, Winter, Oliver, Hartig, Christina, Siebels, Svenja, Szyska, Martin, Tiburzy, Benjamin, Meng, Lingzhang, Kulkarni, Upasana, Fähnrich, Anke, Bommert, Kurt, Bargou, Ralf, Berek, Claudia, Chu, Van Trung, Bogen, Bjarne, Jundt, Franziska, Manz, Rudolf Armin

“…Multiple myeloma is a bone marrow plasma cell tumor which is supported by the external growth factors APRIL and IL-6, among others. Recently, we identified…”
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Persistent autoantibody-production by intermediates between short-and long-lived plasma cells in inflamed lymph nodes of experimental epidermolysis bullosa acquisita by Tiburzy, Benjamin, Szyska, Martin, Iwata, Hiroaki, Chrobok, Navina, Kulkarni, Upasana, Hirose, Misa, Ludwig, Ralf J, Kalies, Kathrin, Westermann, Jürgen, Wong, David, Manz, Rudolf Armin

“…Autoantibodies are believed to be maintained by either the continuous generation of short-lived plasma cells in secondary lymphoid tissues or by long-lived…”
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MHC haplotype and B cell autoimmunity: Correlation with pathogenic IgG autoantibody subclasses and Fc glycosylation patterns by Nogueira Almeida, Larissa, Clauder, Ann‐Katrin, Meng, Lingzhang, Ehlers, Marc, Arce, Sergio, Manz, Rudolf Armin

“…Genome‐wide association studies (GWAS) have identified many genes that are associated with the development of certain autoimmune disorders, but the MHC…”
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IgG Fc N-Glycosylation Translates MHCII Haplotype into Autoimmune Skin Disease by Clauder, Ann-Katrin, Kordowski, Anna, Bartsch, Yannic C., Köhl, Gabriele, Lilienthal, Gina-Maria, Almeida, Larissa N., Lindemann, Timo, Petry, Janina, Rau, Christina N., Gramalla-Schmitz, Anna, Dühring, Lara, Elbracht, Claudia, Kenno, Samyr, Tillmann, Jenny, Wuhrer, Manfred, Ludwig, Ralf J., Ibrahim, Saleh M., Bieber, Katja, Köhl, Jörg, Ehlers, Marc, Manz, Rudolf Armin

“…The major histocompatibility complex haplotype represents the most prevalent genetic risk factor for the development of autoimmune diseases. However, the…”
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