Search Results - "Manvell, Michelle"
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Repeated nebulisation of non-viral CFTR gene therapy in patients with cystic fibrosis: a randomised, double-blind, placebo-controlled, phase 2b trial
Published in The lancet respiratory medicine (01-09-2015)“…Summary Background Lung delivery of plasmid DNA encoding the CFTR gene complexed with a cationic liposome is a potential treatment option for patients with…”
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A randomised, double-blind, placebo-controlled trial of repeated nebulisation of non-viral cystic fibrosis transmembrane conductance regulator (CFTR) gene therapy in patients with cystic fibrosis
Published in Efficacy and mechanism evaluation (01-07-2016)“…Background Cystic fibrosis (CF) is a chronic, life-limiting disease caused by mutations in the CF transmembrane conductance regulator ( CFTR ) gene leading to…”
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Limitations of the murine nose in the development of nonviral airway gene transfer
Published in American journal of respiratory cell and molecular biology (01-07-2010)“…A clinical program to assess whether lipid GL67A-mediated gene transfer can ameliorate cystic fibrosis (CF) lung disease is currently being undertaken by the…”
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An immunocytochemical assay to detect human CFTR expression following gene transfer
Published in Molecular and cellular probes (01-12-2009)“…To assess gene therapy treatment for cystic fibrosis (CF) in clinical trials it is essential to develop robust assays that can accurately detect transgene…”
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