Search Results - "Manuszak, Claire"

Immune modulating activity of the CHK1 inhibitor prexasertib and anti-PD-L1 antibody LY3300054 in patients with high-grade serous ovarian cancer and other solid tumors by Do, Khanh T., Manuszak, Claire, Thrash, Emily, Giobbie-Hurder, Anita, Hu, Jiani, Kelland, Sarah, Powers, Allison, de Jonge, Adrienne, Shapiro, Geoffrey I., Severgnini, Mariano

“…Background Checkpoint kinase 1 (CHK1) has dual roles in both the DNA damage response and in the innate immune response to genotoxic stress. The combination of…”
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A Randomized Phase 2 Study of Pembrolizumab With or Without Radiation in Patients With Recurrent or Metastatic Adenoid Cystic Carcinoma by Mahmood, Umair, Bang, Andrew, Chen, Yu-Hui, Mak, Raymond H., Lorch, Jochen H., Hanna, Glenn J., Nishino, Mizuki, Manuszak, Claire, Thrash, Emily M., Severgnini, Mariano, Sanborn, Matthew, Sridharan, Vishwajith, Margalit, Danielle N., Tishler, Roy B., Busse, Paul M., Willers, Henning, Mamon, Harvey J., Yoo, Hyung-Jin, Pai, Sara I., Wirth, Lori J., Haddad, Robert I., Chau, Nicole G., Schoenfeld, Jonathan D.

“…We evaluated the safety and efficacy of pembrolizumab (pembro) ± radiation therapy (RT) in a phase 2 study among patients with progressive, metastatic adenoid…”
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A Randomized Trial of Combined PD-L1 and CTLA-4 Inhibition with Targeted Low-Dose or Hypofractionated Radiation for Patients with Metastatic Colorectal Cancer by Monjazeb, Arta M, Giobbie-Hurder, Anita, Lako, Ana, Thrash, Emily M, Brennick, Ryan C, Kao, Katrina Z, Manuszak, Claire, Gentzler, Ryan D, Tesfaye, Anteneh, Jabbour, Salma K, Alese, Olatunji B, Rahma, Osama E, Cleary, James M, Sharon, Elad, Mamon, Harvey J, Cho, May, Streicher, Howard, Chen, Helen X, Ahmed, Mansoor M, Mariño-Enríquez, Adrian, Kim-Schulze, Seunghee, Gnjatic, Sacha, Maverakis, Emanual, Marusina, Alina I, Merleev, Alexander A, Severgnini, Mariano, Pfaff, Kathleen L, Lindsay, James, Weirather, Jason L, Ranasinghe, Srinika, Spektor, Alexander, Rodig, Scott J, Hodi, Stephen F, Schoenfeld, Jonathan D

“…Prospective human data are lacking regarding safety, efficacy, and immunologic impacts of different radiation doses administered with combined PD-L1/CTLA-4…”
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Correction: A Randomized Trial of Combined PD-L1 and CTLA-4 Inhibition with Targeted Low-dose or Hypofractionated Radiation for Patients with Metastatic Colorectal Cancer by Monjazeb, Arta M, Giobbie-Hurder, Anita, Lako, Ana, Thrash, Emily M, Brennick, Ryan C, Kao, Katrina Z, Manuszak, Claire, Gentzler, Ryan D, Tesfaye, Anteneh, Jabbour, Salma K, Alese, Olatunji B, Rahma, Osama E, Cleary, James M, Sharon, Elad, Mamon, Harvey J, Cho, May, Streicher, Howard, Chen, Helen X, Ahmed, Mansoor M, Mariño-Enríquez, Adrian, Kim-Schulze, Seunghee, Gnjatic, Sacha, Maverakis, Emanual, Marusina, Alina I, Merleev, Alexander A, Severgnini, Mariano, Pfaff, Kathleen L, Lindsay, James, Weirather, Jason L, Ranasinghe, Srinika, Spektor, Alexander, Rodig, Scott J, Hodi, F Stephen, Schoenfeld, Jonathan D

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Standardized 11-color flow cytometry panel for the functional phenotyping of human T regulatory cells by Manuszak, Claire, Brainard, Martha, Thrash, Emily, Hodi, F Stephen, Severgnini, Mariano

“…T regulatory cells (Tregs) are a cell subset that can suppress immune responses to maintain homeostasis and self-tolerance. In some scenarios, the…”
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Clinical and Immunologic Activity of Ipilimumab Following Decitabine Priming in Post-Allogeneic Transplant and Transplant-Naïve Patients with Relapsed or Refractory Myelodysplastic Syndromes and Acute Myeloid Leukemia: A Multi-Center Phase 1, Two-Arm, Dose-Escalation Study by Garcia, Jacqueline S, Werner, Lillian, Tomlinson, Benjamin K., Keng, Michael, Nahas, Myrna, Brunner, Andrew, Khaled, Samer K., Savell, Alexandra, Luskin, Marlise, Steensma, David P., Wadleigh, Martha, Winer, Eric S., Alyea, Edwin P., Cutler, Corey, Ho, Vincent T., Neuberg, Donna S, Cullen, Nicole, Kantartzis, Andreas, Lako, Ana, Rodig, Scott, Lindsley, R. Coleman, Flamand, Yael, Manuszak, Claire, Brennick, Ryan, Severgnini, Mariano, Andrews, Stephanie, Galinsky, Ilene, Bachireddy, Pavan, Arihara, Yohei, Ritz, Jerome, Davids, Matthew S., Streicher, Howard, Wu, Catherine J., Stone, Richard M., DeAngelo, Daniel J., Soiffer, Robert J.

“…Background: Patients (pts) with MDS or AML who relapse after allogeneic transplantation (allo-HCT) have a very poor prognosis. Hypomethylating agents (HMA) and…”
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Abstract 6397: Immune profiling for improving responsiveness to ipilimumab plus nivolumab checkpoint blockade treatment in patients with metastatic melanoma by Baginska, Joanna, Chen, Jiajia, Tarantino, Giuseppe, Giobbie-Hurder, Anita, Weirather, Jason L., Severgnini, Mariano, Manos, Michael, Burke, Kelly, Russell, Janice D., Brainard, Martha, Gabriel, Elizabeth, Brennick, Ryan, Nazzaro, Matthew, Hathaway, Emma, Holovatska, Marta, Manuszak, Claire, Ranashinge, Srinika, Liu, David, Hodi, F. Stephen

“…Abstract Background:aCTLA-4 and aPD-1 combination therapy has significantly improved clinical outcomes in patients with metastatic melanoma, with 50%-60% of…”
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