Search Results - "Manukyan, Mariuxi C."

SDF-1/CXCR4 mediates acute protection of cardiac function through myocardial STAT3 signaling following global ischemia/reperfusion injury by Huang, Chunyan, Gu, Hongmei, Zhang, Wenjun, Manukyan, Mariuxi C, Shou, Weinian, Wang, Meijing

“…Stromal cell-derived factor-1α (SDF-1) has been reported to mediate cardioprotection through the mobilization of stem cells into injured tissue and an increase…”
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Sca-1+ cardiac stem cells mediate acute cardioprotection via paracrine factor SDF-1 following myocardial ischemia/reperfusion by Huang, Chunyan, Gu, Hongmei, Yu, Qing, Manukyan, Mariuxi C, Poynter, Jeffrey A, Wang, Meijing

“…Cardiac stem cells (CSCs) promote myocardial recovery following ischemia through their regenerative properties. However, little is known regarding the…”
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Signaling via GPR30 protects the myocardium from ischemia/reperfusion injury by Weil, Brent R., MD, Manukyan, Mariuxi C., MD, Herrmann, Jeremy L., MD, Wang, Yue, PhD, Abarbanell, Aaron M., MD, Poynter, Jeffrey A., MD, Meldrum, Daniel R., MD

“…Background Estrogen may protect against the development of cardiovascular disease. Recently, a receptor known as GPR30 that seems to mediate estrogen's…”
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Advances in Mesenchymal Stem Cell Research in Sepsis by Wannemuehler, Todd J., M.S, Manukyan, Mariuxi C., M.D, Brewster, Benjamin D., M.D, Rouch, Joshua, M.S, Poynter, Jeffrey A., M.D, Wang, Yue, Ph.D, Meldrum, Daniel R., M.D

“…Background Sepsis remains a source of morbidity and mortality in the postoperative patient despite appropriate resuscitative and antimicrobial approaches…”
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Mesenchymal stem cells attenuate myocardial functional depression and reduce systemic and myocardial inflammation during endotoxemia by Weil, Brent R., MD, Manukyan, Mariuxi C., MD, Herrmann, Jeremy L., MD, Wang, Yue, PhD, Abarbanell, Aaron M., MD, Poynter, Jeffrey A., MD, Meldrum, Daniel R., MD

“…Background Endotoxemia is associated with depressed cardiac function during sepsis. Mesenchymal stem cells (MSCs) possess an ability to modulate the…”
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Interleukin-10 protects the ischemic heart from reperfusion injury via the STAT3 pathway by Manukyan, Mariuxi C., MD, Alvernaz, Collin H, Poynter, Jeffrey A., MD, Wang, Yue, PhD, Brewster, Benjamin D., MD, Weil, Brent R., MD, Abarbanell, Aaron M., MD, Herrmann, Jeremy L., MD, Crowe, Brandon J, Keck, Andrew C, Meldrum, Daniel R., MD

“…Background Cardiac surgery induces the release of inflammatory mediators that can prolong cardiac dysfunction after operative intervention. Interleukin-10…”
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TLR4 inhibits mesenchymal stem cell (MSC) STAT3 activation and thereby exerts deleterious effects on MSC-mediated cardioprotection by Wang, Yue, Abarbanell, Aaron M, Herrmann, Jeremy L, Weil, Brent R, Manukyan, Mariuxi C, Poynter, Jeffrey A, Meldrum, Daniel R

“…Bone marrow-derived mesenchymal stem cells (MSC) improve myocardial recovery after ischemia/reperfusion (I/R) injury. These effects are mediated in part by the…”
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Pretreating mesenchymal stem cells with interleukin-1β and transforming growth factor-β synergistically increases vascular endothelial growth factor production and improves mesenchymal stem cell–mediated myocardial protection after acute ischemia by Luo, Yong, PhD, Wang, Yue, PhD, Poynter, Jeffrey A., MD, Manukyan, Mariuxi C., MD, Herrmann, Jeremy L., MD, Abarbanell, Aaron M., MD, Weil, Brent R., MD, Meldrum, Daniel R., MD

“…Background Mesenchymal stem cells (MSCs) improve postischemic myocardial function in part through their secretion of growth factors such as vascular…”
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Intracoronary Mesenchymal Stem Cells Promote Postischemic Myocardial Functional Recovery, Decrease Inflammation, and Reduce Apoptosis via a Signal Transducer and Activator of Transcription 3 Mechanism by Poynter, Jeffrey A., MD, Herrmann, Jeremy L., MD, Manukyan, Mariuxi C., MD, Wang, Yue, PhD, Abarbanell, Aaron M., MD, Weil, Brent R., MD, Brewster, Benjamin D., MD, Meldrum, Daniel R., MD, FACS

“…Background Signal transducer and activator of transcription 3 (STAT3) regulates myocardial apoptosis, cellular proliferation, and the immune response after…”
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The phosphoinositide-3 kinase survival signaling mechanism in sepsis by Manukyan, Mariuxi C, Weil, Brent R, Wang, Yue, Abarbanell, Aaron M, Herrmann, Jeremy L, Poynter, Jeffrey A, Meldrum, Daniel R

“…Phosphoinositide-3 kinases (PI3Ks) are critical regulatory proteins in the immunologic defense system against sepsis. The PI3K mechanism helps modulate…”
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Female stem cells are superior to males in preserving myocardial function following endotoxemia by Manukyan, Mariuxi C, Weil, Brent R, Wang, Yue, Abarbanell, Aaron M, Herrmann, Jeremy L, Poynter, Jeffrey A, Brewster, Benjamin D, Meldrum, Daniel R

“…Mesenchymal stem cells (MSCs) may offer therapeutic benefit in the setting of sepsis and endotoxemia. Previous studies suggest that MSCs from female donors may…”
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Systemic pretreatment with dimethyloxalylglycine increases myocardial HIF-1α and VEGF production and improves functional recovery after acute ischemia/reperfusion by Poynter, Jeffrey A., MD, Manukyan, Mariuxi C., MD, Wang, Yue, PhD, Brewster, Benjamin D., MD, Herrmann, Jeremy L., MD, Weil, Brent R., MD, Abarbanell, Aaron M., MD, Meldrum, Daniel R., MD

“…Background Stem cells protect the heart from ischemic damage in part by the release of cytoprotective growth factors, particularly vascular endothelial growth…”
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Transforming Growth Factor-α Enhances Stem Cell-Mediated Postischemic Myocardial Protection by Herrmann, Jeremy L., MD, Abarbanell, Aaron M., MD, Wang, Yue, PhD, Weil, Brent R., MD, Poynter, Jeffrey A., MD, Manukyan, Mariuxi C., MD, Meldrum, Daniel R., MD

“…Background Transforming growth factor-α (TGF-α) has been shown to augment mesenchymal stem cell-mediated cardioprotection during acute ischemia and reperfusion…”
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The Immunomodulatory Properties of Mesenchymal Stem Cells: Implications for Surgical Disease by Weil, Brent R., M.D, Manukyan, Mariuxi C., M.D, Herrmann, Jeremy L., M.D, Abarbanell, Aaron M., M.D, Poynter, Jeffrey A., M.D, Wang, Yue, Ph.D, Meldrum, Daniel R., M.D

“…Mesenchymal stem cells (MSCs) have been used experimentally and clinically in the treatment of a wide variety of pathologies. It is now clear that a number of…”
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Optimizing Stem Cell Function for the Treatment of Ischemic Heart Disease by Herrmann, Jeremy L., M.D, Abarbanell, Aaron M., M.D, Weil, Brent R., M.D, Manukyan, Mariuxi C., M.D, Poynter, Jeffrey A., M.D, Brewster, Benjamin J., M.D, Wang, Yue, Ph.D, Meldrum, Daniel R

“…Background Stem cell-based therapies for myocardial ischemia have demonstrated promising early clinical results, but their benefits have been limited in…”
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Hospital variation in mortality after emergent bowel resections: The role of failure-to-rescue by Mehta, Ambar, Efron, David T, Stevens, Kent, Manukyan, Mariuxi C, Joseph, Bellal, Sakran, Joseph V

“…Hospital variation in failure-to-rescue (FTR) rates has partially explained nationwide differences in mortality after elective surgeries. To examine the role…”
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Surgical Treatment of Atrial Fibrillation: The Time Is Now by Poynter, Jeffrey A., MD, Beckman, Daniel J., MD, Abarbanell, Aaron M., MD, Herrmann, Jeremy L., MD, Manukyan, Mariuxi C., MD, Weil, Brent R., MD, Bumb, Karen, MD, Meldrum, Daniel R., MD

“…Atrial fibrillation (AF) is the most common chronic arrhythmia in the United States and is associated with high morbidity rates and significant healthcare…”
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TGF-α Equalizes Age Disparities in Stem Cell-Mediated Cardioprotection by Herrmann, Jeremy L., M.D, Fiege, Jeremy W, Abarbanell, Aaron M., M.D, Weil, Brent R., M.D, Wang, Yue, Ph.D, Poynter, Jeffrey A., M.D, Manukyan, Mariuxi C., M.D, Brewster, Benjamin D., M.D, Meldrum, Daniel R., M.D

“…Background Neonatal mesenchymal stem cells exhibit less cardioprotective potential than their adult counterparts. Transforming growth factor-α (TGF-α) has been…”
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Pretreatment with intracoronary mimosine improves postischemic myocardial functional recovery by Crowe, Brandon, Poynter, Jeffrey A., MD, Manukyan, Mariuxi C., MD, Wang, Yue, PhD, Brewster, Benjamin D., MD, Herrmann, Jeremy L., MD, Abarbanell, Aaron M., MD, Weil, Brent R., MD, Meldrum, Daniel R., MD

“…Background Cytoprotective growth factors such as vascular endothelial growth factor (VEGF) play important roles in myocardial protection from…”
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Transforming growth factor-alpha does not protect myocardium during acute ischemia/reperfusion by Manukyan, Mariuxi C., MD, Keck, Andrew C, Poynter, Jeffrey A., MD, Wang, Yue, PhD, Weil, Brent R., MD, Abarbanell, Aaron M., MD, Herrmann, Jeremy L., MD, Crowe, Brandon J, Alvernaz, Collin, Meldrum, Daniel R., MD

“…Background The activation of the epidermal growth factor family of receptors may improve cardiac protection after injury. One epidermal growth factor family…”
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