Search Results - "Manuel Paredes"

Cancer epigenetics reaches mainstream oncology by Esteller, Manel, Rodríguez-Paredes, Manuel

“…Epigenetics is one of the most promising and expanding fields in the current biomedical research landscape. Since the inception of epigenetics in the 1940s,…”
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DNA Methylation in Epidermal Differentiation, Aging, and Cancer by Köhler, Florian, Rodríguez-Paredes, Manuel

“…The formation and maintenance of the epidermis depend on epidermal stem cell differentiation and must be tightly regulated. Epigenetic mechanisms such as DNA…”
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The importance of non-histone protein methylation in cancer therapy by Rodríguez-Paredes, Manuel, Lyko, Frank

“…Epigenetic regulatory enzymes are generally considered innovative targets for cancer therapy and several histone methyltransferase inhibitors are currently…”
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Single-cell transcriptomes of the human skin reveal age-related loss of fibroblast priming by Solé-Boldo, Llorenç, Raddatz, Günter, Schütz, Sabrina, Mallm, Jan-Philipp, Rippe, Karsten, Lonsdorf, Anke S., Rodríguez-Paredes, Manuel, Lyko, Frank

“…Fibroblasts are an essential cell population for human skin architecture and function. While fibroblast heterogeneity is well established, this phenomenon has…”
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Reduced DNA methylation patterning and transcriptional connectivity define human skin aging by Bormann, Felix, Rodríguez‐Paredes, Manuel, Hagemann, Sabine, Manchanda, Himanshu, Kristof, Boris, Gutekunst, Julian, Raddatz, Günter, Haas, Rainer, Terstegen, Lara, Wenck, Horst, Kaderali, Lars, Winnefeld, Marc, Lyko, Frank

“…Summary Epigenetic changes represent an attractive mechanism for understanding the phenotypic changes associated with human aging. Age‐related changes in DNA…”
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Functionally distinct cancer-associated fibroblast subpopulations establish a tumor promoting environment in squamous cell carcinoma by Schütz, Sabrina, Solé-Boldo, Llorenç, Lucena-Porcel, Carlota, Hoffmann, Jochen, Brobeil, Alexander, Lonsdorf, Anke S., Rodríguez-Paredes, Manuel, Lyko, Frank

“…Cutaneous squamous cell carcinoma (cSCC) is a serious public health problem due to its high incidence and metastatic potential. It may progress from actinic…”
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Differentiation‐related epigenomic changes define clinically distinct keratinocyte cancer subclasses by Solé‐Boldo, Llorenç, Raddatz, Günter, Gutekunst, Julian, Gilliam, Oliver, Bormann, Felix, Liberio, Michelle S, Hasche, Daniel, Antonopoulos, Wiebke, Mallm, Jan‐Philipp, Lonsdorf, Anke S, Rodríguez‐Paredes, Manuel, Lyko, Frank

“…Keratinocyte cancers (KC) are the most prevalent malignancies in fair‐skinned populations, posing a significant medical and economic burden to health systems…”
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Convergence analysis and mesh optimization of finite element analysis related to helical springs by Cadet, Guillaume, Paredes, Manuel

“…Helical springs are widely used in engineering applications. In order to reduce cost in “try and error” time consuming experimental campaigns, numerical…”
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Cell-of-Origin DNA Methylation Signatures Are Maintained during Colorectal Carcinogenesis by Bormann, Felix, Rodríguez-Paredes, Manuel, Lasitschka, Felix, Edelmann, Dominic, Musch, Tanja, Benner, Axel, Bergman, Yehudit, Dieter, Sebastian M., Ball, Claudia R., Glimm, Hanno, Linhart, Heinz G., Lyko, Frank

“…Colorectal adenomas are precursor lesions of colorectal cancers and represent clonal amplifications of single cells from colonic crypts. DNA methylation…”
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Analysis of population heterogeneity in CHO cells by genome-wide DNA methylation analysis and by multi-modal single-cell sequencing by Böhl, Elias, Raddatz, Günter, Roy, Suki, Huang, Lingzhi, Sandhu, Jasrene Kaur, Igwe, Emeka Ignatius, Rodríguez-Paredes, Manuel, Böhl, Florian, Lyko, Frank

“…CHO cells are major hosts for the industrial production of therapeutic proteins and their production stability is of considerable economic significance. It is…”
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Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin by Rodríguez-Paredes, Manuel, Bormann, Felix, Raddatz, Günter, Gutekunst, Julian, Lucena-Porcel, Carlota, Köhler, Florian, Wurzer, Elisabeth, Schmidt, Katrin, Gallinat, Stefan, Wenck, Horst, Röwert-Huber, Joachim, Denisova, Evgeniya, Feuerbach, Lars, Park, Jeongbin, Brors, Benedikt, Herpel, Esther, Nindl, Ingo, Hofmann, Thomas G., Winnefeld, Marc, Lyko, Frank

“…Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer and usually progresses from a UV-induced precancerous lesion termed actinic…”
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Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford progeria syndrome by Köhler, Florian, Bormann, Felix, Raddatz, Günter, Gutekunst, Julian, Corless, Samuel, Musch, Tanja, Lonsdorf, Anke S, Erhardt, Sylvia, Lyko, Frank, Rodríguez-Paredes, Manuel

“…Hutchinson-Gilford progeria syndrome (HGPS) is a progeroid disease characterized by the early onset of age-related phenotypes including arthritis, loss of body…”
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Epigenetically Regulated Chromosome 14q32 miRNA Cluster Induces Metastasis and Predicts Poor Prognosis in Lung Adenocarcinoma Patients by González-Vallinas, Margarita, Rodríguez-Paredes, Manuel, Albrecht, Marco, Sticht, Carsten, Stichel, Damian, Gutekunst, Julian, Pitea, Adriana, Sass, Steffen, Sánchez-Rivera, Francisco J, Lorenzo-Bermejo, Justo, Schmitt, Jennifer, De La Torre, Carolina, Warth, Arne, Theis, Fabian J, Müller, Nikola S, Gretz, Norbert, Muley, Thomas, Meister, Michael, Tschaharganeh, Darjus F, Schirmacher, Peter, Matthäus, Franziska, Breuhahn, Kai

“…Most lung cancer deaths are related to metastases, which indicates the necessity of detecting and inhibiting tumor cell dissemination. Here, we aimed to…”
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Aggressive PDACs Show Hypomethylation of Repetitive Elements and the Execution of an Intrinsic IFN Program Linked to a Ductal Cell of Origin by Espinet, Elisa, Gu, Zuguang, Imbusch, Charles D, Giese, Nathalia A, Büscher, Magdalena, Safavi, Mariam, Weisenburger, Silke, Klein, Corinna, Vogel, Vanessa, Falcone, Mattia, Insua-Rodríguez, Jacob, Reitberger, Manuel, Thiel, Vera, Kossi, Steffi O, Muckenhuber, Alexander, Sarai, Karnjit, Lee, Alex Y L, Backx, Elyne, Zarei, Soheila, Gaida, Matthias M, Rodríguez-Paredes, Manuel, Donato, Elisa, Yen, Hsi-Yu, Eils, Roland, Schlesner, Matthias, Pfarr, Nicole, Hackert, Thilo, Plass, Christoph, Brors, Benedikt, Steiger, Katja, Weichenhan, Dieter, Arda, H Efsun, Rooman, Ilse, Kopp, Janel L, Strobel, Oliver, Weichert, Wilko, Sprick, Martin R, Trumpp, Andreas

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive desmoplasia, which challenges the molecular analyses of bulk tumor samples. Here we…”
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S4917 My Gut Hurts: Thrombotic Microangiopathy or Pheochromocytoma? by Mardini, Ahmad, Singh, Suyashi, Shah, Krishna, Ahmad, Malik Waseem, Farooqi, Samee, Posen, Matthew, Flores, Manuel Paredes, Rahim, Faizan, Turbay-Caballero, Valentina, Raddawi, Harreth, Chaiban, Joumana

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Stapled helical o -OPE foldamers as new circularly polarized luminescence emitters based on carbophilic interactions with Ag(i)-sensitivity by Morcillo, Sara P, Miguel, Delia, Álvarez de Cienfuegos, Luis, Justicia, José, Abbate, Sergio, Castiglioni, Ettore, Bour, Christophe, Ribagorda, María, Cárdenas, Diego J, Paredes, José Manuel, Crovetto, Luis, Choquesillo-Lazarte, Duane, Mota, Antonio J, Carreño, M Carmen, Longhi, Giovanna, Cuerva, Juan M

“…-Oligo(phenylene)ethynylenes ( -OPEs) stapled with enantiopure 2,3-dihydroxybutane diethers have highly intense circular dichroism (CD) spectra and excellent…”
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First evidence of multiple paternity in the blue shark (Prionace glauca) by Armada‐Tapia, Sofía, Castillo‐Geniz, José Leonardo, Victoria‐Cota, Nelva, Arce‐Valdés, Luis Rodrigo, Enríquez‐Paredes, Luis Manuel

“…Multiple paternity (MP) is defined as the behaviour in which females successfully mate with multiple males leading to offspring from different sires within the…”
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Hatching, embryo death and chicks growth in dual purpose and brawl hens under natural hypobaric conditions by Paredes, Manuel, Quispe, Talía

“…The present study aimed to compare results for hatchability and growing performance of chicks from 2 biotypes, dual purpose (DP) and brawl (BR), in hipobaric…”
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PRODUCTIVE PERFORMANCE OF GENETICALLY DIFFERENT HEN CROSSBREEDS IN PERUVIAN ANDES by Paredes, Manuel, Raico, Fani

“…Three hundred laying hens of two commercial and one experimental crossbreed were evaluated in Peruvian Andes. The Commercial crossbreeds were Babcock Brown and…”
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Abdominal wall muscle weakness outcomes after split abdominal flap repair of large congenital diaphragmatic hernias in newborn by Molino, J. Andrés, Guillen, Gabriela, Khan, Haider Ali, López Fernández, Sergio, Martos Rodríguez, Marta, Rocha, Oscar, López Paredes, Manuel

“…Purpose Split abdominal wall muscle flap (SAWMF) is a technique to repair large defects in congenital diaphragmatic hernia (CDH). A possible objection to this…”
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