Search Results - "Manucha, Walter"

Vitamin D as a Modulator of Neuroinflammation: Implications for Brain Health by Menéndez, Sebastián García, Manucha, Walter

“…Neuroinflammation represents a critical immune response within the brain, playing a pivotal role in defense against injury and infection. However, when this…”
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Role of Mitochondrial Dysfunction in Hypertension and Obesity by Lahera, Vicente, de las Heras, Natalia, López-Farré, Antonio, Manucha, Walter, Ferder, León

“…Mitochondria are essential for the maintenance of normal physiological function of tissue cells. Mitochondria are subject to dynamic processes in order to…”
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Effect of Garlic’s Active Constituents in Inflammation, Obesity and Cardiovascular Disease by Quesada, Isabel, de Paola, Matilde, Torres-Palazzolo, Carolina, Camargo, Alejandra, Ferder, León, Manucha, Walter, Castro, Claudia

“…Purpose of Review Several studies have attributed garlic’s beneficial properties to its high content of organosulfur compounds (OSCs). Here, we summarized…”
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Melatonin: highlighting its use as a potential treatment for SARS-CoV-2 infection by Reiter, Russel J., Sharma, Ramaswamy, Simko, Fedor, Dominguez-Rodriguez, Alberto, Tesarik, Jan, Neel, Richard L., Slominski, Andrzej T., Kleszczynski, Konrad, Martin-Gimenez, Verna M., Manucha, Walter, Cardinali, Daniel P.

“…Numerous pharmaceutical drugs have been repurposed for use as treatments for COVID-19 disease. These drugs have not consistently demonstrated high efficacy in…”
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Bioaccessibility and permeability of bioactive compounds in raw and cooked garlic by Torres-Palazzolo, Carolina, Ramirez, Daniela, Locatelli, Daniela, Manucha, Walter, Castro, Claudia, Camargo, Alejandra

“…•Bioactive compounds of raw and cooked garlic could be absorbed at a moderate rate.•Raw garlic digestion showed a greater organosulfur compounds quantitative…”
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Gut Microbiota Dysbiosis in COVID-19: Modulation and Approaches for Prevention and Therapy by Martín Giménez, Virna Margarita, Modrego, Javier, Gómez-Garre, Dulcenombre, Manucha, Walter, de Las Heras, Natalia

“…Inflammation and oxidative stress are critical underlying mechanisms associated with COVID-19 that contribute to the complications and clinical deterioration…”
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Cellular and Mitochondrial Pathways Contribute to SGLT2 Inhibitors-mediated Tissue Protection: Experimental and Clinical Data by Sanz, Raúl Lelio, Menéndez, Sebastián García, Inserra, Felipe, Ferder, León, Manucha, Walter

“…In metabolic syndrome and diabetes, compromised mitochondrial function emerges as a critical driver of cardiovascular disease, fueling its development and…”
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Vitamin D deficiency in African Americans is associated with a high risk of severe disease and mortality by SARS-CoV-2 by Martín Giménez, Virna Margarita, Inserra, Felipe, Ferder, León, García, Joxel, Manucha, Walter

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Nanopharmacology as a new approach to treat neuroinflammatory disorders by Menéndez, Sebastián García, Manucha, Walter

“…Neuroinflammation, a complex process involving the activation of microglia, astrocytes, and other immune cells in the brain, plays a role in neurodegeneration…”
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Implications of Oxidative Stress and Potential Role of Mitochondrial Dysfunction in COVID-19: Therapeutic Effects of Vitamin D by de las Heras, Natalia, Martín Giménez, Virna Margarita, Ferder, León, Manucha, Walter, Lahera, Vicente

“…Due to its high degree of contagiousness and like almost no other virus, SARS-CoV-2 has put the health of the world population on alert. COVID-19 can provoke…”
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Melatonin and Pathological Cell Interactions: Mitochondrial Glucose Processing in Cancer Cells by Reiter, Russel J, Sharma, Ramaswamy, Rosales-Corral, Sergio, Manucha, Walter, Chuffa, Luiz Gustavo de Almeida, Zuccari, Debora Aparecida Pires de Campos

“…Melatonin is synthesized in the pineal gland at night. Since melatonin is produced in the mitochondria of all other cells in a non-circadian manner, the amount…”
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High-dose vitamin D versus placebo to prevent complications in COVID-19 patients: A structured summary of a study protocol for a randomised controlled trial (CARED-TRIAL) by Mariani, Javier, Tajer, Carlos, Antonietti, Laura, Inserra, Felipe, Ferder, León, Manucha, Walter

“…To evaluate whether a single high dose of oral cholecalciferol improves the respiratory outcomes as compared with placebo among adults COVID-19 patients at…”
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Melatonin as an Anti-Aging Therapy for Age-Related Cardiovascular and Neurodegenerative Diseases by Martín Giménez, Virna Margarita, de las Heras, Natalia, Lahera, Vicente, Tresguerres, Jesús A. F., Reiter, Russel J., Manucha, Walter

“…The concept of “aging” is defined as the set of gradual and progressive changes in an organism that leads to an increased risk of weakness, disease, and death…”
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Melatonin-Loaded Nanocarriers: New Horizons for Therapeutic Applications by Chuffa, Luiz Gustavo de Almeida, Seiva, Fábio Rodrigues Ferreira, Novais, Adriana Alonso, Simão, Vinícius Augusto, Martín Giménez, Virna Margarita, Manucha, Walter, Zuccari, Debora Aparecida Pires de Campos, Reiter, Russel J.

“…The use of nanosized particles has emerged to facilitate selective applications in medicine. Drug-delivery systems represent novel opportunities to provide…”
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Genomic or Non-Genomic? A Question about the Pleiotropic Roles of Vitamin D in Inflammatory-Based Diseases by Holick, Michael F, Mazzei, Luciana, García Menéndez, Sebastián, Martín Giménez, Virna Margarita, Al Anouti, Fatme, Manucha, Walter

“…Vitamin D (vit D) is widely known for its role in calcium metabolism and its importance for the bone system. However, various studies have revealed a myriad of…”
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Nanomedicine applied to cardiovascular diseases: latest developments by Martín Giménez, Virna Margarita, Kassuha, Diego E., Manucha, Walter

“…Cardiovascular diseases are a major cause of disability and they are currently responsible for a significant number of deaths in a large percentage of the…”
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Differences in RAAS/vitamin D linked to genetics and socioeconomic factors could explain the higher mortality rate in African Americans with COVID-19 by Martín Giménez, Virna Margarita, Ferder, León, Inserra, Felipe, García, Joxel, Manucha, Walter

“…COVID-19 is said to be a pandemic that does not distinguish between skin color or ethnic origin. However, data in many parts of the world, especially in the…”
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Aging-Related Ovarian Failure and Infertility: Melatonin to the Rescue by Reiter, Russel J, Sharma, Ramaswamy, Romero, Alejandro, Manucha, Walter, Tan, Dun-Xian, Zuccari, Debora Aparecida Pires de Campos, Chuffa, Luiz Gustavo de Almeida

“…Aging has a major detrimental effect on the optimal function of the ovary with changes in this organ preceding the age-related deterioration in other tissues,…”
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The protective role of vitamin D on the heart and the kidney by Manucha, Walter, Juncos, Luis I.

“…For a long time, vitamin D was regarded as an essential component for the maintenance of appropriate calcium metabolism. Indeed, the calcium-related functions…”
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Novel Possible Biomarkers for the Cardiovascular Disease Prognosis by Martín Giménez, Virna Margarita, Sanz, Raúl Lelio, Mazzei, Luciana Jorgelina, Bonafede, Roberto, Manucha, Walter

“…Background:Cardiovascular disease (CVD), especially heart failure (HF) as its common final pathway, is the leading cause of morbidity and mortality worldwide…”
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