Discriminative validity and interpretability of the mood and feelings questionnaire

Using the Mood and Feelings Questionnaire (MFQ) to differentiate between depression severity levels remains unexplored. We explored the discriminative validity of the MFQ to identify an optimal cut-off MFQ score to distinguish between subthreshold-to-mild and moderate-to-severe depression severity l...

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Bibliographic Details
Published in:	Journal of affective disorders Vol. 363; pp. 552 - 562
Main Authors:	Mansueto, Sara, Kumar, Rohina, Raitman, Michelle R., Jahagirdar, Anisha, Chen, Sheng, Wang, Wei, Krause, Karolin R., Monga, Suneeta, Szatmari, Peter, Courtney, Darren B.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 15-10-2024
Subjects:	Adolescents Depression Discriminative validity Interpretability Mood and feelings questionnaire Receiver Operating Characteristic curve Depression Discriminative validity Adolescents Interpretability Receiver Operating Characteristic curve Mood and feelings questionnaire
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Summary:	Using the Mood and Feelings Questionnaire (MFQ) to differentiate between depression severity levels remains unexplored. We explored the discriminative validity of the MFQ to identify an optimal cut-off MFQ score to distinguish between subthreshold-to-mild and moderate-to-severe depression severity levels. An observational cross-sectional design was used in a sample (N = 67) of help-seeking youth (ages 13 to 18, inclusive) experiencing depressive symptoms. The MFQ was administered verbatim to youth by a research analyst over the phone. Youth were then grouped into subthreshold-to-mild or moderate-to-severe depression severity categories based on scores received on the Kiddie Schedule for Affective Disorders and Schizophrenia-Depression Rating Scale. Receiver Operating Characteristic curve analyses were conducted, with area under the curve (AUC) and Youden Index (J) as primary indices. We hypothesized that the lower limit of the 95 % confidence interval for the area under the curve would be ≥0.70. The primary analysis yielded an AUC of 0.85 (95 % CI: 0.763–0.947) and an optimal cut-off of ≥43 (J = 0.60, positive predictive value = 91.4 %, negative predictive value = 62.5 %, sensitivity = 72.7 %, specificity = 87.0 %). Our study collected a small sample, and as such cannot identify how subgroup classification (e.g., based on race or gender) may moderate outcomes. Further, unknown measurement error of the predictor and reference variable measures can bias the estimates. Our preliminary findings highlight the potential for the MFQ to support clinical decision-making relevant to adolescents experiencing varying severities of depressive symptoms in secondary care settings. •The Mood and Feelings Questionnaire can assist in discriminating severity of depressive symptoms.•A score of ≥43 on the Mood and Feelings Questionnaire signals moderate-to-severe depression.•This cut-off score corresponds to a positive predictive value of 91.4 %.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3
ISSN:	0165-0327 1573-2517 1573-2517
DOI:	10.1016/j.jad.2024.07.085