Search Results - "Mansour, Sarah"

Synergy between conventional antibiotics and anti-biofilm peptides in a murine, sub-cutaneous abscess model caused by recalcitrant ESKAPE pathogens by Pletzer, Daniel, Mansour, Sarah C, Hancock, Robert E W

“…With the antibiotic development pipeline running dry, many fear that we might soon run out of treatment options. High-density infections are particularly…”
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Host defense peptides: front-line immunomodulators by Mansour, Sarah C, Pena, Olga M, Hancock, Robert E.W

“…Highlights • The most relevant biological role of host defense peptides is immunomodulation. • These immunomodulatory functions are therapeutic in several…”
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Antimicrobial Peptides: An Introduction by Haney, Evan F, Mansour, Sarah C, Hancock, Robert E W

“…The "golden era" of antibiotic discovery has long passed, but the need for new antibiotics has never been greater due to the emerging threat of antibiotic…”
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High throughput screening methods for assessing antibiofilm and immunomodulatory activities of synthetic peptides by Haney, Evan F., Mansour, Sarah C., Hilchie, Ashley L., de la Fuente-Núñez, César, Hancock, Robert E.W.

“…•Method to optimize both the antibiofilm and immunomodulatory activities of peptides.•Successfully generated a new peptide, IDR-2009, with an enhanced activity…”
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New Mouse Model for Chronic Infections by Gram-Negative Bacteria Enabling the Study of Anti-Infective Efficacy and Host-Microbe Interactions by Pletzer, Daniel, Mansour, Sarah C, Wuerth, Kelli, Rahanjam, Negin, Hancock, Robert E W

“…Only a few, relatively cumbersome animal models enable long-term Gram-negative bacterial infections that mimic human situations, where untreated infections can…”
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The multifaceted virulence of adherent-invasive Escherichia coli by Mansour, Sarah, Asrar, Tahreem, Elhenawy, Wael

“…The surge in inflammatory bowel diseases, like Crohn's disease (CD), is alarming. While the role of the gut microbiome in CD development is unresolved, the…”
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Material’s Perception Strategy in Terms of Adaptive Re-use Within the Computational, and Parametricism Context by Mansour, Sarah

“…Creativity has been assigned to the design or drawing, with materials most often being specified as a result of design rather than being considered a driver of…”
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New Perspectives in Biofilm Eradication by Wolfmeier, Heidi, Pletzer, Daniel, Mansour, Sarah C, Hancock, Robert E. W

“…Microbial biofilms, which are elaborate and highly resistant microbial aggregates formed on surfaces or medical devices, cause two-thirds of infections and…”
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Computer-aided Discovery of Peptides that Specifically Attack Bacterial Biofilms by Haney, Evan F., Brito-Sánchez, Yoan, Trimble, Michael J., Mansour, Sarah C., Cherkasov, Artem, Hancock, Robert E. W.

“…Biofilms represent a multicellular growth state of bacteria that are intrinsically resistant to conventional antibiotics. It was recently shown that a…”
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Targeted genomic sequencing of avian influenza viruses in wetland sediment from wild bird habitats by Kuchinski, Kevin S, Coombe, Michelle, Mansour, Sarah C, Cortez, Gabrielle Angelo P, Kalhor, Marzieh, Himsworth, Chelsea G, Prystajecky, Natalie A

“…Diverse influenza A viruses (IAVs) circulate in wild birds, including highly pathogenic strains that infect poultry and humans. Consequently, surveillance of…”
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Peptide IDR-1018: modulating the immune system and targeting bacterial biofilms to treat antibiotic-resistant bacterial infections by Mansour, Sarah C., de la Fuente-Núñez, César, Hancock, Robert E. W.

“…Host defense (antimicrobial) peptides, produced by all complex organisms, typically contain an abundance of positively charged and hydrophobic amino acid…”
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Synthesis and Evaluation of Ciprofloxacin-Nitroxide Conjugates as Anti-Biofilm Agents by Verderosa, Anthony D, Mansour, Sarah C, de la Fuente-Núñez, César, Hancock, Robert E W, Fairfull-Smith, Kathryn E

“…As bacterial biofilms are often refractory to conventional antimicrobials, the need for alternative and/or novel strategies for the treatment of biofilm…”
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Cell Competition Modifies Adult Stem Cell and Tissue Population Dynamics in a JAK-STAT-Dependent Manner by Kolahgar, Golnar, Suijkerbuijk, Saskia J.E., Kucinski, Iwo, Poirier, Enzo Z., Mansour, Sarah, Simons, Benjamin D., Piddini, Eugenia

“…Throughout their lifetime, cells may suffer insults that reduce their fitness and disrupt their function, and it is unclear how these potentially harmful cells…”
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Emergence of a Bilaterally Symmetric Pattern from Chiral Components in the Planarian Epidermis by Basquin, Cyril, Ershov, Dmitry, Gaudin, Noémie, Vu, Hanh Thi-Kim, Louis, Bruno, Papon, Jean-François, Orfila, Anne-Marie, Mansour, Sarah, Rink, Jochen Christian, Azimzadeh, Juliette

“…Most animals exhibit mirror-symmetric body plans, yet the molecular constituents from which they are formed are often chiral. In planarian flatworms,…”
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Ciprofloxacin-nitroxide hybrids with potential for biofilm control by Verderosa, Anthony D., de la Fuente-Núñez, César, Mansour, Sarah C., Cao, Jicong, Lu, Timothy K., Hancock, Robert E.W., Fairfull-Smith, Kathryn E.

“…As bacterial biofilms display extreme tolerance to conventional antibiotic treatments, it has become imperative to develop new antibacterial strategies with…”
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Phenotypic, Metabolic, and Functional Characterization of Experimental Models of Foamy Macrophages: Toward Therapeutic Research in Atherosclerosis by Henni Mansour, Amina Sarah, Ragues, Mathilde, Brevier, Julien, Borowczyk, Coraline, Grevelinger, Janaïna, Laroche-Traineau, Jeanny, Garaude, Johan, Marais, Sébastien, Jacobin-Valat, Marie-Josée, Gerbaud, Edouard, Clofent-Sanchez, Gisèle, Ottones, Florence

“…Different types of macrophages (Mφ) are involved in atherogenesis, including inflammatory Mφ and foamy Mφ (FM). Our previous study demonstrated that two-photon…”
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How can tax compliance be incentivized? An experimental examination of voice and empathy by AbdelNabi, Mariam, Wanas, Khedr, Mansour, Sarah

“…Purpose Tax evasion is an economic crime that nearly all world countries suffer from. Its consequences are countless, including poor public spending on…”
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The Nature of the Supramolecular Association of 1,2,5-Chalcogenadiazoles by Cozzolino, Anthony F, Vargas-Baca, Ignacio, Mansour, Sarah, Mahmoudkhani, Amir H

“…Organochalcogen−nitrogen heterocycles such as the 1,2,5-chalcogenadiazoles have a distinct tendency to establish intermolecular links in the solid state…”
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Ceftobiprole for Treatment of MRSA Blood Stream Infection: A Case Series by Mahmoud, Ebrahim, Mansour, Sarah Al, Bosaeed, Mohammad, Alharbi, Ahmad, Alsaedy, Abdulrahman, Aljohani, Sameera, Alalwan, Bassam, Alothman, Adel

“…While methicillin-resistant Staphylococcus aureus (MRSA) bacteremia has poor outcomes, we describe our experience with Ceftobiprole mainly as a combination…”
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Bacterial Abscess Formation Is Controlled by the Stringent Stress Response and Can Be Targeted Therapeutically by Mansour, Sarah C., Pletzer, Daniel, de la Fuente-Núñez, César, Kim, Paul, Cheung, Gordon Y.C., Joo, Hwang-Soo, Otto, Michael, Hancock, Robert E.W.

“…Cutaneous abscess infections are difficult to treat with current therapies and alternatives to conventional antibiotics are needed. Understanding the…”
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