Search Results - "Mansour, Anthony"

An Oncolytic Virus Expressing IL15/IL15Rα Combined with Off-the-Shelf EGFR-CAR NK Cells Targets Glioblastoma by Ma, Rui, Lu, Ting, Li, Zhenlong, Teng, Kun-Yu, Mansour, Anthony G, Yu, Melissa, Tian, Lei, Xu, Bo, Ma, Shoubao, Zhang, Jianying, Barr, Tasha, Peng, Yong, Caligiuri, Michael A, Yu, Jianhua

“…IL15 is a pleiotropic cytokine with multiple roles that improve immune responses to tumor cells. Oncolytic viruses (OV) specifically lyse tumors and activate…”
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Off-the-Shelf Prostate Stem Cell Antigen–Directed Chimeric Antigen Receptor Natural Killer Cell Therapy to Treat Pancreatic Cancer by Teng, Kun-Yu, Mansour, Anthony G., Zhu, Zheng, Li, Zhiyao, Tian, Lei, Ma, Shoubao, Xu, Bo, Lu, Ting, Chen, Hanyu, Hou, David, Zhang, Jianying, Priceman, Saul J., Caligiuri, Michael A., Yu, Jianhua

“…Pancreatic cancer (PC) is the third leading cause of cancer-related death with a 5-year survival rate of approximately 10%. It typically presents as a…”
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PDGF-D-PDGFRβ signaling enhances IL-15-mediated human natural killer cell survival by Ma, Shoubao, Tang, Tingting, Wu, Xiaojin, Mansour, Anthony G, Lu, Ting, Zhang, Jianying, Wang, Li-Shu, Caligiuri, Michael A, Yu, Jianhua

“…The axis of platelet-derived growth factor (PDGF) and PDGF receptor-beta (PDGFRβ) plays prominent roles in cell growth and motility. In addition, PDGF-D…”
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CD56 Expression Marks Human Group 2 Innate Lymphoid Cell Divergence from a Shared NK Cell and Group 3 Innate Lymphoid Cell Developmental Pathway by Chen, Luxi, Youssef, Youssef, Robinson, Cameron, Ernst, Gabrielle F., Carson, Mary Y., Young, Karen A., Scoville, Steven D., Zhang, Xiaoli, Harris, Regine, Sekhri, Palak, Mansour, Anthony G., Chan, Wing K., Nalin, Ansel P., Mao, Hsiaoyin C., Hughes, Tiffany, Mace, Emily M., Pan, Yinghong, Rustagi, Navin, Chatterjee, Sujash S., Gunaratne, Preethi H., Behbehani, Gregory K., Mundy-Bosse, Bethany L., Caligiuri, Michael A., Freud, Aharon G.

“…According to the established model of murine innate lymphoid cell (ILC) development, helper ILCs develop separately from natural killer (NK) cells. However, it…”
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Off-the-shelf CAR natural killer cells secreting IL-15 target spike in treating COVID-19 by Lu, Ting, Ma, Rui, Dong, Wenjuan, Teng, Kun-Yu, Kollath, Daniel S., Li, Zhiyao, Yi, Jinhee, Bustillos, Christian, Ma, Shoubao, Tian, Lei, Mansour, Anthony G., Li, Zhenlong, Settles, Erik W., Zhang, Jianying, Keim, Paul S., Barker, Bridget M., Caligiuri, Michael A., Yu, Jianhua

“…Engineered natural killer (NK) cells represent a promising option for immune therapy option due to their immediate availability in allogeneic settings. Severe…”
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Cbl-b Is Upregulated and Plays a Negative Role in Activated Human NK Cells by Lu, Ting, Chen, Li, Mansour, Anthony G, Yu, Melissa J, Brooks, Noah, Teng, Kun-Yu, Li, Zhenlong, Zhang, Jianying, Barr, Tasha, Yu, Jianhua, Caligiuri, Michael A

“…The E3 ubiquitin ligase Cbl-b has been characterized as an intracellular checkpoint in T cells; however, the function of Cbl-b in primary human NK cells, an…”
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Adipocytes: A Novel Target for IL-15/IL-15Rα Cancer Gene Therapy by Xiao, Run, Mansour, Anthony G., Huang, Wei, Chrislip, Logan A., Wilkins, Ryan K., Queen, Nicholas J., Youssef, Youssef, Mao, Hsiaoyin C., Caligiuri, Michael A., Cao, Lei

“…IL-15 is a proinflammatory cytokine that plays an essential role in the development and activation of natural killer (NK) cells. Adipose tissue acts as an…”
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CD84 is a regulator of the immunosuppressive microenvironment in multiple myeloma by Lewinsky, Hadas, Gunes, Emine G, David, Keren, Radomir, Lihi, Kramer, Matthias P, Pellegrino, Bianca, Perpinial, Michal, Chen, Jing, He, Ting-Fang, Mansour, Anthony G, Teng, Kun-Yu, Bhattacharya, Supriyo, Caserta, Enrico, Troadec, Estelle, Lee, Peter, Feng, Mingye, Keats, Jonathan, Krishnan, Amrita, Rosenzweig, Michael, Yu, Jianhua, Caligiuri, Michael A, Cohen, Yosef, Shevetz, Olga, Becker-Herman, Shirly, Pichiorri, Flavia, Rosen, Steven, Shachar, Idit

“…Multiple myeloma (MM) is characterized by an accumulation of malignant plasma cells (PCs) within the BM. The BM microenvironment supports survival of the…”
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Enriched environment regulates thymocyte development and alleviates experimental autoimmune encephalomyelitis in mice by Xiao, Run, Bergin, Stephen M., Huang, Wei, Mansour, Anthony G, Liu, Xianglan, Judd, Ryan T, Widstrom, Kyle J., Queen, Nicholas J., Wilkins, Ryan K., Siu, Jason J., Ali, Seemaab, Caligiuri, Michael A., Cao, Lei

“…•Environmental enrichment (EE) modulates thymocyte maturation and selection in mice.•Hypothalamic BDNF mediates the EE-induced thymic phenotypes.•Adrenalectomy…”
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Enriched environment enhances NK cell maturation through hypothalamic BDNF in male mice by Mansour, Anthony G., Xiao, Run, Bergin, Stephen M., Huang, Wei, Chrislip, Logan A., Zhang, Jianying, Ali, Seemaab, Queen, Nicholas J., Caligiuri, Michael A., Cao, Lei

“…Macroenvironmental factors, including a patient's physical and social environment, play a role in cancer risk and progression. Our previous preclinical studies…”
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Preclinical Evaluation of Off-The-Shelf PD-L1+ Human Natural Killer Cells Secreting IL15 to Treat Non-Small Cell Lung Cancer by Lu, Ting, Ma, Rui, Mansour, Anthony G, Bustillos, Christian, Li, Zhiyao, Li, Zhenlong, Ma, Shoubao, Teng, Kun-Yu, Chen, Hanyu, Zhang, Jianying, Villalona-Calero, Miguel A, Caligiuri, Michael A, Yu, Jianhua

“…We described previously a human natural killer (NK) cell population that upregulates PD-L1 expression upon recognizing and reacting to tumor cells or exposure…”
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Vitamin K2 supplementation and arterial stiffness among renal transplant recipients-a single-arm, single-center clinical trial by Mansour, Anthony G, Hariri, Essa, Daaboul, Yazan, Korjian, Serge, El Alam, Andrew, Protogerou, Athanase D, Kilany, Hala, Karam, Albert, Stephan, Antoine, Bahous, Sola Aoun

“…Subclinical vitamin K deficiency is prevalent among renal transplant recipients and is associated with an increased risk of cardiovascular disease. However,…”
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Adipocyte CD1d Gene Transfer Induces T Cell Expansion and Adipocyte Inflammation in CD1d Knockout Mice by Xiao, Run, Mansour, Anthony G, Huang, Wei, Hassan, 2nd, Quais N, Wilkins, Ryan K, Komatineni, Suraj V, Bates, Rhiannon, Ali, Seemaab, Chrislip, Logan A, Queen, Nicholas J, Ma, Shoubao, Yu, Jianhua, Lordo, Matthew R, Mundy-Bosse, Bethany L, Caligiuri, Michael A, Cao, Lei

“…CD1d, a lipid Ag-presenting molecule for invariant NKT (iNKT) cells, is abundantly expressed on adipocytes and regulates adipose homeostasis through iNKT…”
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Vitamin K2 Status and Arterial Stiffness Among Untreated Migraine Patients: A Case‐Control Study by Mansour, Anthony G., Ahdab, Rechdi, Daaboul, Yazan, Korjian, Serge, Morrison, Daniel Alexander, Hariri, Essa, Salem, Maher, El Khoury, Christelle, Riachi, Naji, Aoun Bahous, Sola

“…Objective We aimed to examine arterial stiffness and vitamin K2 status in migraine subjects by comparison to controls. Background Migraine is a primary…”
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Environmental activation of a hypothalamic BDNF-adipocyte IL-15 axis regulates adipose-natural killer cells by Bergin, Stephen M., Xiao, Run, Huang, Wei, Judd, C. Ryan T., Liu, Xianglan, Mansour, Anthony G., Queen, Nicholas, Widstrom, Kyle J., Caligiuri, Michael A., Cao, Lei

“…•Environmental enrichment stimulates expansion of natural killer (NK) cells in fat.•Hypothalamic BDNF is the upstream brain mediator underlying this…”
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Hijacking TYRO3 from Tumor Cells via Trogocytosis Enhances NK-cell Effector Functions and Proliferation by Lu, Ting, Ma, Rui, Li, Zhenlong, Mansour, Anthony G, Teng, Kun-Yu, Chen, Li, Zhang, Jianying, Barr, Tasha, Caligiuri, Michael A, Yu, Jianhua

“…Trogocytosis is a fast, cell-cell contact-dependent uptake of membrane patches and associated molecules by one cell from another. Here, we report our…”
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CSF1R inhibitor PLX5622 and environmental enrichment additively improve metabolic outcomes in middle-aged female mice by Ali, Seemaab, Mansour, Anthony G, Huang, Wei, Queen, Nicholas J, Mo, Xiaokui, Anderson, Jacqueline M, Hassan, 2nd, Quais N, Patel, Ripal S, Wilkins, Ryan K, Caligiuri, Michael A, Cao, Lei

“…As the elderly population grows, chronic metabolic dysfunction including obesity and diabetes are becoming increasingly common comorbidities. Hypothalamic…”
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Social isolation exacerbates diet-induced obesity and peripheral inflammation in young male mice under thermoneutrality by Queen, Nicholas J., Huang, Wei, Komatineni, Suraj, Mansour, Anthony G., Xiao, Run, Chrislip, Logan A., Cao, Lei

“…Social isolation (SI) is associated with an increased risk of mortality and various chronic diseases—including obesity—in humans. Murine studies probing SI…”
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Transfusion Therapy in Children With Sickle Cell Disease by Inati, Adlette, Mansour, Anthony G, Sabbouh, Toni, Amhez, Ghid, Hachem, Ahmad, Abbas, Hussein A

“…Hydroxyurea, blood transfusions, and hematopoietic stem cell transplantation represent the 3 disease-modifying therapies in children with sickle cell disease…”
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An optimized xylene-free protein extraction method adapted to formalin-fixed paraffin embedded tissue sections for western blot analysis by Mansour, Anthony G, Khalil, Pamela Abou, Bejjani, Noha, Chatila, Rajaa, Dagher-Hamalian, Carole, Faour, Wissam H

“…Deparaffinization of formalin-fixed paraffin embedded (FFPE) tissues with xylene currently remains a major challenge to the biomedical community. We developed…”
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