Search Results - "Mansoor, Najia"
-
1
Anticancer effect of Indanone-based thiazolyl hydrazone derivative on p53 mutant colorectal cancer cell lines: An in vitro and in vivo study
Published in Frontiers in oncology (04-08-2022)“…Colorectal cancer is a major health problem, and it is the third most diagnosed cancer in the United States. The current treatment for colorectal cancer…”
Get full text
Journal Article -
2
Enzyme and Transporter Kinetics for CPT-11 (Irinotecan) and SN-38: An Insight on Tumor Tissue Compartment Pharmacokinetics Using PBPK
Published in Recent patents on anti-cancer drug discovery (01-01-2019)“…Computational tools are becoming more and more powerful and comprehensive as compared to past decades in facilitating pharmaceutical, pharmacological and…”
Get more information
Journal Article -
3
Prediction of Clearance in Neonates and Infants (≤ 3 Months of Age) for Drugs That Are Glucuronidated: A Comparative Study Between Allometric Scaling and Physiologically Based Pharmacokinetic Modeling
Published in Journal of clinical pharmacology (01-04-2017)“…The objective of this study was to evaluate the predictive performances of allometric models and a physiologically based pharmacokinetic model (PBPK) to…”
Get full text
Journal Article -
4
Pharmacokinetics of Midazolam in preterm neonates with an insight in brain Tissue: A PBPK approach
Published in Pakistan journal of pharmaceutical sciences (01-09-2022)“…Physiological maturity is a gradual process taking place throughout infancy and childhood. Though for years anatomical growth has been the basis for dose…”
Get full text
Journal Article -
5
Prediction of Clearance and Dose of Midazolam in Preterm and Term Neonates: A Comparative Study Between Allometric Scaling and Physiologically Based Pharmacokinetic Modeling
Published in American journal of therapeutics (01-01-2019)“…Children are not small adults because besides size there are subtle physiological and biochemical differences between children and adults. Like adults,…”
Get full text
Journal Article -
6
Physiologically based pharmacokinetic modeling for predicting irinotecan exposure in human body
Published in Oncotarget (18-07-2017)“…Colorectal cancer is the third leading cause of cancer-related deaths in the United States. Treatment of colorectal cancer remains a challenge to clinicians as…”
Get full text
Journal Article -
7
WB‐PBPK approach in predicting zidovudine pharmacokinetics in preterm neonates
Published in Biopharmaceutics & drug disposition (01-11-2019)“…Antiretroviral therapy has been the mainstay of treatment for neonates born to HIV infected mothers. Neonates born prematurely to HIV positive mothers are…”
Get full text
Journal Article -
8
Analyses of bile from gallbladders of Arius platystomus, Arius tenuispinis, Pomadasys commersonni and Kishinoella tonggol
Published in Pakistan journal of pharmaceutical sciences (01-07-2015)“…Bile from gallbladders of Arius platystomus (Singhara), Arius tenuispinis (Khagga), Pomadasys commersonni (Holoola) and Kishinoella tonggol (Dawan) were…”
Get full text
Journal Article -
9
Antineoplastic activity of Holoptelea integrifolia (Roxb.) Planch bark extracts (in vitro)
Published in Pakistan journal of pharmaceutical sciences (01-11-2013)“…Cancer remains the major public health concern with a number of cancer patients relying on chemotherapy as a treatment option. Although, advances in biomedical…”
Get full text
Journal Article -
10
Antineoplastic activity of Holoptelea integrifolia
Published in Pakistan journal of pharmaceutical sciences (01-11-2013)Get full text
Journal Article