Search Results - "Mansfield, Pamela J."

Interleukin 18 induces angiogenesis in vitro and in vivo via Src and Jnk kinases by Amin, M Asif, Rabquer, Bradley J, Mansfield, Pamela J, Ruth, Jeffrey H, Marotte, Hubert, Haas, Christian S, Reamer, Elyse N, Koch, Alisa E

“…Interleukin 18 (IL-18) is a novel mediator of angiogenesis in rheumatoid arthritis (RA). To examine the role of IL-18 in RA angiogenesis and the signalling…”
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Enhanced Phagocytosis through Inhibition of de Novo Ceramide Synthesis by Hinkovska-Galcheva, Vania, Boxer, Laurence, Mansfield, Pamela J., Schreiber, Alan D., Shayman, James A.

“…Fcγ receptors are important mediators of the binding of IgG to and induction of phagocytosis in neutrophils. COS-1 cells provide a potentially useful model for…”
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Migration inhibitory factor up-regulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 via Src, PI3 kinase, and NFκB by Amin, M. Asif, Haas, Christian S., Zhu, Kui, Mansfield, Pamela J., Kim, Michael J., Lackowski, Nicholas P., Koch, Alisa E.

“…Cell adhesion molecules are critical in monocyte (MN) recruitment in immune-mediated and hematologic diseases. We investigated the novel role of recombinant…”
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Regulation of polymorphonuclear leukocyte degranulation and oxidant production by ceramide through inhibition of phospholipase D by Mansfield, Pamela J., Hinkovska-Galcheva, Vania, Carey, Shannon S., Shayman, James A., Boxer, Laurence A.

“…Exogenous C2-ceramide has been shown to inhibit polymorphonuclear leukocyte (PMN) phagocytosis through inhibition of phospholipase D (PLD) and downstream…”
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Regulation of polymorphonuclear leukocyte phagocytosis by myosin light chain kinase after activation of mitogen-activated protein kinase by Mansfield, Pamela J., Shayman, James A., Boxer, Laurence A.

“…Polymorphonuclear leukocyte (PMNL) phagocytosis mediated by FcγRII proceeds in concert with activation of the mitogen-activated protein (MAP) kinase,…”
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Interleukin‐18 induces angiogenic factors in rheumatoid arthritis synovial tissue fibroblasts via distinct signaling pathways by Amin, Mohammad A., Mansfield, Pamela J., Pakozdi, Angela, Campbell, Phillip L., Ahmed, Salahuddin, Martinez, Rita J., Koch, Alisa E.

“…Objective Interleukin‐18 (IL‐18) is a proinflammatory cytokine implicated in the pathogenesis of rheumatoid arthritis (RA). This study was undertaken to…”
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The Formation of Ceramide-1-phosphate during Neutrophil Phagocytosis and Its Role in Liposome Fusion by Hinkovska-Galcheva, V T, Boxer, L A, Mansfield, P J, Harsh, D, Blackwood, A, Shayman, J A

“…Ceramide, a product of agonist-stimulated sphingomyelinase activation, is known to be generated during the phagocytosis of antibody-coated erythrocytes by…”
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Syk Activation Initiates Downstream Signaling Events During Human Polymorphonuclear Leukocyte Phagocytosis by Raeder, Evelin M. B, Mansfield, Pamela J, Hinkovska-Galcheva, Vania, Shayman, James A, Boxer, Laurence A

“…We investigated the requirement for Syk activation to initiate downstream signaling events during polymorphonuclear leukocyte (PMN) phagocytosis of Ab-coated…”
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Ceramide inhibition of phospholipase D and its relationship to RhoA and ARF1 translocation in GTPγS-stimulated polymorphonuclear leukocytes by Mansfield, Pamela J., Carey, Shannon S., Hinkovska-Galcheva, Vania, Shayman, James A., Boxer, Laurence A.

“…Phospholipase D (PLD) regulates the polymorphonuclear leukocyte (PMN) functions of phagocytosis, degranulation, and oxidant production. Ceramide inhibition of…”
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Sphingosine Blocks Human Polymorphonuclear Leukocyte Phagocytosis Through Inhibition of Mitogen-Activated Protein Kinase Activation by Raeder, Evelin M.B., Mansfield, Pamela J., Hinkovska-Galcheva, Vania, Kjeldsen, Lars, Shayman, James A., Boxer, Laurence A.

“…In the present study, we investigated the mechanism by which sphingosine and its analogues, dihydrosphingosine and phytosphingosine, inhibit polymorphonuclear…”
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Neutrophil thrombospondin receptors are linked to GTP-binding proteins by Suchard, Suzanne J., Mansfield, Pamela J.

“…The extracellular matrix (ECM) protein thrombospondin (TSP) binds to specific receptors on polymorphonuclear leukocytes (PMNs) and stimulates motility. TSP can…”
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Motility of human carcinoma cells in response to thrombospondin : relationship to metastatic potential and thrombospondin structural domains by YABKOWITZ, R, MANSFIELD, P. J, DIXIT, V. M, SUCHARD, S. J

“…The interactions of tumorigenic cells with the extracellular matrix play a critical role in the establishment of metastases. Thrombospondin (TSP) is prominent…”
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H‐2g, a glucose analog of blood group H antigen, mediates mononuclear cell recruitment via Src and phosphatidylinositol 3‐kinase pathways by Amin, M. Asif, Ruth, Jeffrey H., Haas, Christian S., Pakozdi, Angela, Mansfield, Pamela J., Haghshenas, Jafar, Koch, Alisa E.

“…Objective Monocyte recruitment by proinflammatory cytokines is a hallmark of rheumatoid arthritis (RA). Lewisy‐6 and H (Ley/H) are blood group antigens…”
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Regulation of polymorphonuclear leukocyte phagocytosis by myosin light chain kinase after activation of mitogen-activated protein kinase by Mansfield, Pamela J., Shayman, James A., Boxer, Laurence A.

“…Polymorphonuclear leukocyte (PMNL) phagocytosis mediated by FcγRII proceeds in concert with activation of the mitogen-activated protein (MAP) kinase,…”
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Granulocyte colony-stimulating factor primes NADPH oxidase in neutrophils through translocation of cytochrome b558 by gelatinase-granule release by Mansfield, Pamela J., Hinkovska-Galcheva, Vania, Shayman, James A., Boxer, Laurence A.

“…Granulocyte colony-stimulating factor (GCSF) primes reduced neutrophil nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity in response to…”
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Response of bacteria and phytoplankton to contaminated sediments from Trenton channel, Detroit River by MOLL, R. A, MANSFIELD, P. J

“…The effect of contaminated sediments on natural bacterial and phytoplankton populations from the Trenton Channel, Detroit river, was investigated in 1986/87…”
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Phagocytic signaling molecules in lipid rafts of COS-1 cells transfected with FcgammaRIIA by Mansfield, Pamela J, Hinkovska-Galcheva, Vania, Borofsky, Michael S, Shayman, James A, Boxer, Laurence A

“…COS-1 cells bearing FcgammaRIIA were used as a model to demonstrate co-localization of several enzymes previously shown to regulate neutrophil phagocytosis. In…”
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Migration inhibitory factor up-regulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 via Src, PI3 kinase, and NFkappaB by Amin, M Asif, Haas, Christian S, Zhu, Kui, Mansfield, Pamela J, Kim, Michael J, Lackowski, Nicholas P, Koch, Alisa E

“…Cell adhesion molecules are critical in monocyte (MN) recruitment in immune-mediated and hematologic diseases. We investigated the novel role of recombinant…”
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Phagocytic Signaling Molecules in Lipid Rafts of COS-1 Cells Transfected with FcγRIIA by Mansfield, Pamela J., Hinkovska-Galcheva, Vania, Borofsky, Michael, Shayman, James A., Boxer, Laurence A.

“…FcγRIIA-mediated phagocytosis involves a number of signaling proteins and lipids, which increasingly are viewed as localizing subcellularly in plasma membrane…”
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Phagocytic signaling molecules in lipid rafts of COS-1 cells transfected with FcγRIIA by Mansfield, Pamela J., Hinkovska-Galcheva, Vania, Borofsky, Michael S., Shayman, James A., Boxer, Laurence A.

“…COS-1 cells bearing FcγRIIA were used as a model to demonstrate co-localization of several enzymes previously shown to regulate neutrophil phagocytosis. In…”
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