Search Results - "Mansfield, John C."

Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease by Lee, James C, Biasci, Daniele, Roberts, Rebecca, Gearry, Richard B, Mansfield, John C, Ahmad, Tariq, Prescott, Natalie J, Satsangi, Jack, Wilson, David C, Jostins, Luke, Anderson, Carl A, Traherne, James A, Lyons, Paul A, Parkes, Miles, Smith, Kenneth G C

“…James Lee, Kenneth Smith and colleagues report a within-cases genome-wide association analysis for Crohn's disease to identify genetic loci specifically…”
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Oral Ferric Maltol Does Not Adversely Affect the Intestinal Microbiome of Patients or Mice, But Ferrous Sulphate Does by Mahalhal, Awad, Frau, Alessandra, Burkitt, Michael D, Ijaz, Umer Z, Lamb, Christopher A, Mansfield, John C, Lewis, Stephen, Pritchard, D Mark, Probert, Chris S

“…Altering dietary ferrous sulphate (FS) consumption exacerbates a murine model of colitis and alters the intestinal microbiome. We investigated the impact of…”
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Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease by de Lange, Katrina M, Moutsianas, Loukas, Lee, James C, Lamb, Christopher A, Luo, Yang, Kennedy, Nicholas A, Jostins, Luke, Rice, Daniel L, Gutierrez-Achury, Javier, Ji, Sun-Gou, Heap, Graham, Nimmo, Elaine R, Edwards, Cathryn, Henderson, Paul, Mowat, Craig, Sanderson, Jeremy, Satsangi, Jack, Simmons, Alison, Wilson, David C, Tremelling, Mark, Hart, Ailsa, Mathew, Christopher G, Newman, William G, Parkes, Miles, Lees, Charlie W, Uhlig, Holm, Hawkey, Chris, Prescott, Natalie J, Ahmad, Tariq, Mansfield, John C, Anderson, Carl A, Barrett, Jeffrey C

“…Jeffrey Barrett, Carl Anderson and colleagues report the results of a large genome-wide association study of inflammatory bowel disease. They identify 25 new…”
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Sexually transmitted infections manifesting as proctitis by Lamb, Chris A, Lamb, Elizabeth Iris Mary, Mansfield, John C, Sankar, K Nathan

“…There is a rising incidence of several sexually transmitted infections (STIs), many of which can present with proctitis. Causative organisms include Neisseria…”
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Etrolizumab as induction therapy for ulcerative colitis: a randomised, controlled, phase 2 trial by Vermeire, Séverine, Dr, O'Byrne, Sharon, MD, Keir, Mary, PhD, Williams, Marna, PhD, Lu, Timothy T, MD, Mansfield, John C, MD, Lamb, Christopher A, MD, Feagan, Brian G, MD, Panes, Julian, MD, Salas, Azucena, PhD, Baumgart, Daniel C, MD, Schreiber, Stefan, MD, Dotan, Iris, MD, Sandborn, William J, MD, Tew, Gaik W, MSc, Luca, Diana, PhD, Tang, Meina T, PhD, Diehl, Lauri, DVM, Eastham-Anderson, Jeffrey, MS, De Hertogh, Gert, MD, Perrier, Clementine, PhD, Egen, Jackson G, PhD, Kirby, John A, PhD, van Assche, Gert, MD, Rutgeerts, Paul, MD

“…Summary Background Etrolizumab is a humanised monoclonal antibody that selectively binds the β7 subunit of the heterodimeric integrins α4β7 and αEβ7. We aimed…”
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Conserved γδ T cell selection by BTNL proteins limits progression of human inflammatory bowel disease by Dart, Robin J, Zlatareva, Iva, Vantourout, Pierre, Theodoridis, Efstathios, Amar, Ariella, Kannambath, Shichina, East, Philip, Recaldin, Timothy, Mansfield, John C, Lamb, Christopher A, Parkes, Miles, Irving, Peter M, Prescott, Natalie J, Hayday, Adrian C

“…Murine intraepithelial γδ T cells include distinct tissue-protective cells selected by epithelial butyrophilin-like (BTNL) heteromers. To determine whether…”
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Regulation and Role of αE Integrin and Gut Homing Integrins in Migration and Retention of Intestinal Lymphocytes during Inflammatory Bowel Disease by Keir, Mary E., Fuh, Franklin, Ichikawa, Ryan, Acres, Meghan, Hackney, Jason A., Hulme, Gillian, Carey, Christopher D., Palmer, Jeremy, Jones, Claire J., Long, Anna K., Jiang, Jenny, Klabunde, Sha, Mansfield, John C., Looney, Cary M., Faubion, William A., Filby, Andrew, Kirby, John A., McBride, Jacqueline, Lamb, Christopher A.

“…Abstract Targeting interactions between α4β7 integrin and endothelial adhesion molecule MAdCAM-1 to inhibit lymphocyte migration to the gastrointestinal tract…”
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Association Between Response to Etrolizumab and Expression of Integrin αE and Granzyme A in Colon Biopsies of Patients With Ulcerative Colitis by Tew, Gaik W, Hackney, Jason A, Gibbons, Deena, Lamb, Christopher A, Luca, Diana, Egen, Jackson G, Diehl, Lauri, Eastham Anderson, Jeff, Vermeire, Severine, Mansfield, John C, Feagan, Brian G, Panes, Julian, Baumgart, Daniel C, Schreiber, Stefan, Dotan, Iris, Sandborn, William J, Kirby, John A, Irving, Peter M, De Hertogh, Gert, Van Assche, Gert A, Rutgeerts, Paul, O’Byrne, Sharon, Hayday, Adrian, Keir, Mary E

“…Background & Aims Etrolizumab is a humanized monoclonal antibody against the β7 integrin subunit that has shown efficacy vs placebo in patients with moderate…”
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Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7 by Luo, Yang, de Lange, Katrina M, Jostins, Luke, Moutsianas, Loukas, Randall, Joshua, Kennedy, Nicholas A, Lamb, Christopher A, McCarthy, Shane, Ahmad, Tariq, Edwards, Cathryn, Serra, Eva Goncalves, Hart, Ailsa, Hawkey, Chris, Mansfield, John C, Mowat, Craig, Newman, William G, Nichols, Sam, Pollard, Martin, Satsangi, Jack, Simmons, Alison, Tremelling, Mark, Uhlig, Holm, Wilson, David C, Lee, James C, Prescott, Natalie J, Lees, Charlie W, Mathew, Christopher G, Parkes, Miles, Barrett, Jeffrey C, Anderson, Carl A

“…Carl Anderson, Jeffrey Barrett and colleagues use whole-genome sequencing and imputation to explore the genetic architecture of inflammatory bowel disease…”
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Dose escalation randomised study of efmarodocokin alfa in healthy volunteers and patients with ulcerative colitis by Wagner, Frank, Mansfield, John C, Lekkerkerker, Annemarie N, Wang, Yehong, Keir, Mary, Dash, Ajit, Butcher, Brandon, Harder, Brandon, Orozco, Luz D, Mar, Jordan S, Chen, Hao, Rothenberg, Michael E

“…The interleukin-22 cytokine (IL-22) has demonstrated efficacy in preclinical colitis models with non-immunosuppressive mechanism of action. Efmarodocokin alfa…”
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A randomised phase I study of etrolizumab (rhuMAb β7) in moderate to severe ulcerative colitis by Rutgeerts, Paul J, Fedorak, Richard N, Hommes, Daan W, Sturm, Andreas, Baumgart, Daniel C, Bressler, Brian, Schreiber, Stefan, Mansfield, John C, Williams, Marna, Tang, Meina, Visich, Jennifer, Wei, Xiaohui, Keir, Mary, Luca, Diana, Danilenko, Dimitri, Egen, Jackson, O'Byrne, Sharon

“…Etrolizumab (rhuMAb β7, anti-β7, PRO145223) is a humanised monoclonal antibody targeting the β7 subunit of the heterodimeric integrins α4β7 and αEβ7, which are…”
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Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway by Lee, James C., Espéli, Marion, Anderson, Carl A., Linterman, Michelle A., Pocock, Joanna M., Williams, Naomi J., Roberts, Rebecca, Viatte, Sebastien, Fu, Bo, Peshu, Norbert, Hien, Tran Tinh, Phu, Nguyen Hoan, Wesley, Emma, Edwards, Cathryn, Ahmad, Tariq, Mansfield, John C., Gearry, Richard, Dunstan, Sarah, Williams, Thomas N., Barton, Anne, Vinuesa, Carola G., Phillips, Anne, Mowat, Craig, Drummond, Hazel, Kennedy, Nick, Lees, Charlie W., Satsangi, Jack, Taylor, Kirstin, Prescott, Natalie J., Mathew, Christopher G., Simpson, Peter, Simmons, Alison, Khan, Mohammed, Newman, William G., Hawkey, Christopher, Hart, Ailsa, Wilson, David C., Henderson, Paul, Barrett, Jeffrey C., Parkes, Miles, Lyons, Paul A., Smith, Kenneth G.C.

“…The clinical course and eventual outcome, or prognosis, of complex diseases varies enormously between affected individuals. This variability critically…”
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Negligible impact of rare autoimmune-locus coding-region variants on missing heritability by Hunt, Karen A., Mistry, Vanisha, Bockett, Nicholas A., Ahmad, Tariq, Ban, Maria, Barker, Jonathan N., Barrett, Jeffrey C., Blackburn, Hannah, Brand, Oliver, Burren, Oliver, Capon, Francesca, Compston, Alastair, Gough, Stephen C. L., Jostins, Luke, Kong, Yong, Lee, James C., Lek, Monkol, MacArthur, Daniel G., Mansfield, John C., Mathew, Christopher G., Mein, Charles A., Mirza, Muddassar, Nutland, Sarah, Onengut-Gumuscu, Suna, Papouli, Efterpi, Parkes, Miles, Rich, Stephen S., Sawcer, Steven, Satsangi, Jack, Simmonds, Matthew J., Trembath, Richard C., Walker, Neil M., Wozniak, Eva, Todd, John A., Simpson, Michael A., Plagnol, Vincent, van Heel, David A.

“…A search for variants in coding exons of 25 genome-wide association study risk genes in a large cohort of autoimmune patients finds that rare coding-region…”
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Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility by Parkes, Miles, Barrett, Jeffrey C, Prescott, Natalie J, Tremelling, Mark, Anderson, Carl A, Fisher, Sheila A, Roberts, Roland G, Nimmo, Elaine R, Cummings, Fraser R, Soars, Dianne, Drummond, Hazel, Lees, Charlie W, Khawaja, Saud A, Bagnall, Richard, Burke, Denis A, Todhunter, Catherine E, Ahmad, Tariq, Onnie, Clive M, McArdle, Wendy, Strachan, David, Bethel, Graeme, Bryan, Claire, Lewis, Cathryn M, Deloukas, Panos, Forbes, Alastair, Sanderson, Jeremy, Jewell, Derek P, Satsangi, Jack, Mansfield, John C, Cardon, Lon, Mathew, Christopher G

“…A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel…”
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The Impact of NOD2 Genetic Variants on the Gut Mycobiota in Crohn’s Disease Patients in Remission and in Individuals Without Gastrointestinal Inflammation by Nelson, Andrew, Stewart, Christopher J, Kennedy, Nicholas A, Lodge, John K, Tremelling, Mark, Probert, Chris S, Parkes, Miles, Mansfield, John C, Smith, Darren L, Hold, Georgina L, Lees, Charlie W, Bridge, Simon H, Lamb, Christopher A

“…Abstract Background and Aims Historical and emerging data implicate fungi in Crohn’s disease [CD] pathogenesis. However, a causal link between mycobiota,…”
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αEβ7 Integrin Identifies Subsets of Pro-Inflammatory Colonic CD4+ T Lymphocytes in Ulcerative Colitis by Lamb, Christopher A, Mansfield, John C, Tew, Gaik W, Gibbons, Deena, Long, Anna K, Irving, Peter, Diehl, Lauri, Eastham-Anderson, Jeff, Price, Maria B, O'Boyle, Graeme, Jones, David E J, O'Byrne, Sharon, Hayday, Adrian, Keir, Mary E, Egen, Jackson G, Kirby, John A

“…The αEβ7 integrin is crucial for retention of T lymphocytes at mucosal surfaces through its interaction with E-cadherin. Pathogenic or protective functions of…”
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Measurement methods and accuracy in copy number variation: failure to replicate associations of beta-defensin copy number with Crohn's disease by Aldhous, Marian C., Abu Bakar, Suhaili, Prescott, Natalie J., Palla, Raquel, Soo, Kimberley, Mansfield, John C., Mathew, Christopher G., Satsangi, Jack, Armour, John A.L.

“…The copy number variation in beta-defensin genes on human chromosome 8 has been proposed to underlie susceptibility to inflammatory disorders, but presents…”
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Investigation of Crohn's Disease Risk Loci in Ulcerative Colitis Further Defines Their Molecular Relationship by Anderson, Carl A, Massey, Dunecan C.O, Barrett, Jeffrey C, Prescott, Natalie J, Tremelling, Mark, Fisher, Sheila A, Gwilliam, Rhian, Jacob, Jemima, Nimmo, Elaine R, Drummond, Hazel, Lees, Charlie W, Onnie, Clive M, Hanson, Catherine, Blaszczyk, Katarzyna, Ravindrarajah, Radhi, Hunt, Sarah, Varma, Dhiraj, Hammond, Naomi, Lewis, Gregory, Attlesey, Heather, Watkins, Nick, Ouwehand, Willem, Strachan, David, McArdle, Wendy, Lewis, Cathryn M, Lobo, Alan, Sanderson, Jeremy, Jewell, Derek P, Deloukas, Panos, Mansfield, John C, Mathew, Christopher G, Satsangi, Jack, Parkes, Miles

“…Background & Aims Identifying shared and disease-specific susceptibility loci for Crohn's disease (CD) and ulcerative colitis (UC) would help define the…”
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The prevention and management of Crohn’s disease postoperative recurrence: results from the Y-ECCO/ClinCom 2019 Survey by Dragoni, Gabriele, Ding, Nik, Gecse, Krisztina B., Mansfield, John C., Kopylov, Uri, Beaugerie, Laurent, Bossuyt, Peter, Sebastian, Shaji, Milla, Monica, Bagnoli, Siro, Yassin, Nuha A., Bettenworth, Dominik, Burisch, Johan, Hedin, Charlotte, Gisbert, Javier P., Ferrante, Marc

“…BACKGROUND:Prevention and management of postoperative recurrence (POR) is a controversial field in Crohn’s disease. The aim of this survey was to report common…”
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Pooled sequencing of 531 genes in inflammatory bowel disease identifies an associated rare variant in BTNL2 and implicates other immune related genes by Prescott, Natalie J, Lehne, Benjamin, Stone, Kristina, Lee, James C, Taylor, Kirstin, Knight, Jo, Papouli, Efterpi, Mirza, Muddassar M, Simpson, Michael A, Spain, Sarah L, Lu, Grace, Fraternali, Franca, Bumpstead, Suzannah J, Gray, Emma, Amar, Ariella, Bye, Hannah, Green, Peter, Chung-Faye, Guy, Hayee, Bu'Hussain, Pollok, Richard, Satsangi, Jack, Parkes, Miles, Barrett, Jeffrey C, Mansfield, John C, Sanderson, Jeremy, Lewis, Cathryn M, Weale, Michael E, Schlitt, Thomas, Mathew, Christopher G

“…The contribution of rare coding sequence variants to genetic susceptibility in complex disorders is an important but unresolved question. Most studies thus far…”
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