Search Results - "Mansergh, Fiona C."

Cell therapy using retinal progenitor cells shows therapeutic effect in a chemically-induced rotenone mouse model of Leber hereditary optic neuropathy by Mansergh, Fiona C, Chadderton, Naomi, Kenna, Paul F, Gobbo, Oliviero L, Farrar, G Jane

“…Primary mitochondrial disorders occur at a prevalence of one in 10 000; ∼50% of these demonstrate ocular pathology. Leber hereditary optic neuropathy (LHON) is…”
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Risk factors and biomarkers of age-related macular degeneration by Lambert, Nathan G., ElShelmani, Hanan, Singh, Malkit K., Mansergh, Fiona C., Wride, Michael A., Padilla, Maximilian, Keegan, David, Hogg, Ruth E., Ambati, Balamurali K.

“…A biomarker can be a substance or structure measured in body parts, fluids or products that can affect or predict disease incidence. As age-related macular…”
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Osteopenia in Sparc (osteonectin)-deficient mice: characterization of phenotypic determinants of femoral strength and changes in gene expression by Mansergh, Fiona C, Wells, Timothy, Elford, Carole, Evans, Samuel L, Perry, Mark J, Evans, Martin J, Evans, Bronwen A. J

“…1 School of Biosciences, Cardiff University, Cardiff 2 Department of Child Health, Cardiff University, Cardiff 3 School of Engineering, Cardiff University,…”
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Gene expression changes during retinal development and rod specification by Mansergh, Fiona C, Carrigan, Matthew, Hokamp, Karsten, Farrar, G Jane

“…Retinitis pigmentosa (RP) typically results from individual mutations in any one of >70 genes that cause rod photoreceptor cells to degenerate prematurely,…”
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Gene therapies for inherited retinal disorders by Farrar, G Jane, Millington-Ward, Sophia, Chadderton, Naomi, Mansergh, Fiona C, Palfi, Arpad

“…Significant advances have been made over the last decade or two in the elucidation of the molecular pathogenesis of inherited ocular disorders. In particular,…”
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Survivin expression is associated with lens epithelial cell proliferation and fiber cell differentiation by Jarrin, Miguel, Mansergh, Fiona C, Boulton, Michael E, Gunhaga, Lena, Wride, Michael A

“…Survivin (Birc5) is the smallest member of the inhibitor of apoptosis (IAP) protein family, which regulates the cell cycle/apoptosis balance. The purpose of…”
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Loss of photoreceptor potential from retinal progenitor cell cultures, despite improvements in survival by Mansergh, Fiona C., Vawda, Reaz, Millington-Ward, Sophia, Kenna, Paul F., Haas, Jochen, Gallagher, Clair, Wilson, John H., Humphries, Peter, Ader, Marius, Farrar, G. Jane

“…Retinal degeneration (RD) results from photoreceptor apoptosis. Cell transplantation, one potential therapeutic approach, requires expandable stem cells that…”
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Apoptosis gene profiling reveals spatio-temporal regulated expression of the p53/Mdm2 pathway during lens development by Geatrell, Jenny C., Mui (Iryn) Gan, Peng, Mansergh, Fiona C., Kisiswa, Lilian, Jarrin, Miguel, Williams, Llinos A., Evans, Martin J., Boulton, Mike E., Wride, Michael A.

“…Evidence is emerging for apoptosis gene expression in the lens during development. Therefore, here we used a filter array to assess expression of 243…”
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Gene expression profiles during early differentiation of mouse embryonic stem cells by Mansergh, Fiona C, Daly, Carl S, Hurley, Anna L, Wride, Michael A, Hunter, Susan M, Evans, Martin J

“…Understanding the mechanisms controlling stem cell differentiation is the key to future advances in tissue and organ regeneration. Embryonic stem (ES) cell…”
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Developmentally regulated expression of hemoglobin subunits in avascular tissues by Mansergh, Fiona C, Hunter, Susan M, Geatrell, Jenny C, Jarrin, Miguel, Powell, Kate, Evans, Martin J, Wride, Michael A

“…We investigated the spatio-temporal profile of hemoglobin subunit expression in developing avascular tissues. Significant up-regulation of hemoglobin subunits…”
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Expression profiling and gene discovery in the mouse lens by Wride, Michael A, Mansergh, Fiona C, Adams, Steffan, Everitt, Rebecca, Minnema, Stephanie E, Rancourt, Derrick E, Evans, Martin J

“…Defects in the development and physiology of the lens can result in cataracts (opacification of the lens), which are currently treatable only by surgical…”
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Gene expression changes during cataract progression in Sparc null mice: differential regulation of mouse globins in the lens by Mansergh, Fiona C, Wride, Michael A, Walker, Veronica E, Adams, Steffan, Hunter, Susan M, Evans, Martin J

“…Sparc/osteonectin is a hydroxyapatite, calcium and, collagen binding protein, implicated in tissue morphogenesis, cell proliferation, and repair. Sparc null…”
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Developmentally regulated expression of hemoglobin subunits in avascular tissues by Mansergh, Fiona C., Hunter, Susan M., Geatrell, Jenny C., Jarrin, Miguel, Powell, Kate, Evans, Martin J., Wride, Michael A.

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Novel mutations in the TIGR gene in early and late onset open angle glaucoma by Mansergh, Fiona C., Kenna, Paul F., Ayuso, Carmen, Kiang, Anna-Sophia, Humphries, Peter, Farrar, G. Jane

“…A gene for juvenile onset, open angle glaucoma (JOAG) has been localized to chromosome 1q21‐31 in several families. Mutations in the trabecular…”
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Characterization and in silico mapping of a novel murine zinc finger transcription factor by Wride, Michael A, Mansergh, Fiona C, Somani, Jamila M, Winkfein, Robert J, Rancourt, Derrick E

“…Transcription factors play important roles in development and homeostasis. We have completed an embryonic stem cell-based neural differentiation screen, which…”
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Optimization of minuscule samples for use with cDNA microarrays by Hunter, Susan McLean, Mansergh, Fiona C., Evans, Martin J.

“…The recent advent of microarray technology and RNA amplification allows us to compare the expression profiles of thousands of genes from small amounts of…”
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Deficiency of SPARC suppresses intestinal tumorigenesis in APCMin/+ mice. Commentary by GREGORIEFF, Alex, CLEVERS, Hans, SANSOM, Owen J, MANSERGH, Fiona C, EVANS, Martin J, WILKINS, Julie A, CLARKE, Alan R

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Deficiency of SPARC suppresses intestinal tumorigenesis in APCMin/+ mice by Sansom, Owen J, Mansergh, Fiona C, Evans, Martin J, Wilkins, Julie A, Clarke, Alan R

“…Background and aims: SPARC (secreted protein acidic, rich in cysteine) is a matricellular protein that has been found to be activated in a number of human…”
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A novel Asp380Ala mutation in the GLC1A/myocilin gene in a family with juvenile onset primary open angle glaucoma by Kennan, A M, Mansergh, F C, Fingert, J H, Clark, T, Ayuso, C, Kenna, P F, Humphries, P, Farrar, G J

“…Glaucoma describes a clinically and genetically heterogeneous group of diseases that result in optic neuropathy and progressive loss of visual fields. A gene…”
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Retinitis Pigmentosa and Progressive Sensorineural Hearing Loss Caused by a C12258A Mutation in the Mitochondrial MTTS2 Gene by Mansergh, Fiona C., Millington-Ward, Sophia, Kennan, Avril, Kiang, Anna-Sophia, Humphries, Marian, Farrar, G. Jane, Humphries, Peter, Kenna, Paul F.

“…Family ZMK is a large Irish kindred that segregates progressive sensorineural hearing loss and retinitis pigmentosa. The symptoms in the family are almost…”
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