Search Results - "Mans, A."

CCDC151 Mutations Cause Primary Ciliary Dyskinesia by Disruption of the Outer Dynein Arm Docking Complex Formation by Hjeij, Rim, Onoufriadis, Alexandros, Watson, Christopher M., Slagle, Christopher E., Klena, Nikolai T., Dougherty, Gerard W., Kurkowiak, Małgorzata, Loges, Niki T., Diggle, Christine P., Morante, Nicholas F.C., Gabriel, George C., Lemke, Kristi L., Li, You, Pennekamp, Petra, Menchen, Tabea, Konert, Franziska, Marthin, June Kehlet, Mans, Dorus A., Letteboer, Stef J.F., Werner, Claudius, Burgoyne, Thomas, Westermann, Cordula, Rutman, Andrew, Carr, Ian M., O’Callaghan, Christopher, Moya, Eduardo, Chung, Eddie M.K., Sheridan, Eamonn, Nielsen, Kim G., Roepman, Ronald, Bartscherer, Kerstin, Burdine, Rebecca D., Lo, Cecilia W., Omran, Heymut, Mitchison, Hannah M.

“…A diverse family of cytoskeletal dynein motors powers various cellular transport systems, including axonemal dyneins generating the force for ciliary and…”
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Overexpression of Human Apolipoprotein A-I Preserves Cognitive Function and Attenuates Neuroinflammation and Cerebral Amyloid Angiopathy in a Mouse Model of Alzheimer Disease by Lewis, Terry L., Cao, Dongfeng, Lu, Hailin, Mans, Robert A., Su, Yan Ru, Jungbauer, Lisa, Linton, MacRae F., Fazio, Sergio, LaDu, Mary Jo, Li, Ling

“…To date there is no effective therapy for Alzheimer disease (AD). High levels of circulating high density lipoprotein (HDL) and its main protein,…”
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Characterization of the a-Si EPID in the unity MR-linac for dosimetric applications by Torres-Xirau, I, Olaciregui-Ruiz, I, Baldvinsson, G, Mijnheer, B J, van der Heide, U A, Mans, A

“…Electronic portal imaging devices (EPIDs) are frequently used in external beam radiation therapy for dose verification purposes. The aim of this study was to…”
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Active transport and diffusion barriers restrict Joubert Syndrome-associated ARL13B/ARL-13 to an Inv-like ciliary membrane subdomain by Cevik, Sebiha, Sanders, Anna A W M, Van Wijk, Erwin, Boldt, Karsten, Clarke, Lara, van Reeuwijk, Jeroen, Hori, Yuji, Horn, Nicola, Hetterschijt, Lisette, Wdowicz, Anita, Mullins, Andrea, Kida, Katarzyna, Kaplan, Oktay I, van Beersum, Sylvia E C, Man Wu, Ka, Letteboer, Stef J F, Mans, Dorus A, Katada, Toshiaki, Kontani, Kenji, Ueffing, Marius, Roepman, Ronald, Kremer, Hannie, Blacque, Oliver E

“…Cilia are microtubule-based cell appendages, serving motility, chemo-/mechano-/photo- sensation, and developmental signaling functions. Cilia are comprised of…”
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Error detection during VMAT delivery using EPID-based 3D transit dosimetry by Mijnheer, B., Jomehzadeh, A., González, P., Olaciregui-Ruiz, I., Rozendaal, R., Shokrani, P., Spreeuw, H., Tielenburg, R., Mans, A.

“…•EPID-based 3D transit dosimetry can pick up serious delivery errors.•A change in phantom thickness of 1 cm was detected for all cases.•Errors in setup and…”
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Automatic in vivo portal dosimetry of all treatments by Olaciregui-Ruiz, I, Rozendaal, R, Mijnheer, B, van Herk, M, Mans, A

“…At our institution EPID (electronic portal imaging device) dosimetry is routinely applied to perform in vivo dose verification of all patient treatments with…”
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Catching errors with in vivo EPID dosimetry by Mans, A., Wendling, M., McDermott, L. N., Sonke, J.-J., Tielenburg, R., Vijlbrief, R., Mijnheer, B., van Herk, M., Stroom, J. C.

“…The potential for detrimental incidents and the ever increasing complexity of patient treatments emphasize the need for accurate dosimetric verification in…”
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Rapid Angiogenesis Onset after Discontinuation of Sunitinib Treatment of Renal Cell Carcinoma Patients by GRIFFIOEN, Arjan W, MANS, Laurie A, DE GRAAF, Annemarie M. A, NOWAK-SLIWINSKA, Patrycja, DE HOOG, Céline L. M. M, DE JONG, Trees A. M, VYTH-DREESE, Florry A, BEIJNUM, Judy R. Van, BEX, Axel, JONASCH, Eric

“…To investigate the angiogenic changes in primary tumor tissue of renal cell carcinoma (RCC) patients treated with VEGF-targeted therapy. Phase II trials of…”
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Non-syndromic retinal ciliopathies: translating gene discovery into therapy by ESTRADA-CUZCANO, Alejandro, ROEPMAN, Ronald, CREMERS, Frans P. M, DEN HOLLANDER, Anneke I, MANS, Dorus A

“…Homozygosity mapping and exome sequencing have accelerated the discovery of gene mutations and modifier alleles implicated in inherited retinal degeneration in…”
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C14ORF179 encoding IFT43 is mutated in Sensenbrenner syndrome by Arts, Heleen H, Bongers, Ernie M H F, Mans, Dorus A, van Beersum, Sylvia E C, Oud, Machteld M, Bolat, Emine, Spruijt, Liesbeth, Cornelissen, Elisabeth A M, Schuurs-Hoeijmakers, Janneke H M, de Leeuw, Nicole, Cormier-Daire, Valérie, Brunner, Han G, Knoers, Nine V A M, Roepman, Ronald

“…Sensenbrenner syndrome is a heterogeneous ciliopathy that is characterised by skeletal and ectodermal anomalies, accompanied by chronic renal failure, heart…”
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The Ciliopathy Protein CC2D2A Associates with NINL and Functions in RAB8-MICAL3-Regulated Vesicle Trafficking by Bachmann-Gagescu, Ruxandra, Dona, Margo, Hetterschijt, Lisette, Tonnaer, Edith, Peters, Theo, de Vrieze, Erik, Mans, Dorus A, van Beersum, Sylvia E C, Phelps, Ian G, Arts, Heleen H, Keunen, Jan E, Ueffing, Marius, Roepman, Ronald, Boldt, Karsten, Doherty, Dan, Moens, Cecilia B, Neuhauss, Stephan C F, Kremer, Hannie, van Wijk, Erwin

“…Ciliopathies are a group of human disorders caused by dysfunction of primary cilia, ubiquitous microtubule-based organelles involved in transduction of…”
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Ciliopathies with Skeletal Anomalies and Renal Insufficiency due to Mutations in the IFT-A Gene WDR19 by Bredrup, Cecilie, Saunier, Sophie, Oud, Machteld M., Fiskerstrand, Torunn, Hoischen, Alexander, Brackman, Damien, Leh, Sabine M., Midtbø, Marit, Filhol, Emilie, Bole-Feysot, Christine, Nitschké, Patrick, Gilissen, Christian, Haugen, Olav H., Sanders, Jan-Stephan F., Stolte-Dijkstra, Irene, Mans, Dorus A., Steenbergen, Eric J., Hamel, Ben C.J., Matignon, Marie, Pfundt, Rolph, Jeanpierre, Cécile, Boman, Helge, Rødahl, Eyvind, Veltman, Joris A., Knappskog, Per M., Knoers, Nine V.A.M., Roepman, Ronald, Arts, Heleen H.

“…A subset of ciliopathies, including Sensenbrenner, Jeune, and short-rib polydactyly syndromes are characterized by skeletal anomalies accompanied by multiorgan…”
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Possible Risk Factors and Their Potential Associations with Combined Heavy Metal Exposures in Pregnant Women in the Republic of Suriname by Sewberath Misser, Vinoj H, Hindori-Mohangoo, Ashna D, Shankar, Arti, Lichtveld, Maureen, Wickliffe, Jeffrey, Mans, Dennis R A

“…The exposure of pregnant women to multiple environmental pollutants may be more disadvantageous to birth outcomes when compared to single-compound…”
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The tumor suppressor LKB1 regulates starvation-induced autophagy under systemic metabolic stress by Mans, Laurie A., Querol Cano, Laia, van Pelt, Jason, Giardoglou, Panagiota, Keune, Willem-Jan, Haramis, Anna-Pavlina G.

“…Autophagy is an evolutionarily conserved process that degrades cellular components to restore energy homeostasis under limited nutrient conditions. How this…”
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Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation by Mans, R.A, McMahon, L.L, Li, L

“…Abstract Simvastatin (SV), a competitive inhibitor of 3-hydroxy-3-methylglutaryl CoA reductase and a widely prescribed treatment for hypercholesterolemia,…”
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Disruption of intraflagellar protein transport in photoreceptor cilia causes Leber congenital amaurosis in humans and mice by Boldt, Karsten, Mans, Dorus A, Won, Jungyeon, van Reeuwijk, Jeroen, Vogt, Andreas, Kinkl, Norbert, Letteboer, Stef J F, Hicks, Wanda L, Hurd, Ron E, Naggert, Jürgen K, Texier, Yves, den Hollander, Anneke I, Koenekoop, Robert K, Bennett, Jean, Cremers, Frans P M, Gloeckner, Christian J, Nishina, Patsy M, Roepman, Ronald, Ueffing, Marius

“…The mutations that cause Leber congenital amaurosis (LCA) lead to photoreceptor cell death at an early age, causing childhood blindness. To unravel the…”
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Simvastatin enhances hippocampal long-term potentiation in C57BL/6 mice by Mans, R.A, Chowdhury, N, Cao, D, McMahon, L.L, Li, L

“…Abstract Statins inhibit 3-hydroxy-3-methylglutaryl CoA reductase, the rate-limiting enzyme in the cholesterol biosynthetic pathway, and they are widely used…”
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Elution Profile Analysis of SDS-induced Subcomplexes by Quantitative Mass Spectrometry by Texier, Yves, Toedt, Grischa, Gorza, Matteo, Mans, Dorus A., van Reeuwijk, Jeroen, Horn, Nicola, Willer, Jason, Katsanis, Nicholas, Roepman, Ronald, Gibson, Toby J., Ueffing, Marius, Boldt, Karsten

“…Analyzing the molecular architecture of native multiprotein complexes via biochemical methods has so far been difficult and error prone. Protein complex…”
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Quantifying the Effect of Delivery Uncertainties on In Vivo 3-Dimensional Treatment Dose Verification Results by Ruiz, I. Olaciregui, Rozendaal, R.A, Gonzalez, P, van Oers, R.F.M, Mijnheer, B, Mans, A

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A back-projection algorithm in the presence of an extra attenuating medium: towards EPID dosimetry for the MR-Linac by Torres-Xirau, I, Olaciregui-Ruiz, I, Rozendaal, R A, González, P, Mijnheer, B J, Sonke, J-J, van der Heide, U A, Mans, A

“…In external beam radiotherapy, electronic portal imaging devices (EPIDs) are frequently used for pre-treatment and for in vivo dose verification. Currently,…”
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